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20 similar compounds to monomer 14361

Compile data set for download or QSAR
Wt: 321.3
BDBM50017117
Wt: 261.3
BDBM50017114
Wt: 277.3
BDBM50017115
Wt: 247.2
BDBM50017118
Wt: 263.3
BDBM50017092
Wt: 293.3
BDBM50017095
Wt: 233.3
BDBM50017100
Wt: 263.3
BDBM50017102
Wt: 348.4
BDBM50017109
Wt: 263.3
BDBM50017110
Wt: 275.3
BDBM50042056
Purchase
Wt: 275.3
BDBM50042058
Purchase
Wt: 289.3
BDBM50393515
Wt: 289.3
BDBM50393516
Wt: 365.4
BDBM50393517
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50017117,50017114,50017115,50017118,50017092,50017095,50017100,50017102,50017109,50017110,50042056,50042058,50393515,50393516,50393517   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50042056
PNG
((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of partially-purified PDE 4 from human monocytes


J Med Chem 36: 3274-7 (1993)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50393516
PNG
(CHEMBL2158062)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CN(C)C(=O)C1
Show InChI InChI=1S/C17H23NO3/c1-18-11-13(10-17(18)19)12-7-8-15(20-2)16(9-12)21-14-5-3-4-6-14/h7-9,13-14H,3-6,10-11H2,1-2H3/t13-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50393515
PNG
(CHEMBL2158061)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C)C(=O)C1
Show InChI InChI=1S/C17H23NO3/c1-18-11-13(10-17(18)19)12-7-8-15(20-2)16(9-12)21-14-5-3-4-6-14/h7-9,13-14H,3-6,10-11H2,1-2H3/t13-/m0/s1
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n/an/an/an/a 500n/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50393517
PNG
(CHEMBL2158063)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(Cc2ccccc2)C(=O)C1
Show InChI InChI=1S/C23H27NO3/c1-26-21-12-11-18(13-22(21)27-20-9-5-6-10-20)19-14-23(25)24(16-19)15-17-7-3-2-4-8-17/h2-4,7-8,11-13,19-20H,5-6,9-10,14-16H2,1H3/t19-/m0/s1
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n/an/an/an/a 2.10E+3n/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017095
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES COc1ccc(cc1OCCCC(O)=O)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO5/c1-20-12-5-4-10(11-8-14(17)16-9-11)7-13(12)21-6-2-3-15(18)19/h4-5,7,11H,2-3,6,8-9H2,1H3,(H,16,17)(H,18,19)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017110
PNG
(4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1ccc(cc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-13-6-5-11(8-14(13)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017092
PNG
(4-(3-Isobutoxy-4-methoxy-phenyl)-pyrrolidin-2-one ...)
Show SMILES COc1ccc(cc1OCC(C)C)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,10,12H,7-9H2,1-3H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017115
PNG
(4-[4-Methoxy-3-(2-methyl-butoxy)-phenyl]-pyrrolidi...)
Show SMILES CCC(C)COc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C16H23NO3/c1-4-11(2)10-20-15-7-12(5-6-14(15)19-3)13-8-16(18)17-9-13/h5-7,11,13H,4,8-10H2,1-3H3,(H,17,18)
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n/an/a 2.00E+5n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017118
PNG
(4-(3-Allyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |...)
Show SMILES COc1ccc(cc1OCC=C)C1CNC(=O)C1
Show InChI InChI=1S/C14H17NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h3-5,7,11H,1,6,8-9H2,2H3,(H,15,16)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017100
PNG
(4-(3-Butoxy-phenyl)-pyrrolidin-2-one | CHEMBL32226)
Show SMILES CCCCOc1cccc(c1)C1CNC(=O)C1
Show InChI InChI=1S/C14H19NO2/c1-2-3-7-17-13-6-4-5-11(8-13)12-9-14(16)15-10-12/h4-6,8,12H,2-3,7,9-10H2,1H3,(H,15,16)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017114
PNG
(4-[4-Methoxy-3-(2-methyl-allyloxy)-phenyl]-pyrroli...)
Show SMILES COc1ccc(cc1OCC(C)=C)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,12H,1,7-9H2,2-3H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017102
PNG
(4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-14-8-11(5-6-13(14)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017117
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 5A


(Bos taurus)
BDBM50017109
PNG
(CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...)
Show SMILES CCCCNC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C19H28N2O4/c1-3-4-9-20-18(22)6-5-10-25-17-11-14(7-8-16(17)24-2)15-12-19(23)21-13-15/h7-8,11,15H,3-6,9-10,12-13H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50393515
PNG
(CHEMBL2158061)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(C)C(=O)C1
Show InChI InChI=1S/C17H23NO3/c1-18-11-13(10-17(18)19)12-7-8-15(20-2)16(9-12)21-14-5-3-4-6-14/h7-9,13-14H,3-6,10-11H2,1-2H3/t13-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50393517
PNG
(CHEMBL2158063)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CN(Cc2ccccc2)C(=O)C1
Show InChI InChI=1S/C23H27NO3/c1-26-21-12-11-18(13-22(21)27-20-9-5-6-10-20)19-14-23(25)24(16-19)15-17-7-3-2-4-8-17/h2-4,7-8,11-13,19-20H,5-6,9-10,14-16H2,1H3/t19-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50042056
PNG
((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/an/an/a 3.40E+3n/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/an/an/a 480n/an/an/an/a



University of Glasgow

Curated by ChEMBL


Assay Description
Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci


J Med Chem 54: 3331-47 (2011)


Article DOI: 10.1021/jm200070e
BindingDB Entry DOI: 10.7270/Q2CF9R75
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
PDE4A activity assessed using human recombinant purified GST-PDE4A248


Bioorg Med Chem Lett 9: 323-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00742-2
BindingDB Entry DOI: 10.7270/Q27S7MXX
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50042056
PNG
((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/a 1.06E+3n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of PDE4D2 catalytic domain (86 to 413 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counti...


Eur J Med Chem 114: 134-40 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.002
BindingDB Entry DOI: 10.7270/Q2765H8J
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50042056
PNG
((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of PDE4D2 catalytic domain (86 to 413 residues) (unknown origin)


Eur J Med Chem 114: 134-40 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.002
BindingDB Entry DOI: 10.7270/Q2765H8J
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2-mediated cAMP hydrolysis for 30 mins by colorimetric assay


Bioorg Med Chem Lett 22: 1523-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.013
BindingDB Entry DOI: 10.7270/Q2794548
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 622n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4D


J Med Chem 50: 344-9 (2007)


Article DOI: 10.1021/jm060904g
BindingDB Entry DOI: 10.7270/Q2K0753Z
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 231n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B


J Med Chem 50: 344-9 (2007)


Article DOI: 10.1021/jm060904g
BindingDB Entry DOI: 10.7270/Q2K0753Z
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Homo sapiens)
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 3.69E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4C


J Med Chem 50: 344-9 (2007)


Article DOI: 10.1021/jm060904g
BindingDB Entry DOI: 10.7270/Q2K0753Z
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 162n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4A


J Med Chem 50: 344-9 (2007)


Article DOI: 10.1021/jm060904g
BindingDB Entry DOI: 10.7270/Q2K0753Z
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017092
PNG
(4-(3-Isobutoxy-4-methoxy-phenyl)-pyrrolidin-2-one ...)
Show SMILES COc1ccc(cc1OCC(C)C)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,10,12H,7-9H2,1-3H3,(H,16,17)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017114
PNG
(4-[4-Methoxy-3-(2-methyl-allyloxy)-phenyl]-pyrroli...)
Show SMILES COc1ccc(cc1OCC(C)=C)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,12H,1,7-9H2,2-3H3,(H,16,17)
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n/an/a 2.40E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017110
PNG
(4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1ccc(cc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-13-6-5-11(8-14(13)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017118
PNG
(4-(3-Allyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |...)
Show SMILES COc1ccc(cc1OCC=C)C1CNC(=O)C1
Show InChI InChI=1S/C14H17NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h3-5,7,11H,1,6,8-9H2,2H3,(H,15,16)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017102
PNG
(4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-14-8-11(5-6-13(14)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017117
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)
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Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017102
PNG
(4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-14-8-11(5-6-13(14)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017100
PNG
(4-(3-Butoxy-phenyl)-pyrrolidin-2-one | CHEMBL32226)
Show SMILES CCCCOc1cccc(c1)C1CNC(=O)C1
Show InChI InChI=1S/C14H19NO2/c1-2-3-7-17-13-6-4-5-11(8-13)12-9-14(16)15-10-12/h4-6,8,12H,2-3,7,9-10H2,1H3,(H,15,16)
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Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017110
PNG
(4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one | C...)
Show SMILES CCCCOc1ccc(cc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-13-6-5-11(8-14(13)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)
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Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017109
PNG
(CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...)
Show SMILES CCCCNC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C19H28N2O4/c1-3-4-9-20-18(22)6-5-10-25-17-11-14(7-8-16(17)24-2)15-12-19(23)21-13-15/h7-8,11,15H,3-6,9-10,12-13H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017095
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES COc1ccc(cc1OCCCC(O)=O)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO5/c1-20-12-5-4-10(11-8-14(17)16-9-11)7-13(12)21-6-2-3-15(18)19/h4-5,7,11H,2-3,6,8-9H2,1H3,(H,16,17)(H,18,19)
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Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017117
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017092
PNG
(4-(3-Isobutoxy-4-methoxy-phenyl)-pyrrolidin-2-one ...)
Show SMILES COc1ccc(cc1OCC(C)C)C1CNC(=O)C1
Show InChI InChI=1S/C15H21NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,10,12H,7-9H2,1-3H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017115
PNG
(4-[4-Methoxy-3-(2-methyl-butoxy)-phenyl]-pyrrolidi...)
Show SMILES CCC(C)COc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C16H23NO3/c1-4-11(2)10-20-15-7-12(5-6-14(15)19-3)13-8-16(18)17-9-13/h5-7,11,13H,4,8-10H2,1-3H3,(H,17,18)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017114
PNG
(4-[4-Methoxy-3-(2-methyl-allyloxy)-phenyl]-pyrroli...)
Show SMILES COc1ccc(cc1OCC(C)=C)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,12H,1,7-9H2,2-3H3,(H,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017100
PNG
(4-(3-Butoxy-phenyl)-pyrrolidin-2-one | CHEMBL32226)
Show SMILES CCCCOc1cccc(c1)C1CNC(=O)C1
Show InChI InChI=1S/C14H19NO2/c1-2-3-7-17-13-6-4-5-11(8-13)12-9-14(16)15-10-12/h4-6,8,12H,2-3,7,9-10H2,1H3,(H,15,16)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017109
PNG
(CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...)
Show SMILES CCCCNC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C19H28N2O4/c1-3-4-9-20-18(22)6-5-10-25-17-11-14(7-8-16(17)24-2)15-12-19(23)21-13-15/h7-8,11,15H,3-6,9-10,12-13H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Bos taurus-BOVINE)
BDBM50017118
PNG
(4-(3-Allyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |...)
Show SMILES COc1ccc(cc1OCC=C)C1CNC(=O)C1
Show InChI InChI=1S/C14H17NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h3-5,7,11H,1,6,8-9H2,2H3,(H,15,16)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017095
PNG
(4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...)
Show SMILES COc1ccc(cc1OCCCC(O)=O)C1CNC(=O)C1
Show InChI InChI=1S/C15H19NO5/c1-20-12-5-4-10(11-8-14(17)16-9-11)7-13(12)21-6-2-3-15(18)19/h4-5,7,11H,2-3,6,8-9H2,1H3,(H,16,17)(H,18,19)
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n/an/a 4.00E+5n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50017115
PNG
(4-[4-Methoxy-3-(2-methyl-butoxy)-phenyl]-pyrrolidi...)
Show SMILES CCC(C)COc1cc(ccc1OC)C1CNC(=O)C1
Show InChI InChI=1S/C16H23NO3/c1-4-11(2)10-20-15-7-12(5-6-14(15)19-3)13-8-16(18)17-9-13/h5-7,11,13H,4,8-10H2,1-3H3,(H,17,18)
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n/an/a 4.60E+4n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.


J Med Chem 32: 1450-7 (1989)


Article DOI: 10.1021/jm00127a009
BindingDB Entry DOI: 10.7270/Q2DN441H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B2 assessed as decrease in cAMP hydrolysis preincubated with substrate prior to enzyme addition measured after 30...


Bioorg Med Chem Lett 23: 1548-52 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.058
BindingDB Entry DOI: 10.7270/Q2WM1FRH
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B by scintillation proximity assay


Bioorg Med Chem Lett 19: 5261-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.012
BindingDB Entry DOI: 10.7270/Q2K075HB
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50042058
PNG
((-)-rolipram | (4R)-4-[3-(cyclopentyloxy)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of partially-purified PDE 4 from human monocytes


J Med Chem 36: 3274-7 (1993)

More data for this
Ligand-Target Pair
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