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17 similar compounds to monomer 50008379

Compile data set for download or QSAR
Wt: 4616.3
BDBM50087711
Wt: 4609.3
BDBM50158956
Wt: 4609.3
BDBM50158962
Wt: 4594.3
BDBM50158967
Wt: 4594.3
BDBM50158969
Wt: 4594.3
BDBM50158970
Wt: 4594.3
BDBM50158971
Wt: 4600.2
BDBM50158983
Wt: 4582.3
BDBM50158987
Wt: 4538.2
BDBM50158988
Wt: 4624.3
BDBM50158989
Wt: 4580.3
BDBM50158990
Wt: 4609.3
BDBM50158993
Wt: 4609.3
BDBM50158996
Wt: 4610.3
BDBM50158998
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50087711,50158956,50158962,50158967,50158969,50158970,50158971,50158983,50158987,50158988,50158989,50158990,50158993,50158996,50158998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr0-sauvagine from CRF1 receptor (unknown origin)


Bioorg Med Chem Lett 25: 5111-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.010
BindingDB Entry DOI: 10.7270/Q2XW4MM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr0-sauvagine from human CRF1 receptor expressed in HEK293T cells after 2 hrs by scintillation counting


Bioorg Med Chem Lett 25: 5111-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.010
BindingDB Entry DOI: 10.7270/Q2XW4MM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Homo sapiens (Human))
BDBM50087711
PNG
(CHEMBL429560 | Sauvagine-frog(QGPPISIDLSLELLRKMIEI...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C202H349N57O63S/c1-29-103(20)156(162(214)284)252-199(321)161(110(27)262)257-191(313)137(92-155(282)283)248-186(308)132(87-101(16)17)244-185(307)131(86-100(14)15)243-183(305)129(84-98(10)11)240-172(294)117(51-43-78-220-202(217)218)229-188(310)135(90-147(213)268)247-189(311)134(89-146(212)267)239-164(286)109(26)222-163(285)108(25)223-166(288)118(55-64-143(209)264)230-173(295)119(56-65-144(210)265)231-167(289)112(46-34-38-73-203)225-175(297)121(58-67-149(270)271)233-169(291)114(48-36-40-75-205)226-176(298)122(59-68-150(272)273)234-174(296)120(57-66-145(211)266)232-168(290)113(47-35-39-74-204)227-177(299)124(61-70-152(276)277)237-195(317)157(104(21)30-2)253-179(301)125(62-71-153(278)279)238-196(318)158(105(22)31-3)254-180(302)126(72-81-323-28)236-170(292)115(49-37-41-76-206)224-171(293)116(50-42-77-219-201(215)216)228-181(303)127(82-96(6)7)242-184(306)130(85-99(12)13)241-178(300)123(60-69-151(274)275)235-182(304)128(83-97(8)9)246-192(314)138(94-260)250-187(309)133(88-102(18)19)245-190(312)136(91-154(280)281)249-197(319)159(106(23)32-4)255-193(315)139(95-261)251-198(320)160(107(24)33-5)256-194(316)140-52-44-80-259(140)200(322)141-53-45-79-258(141)148(269)93-221-165(287)111(207)54-63-142(208)263/h96-141,156-161,260-262H,29-95,203-207H2,1-28H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,284)(H,221,287)(H,222,285)(H,223,288)(H,224,293)(H,225,297)(H,226,298)(H,227,299)(H,228,303)(H,229,310)(H,230,295)(H,231,289)(H,232,290)(H,233,291)(H,234,296)(H,235,304)(H,236,292)(H,237,317)(H,238,318)(H,239,286)(H,240,294)(H,241,300)(H,242,306)(H,243,305)(H,244,307)(H,245,312)(H,246,314)(H,247,311)(H,248,308)(H,249,319)(H,250,309)(H,251,320)(H,252,321)(H,253,301)(H,254,302)(H,255,315)(H,256,316)(H,257,313)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,156-,157-,158-,159-,160-,161-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.73n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the receptor h-CRF2-alpha with peptidic agonists


J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50087711
PNG
(CHEMBL429560 | Sauvagine-frog(QGPPISIDLSLELLRKMIEI...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C202H349N57O63S/c1-29-103(20)156(162(214)284)252-199(321)161(110(27)262)257-191(313)137(92-155(282)283)248-186(308)132(87-101(16)17)244-185(307)131(86-100(14)15)243-183(305)129(84-98(10)11)240-172(294)117(51-43-78-220-202(217)218)229-188(310)135(90-147(213)268)247-189(311)134(89-146(212)267)239-164(286)109(26)222-163(285)108(25)223-166(288)118(55-64-143(209)264)230-173(295)119(56-65-144(210)265)231-167(289)112(46-34-38-73-203)225-175(297)121(58-67-149(270)271)233-169(291)114(48-36-40-75-205)226-176(298)122(59-68-150(272)273)234-174(296)120(57-66-145(211)266)232-168(290)113(47-35-39-74-204)227-177(299)124(61-70-152(276)277)237-195(317)157(104(21)30-2)253-179(301)125(62-71-153(278)279)238-196(318)158(105(22)31-3)254-180(302)126(72-81-323-28)236-170(292)115(49-37-41-76-206)224-171(293)116(50-42-77-219-201(215)216)228-181(303)127(82-96(6)7)242-184(306)130(85-99(12)13)241-178(300)123(60-69-151(274)275)235-182(304)128(83-97(8)9)246-192(314)138(94-260)250-187(309)133(88-102(18)19)245-190(312)136(91-154(280)281)249-197(319)159(106(23)32-4)255-193(315)139(95-261)251-198(320)160(107(24)33-5)256-194(316)140-52-44-80-259(140)200(322)141-53-45-79-258(141)148(269)93-221-165(287)111(207)54-63-142(208)263/h96-141,156-161,260-262H,29-95,203-207H2,1-28H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,284)(H,221,287)(H,222,285)(H,223,288)(H,224,293)(H,225,297)(H,226,298)(H,227,299)(H,228,303)(H,229,310)(H,230,295)(H,231,289)(H,232,290)(H,233,291)(H,234,296)(H,235,304)(H,236,292)(H,237,317)(H,238,318)(H,239,286)(H,240,294)(H,241,300)(H,242,306)(H,243,305)(H,244,307)(H,245,312)(H,246,314)(H,247,311)(H,248,308)(H,249,319)(H,250,309)(H,251,320)(H,252,321)(H,253,301)(H,254,302)(H,255,315)(H,256,316)(H,257,313)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.30n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the receptor corticotropin releasing factor receptor with peptidic agonists


J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158970
PNG
(CHEMBL441564 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-105(20)157(250-180(297)128(67-75-154(276)277)238-195(312)158(106(21)32-2)251-181(298)129(76-86-322-30)236-172(289)118(54-41-45-80-209)225-173(290)119(55-46-81-219-204(215)216)229-182(299)130(87-99(8)9)241-186(303)134(91-103(16)17)246-197(314)161(109(24)35-5)255-199(316)162(110(25)36-6)254-192(309)141-57-48-84-259(141)201(318)139(92-104(18)19)248-189(306)137(95-155(278)279)247-196(313)159(107(22)33-3)252-191(308)140(98-261)249-198(315)160(108(23)34-4)253-193(310)142-58-49-85-260(142)202(319)143-59-50-83-258(143)150(269)97-221-167(284)121-63-71-149(268)224-121)194(311)237-127(66-74-153(274)275)179(296)228-116(52-39-43-78-207)170(287)233-124(62-70-146(212)265)176(293)235-126(65-73-152(272)273)178(295)227-117(53-40-44-79-208)171(288)234-125(64-72-151(270)271)177(294)226-115(51-38-42-77-206)169(286)232-123(61-69-145(211)264)175(292)231-122(60-68-144(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-135(93-147(213)266)188(305)244-136(94-148(214)267)187(304)230-120(56-47-82-220-205(217)218)174(291)240-131(88-100(10)11)183(300)242-132(89-101(12)13)184(301)243-133(90-102(14)15)185(302)245-138(96-156(280)281)190(307)257-164(114(29)262)200(317)256-163(203(320)321)111(26)37-7/h99-143,157-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,304)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,311)(H,238,312)(H,239,283)(H,240,291)(H,241,303)(H,242,300)(H,243,301)(H,244,305)(H,245,302)(H,246,314)(H,247,313)(H,248,306)(H,249,315)(H,250,297)(H,251,298)(H,252,308)(H,253,310)(H,254,309)(H,255,316)(H,256,317)(H,257,307)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,157-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158971
PNG
(CHEMBL427923 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-106(21)158(251-180(297)128(66-74-155(276)277)238-196(313)159(107(22)32-2)252-181(298)129(75-85-322-30)236-172(289)118(53-40-44-79-209)225-173(290)119(54-45-80-219-204(215)216)229-182(299)130(86-99(7)8)241-186(303)134(90-103(15)16)247-197(314)160(108(23)33-3)253-190(307)135(91-104(17)18)246-193(310)142-56-47-83-259(142)201(318)140(92-105(19)20)249-189(306)138(95-156(278)279)248-198(315)161(109(24)34-4)254-192(309)141(98-261)250-199(316)162(110(25)35-5)255-194(311)143-57-48-84-260(143)202(319)144-58-49-82-258(144)151(269)97-221-167(284)121-62-70-150(268)224-121)195(312)237-127(65-73-154(274)275)179(296)228-116(51-38-42-77-207)170(287)233-124(61-69-147(212)265)176(293)235-126(64-72-153(272)273)178(295)227-117(52-39-43-78-208)171(288)234-125(63-71-152(270)271)177(294)226-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)231-122(59-67-145(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-136(93-148(213)266)188(305)244-137(94-149(214)267)187(304)230-120(55-46-81-220-205(217)218)174(291)240-131(87-100(9)10)183(300)242-132(88-101(11)12)184(301)243-133(89-102(13)14)185(302)245-139(96-157(280)281)191(308)257-164(114(29)262)200(317)256-163(203(320)321)111(26)36-6/h99-144,158-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,304)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,312)(H,238,313)(H,239,283)(H,240,291)(H,241,303)(H,242,300)(H,243,301)(H,244,305)(H,245,302)(H,246,310)(H,247,314)(H,248,315)(H,249,306)(H,250,316)(H,251,297)(H,252,298)(H,253,307)(H,254,309)(H,255,311)(H,256,317)(H,257,308)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 106n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158970
PNG
(CHEMBL441564 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-105(20)157(250-180(297)128(67-75-154(276)277)238-195(312)158(106(21)32-2)251-181(298)129(76-86-322-30)236-172(289)118(54-41-45-80-209)225-173(290)119(55-46-81-219-204(215)216)229-182(299)130(87-99(8)9)241-186(303)134(91-103(16)17)246-197(314)161(109(24)35-5)255-199(316)162(110(25)36-6)254-192(309)141-57-48-84-259(141)201(318)139(92-104(18)19)248-189(306)137(95-155(278)279)247-196(313)159(107(22)33-3)252-191(308)140(98-261)249-198(315)160(108(23)34-4)253-193(310)142-58-49-85-260(142)202(319)143-59-50-83-258(143)150(269)97-221-167(284)121-63-71-149(268)224-121)194(311)237-127(66-74-153(274)275)179(296)228-116(52-39-43-78-207)170(287)233-124(62-70-146(212)265)176(293)235-126(65-73-152(272)273)178(295)227-117(53-40-44-79-208)171(288)234-125(64-72-151(270)271)177(294)226-115(51-38-42-77-206)169(286)232-123(61-69-145(211)264)175(292)231-122(60-68-144(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-135(93-147(213)266)188(305)244-136(94-148(214)267)187(304)230-120(56-47-82-220-205(217)218)174(291)240-131(88-100(10)11)183(300)242-132(89-101(12)13)184(301)243-133(90-102(14)15)185(302)245-138(96-156(280)281)190(307)257-164(114(29)262)200(317)256-163(203(320)321)111(26)37-7/h99-143,157-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,304)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,311)(H,238,312)(H,239,283)(H,240,291)(H,241,303)(H,242,300)(H,243,301)(H,244,305)(H,245,302)(H,246,314)(H,247,313)(H,248,306)(H,249,315)(H,250,297)(H,251,298)(H,252,308)(H,253,310)(H,254,309)(H,255,316)(H,256,317)(H,257,307)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,157-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158990
PNG
(CHEMBL438601 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H349N55O61S/c1-31-106(22)158(251-179(296)127(65-73-154(275)276)237-196(313)159(107(23)32-2)252-180(297)128(74-84-321-30)235-171(288)117(52-39-43-78-208)224-172(289)118(53-44-79-218-203(214)215)228-181(298)129(85-98(6)7)240-185(302)133(89-102(14)15)246-194(311)157(105(20)21)250-189(306)134(90-103(16)17)245-192(309)141-55-46-82-258(141)200(317)139(91-104(18)19)248-188(305)137(94-155(277)278)247-197(314)160(108(24)33-3)253-191(308)140(97-260)249-198(315)161(109(25)34-4)254-193(310)142-56-47-83-259(142)201(318)143-57-48-81-257(143)150(268)96-220-166(283)120-61-69-149(267)223-120)195(312)236-126(64-72-153(273)274)178(295)227-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)234-125(63-71-152(271)272)177(294)226-116(51-38-42-77-207)170(287)233-124(62-70-151(269)270)176(293)225-114(49-36-40-75-205)168(285)231-122(59-67-145(210)263)174(291)230-121(58-66-144(209)262)167(284)222-111(27)164(281)221-112(28)165(282)238-135(92-147(212)265)187(304)243-136(93-148(213)266)186(303)229-119(54-45-80-219-204(216)217)173(290)239-130(86-99(8)9)182(299)241-131(87-100(10)11)183(300)242-132(88-101(12)13)184(301)244-138(95-156(279)280)190(307)256-163(113(29)261)199(316)255-162(202(319)320)110(26)35-5/h98-143,157-163,260-261H,31-97,205-208H2,1-30H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,283)(H,221,281)(H,222,284)(H,223,267)(H,224,289)(H,225,293)(H,226,294)(H,227,295)(H,228,298)(H,229,303)(H,230,291)(H,231,285)(H,232,286)(H,233,287)(H,234,292)(H,235,288)(H,236,312)(H,237,313)(H,238,282)(H,239,290)(H,240,302)(H,241,299)(H,242,300)(H,243,304)(H,244,301)(H,245,309)(H,246,311)(H,247,314)(H,248,305)(H,249,315)(H,250,306)(H,251,296)(H,252,297)(H,253,308)(H,254,310)(H,255,316)(H,256,307)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,319,320)(H4,214,215,218)(H4,216,217,219)/t106-,107-,108-,109-,110-,111-,112-,113+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.5n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 60n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158956
PNG
(CHEMBL409748 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)237-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)131(87-100(10)11)242-179(298)123(59-68-147(212)266)236-183(302)134(90-103(16)17)248-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)246-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)184(303)244-132(88-101(12)13)186(305)245-133(89-102(14)15)187(306)247-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,302)(H,237,290)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,303)(H,245,305)(H,246,308)(H,247,306)(H,248,312)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 423n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158967
PNG
(CHEMBL414130 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-107(22)159(252-180(297)128(65-73-156(276)277)238-197(314)160(108(23)32-2)253-181(298)129(74-84-322-30)236-172(289)118(52-39-43-78-209)225-173(290)119(53-44-79-219-204(215)216)229-182(299)130(85-99(6)7)241-184(301)132(87-101(10)11)243-186(303)134(89-103(14)15)245-188(305)136(91-105(18)19)248-194(311)143-55-46-82-259(143)201(318)141(92-106(20)21)250-191(308)139(95-157(278)279)249-198(315)161(109(24)33-3)254-193(310)142(98-261)251-199(316)162(110(25)34-4)255-195(312)144-56-47-83-260(144)202(319)145-57-48-81-258(145)152(269)97-221-167(284)121-61-69-151(268)224-121)196(313)237-127(64-72-155(274)275)179(296)228-116(50-37-41-76-207)170(287)233-124(60-68-148(212)265)176(293)235-126(63-71-154(272)273)178(295)227-117(51-38-42-77-208)171(288)234-125(62-70-153(270)271)177(294)226-115(49-36-40-75-206)169(286)232-123(59-67-147(211)264)175(292)231-122(58-66-146(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-137(93-149(213)266)190(307)246-138(94-150(214)267)189(306)230-120(54-45-80-220-205(217)218)174(291)240-131(86-100(8)9)183(300)242-133(88-102(12)13)185(302)244-135(90-104(16)17)187(304)247-140(96-158(280)281)192(309)257-164(114(29)262)200(317)256-163(203(320)321)111(26)35-5/h99-145,159-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,306)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,313)(H,238,314)(H,239,283)(H,240,291)(H,241,301)(H,242,300)(H,243,303)(H,244,302)(H,245,305)(H,246,307)(H,247,304)(H,248,311)(H,249,315)(H,250,308)(H,251,316)(H,252,297)(H,253,298)(H,254,310)(H,255,312)(H,256,317)(H,257,309)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.40n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158987
PNG
(CHEMBL439887 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C203H347N55O62S/c1-30-103(19)155(248-178(296)126(65-73-152(275)276)236-193(311)156(104(20)31-2)249-179(297)127(74-84-321-29)234-170(288)116(52-39-43-78-207)223-171(289)117(53-44-79-217-202(213)214)227-180(298)128(85-97(7)8)239-184(302)132(89-101(15)16)244-195(313)159(107(23)34-5)252-197(315)162(112(28)261)255-191(309)139-55-46-82-257(139)199(317)137(90-102(17)18)246-187(305)135(93-153(277)278)245-194(312)157(105(21)32-3)250-189(307)138(96-259)247-196(314)158(106(22)33-4)251-190(308)140-56-47-83-258(140)200(318)141-57-48-81-256(141)148(268)95-219-165(283)119-61-69-147(267)222-119)192(310)235-125(64-72-151(273)274)177(295)226-114(50-37-41-76-205)168(286)231-122(60-68-144(210)264)174(292)233-124(63-71-150(271)272)176(294)225-115(51-38-42-77-206)169(287)232-123(62-70-149(269)270)175(293)224-113(49-36-40-75-204)167(285)230-121(59-67-143(209)263)173(291)229-120(58-66-142(208)262)166(284)221-109(25)163(281)220-110(26)164(282)237-133(91-145(211)265)186(304)242-134(92-146(212)266)185(303)228-118(54-45-80-218-203(215)216)172(290)238-129(86-98(9)10)181(299)240-130(87-99(11)12)182(300)241-131(88-100(13)14)183(301)243-136(94-154(279)280)188(306)254-161(111(27)260)198(316)253-160(201(319)320)108(24)35-6/h97-141,155-162,259-261H,30-96,204-207H2,1-29H3,(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H,219,283)(H,220,281)(H,221,284)(H,222,267)(H,223,289)(H,224,293)(H,225,294)(H,226,295)(H,227,298)(H,228,303)(H,229,291)(H,230,285)(H,231,286)(H,232,287)(H,233,292)(H,234,288)(H,235,310)(H,236,311)(H,237,282)(H,238,290)(H,239,302)(H,240,299)(H,241,300)(H,242,304)(H,243,301)(H,244,313)(H,245,312)(H,246,305)(H,247,314)(H,248,296)(H,249,297)(H,250,307)(H,251,308)(H,252,315)(H,253,316)(H,254,306)(H,255,309)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,319,320)(H4,213,214,217)(H4,215,216,218)/t103-,104-,105-,106-,107-,108-,109-,110-,111+,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,155-,156-,157-,158-,159-,160-,161-,162-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158993
PNG
(CHEMBL437289 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-104(19)157(251-180(299)127(65-74-154(277)278)239-195(314)158(105(20)30-2)253-181(300)128(75-85-323-28)236-171(290)116(51-38-42-79-208)225-172(291)117(52-43-80-219-203(215)216)229-182(301)129(86-98(7)8)242-186(305)133(90-102(15)16)247-196(315)159(106(21)31-3)252-179(298)123(60-69-146(212)266)237-192(311)140-54-45-83-259(140)200(319)138(91-103(17)18)249-189(308)136(94-155(279)280)248-197(316)160(107(22)32-4)254-191(310)139(97-261)250-198(317)161(108(23)33-5)255-193(312)141-55-46-84-260(141)201(320)142-56-47-82-258(142)150(270)96-221-166(285)119-61-70-149(269)224-119)194(313)238-126(64-73-153(275)276)178(297)228-114(49-36-40-77-206)169(288)233-122(59-68-145(211)265)175(294)235-125(63-72-152(273)274)177(296)227-115(50-37-41-78-207)170(289)234-124(62-71-151(271)272)176(295)226-113(48-35-39-76-205)168(287)232-121(58-67-144(210)264)174(293)231-120(57-66-143(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-134(92-147(213)267)188(307)245-135(93-148(214)268)187(306)230-118(53-44-81-220-204(217)218)173(292)241-130(87-99(9)10)183(302)243-131(88-100(11)12)184(303)244-132(89-101(13)14)185(304)246-137(95-156(281)282)190(309)257-163(112(27)262)199(318)256-162(202(321)322)109(24)34-6/h98-142,157-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,306)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,311)(H,238,313)(H,239,314)(H,240,284)(H,241,292)(H,242,305)(H,243,302)(H,244,303)(H,245,307)(H,246,304)(H,247,315)(H,248,316)(H,249,308)(H,250,317)(H,251,299)(H,252,298)(H,253,300)(H,254,310)(H,255,312)(H,256,318)(H,257,309)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t104-,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 707n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158989
PNG
(CHEMBL440427 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C203H345N57O63S/c1-27-103(18)157(252-180(301)126(63-73-154(278)279)240-195(316)158(104(19)28-2)253-181(302)127(74-84-324-26)237-170(291)114(48-35-39-78-207)225-171(292)115(49-40-79-219-202(215)216)229-182(303)128(85-97(6)7)244-184(305)130(87-99(10)11)243-179(300)121(57-67-145(211)266)234-175(296)122(58-68-146(212)267)238-192(313)139-51-42-82-259(139)199(320)137(90-102(16)17)250-189(310)135(93-155(280)281)249-196(317)159(105(20)29-3)254-191(312)138(96-261)251-197(318)160(106(21)30-4)255-193(314)140-52-43-83-260(140)200(321)141-53-44-81-258(141)150(271)95-221-165(286)117-59-69-149(270)224-117)194(315)239-125(62-72-153(276)277)178(299)228-112(46-33-37-76-205)168(289)233-120(56-66-144(210)265)174(295)236-124(61-71-152(274)275)177(298)227-113(47-34-38-77-206)169(290)235-123(60-70-151(272)273)176(297)226-111(45-32-36-75-204)167(288)232-119(55-65-143(209)264)173(294)231-118(54-64-142(208)263)166(287)223-108(23)163(284)222-109(24)164(285)241-133(91-147(213)268)188(309)247-134(92-148(214)269)187(308)230-116(50-41-80-220-203(217)218)172(293)242-129(86-98(8)9)183(304)245-131(88-100(12)13)185(306)246-132(89-101(14)15)186(307)248-136(94-156(282)283)190(311)257-162(110(25)262)198(319)256-161(201(322)323)107(22)31-5/h97-141,157-162,261-262H,27-96,204-207H2,1-26H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H,221,286)(H,222,284)(H,223,287)(H,224,270)(H,225,292)(H,226,297)(H,227,298)(H,228,299)(H,229,303)(H,230,308)(H,231,294)(H,232,288)(H,233,289)(H,234,296)(H,235,290)(H,236,295)(H,237,291)(H,238,313)(H,239,315)(H,240,316)(H,241,285)(H,242,293)(H,243,300)(H,244,305)(H,245,304)(H,246,306)(H,247,309)(H,248,307)(H,249,317)(H,250,310)(H,251,318)(H,252,301)(H,253,302)(H,254,312)(H,255,314)(H,256,319)(H,257,311)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,322,323)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,157-,158-,159-,160-,161-,162-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158988
PNG
(CHEMBL412296 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C201H343N55O61S/c1-29-104(20)156(248-178(295)125(63-71-153(273)274)236-193(310)157(105(21)30-2)249-179(296)126(72-82-318-28)234-170(287)115(50-37-41-76-205)223-171(288)116(51-42-77-215-200(211)212)227-181(298)129(85-99(10)11)239-180(297)128(84-98(8)9)222-148(265)94-217-165(282)127(83-97(6)7)244-190(307)139-53-44-80-255(139)197(314)137(89-103(18)19)246-187(304)135(92-154(275)276)245-194(311)158(106(22)31-3)250-189(306)138(96-257)247-195(312)159(107(23)32-4)251-191(308)140-54-45-81-256(140)198(315)141-55-46-79-254(141)149(266)95-218-164(281)118-59-67-147(264)221-118)192(309)235-124(62-70-152(271)272)177(294)226-113(48-35-39-74-203)168(285)231-121(58-66-144(208)261)174(291)233-123(61-69-151(269)270)176(293)225-114(49-36-40-75-204)169(286)232-122(60-68-150(267)268)175(292)224-112(47-34-38-73-202)167(284)230-120(57-65-143(207)260)173(290)229-119(56-64-142(206)259)166(283)220-109(25)162(279)219-110(26)163(280)237-133(90-145(209)262)186(303)242-134(91-146(210)263)185(302)228-117(52-43-78-216-201(213)214)172(289)238-130(86-100(12)13)182(299)240-131(87-101(14)15)183(300)241-132(88-102(16)17)184(301)243-136(93-155(277)278)188(305)253-161(111(27)258)196(313)252-160(199(316)317)108(24)33-5/h97-141,156-161,257-258H,29-96,202-205H2,1-28H3,(H2,206,259)(H2,207,260)(H2,208,261)(H2,209,262)(H2,210,263)(H,217,282)(H,218,281)(H,219,279)(H,220,283)(H,221,264)(H,222,265)(H,223,288)(H,224,292)(H,225,293)(H,226,294)(H,227,298)(H,228,302)(H,229,290)(H,230,284)(H,231,285)(H,232,286)(H,233,291)(H,234,287)(H,235,309)(H,236,310)(H,237,280)(H,238,289)(H,239,297)(H,240,299)(H,241,300)(H,242,303)(H,243,301)(H,244,307)(H,245,311)(H,246,304)(H,247,312)(H,248,295)(H,249,296)(H,250,306)(H,251,308)(H,252,313)(H,253,305)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,316,317)(H4,211,212,215)(H4,213,214,216)/t104-,105-,106-,107-,108-,109-,110-,111+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 312n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 18n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158996
PNG
(CHEMBL438760 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)132(88-101(12)13)245-184(303)131(87-100(10)11)242-179(298)123(59-68-147(212)266)237-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)247-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)183(302)244-133(89-102(14)15)186(305)246-134(90-103(16)17)187(306)248-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,312)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,302)(H,245,303)(H,246,305)(H,247,308)(H,248,306)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 28n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158998
PNG
(CHEMBL414711 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H347N55O63S/c1-29-105(20)158(251-180(299)127(64-73-155(277)278)238-196(315)159(106(21)30-2)252-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)224-172(291)117(51-42-79-218-203(214)215)228-182(301)129(85-98(6)7)242-185(304)131(87-100(10)11)241-179(298)125(62-71-153(273)274)235-183(302)134(90-103(16)17)247-193(312)141-53-44-82-258(141)200(319)139(91-104(18)19)249-190(309)137(94-156(279)280)248-197(316)160(107(22)31-3)253-192(311)140(97-260)250-198(317)161(108(23)32-4)254-194(313)142-54-45-83-259(142)201(320)143-55-46-81-257(143)150(268)96-220-166(285)119-59-68-149(267)223-119)195(314)237-126(63-72-154(275)276)178(297)227-114(48-35-39-76-206)169(288)232-122(58-67-146(211)264)175(294)234-124(61-70-152(271)272)177(296)226-115(49-36-40-77-207)170(289)233-123(60-69-151(269)270)176(295)225-113(47-34-38-75-205)168(287)231-121(57-66-145(210)263)174(293)230-120(56-65-144(209)262)167(286)222-110(25)164(283)221-111(26)165(284)239-135(92-147(212)265)189(308)245-136(93-148(213)266)188(307)229-118(52-43-80-219-204(216)217)173(292)240-130(86-99(8)9)184(303)243-132(88-101(12)13)186(305)244-133(89-102(14)15)187(306)246-138(95-157(281)282)191(310)256-163(112(27)261)199(318)255-162(202(321)322)109(24)33-5/h98-143,158-163,260-261H,29-97,205-208H2,1-28H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,285)(H,221,283)(H,222,286)(H,223,267)(H,224,291)(H,225,295)(H,226,296)(H,227,297)(H,228,301)(H,229,307)(H,230,293)(H,231,287)(H,232,288)(H,233,289)(H,234,294)(H,235,302)(H,236,290)(H,237,314)(H,238,315)(H,239,284)(H,240,292)(H,241,298)(H,242,304)(H,243,303)(H,244,305)(H,245,308)(H,246,306)(H,247,312)(H,248,316)(H,249,309)(H,250,317)(H,251,299)(H,252,300)(H,253,311)(H,254,313)(H,255,318)(H,256,310)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,214,215,218)(H4,216,217,219)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158987
PNG
(CHEMBL439887 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C203H347N55O62S/c1-30-103(19)155(248-178(296)126(65-73-152(275)276)236-193(311)156(104(20)31-2)249-179(297)127(74-84-321-29)234-170(288)116(52-39-43-78-207)223-171(289)117(53-44-79-217-202(213)214)227-180(298)128(85-97(7)8)239-184(302)132(89-101(15)16)244-195(313)159(107(23)34-5)252-197(315)162(112(28)261)255-191(309)139-55-46-82-257(139)199(317)137(90-102(17)18)246-187(305)135(93-153(277)278)245-194(312)157(105(21)32-3)250-189(307)138(96-259)247-196(314)158(106(22)33-4)251-190(308)140-56-47-83-258(140)200(318)141-57-48-81-256(141)148(268)95-219-165(283)119-61-69-147(267)222-119)192(310)235-125(64-72-151(273)274)177(295)226-114(50-37-41-76-205)168(286)231-122(60-68-144(210)264)174(292)233-124(63-71-150(271)272)176(294)225-115(51-38-42-77-206)169(287)232-123(62-70-149(269)270)175(293)224-113(49-36-40-75-204)167(285)230-121(59-67-143(209)263)173(291)229-120(58-66-142(208)262)166(284)221-109(25)163(281)220-110(26)164(282)237-133(91-145(211)265)186(304)242-134(92-146(212)266)185(303)228-118(54-45-80-218-203(215)216)172(290)238-129(86-98(9)10)181(299)240-130(87-99(11)12)182(300)241-131(88-100(13)14)183(301)243-136(94-154(279)280)188(306)254-161(111(27)260)198(316)253-160(201(319)320)108(24)35-6/h97-141,155-162,259-261H,30-96,204-207H2,1-29H3,(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H,219,283)(H,220,281)(H,221,284)(H,222,267)(H,223,289)(H,224,293)(H,225,294)(H,226,295)(H,227,298)(H,228,303)(H,229,291)(H,230,285)(H,231,286)(H,232,287)(H,233,292)(H,234,288)(H,235,310)(H,236,311)(H,237,282)(H,238,290)(H,239,302)(H,240,299)(H,241,300)(H,242,304)(H,243,301)(H,244,313)(H,245,312)(H,246,305)(H,247,314)(H,248,296)(H,249,297)(H,250,307)(H,251,308)(H,252,315)(H,253,316)(H,254,306)(H,255,309)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,319,320)(H4,213,214,217)(H4,215,216,218)/t103-,104-,105-,106-,107-,108-,109-,110-,111+,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,155-,156-,157-,158-,159-,160-,161-,162-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158990
PNG
(CHEMBL438601 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H349N55O61S/c1-31-106(22)158(251-179(296)127(65-73-154(275)276)237-196(313)159(107(23)32-2)252-180(297)128(74-84-321-30)235-171(288)117(52-39-43-78-208)224-172(289)118(53-44-79-218-203(214)215)228-181(298)129(85-98(6)7)240-185(302)133(89-102(14)15)246-194(311)157(105(20)21)250-189(306)134(90-103(16)17)245-192(309)141-55-46-82-258(141)200(317)139(91-104(18)19)248-188(305)137(94-155(277)278)247-197(314)160(108(24)33-3)253-191(308)140(97-260)249-198(315)161(109(25)34-4)254-193(310)142-56-47-83-259(142)201(318)143-57-48-81-257(143)150(268)96-220-166(283)120-61-69-149(267)223-120)195(312)236-126(64-72-153(273)274)178(295)227-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)234-125(63-71-152(271)272)177(294)226-116(51-38-42-77-207)170(287)233-124(62-70-151(269)270)176(293)225-114(49-36-40-75-205)168(285)231-122(59-67-145(210)263)174(291)230-121(58-66-144(209)262)167(284)222-111(27)164(281)221-112(28)165(282)238-135(92-147(212)265)187(304)243-136(93-148(213)266)186(303)229-119(54-45-80-219-204(216)217)173(290)239-130(86-99(8)9)182(299)241-131(87-100(10)11)183(300)242-132(88-101(12)13)184(301)244-138(95-156(279)280)190(307)256-163(113(29)261)199(316)255-162(202(319)320)110(26)35-5/h98-143,157-163,260-261H,31-97,205-208H2,1-30H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,283)(H,221,281)(H,222,284)(H,223,267)(H,224,289)(H,225,293)(H,226,294)(H,227,295)(H,228,298)(H,229,303)(H,230,291)(H,231,285)(H,232,286)(H,233,287)(H,234,292)(H,235,288)(H,236,312)(H,237,313)(H,238,282)(H,239,290)(H,240,302)(H,241,299)(H,242,300)(H,243,304)(H,244,301)(H,245,309)(H,246,311)(H,247,314)(H,248,305)(H,249,315)(H,250,306)(H,251,296)(H,252,297)(H,253,308)(H,254,310)(H,255,316)(H,256,307)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,319,320)(H4,214,215,218)(H4,216,217,219)/t106-,107-,108-,109-,110-,111-,112-,113+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 266n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158969
PNG
(CHEMBL428975 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-106(21)158(251-180(297)128(66-74-155(276)277)238-196(313)159(107(22)32-2)252-181(298)129(75-85-322-30)236-172(289)118(53-40-44-79-209)225-173(290)119(54-45-80-219-204(215)216)229-182(299)130(86-99(7)8)241-184(301)133(89-102(13)14)244-187(304)135(91-104(17)18)247-198(315)161(109(24)34-4)254-193(310)142-56-47-83-259(142)201(318)140(92-105(19)20)249-190(307)138(95-156(278)279)248-197(314)160(108(23)33-3)253-192(309)141(98-261)250-199(316)162(110(25)35-5)255-194(311)143-57-48-84-260(143)202(319)144-58-49-82-258(144)151(269)97-221-167(284)121-62-70-150(268)224-121)195(312)237-127(65-73-154(274)275)179(296)228-116(51-38-42-77-207)170(287)233-124(61-69-147(212)265)176(293)235-126(64-72-153(272)273)178(295)227-117(52-39-43-78-208)171(288)234-125(63-71-152(270)271)177(294)226-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)231-122(59-67-145(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-136(93-148(213)266)189(306)245-137(94-149(214)267)188(305)230-120(55-46-81-220-205(217)218)174(291)240-131(87-100(9)10)183(300)242-132(88-101(11)12)185(302)243-134(90-103(15)16)186(303)246-139(96-157(280)281)191(308)257-164(114(29)262)200(317)256-163(203(320)321)111(26)36-6/h99-144,158-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,305)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,312)(H,238,313)(H,239,283)(H,240,291)(H,241,301)(H,242,300)(H,243,302)(H,244,304)(H,245,306)(H,246,303)(H,247,315)(H,248,314)(H,249,307)(H,250,316)(H,251,297)(H,252,298)(H,253,309)(H,254,310)(H,255,311)(H,256,317)(H,257,308)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158989
PNG
(CHEMBL440427 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C203H345N57O63S/c1-27-103(18)157(252-180(301)126(63-73-154(278)279)240-195(316)158(104(19)28-2)253-181(302)127(74-84-324-26)237-170(291)114(48-35-39-78-207)225-171(292)115(49-40-79-219-202(215)216)229-182(303)128(85-97(6)7)244-184(305)130(87-99(10)11)243-179(300)121(57-67-145(211)266)234-175(296)122(58-68-146(212)267)238-192(313)139-51-42-82-259(139)199(320)137(90-102(16)17)250-189(310)135(93-155(280)281)249-196(317)159(105(20)29-3)254-191(312)138(96-261)251-197(318)160(106(21)30-4)255-193(314)140-52-43-83-260(140)200(321)141-53-44-81-258(141)150(271)95-221-165(286)117-59-69-149(270)224-117)194(315)239-125(62-72-153(276)277)178(299)228-112(46-33-37-76-205)168(289)233-120(56-66-144(210)265)174(295)236-124(61-71-152(274)275)177(298)227-113(47-34-38-77-206)169(290)235-123(60-70-151(272)273)176(297)226-111(45-32-36-75-204)167(288)232-119(55-65-143(209)264)173(294)231-118(54-64-142(208)263)166(287)223-108(23)163(284)222-109(24)164(285)241-133(91-147(213)268)188(309)247-134(92-148(214)269)187(308)230-116(50-41-80-220-203(217)218)172(293)242-129(86-98(8)9)183(304)245-131(88-100(12)13)185(306)246-132(89-101(14)15)186(307)248-136(94-156(282)283)190(311)257-162(110(25)262)198(319)256-161(201(322)323)107(22)31-5/h97-141,157-162,261-262H,27-96,204-207H2,1-26H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H,221,286)(H,222,284)(H,223,287)(H,224,270)(H,225,292)(H,226,297)(H,227,298)(H,228,299)(H,229,303)(H,230,308)(H,231,294)(H,232,288)(H,233,289)(H,234,296)(H,235,290)(H,236,295)(H,237,291)(H,238,313)(H,239,315)(H,240,316)(H,241,285)(H,242,293)(H,243,300)(H,244,305)(H,245,304)(H,246,306)(H,247,309)(H,248,307)(H,249,317)(H,250,310)(H,251,318)(H,252,301)(H,253,302)(H,254,312)(H,255,314)(H,256,319)(H,257,311)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,322,323)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,157-,158-,159-,160-,161-,162-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158988
PNG
(CHEMBL412296 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C201H343N55O61S/c1-29-104(20)156(248-178(295)125(63-71-153(273)274)236-193(310)157(105(21)30-2)249-179(296)126(72-82-318-28)234-170(287)115(50-37-41-76-205)223-171(288)116(51-42-77-215-200(211)212)227-181(298)129(85-99(10)11)239-180(297)128(84-98(8)9)222-148(265)94-217-165(282)127(83-97(6)7)244-190(307)139-53-44-80-255(139)197(314)137(89-103(18)19)246-187(304)135(92-154(275)276)245-194(311)158(106(22)31-3)250-189(306)138(96-257)247-195(312)159(107(23)32-4)251-191(308)140-54-45-81-256(140)198(315)141-55-46-79-254(141)149(266)95-218-164(281)118-59-67-147(264)221-118)192(309)235-124(62-70-152(271)272)177(294)226-113(48-35-39-74-203)168(285)231-121(58-66-144(208)261)174(291)233-123(61-69-151(269)270)176(293)225-114(49-36-40-75-204)169(286)232-122(60-68-150(267)268)175(292)224-112(47-34-38-73-202)167(284)230-120(57-65-143(207)260)173(290)229-119(56-64-142(206)259)166(283)220-109(25)162(279)219-110(26)163(280)237-133(90-145(209)262)186(303)242-134(91-146(210)263)185(302)228-117(52-43-78-216-201(213)214)172(289)238-130(86-100(12)13)182(299)240-131(87-101(14)15)183(300)241-132(88-102(16)17)184(301)243-136(93-155(277)278)188(305)253-161(111(27)258)196(313)252-160(199(316)317)108(24)33-5/h97-141,156-161,257-258H,29-96,202-205H2,1-28H3,(H2,206,259)(H2,207,260)(H2,208,261)(H2,209,262)(H2,210,263)(H,217,282)(H,218,281)(H,219,279)(H,220,283)(H,221,264)(H,222,265)(H,223,288)(H,224,292)(H,225,293)(H,226,294)(H,227,298)(H,228,302)(H,229,290)(H,230,284)(H,231,285)(H,232,286)(H,233,291)(H,234,287)(H,235,309)(H,236,310)(H,237,280)(H,238,289)(H,239,297)(H,240,299)(H,241,300)(H,242,303)(H,243,301)(H,244,307)(H,245,311)(H,246,304)(H,247,312)(H,248,295)(H,249,296)(H,250,306)(H,251,308)(H,252,313)(H,253,305)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,316,317)(H4,211,212,215)(H4,213,214,216)/t104-,105-,106-,107-,108-,109-,110-,111+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 22n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158962
PNG
(CHEMBL411474 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-104(19)157(251-180(299)127(65-74-154(277)278)239-195(314)158(105(20)30-2)252-181(300)128(75-85-323-28)236-171(290)116(51-38-42-79-208)225-172(291)117(52-43-80-219-203(215)216)229-182(301)129(86-98(7)8)243-184(303)131(88-100(11)12)242-179(298)123(60-69-146(212)266)237-196(315)160(107(22)32-4)254-192(311)140-54-45-83-259(140)200(319)138(91-103(17)18)249-189(308)136(94-155(279)280)248-197(316)159(106(21)31-3)253-191(310)139(97-261)250-198(317)161(108(23)33-5)255-193(312)141-55-46-84-260(141)201(320)142-56-47-82-258(142)150(270)96-221-166(285)119-61-70-149(269)224-119)194(313)238-126(64-73-153(275)276)178(297)228-114(49-36-40-77-206)169(288)233-122(59-68-145(211)265)175(294)235-125(63-72-152(273)274)177(296)227-115(50-37-41-78-207)170(289)234-124(62-71-151(271)272)176(295)226-113(48-35-39-76-205)168(287)232-121(58-67-144(210)264)174(293)231-120(57-66-143(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-134(92-147(213)267)188(307)246-135(93-148(214)268)187(306)230-118(53-44-81-220-204(217)218)173(292)241-130(87-99(9)10)183(302)244-132(89-101(13)14)185(304)245-133(90-102(15)16)186(305)247-137(95-156(281)282)190(309)257-163(112(27)262)199(318)256-162(202(321)322)109(24)34-6/h98-142,157-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,306)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,315)(H,238,313)(H,239,314)(H,240,284)(H,241,292)(H,242,298)(H,243,303)(H,244,302)(H,245,304)(H,246,307)(H,247,305)(H,248,316)(H,249,308)(H,250,317)(H,251,299)(H,252,300)(H,253,310)(H,254,311)(H,255,312)(H,256,318)(H,257,309)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t104-,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158993
PNG
(CHEMBL437289 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-104(19)157(251-180(299)127(65-74-154(277)278)239-195(314)158(105(20)30-2)253-181(300)128(75-85-323-28)236-171(290)116(51-38-42-79-208)225-172(291)117(52-43-80-219-203(215)216)229-182(301)129(86-98(7)8)242-186(305)133(90-102(15)16)247-196(315)159(106(21)31-3)252-179(298)123(60-69-146(212)266)237-192(311)140-54-45-83-259(140)200(319)138(91-103(17)18)249-189(308)136(94-155(279)280)248-197(316)160(107(22)32-4)254-191(310)139(97-261)250-198(317)161(108(23)33-5)255-193(312)141-55-46-84-260(141)201(320)142-56-47-82-258(142)150(270)96-221-166(285)119-61-70-149(269)224-119)194(313)238-126(64-73-153(275)276)178(297)228-114(49-36-40-77-206)169(288)233-122(59-68-145(211)265)175(294)235-125(63-72-152(273)274)177(296)227-115(50-37-41-78-207)170(289)234-124(62-71-151(271)272)176(295)226-113(48-35-39-76-205)168(287)232-121(58-67-144(210)264)174(293)231-120(57-66-143(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-134(92-147(213)267)188(307)245-135(93-148(214)268)187(306)230-118(53-44-81-220-204(217)218)173(292)241-130(87-99(9)10)183(302)243-131(88-100(11)12)184(303)244-132(89-101(13)14)185(304)246-137(95-156(281)282)190(309)257-163(112(27)262)199(318)256-162(202(321)322)109(24)34-6/h98-142,157-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,306)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,311)(H,238,313)(H,239,314)(H,240,284)(H,241,292)(H,242,305)(H,243,302)(H,244,303)(H,245,307)(H,246,304)(H,247,315)(H,248,316)(H,249,308)(H,250,317)(H,251,299)(H,252,298)(H,253,300)(H,254,310)(H,255,312)(H,256,318)(H,257,309)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t104-,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.5n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158998
PNG
(CHEMBL414711 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H347N55O63S/c1-29-105(20)158(251-180(299)127(64-73-155(277)278)238-196(315)159(106(21)30-2)252-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)224-172(291)117(51-42-79-218-203(214)215)228-182(301)129(85-98(6)7)242-185(304)131(87-100(10)11)241-179(298)125(62-71-153(273)274)235-183(302)134(90-103(16)17)247-193(312)141-53-44-82-258(141)200(319)139(91-104(18)19)249-190(309)137(94-156(279)280)248-197(316)160(107(22)31-3)253-192(311)140(97-260)250-198(317)161(108(23)32-4)254-194(313)142-54-45-83-259(142)201(320)143-55-46-81-257(143)150(268)96-220-166(285)119-59-68-149(267)223-119)195(314)237-126(63-72-154(275)276)178(297)227-114(48-35-39-76-206)169(288)232-122(58-67-146(211)264)175(294)234-124(61-70-152(271)272)177(296)226-115(49-36-40-77-207)170(289)233-123(60-69-151(269)270)176(295)225-113(47-34-38-75-205)168(287)231-121(57-66-145(210)263)174(293)230-120(56-65-144(209)262)167(286)222-110(25)164(283)221-111(26)165(284)239-135(92-147(212)265)189(308)245-136(93-148(213)266)188(307)229-118(52-43-80-219-204(216)217)173(292)240-130(86-99(8)9)184(303)243-132(88-101(12)13)186(305)244-133(89-102(14)15)187(306)246-138(95-157(281)282)191(310)256-163(112(27)261)199(318)255-162(202(321)322)109(24)33-5/h98-143,158-163,260-261H,29-97,205-208H2,1-28H3,(H2,209,262)(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H,220,285)(H,221,283)(H,222,286)(H,223,267)(H,224,291)(H,225,295)(H,226,296)(H,227,297)(H,228,301)(H,229,307)(H,230,293)(H,231,287)(H,232,288)(H,233,289)(H,234,294)(H,235,302)(H,236,290)(H,237,314)(H,238,315)(H,239,284)(H,240,292)(H,241,298)(H,242,304)(H,243,303)(H,244,305)(H,245,308)(H,246,306)(H,247,312)(H,248,316)(H,249,309)(H,250,317)(H,251,299)(H,252,300)(H,253,311)(H,254,313)(H,255,318)(H,256,310)(H,269,270)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,214,215,218)(H4,216,217,219)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 96n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158996
PNG
(CHEMBL438760 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)236-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)132(88-101(12)13)245-184(303)131(87-100(10)11)242-179(298)123(59-68-147(212)266)237-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)247-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)183(302)244-133(89-102(14)15)186(305)246-134(90-103(16)17)187(306)248-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,312)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,302)(H,245,303)(H,246,305)(H,247,308)(H,248,306)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 447n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158971
PNG
(CHEMBL427923 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-106(21)158(251-180(297)128(66-74-155(276)277)238-196(313)159(107(22)32-2)252-181(298)129(75-85-322-30)236-172(289)118(53-40-44-79-209)225-173(290)119(54-45-80-219-204(215)216)229-182(299)130(86-99(7)8)241-186(303)134(90-103(15)16)247-197(314)160(108(23)33-3)253-190(307)135(91-104(17)18)246-193(310)142-56-47-83-259(142)201(318)140(92-105(19)20)249-189(306)138(95-156(278)279)248-198(315)161(109(24)34-4)254-192(309)141(98-261)250-199(316)162(110(25)35-5)255-194(311)143-57-48-84-260(143)202(319)144-58-49-82-258(144)151(269)97-221-167(284)121-62-70-150(268)224-121)195(312)237-127(65-73-154(274)275)179(296)228-116(51-38-42-77-207)170(287)233-124(61-69-147(212)265)176(293)235-126(64-72-153(272)273)178(295)227-117(52-39-43-78-208)171(288)234-125(63-71-152(270)271)177(294)226-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)231-122(59-67-145(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-136(93-148(213)266)188(305)244-137(94-149(214)267)187(304)230-120(55-46-81-220-205(217)218)174(291)240-131(87-100(9)10)183(300)242-132(88-101(11)12)184(301)243-133(89-102(13)14)185(302)245-139(96-157(280)281)191(308)257-164(114(29)262)200(317)256-163(203(320)321)111(26)36-6/h99-144,158-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,304)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,312)(H,238,313)(H,239,283)(H,240,291)(H,241,303)(H,242,300)(H,243,301)(H,244,305)(H,245,302)(H,246,310)(H,247,314)(H,248,315)(H,249,306)(H,250,316)(H,251,297)(H,252,298)(H,253,307)(H,254,309)(H,255,311)(H,256,317)(H,257,308)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Homo sapiens (Human))
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (CRF2beta) assayed using nonselective [125I]-labeled agonist [Tyr0,Glu...


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50087711
PNG
(CHEMBL429560 | Sauvagine-frog(QGPPISIDLSLELLRKMIEI...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C202H349N57O63S/c1-29-103(20)156(162(214)284)252-199(321)161(110(27)262)257-191(313)137(92-155(282)283)248-186(308)132(87-101(16)17)244-185(307)131(86-100(14)15)243-183(305)129(84-98(10)11)240-172(294)117(51-43-78-220-202(217)218)229-188(310)135(90-147(213)268)247-189(311)134(89-146(212)267)239-164(286)109(26)222-163(285)108(25)223-166(288)118(55-64-143(209)264)230-173(295)119(56-65-144(210)265)231-167(289)112(46-34-38-73-203)225-175(297)121(58-67-149(270)271)233-169(291)114(48-36-40-75-205)226-176(298)122(59-68-150(272)273)234-174(296)120(57-66-145(211)266)232-168(290)113(47-35-39-74-204)227-177(299)124(61-70-152(276)277)237-195(317)157(104(21)30-2)253-179(301)125(62-71-153(278)279)238-196(318)158(105(22)31-3)254-180(302)126(72-81-323-28)236-170(292)115(49-37-41-76-206)224-171(293)116(50-42-77-219-201(215)216)228-181(303)127(82-96(6)7)242-184(306)130(85-99(12)13)241-178(300)123(60-69-151(274)275)235-182(304)128(83-97(8)9)246-192(314)138(94-260)250-187(309)133(88-102(18)19)245-190(312)136(91-154(280)281)249-197(319)159(106(23)32-4)255-193(315)139(95-261)251-198(320)160(107(24)33-5)256-194(316)140-52-44-80-259(140)200(322)141-53-45-79-258(141)148(269)93-221-165(287)111(207)54-63-142(208)263/h96-141,156-161,260-262H,29-95,203-207H2,1-28H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,284)(H,221,287)(H,222,285)(H,223,288)(H,224,293)(H,225,297)(H,226,298)(H,227,299)(H,228,303)(H,229,310)(H,230,295)(H,231,289)(H,232,290)(H,233,291)(H,234,296)(H,235,304)(H,236,292)(H,237,317)(H,238,318)(H,239,286)(H,240,294)(H,241,300)(H,242,306)(H,243,305)(H,244,307)(H,245,312)(H,246,314)(H,247,311)(H,248,308)(H,249,319)(H,250,309)(H,251,320)(H,252,321)(H,253,301)(H,254,302)(H,255,315)(H,256,316)(H,257,313)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.40n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay


J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Homo sapiens (Human))
BDBM50087711
PNG
(CHEMBL429560 | Sauvagine-frog(QGPPISIDLSLELLRKMIEI...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C202H349N57O63S/c1-29-103(20)156(162(214)284)252-199(321)161(110(27)262)257-191(313)137(92-155(282)283)248-186(308)132(87-101(16)17)244-185(307)131(86-100(14)15)243-183(305)129(84-98(10)11)240-172(294)117(51-43-78-220-202(217)218)229-188(310)135(90-147(213)268)247-189(311)134(89-146(212)267)239-164(286)109(26)222-163(285)108(25)223-166(288)118(55-64-143(209)264)230-173(295)119(56-65-144(210)265)231-167(289)112(46-34-38-73-203)225-175(297)121(58-67-149(270)271)233-169(291)114(48-36-40-75-205)226-176(298)122(59-68-150(272)273)234-174(296)120(57-66-145(211)266)232-168(290)113(47-35-39-74-204)227-177(299)124(61-70-152(276)277)237-195(317)157(104(21)30-2)253-179(301)125(62-71-153(278)279)238-196(318)158(105(22)31-3)254-180(302)126(72-81-323-28)236-170(292)115(49-37-41-76-206)224-171(293)116(50-42-77-219-201(215)216)228-181(303)127(82-96(6)7)242-184(306)130(85-99(12)13)241-178(300)123(60-69-151(274)275)235-182(304)128(83-97(8)9)246-192(314)138(94-260)250-187(309)133(88-102(18)19)245-190(312)136(91-154(280)281)249-197(319)159(106(23)32-4)255-193(315)139(95-261)251-198(320)160(107(24)33-5)256-194(316)140-52-44-80-259(140)200(322)141-53-45-79-258(141)148(269)93-221-165(287)111(207)54-63-142(208)263/h96-141,156-161,260-262H,29-95,203-207H2,1-28H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,284)(H,221,287)(H,222,285)(H,223,288)(H,224,293)(H,225,297)(H,226,298)(H,227,299)(H,228,303)(H,229,310)(H,230,295)(H,231,289)(H,232,290)(H,233,291)(H,234,296)(H,235,304)(H,236,292)(H,237,317)(H,238,318)(H,239,286)(H,240,294)(H,241,300)(H,242,306)(H,243,305)(H,244,307)(H,245,312)(H,246,314)(H,247,311)(H,248,308)(H,249,319)(H,250,309)(H,251,320)(H,252,321)(H,253,301)(H,254,302)(H,255,315)(H,256,316)(H,257,313)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,156-,157-,158-,159-,160-,161-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on h-CRF2-alpha receptor using agonist-stimulated adenylate cyclase assay


J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158969
PNG
(CHEMBL428975 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-106(21)158(251-180(297)128(66-74-155(276)277)238-196(313)159(107(22)32-2)252-181(298)129(75-85-322-30)236-172(289)118(53-40-44-79-209)225-173(290)119(54-45-80-219-204(215)216)229-182(299)130(86-99(7)8)241-184(301)133(89-102(13)14)244-187(304)135(91-104(17)18)247-198(315)161(109(24)34-4)254-193(310)142-56-47-83-259(142)201(318)140(92-105(19)20)249-190(307)138(95-156(278)279)248-197(314)160(108(23)33-3)253-192(309)141(98-261)250-199(316)162(110(25)35-5)255-194(311)143-57-48-84-260(143)202(319)144-58-49-82-258(144)151(269)97-221-167(284)121-62-70-150(268)224-121)195(312)237-127(65-73-154(274)275)179(296)228-116(51-38-42-77-207)170(287)233-124(61-69-147(212)265)176(293)235-126(64-72-153(272)273)178(295)227-117(52-39-43-78-208)171(288)234-125(63-71-152(270)271)177(294)226-115(50-37-41-76-206)169(286)232-123(60-68-146(211)264)175(292)231-122(59-67-145(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-136(93-148(213)266)189(306)245-137(94-149(214)267)188(305)230-120(55-46-81-220-205(217)218)174(291)240-131(87-100(9)10)183(300)242-132(88-101(11)12)185(302)243-134(90-103(15)16)186(303)246-139(96-157(280)281)191(308)257-164(114(29)262)200(317)256-163(203(320)321)111(26)36-6/h99-144,158-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,305)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,312)(H,238,313)(H,239,283)(H,240,291)(H,241,301)(H,242,300)(H,243,302)(H,244,304)(H,245,306)(H,246,303)(H,247,315)(H,248,314)(H,249,307)(H,250,316)(H,251,297)(H,252,298)(H,253,309)(H,254,310)(H,255,311)(H,256,317)(H,257,308)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t106-,107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,158-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158967
PNG
(CHEMBL414130 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C205H351N55O61S/c1-31-107(22)159(252-180(297)128(65-73-156(276)277)238-197(314)160(108(23)32-2)253-181(298)129(74-84-322-30)236-172(289)118(52-39-43-78-209)225-173(290)119(53-44-79-219-204(215)216)229-182(299)130(85-99(6)7)241-184(301)132(87-101(10)11)243-186(303)134(89-103(14)15)245-188(305)136(91-105(18)19)248-194(311)143-55-46-82-259(143)201(318)141(92-106(20)21)250-191(308)139(95-157(278)279)249-198(315)161(109(24)33-3)254-193(310)142(98-261)251-199(316)162(110(25)34-4)255-195(312)144-56-47-83-260(144)202(319)145-57-48-81-258(145)152(269)97-221-167(284)121-61-69-151(268)224-121)196(313)237-127(64-72-155(274)275)179(296)228-116(50-37-41-76-207)170(287)233-124(60-68-148(212)265)176(293)235-126(63-71-154(272)273)178(295)227-117(51-38-42-77-208)171(288)234-125(62-70-153(270)271)177(294)226-115(49-36-40-75-206)169(286)232-123(59-67-147(211)264)175(292)231-122(58-66-146(210)263)168(285)223-112(27)165(282)222-113(28)166(283)239-137(93-149(213)266)190(307)246-138(94-150(214)267)189(306)230-120(54-45-80-220-205(217)218)174(291)240-131(86-100(8)9)183(300)242-133(88-102(12)13)185(302)244-135(90-104(16)17)187(304)247-140(96-158(280)281)192(309)257-164(114(29)262)200(317)256-163(203(320)321)111(26)35-5/h99-145,159-164,261-262H,31-98,206-209H2,1-30H3,(H2,210,263)(H2,211,264)(H2,212,265)(H2,213,266)(H2,214,267)(H,221,284)(H,222,282)(H,223,285)(H,224,268)(H,225,290)(H,226,294)(H,227,295)(H,228,296)(H,229,299)(H,230,306)(H,231,292)(H,232,286)(H,233,287)(H,234,288)(H,235,293)(H,236,289)(H,237,313)(H,238,314)(H,239,283)(H,240,291)(H,241,301)(H,242,300)(H,243,303)(H,244,302)(H,245,305)(H,246,307)(H,247,304)(H,248,311)(H,249,315)(H,250,308)(H,251,316)(H,252,297)(H,253,298)(H,254,310)(H,255,312)(H,256,317)(H,257,309)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,215,216,219)(H4,217,218,220)/t107-,108-,109-,110-,111-,112-,113-,114+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 163n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing hormone receptor 2


(Sus scrofa)
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

KEGG

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.580n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]sauvagine from CRF2 receptor in pig choroid plexus by rapid filtration technique


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158956
PNG
(CHEMBL409748 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-105(20)158(252-180(299)127(64-73-155(277)278)239-196(315)159(106(21)30-2)253-181(300)128(74-84-323-28)237-171(290)116(50-37-41-78-208)225-172(291)117(51-42-79-219-203(215)216)229-182(301)129(85-98(6)7)243-185(304)131(87-100(10)11)242-179(298)123(59-68-147(212)266)236-183(302)134(90-103(16)17)248-193(312)141-53-44-82-259(141)200(319)139(91-104(18)19)250-190(309)137(94-156(279)280)249-197(316)160(107(22)31-3)254-192(311)140(97-261)251-198(317)161(108(23)32-4)255-194(313)142-54-45-83-260(142)201(320)143-55-46-81-258(143)151(270)96-221-166(285)119-60-69-150(269)224-119)195(314)238-126(63-72-154(275)276)178(297)228-114(48-35-39-76-206)169(288)233-122(58-67-146(211)265)175(294)235-125(62-71-153(273)274)177(296)227-115(49-36-40-77-207)170(289)234-124(61-70-152(271)272)176(295)226-113(47-34-38-75-205)168(287)232-121(57-66-145(210)264)174(293)231-120(56-65-144(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-135(92-148(213)267)189(308)246-136(93-149(214)268)188(307)230-118(52-43-80-220-204(217)218)173(292)241-130(86-99(8)9)184(303)244-132(88-101(12)13)186(305)245-133(89-102(14)15)187(306)247-138(95-157(281)282)191(310)257-163(112(27)262)199(318)256-162(202(321)322)109(24)33-5/h98-143,158-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,307)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,302)(H,237,290)(H,238,314)(H,239,315)(H,240,284)(H,241,292)(H,242,298)(H,243,304)(H,244,303)(H,245,305)(H,246,308)(H,247,306)(H,248,312)(H,249,316)(H,250,309)(H,251,317)(H,252,299)(H,253,300)(H,254,311)(H,255,313)(H,256,318)(H,257,310)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.5n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158962
PNG
(CHEMBL411474 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C204H348N56O62S/c1-29-104(19)157(251-180(299)127(65-74-154(277)278)239-195(314)158(105(20)30-2)252-181(300)128(75-85-323-28)236-171(290)116(51-38-42-79-208)225-172(291)117(52-43-80-219-203(215)216)229-182(301)129(86-98(7)8)243-184(303)131(88-100(11)12)242-179(298)123(60-69-146(212)266)237-196(315)160(107(22)32-4)254-192(311)140-54-45-83-259(140)200(319)138(91-103(17)18)249-189(308)136(94-155(279)280)248-197(316)159(106(21)31-3)253-191(310)139(97-261)250-198(317)161(108(23)33-5)255-193(312)141-55-46-84-260(141)201(320)142-56-47-82-258(142)150(270)96-221-166(285)119-61-70-149(269)224-119)194(313)238-126(64-73-153(275)276)178(297)228-114(49-36-40-77-206)169(288)233-122(59-68-145(211)265)175(294)235-125(63-72-152(273)274)177(296)227-115(50-37-41-78-207)170(289)234-124(62-71-151(271)272)176(295)226-113(48-35-39-76-205)168(287)232-121(58-67-144(210)264)174(293)231-120(57-66-143(209)263)167(286)223-110(25)164(283)222-111(26)165(284)240-134(92-147(213)267)188(307)246-135(93-148(214)268)187(306)230-118(53-44-81-220-204(217)218)173(292)241-130(87-99(9)10)183(302)244-132(89-101(13)14)185(304)245-133(90-102(15)16)186(305)247-137(95-156(281)282)190(309)257-163(112(27)262)199(318)256-162(202(321)322)109(24)34-6/h98-142,157-163,261-262H,29-97,205-208H2,1-28H3,(H2,209,263)(H2,210,264)(H2,211,265)(H2,212,266)(H2,213,267)(H2,214,268)(H,221,285)(H,222,283)(H,223,286)(H,224,269)(H,225,291)(H,226,295)(H,227,296)(H,228,297)(H,229,301)(H,230,306)(H,231,293)(H,232,287)(H,233,288)(H,234,289)(H,235,294)(H,236,290)(H,237,315)(H,238,313)(H,239,314)(H,240,284)(H,241,292)(H,242,298)(H,243,303)(H,244,302)(H,245,304)(H,246,307)(H,247,305)(H,248,316)(H,249,308)(H,250,317)(H,251,299)(H,252,300)(H,253,310)(H,254,311)(H,255,312)(H,256,318)(H,257,309)(H,271,272)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,321,322)(H4,215,216,219)(H4,217,218,220)/t104-,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,157-,158-,159-,160-,161-,162-,163-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair