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34 similar compounds to monomer 50451762

Compile data set for download or QSAR
Wt: 820.9
BDBM50451760
Wt: 720.8
BDBM50014096
Wt: 1055.2
BDBM50117493
Wt: 820.9
BDBM50451761
Wt: 800.7
BDBM50124777
Wt: 781.9
BDBM50124767
Wt: 570.6
BDBM50122068
Wt: 646.7
BDBM50122069
Wt: 722.8
BDBM50122070
Wt: 636.7
BDBM50122071
Wt: 696.7
BDBM50122073
Wt: 696.7
BDBM50122076
Wt: 646.7
BDBM50122061
Wt: 722.8
BDBM50122063
Wt: 696.7
BDBM50122066
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 50451760,50014096,50117493,50451761,50124777,50124767,50122068,50122069,50122070,50122071,50122073,50122076,50122061,50122063,50122066   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50451760
PNG
(CHEMBL2371220)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-9-37(56)51-35(20-28-22-46-24-50-28)41(60)54-34(18-26-12-7-11-25-10-3-4-13-29(25)26)40(59)52-32(16-8-17-47-42(44)45)39(58)53-33(38(57)49-23-36(43)55)19-27-21-48-31-15-6-5-14-30(27)31/h3-7,10-15,21-22,24,32-35,48H,2,8-9,16-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,44,45,47)/t32-,33-,34+,35-/m0/s1
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n/an/an/an/a 65n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC4R using HEK293 cells was determined by measuring cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50117493
PNG
(CHEMBL2369934 | H-His-Ser-Lys-Arg-Arg-Leu-Ile-Phe-...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C48H82N18O9/c1-5-28(4)38(46(75)63-35(39(51)68)22-29-13-7-6-8-14-29)66-44(73)36(21-27(2)3)64-43(72)34(17-12-20-58-48(54)55)61-42(71)33(16-11-19-57-47(52)53)60-41(70)32(15-9-10-18-49)62-45(74)37(25-67)65-40(69)31(50)23-30-24-56-26-59-30/h6-8,13-14,24,26-28,31-38,67H,5,9-12,15-23,25,49-50H2,1-4H3,(H2,51,68)(H,56,59)(H,60,70)(H,61,71)(H,62,74)(H,63,75)(H,64,72)(H,65,69)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t28-,31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
In vitro inhibition of CDK2-cyclin A kinase activity on retinoblastoma protein


Bioorg Med Chem Lett 12: 2501-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00508-5
BindingDB Entry DOI: 10.7270/Q2CC101N
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50124767
PNG
((S)-2-{2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-...)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C40H51N11O6/c1-2-10-35(53)48-33(21-28-22-44-24-47-28)39(57)50-31(19-25-11-4-3-5-12-25)38(56)49-30(17-9-18-45-40(42)43)37(55)51-32(36(54)46-23-34(41)52)20-27-15-8-14-26-13-6-7-16-29(26)27/h3-8,11-16,22,24,30-33H,2,9-10,17-21,23H2,1H3,(H2,41,52)(H,44,47)(H,46,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)(H4,42,43,45)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 140n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC4R using HEK293 cells was determined by measuring cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50451761
PNG
(CHEMBL2371218)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-8-37(56)51-35(20-29-22-46-24-50-29)41(60)53-33(18-25-14-15-26-9-3-4-10-27(26)17-25)40(59)52-32(13-7-16-47-42(44)45)39(58)54-34(38(57)49-23-36(43)55)19-28-21-48-31-12-6-5-11-30(28)31/h3-6,9-12,14-15,17,21-22,24,32-35,48H,2,7-8,13,16,18-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,60)(H,54,58)(H4,44,45,47)/t32-,33+,34-,35-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC4R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50451761
PNG
(CHEMBL2371218)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-8-37(56)51-35(20-29-22-46-24-50-29)41(60)53-33(18-25-14-15-26-9-3-4-10-27(26)17-25)40(59)52-32(13-7-16-47-42(44)45)39(58)54-34(38(57)49-23-36(43)55)19-28-21-48-31-12-6-5-11-30(28)31/h3-6,9-12,14-15,17,21-22,24,32-35,48H,2,7-8,13,16,18-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,60)(H,54,58)(H4,44,45,47)/t32-,33+,34-,35-/m0/s1
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n/an/an/an/a 48n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC1R using HEK293 cells was determined by measuring the cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50124767
PNG
((S)-2-{2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-...)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C40H51N11O6/c1-2-10-35(53)48-33(21-28-22-44-24-47-28)39(57)50-31(19-25-11-4-3-5-12-25)38(56)49-30(17-9-18-45-40(42)43)37(55)51-32(36(54)46-23-34(41)52)20-27-15-8-14-26-13-6-7-16-29(26)27/h3-8,11-16,22,24,30-33H,2,9-10,17-21,23H2,1H3,(H2,41,52)(H,44,47)(H,46,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)(H4,42,43,45)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC1R using HEK293 cells was determined by measuring the cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))
BDBM50014096
PNG
(1-Acetyl-pyrrolidine-2-carboxylic acid {1-[1-{1-[(...)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CN[C@@H](Cc1ccccc1)C(N)=O)Cc1ccccc1
Show InChI InChI=1S/C40H48N8O5/c1-27(49)48-19-11-18-36(48)40(53)47-34(22-30-16-9-4-10-17-30)39(52)46-35(23-31-24-42-26-44-31)38(51)45-32(20-28-12-5-2-6-13-28)25-43-33(37(41)50)21-29-14-7-3-8-15-29/h2-10,12-17,24,26,32-36,43H,11,18-23,25H2,1H3,(H2,41,50)(H,42,44)(H,45,51)(H,46,52)(H,47,53)
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n/an/an/a 29n/an/an/an/an/a



Upjohn Company

Curated by ChEMBL


Assay Description
Dissociation constant (Kd) of renin inhibitor was determined over a temperature range of 8-37 degree by the fluorescence displacement assay


J Med Chem 33: 2080-6 (1990)


Article DOI: 10.1021/jm00170a006
BindingDB Entry DOI: 10.7270/Q2D50KX6
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50124777
PNG
((S)-2-{(S)-2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-...)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)NCC(N)=O
Show InChI InChI=1S/C36H47Cl2N11O6/c1-2-7-31(51)46-29(17-23-18-42-20-45-23)35(55)49-28(15-21-8-4-3-5-9-21)34(54)47-26(10-6-13-43-36(40)41)33(53)48-27(32(52)44-19-30(39)50)16-22-11-12-24(37)25(38)14-22/h3-5,8-9,11-12,14,18,20,26-29H,2,6-7,10,13,15-17,19H2,1H3,(H2,39,50)(H,42,45)(H,44,52)(H,46,51)(H,47,54)(H,48,53)(H,49,55)(H4,40,41,43)/t26-,27-,28+,29-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC1R using HEK293 cells was determined by measuring the cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122061
PNG
(Ac-His-D-Phe-Arg-Phe-NH2 | CHEMBL152986)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25+,26-,27-/m0/s1
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n/an/an/an/a 2.70E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122063
PNG
(Ac-His-D-Phe-Arg-Bip-NH2 | CHEMBL347364)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 51.9n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122066
PNG
(Ac-His-D-Phe-Arg-Nal(2')-NH2 | CHEMBL357558)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 17.9n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122068
PNG
(Ac-His-D-Phe-Arg-Ala-NH2 | CHEMBL359318)
Show SMILES CC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C26H38N10O5/c1-15(22(27)38)33-23(39)19(9-6-10-31-26(28)29)35-24(40)20(11-17-7-4-3-5-8-17)36-25(41)21(34-16(2)37)12-18-13-30-14-32-18/h3-5,7-8,13-15,19-21H,6,9-12H2,1-2H3,(H2,27,38)(H,30,32)(H,33,39)(H,34,37)(H,35,40)(H,36,41)(H4,28,29,31)/t15?,19-,20-,21-/m0/s1
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n/an/an/an/a 3.84E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122061
PNG
(Ac-His-D-Phe-Arg-Phe-NH2 | CHEMBL152986)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25+,26-,27-/m0/s1
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n/an/an/an/a 890n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122069
PNG
(Ac-His-D-Phe-Arg-D-Phe-NH2 | CHEMBL154251)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25-,26-,27-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122063
PNG
(Ac-His-D-Phe-Arg-Bip-NH2 | CHEMBL347364)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122070
PNG
(Ac-His-D-Phe-Arg-D-Bip-NH2 | CHEMBL348901)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1
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n/an/an/an/a 1.50E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122070
PNG
(Ac-His-D-Phe-Arg-D-Bip-NH2 | CHEMBL348901)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122071
PNG
(Ac-His-D-Phe-Arg-His-NH2 | CHEMBL350012)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C29H40N12O5/c1-17(42)38-24(12-20-14-34-16-37-20)28(46)41-23(10-18-6-3-2-4-7-18)27(45)39-21(8-5-9-35-29(31)32)26(44)40-22(25(30)43)11-19-13-33-15-36-19/h2-4,6-7,13-16,21-24H,5,8-12H2,1H3,(H2,30,43)(H,33,36)(H,34,37)(H,38,42)(H,39,45)(H,40,44)(H,41,46)(H4,31,32,35)/t21-,22+,23-,24-/m0/s1
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n/an/an/an/a 2.76E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122068
PNG
(Ac-His-D-Phe-Arg-Ala-NH2 | CHEMBL359318)
Show SMILES CC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C26H38N10O5/c1-15(22(27)38)33-23(39)19(9-6-10-31-26(28)29)35-24(40)20(11-17-7-4-3-5-8-17)36-25(41)21(34-16(2)37)12-18-13-30-14-32-18/h3-5,7-8,13-15,19-21H,6,9-12H2,1-2H3,(H2,27,38)(H,30,32)(H,33,39)(H,34,37)(H,35,40)(H,36,41)(H4,28,29,31)/t15?,19-,20-,21-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122069
PNG
(Ac-His-D-Phe-Arg-D-Phe-NH2 | CHEMBL154251)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25-,26-,27-/m0/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122068
PNG
(Ac-His-D-Phe-Arg-Ala-NH2 | CHEMBL359318)
Show SMILES CC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C26H38N10O5/c1-15(22(27)38)33-23(39)19(9-6-10-31-26(28)29)35-24(40)20(11-17-7-4-3-5-8-17)36-25(41)21(34-16(2)37)12-18-13-30-14-32-18/h3-5,7-8,13-15,19-21H,6,9-12H2,1-2H3,(H2,27,38)(H,30,32)(H,33,39)(H,34,37)(H,35,40)(H,36,41)(H4,28,29,31)/t15?,19-,20-,21-/m0/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122070
PNG
(Ac-His-D-Phe-Arg-D-Bip-NH2 | CHEMBL348901)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1
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n/an/an/an/a 1.62E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122061
PNG
(Ac-His-D-Phe-Arg-Phe-NH2 | CHEMBL152986)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25+,26-,27-/m0/s1
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n/an/an/an/a 7.80E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122070
PNG
(Ac-His-D-Phe-Arg-D-Bip-NH2 | CHEMBL348901)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1
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n/an/an/an/a 310n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122071
PNG
(Ac-His-D-Phe-Arg-His-NH2 | CHEMBL350012)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C29H40N12O5/c1-17(42)38-24(12-20-14-34-16-37-20)28(46)41-23(10-18-6-3-2-4-7-18)27(45)39-21(8-5-9-35-29(31)32)26(44)40-22(25(30)43)11-19-13-33-15-36-19/h2-4,6-7,13-16,21-24H,5,8-12H2,1H3,(H2,30,43)(H,33,36)(H,34,37)(H,38,42)(H,39,45)(H,40,44)(H,41,46)(H4,31,32,35)/t21-,22+,23-,24-/m0/s1
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n/an/an/an/a 3.60E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122073
PNG
(Ac-His-D-Phe-Arg-Nal(1')-NH2 | CHEMBL154153)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 730n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122073
PNG
(Ac-His-D-Phe-Arg-Nal(1')-NH2 | CHEMBL154153)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122063
PNG
(Ac-His-D-Phe-Arg-Bip-NH2 | CHEMBL347364)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 1.34E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122069
PNG
(Ac-His-D-Phe-Arg-D-Phe-NH2 | CHEMBL154251)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25-,26-,27-/m0/s1
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n/an/an/an/a 1.50E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122063
PNG
(Ac-His-D-Phe-Arg-Bip-NH2 | CHEMBL347364)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31+,32-,33-/m0/s1
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n/an/an/an/a 100n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122076
PNG
(Ac-His-D-Phe-Arg-D-Nal(2')-NH2 | CHEMBL347216)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1
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n/an/an/an/a 12.1n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122061
PNG
(Ac-His-D-Phe-Arg-Phe-NH2 | CHEMBL152986)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25+,26-,27-/m0/s1
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n/an/an/an/a 530n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122073
PNG
(Ac-His-D-Phe-Arg-Nal(1')-NH2 | CHEMBL154153)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 260n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122066
PNG
(Ac-His-D-Phe-Arg-Nal(2')-NH2 | CHEMBL357558)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 15.8n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122071
PNG
(Ac-His-D-Phe-Arg-His-NH2 | CHEMBL350012)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C29H40N12O5/c1-17(42)38-24(12-20-14-34-16-37-20)28(46)41-23(10-18-6-3-2-4-7-18)27(45)39-21(8-5-9-35-29(31)32)26(44)40-22(25(30)43)11-19-13-33-15-36-19/h2-4,6-7,13-16,21-24H,5,8-12H2,1H3,(H2,30,43)(H,33,36)(H,34,37)(H,38,42)(H,39,45)(H,40,44)(H,41,46)(H4,31,32,35)/t21-,22+,23-,24-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122068
PNG
(Ac-His-D-Phe-Arg-Ala-NH2 | CHEMBL359318)
Show SMILES CC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C26H38N10O5/c1-15(22(27)38)33-23(39)19(9-6-10-31-26(28)29)35-24(40)20(11-17-7-4-3-5-8-17)36-25(41)21(34-16(2)37)12-18-13-30-14-32-18/h3-5,7-8,13-15,19-21H,6,9-12H2,1-2H3,(H2,27,38)(H,30,32)(H,33,39)(H,34,37)(H,35,40)(H,36,41)(H4,28,29,31)/t15?,19-,20-,21-/m0/s1
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n/an/an/an/a 4.37E+4n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122069
PNG
(Ac-His-D-Phe-Arg-D-Phe-NH2 | CHEMBL154251)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25-,26-,27-/m0/s1
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n/an/an/an/a 470n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122076
PNG
(Ac-His-D-Phe-Arg-D-Nal(2')-NH2 | CHEMBL347216)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1
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n/an/an/an/a 127n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122073
PNG
(Ac-His-D-Phe-Arg-Nal(1')-NH2 | CHEMBL154153)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 33.1n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Mus musculus (Mouse))
BDBM50122066
PNG
(Ac-His-D-Phe-Arg-Nal(2')-NH2 | CHEMBL357558)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 4.86n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-5 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122076
PNG
(Ac-His-D-Phe-Arg-D-Nal(2')-NH2 | CHEMBL347216)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1
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n/an/an/an/a 1.62E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50122071
PNG
(Ac-His-D-Phe-Arg-His-NH2 | CHEMBL350012)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C29H40N12O5/c1-17(42)38-24(12-20-14-34-16-37-20)28(46)41-23(10-18-6-3-2-4-7-18)27(45)39-21(8-5-9-35-29(31)32)26(44)40-22(25(30)43)11-19-13-33-15-36-19/h2-4,6-7,13-16,21-24H,5,8-12H2,1H3,(H2,30,43)(H,33,36)(H,34,37)(H,38,42)(H,39,45)(H,40,44)(H,41,46)(H4,31,32,35)/t21-,22+,23-,24-/m0/s1
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n/an/an/an/a 3.80E+3n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Mus musculus)
BDBM50122076
PNG
(Ac-His-D-Phe-Arg-D-Nal(2')-NH2 | CHEMBL347216)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1
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n/an/an/an/a 46.2n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-4 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Mus musculus)
BDBM50122066
PNG
(Ac-His-D-Phe-Arg-Nal(2')-NH2 | CHEMBL357558)
Show SMILES CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1
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n/an/an/an/a 740n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-3 receptor (mMC3R) stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)


Article DOI: 10.1021/jm020296e
BindingDB Entry DOI: 10.7270/Q2Q2410R
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50451761
PNG
(CHEMBL2371218)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-8-37(56)51-35(20-29-22-46-24-50-29)41(60)53-33(18-25-14-15-26-9-3-4-10-27(26)17-25)40(59)52-32(13-7-16-47-42(44)45)39(58)54-34(38(57)49-23-36(43)55)19-28-21-48-31-12-6-5-11-30(28)31/h3-6,9-12,14-15,17,21-22,24,32-35,48H,2,7-8,13,16,18-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,60)(H,54,58)(H4,44,45,47)/t32-,33+,34-,35-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC4R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50124767
PNG
((S)-2-{2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-...)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C40H51N11O6/c1-2-10-35(53)48-33(21-28-22-44-24-47-28)39(57)50-31(19-25-11-4-3-5-12-25)38(56)49-30(17-9-18-45-40(42)43)37(55)51-32(36(54)46-23-34(41)52)20-27-15-8-14-26-13-6-7-16-29(26)27/h3-8,11-16,22,24,30-33H,2,9-10,17-21,23H2,1H3,(H2,41,52)(H,44,47)(H,46,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)(H4,42,43,45)/t30-,31+,32-,33-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Effective concentration against hMC1R using HEK293 cells was determined by measuring the cAMP accumulation


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50451760
PNG
(CHEMBL2371220)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-9-37(56)51-35(20-28-22-46-24-50-28)41(60)54-34(18-26-12-7-11-25-10-3-4-13-29(25)26)40(59)52-32(16-8-17-47-42(44)45)39(58)53-33(38(57)49-23-36(43)55)19-27-21-48-31-15-6-5-14-30(27)31/h3-7,10-15,21-22,24,32-35,48H,2,8-9,16-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,44,45,47)/t32-,33-,34+,35-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC1R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50451760
PNG
(CHEMBL2371220)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-9-37(56)51-35(20-28-22-46-24-50-28)41(60)54-34(18-26-12-7-11-25-10-3-4-13-29(25)26)40(59)52-32(16-8-17-47-42(44)45)39(58)53-33(38(57)49-23-36(43)55)19-27-21-48-31-15-6-5-14-30(27)31/h3-7,10-15,21-22,24,32-35,48H,2,8-9,16-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,44,45,47)/t32-,33-,34+,35-/m0/s1
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n/an/an/an/a 30n/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC4R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocortin receptor (M1 and M4)


(Homo sapiens (Human))
BDBM50124767
PNG
((S)-2-{2-[(S)-2-Butyrylamino-3-(3H-imidazol-4-yl)-...)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C40H51N11O6/c1-2-10-35(53)48-33(21-28-22-44-24-47-28)39(57)50-31(19-25-11-4-3-5-12-25)38(56)49-30(17-9-18-45-40(42)43)37(55)51-32(36(54)46-23-34(41)52)20-27-15-8-14-26-13-6-7-16-29(26)27/h3-8,11-16,22,24,30-33H,2,9-10,17-21,23H2,1H3,(H2,41,52)(H,44,47)(H,46,54)(H,48,53)(H,49,56)(H,50,57)(H,51,55)(H4,42,43,45)/t30-,31+,32-,33-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC4R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50451760
PNG
(CHEMBL2371220)
Show SMILES CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O
Show InChI InChI=1S/C42H52N12O6/c1-2-9-37(56)51-35(20-28-22-46-24-50-28)41(60)54-34(18-26-12-7-11-25-10-3-4-13-29(25)26)40(59)52-32(16-8-17-47-42(44)45)39(58)53-33(38(57)49-23-36(43)55)19-27-21-48-31-15-6-5-14-30(27)31/h3-7,10-15,21-22,24,32-35,48H,2,8-9,16-20,23H2,1H3,(H2,43,55)(H,46,50)(H,49,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,44,45,47)/t32-,33-,34+,35-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound was determined against hMC1R through displacement of NDP-MSH radioligand using HEK293 cells


Bioorg Med Chem Lett 13: 649-52 (2003)


Article DOI: 10.1016/s0960-894x(02)01052-1
BindingDB Entry DOI: 10.7270/Q2V69J0G
More data for this
Ligand-Target Pair