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11 similar compounds to monomer 50358321

Compile data set for download or QSAR
Wt: 231.2
BDBM50289173
Wt: 287.3
BDBM50289174
Wt: 259.3
BDBM50289175
Wt: 315.4
BDBM50289176
Wt: 371.5
BDBM50289178
Wt: 427.6
BDBM50289179
Wt: 287.3
BDBM50358322
Wt: 409.8
BDBM50166778
Wt: 375.4
BDBM50166781
Wt: 409.8
BDBM50166780
Wt: 249.2
BDBM50024122

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50289173,50289174,50289175,50289176,50289178,50289179,50358322,50166778,50166781,50166780,50024122   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50289173
PNG
((1R,3S,6R)-6-Butylamino-4-hydroxymethyl-cyclohex-4...)
Show SMILES CCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H21NO4/c1-2-3-4-12-8-5-7(6-13)9(14)11(16)10(8)15/h5,8-16H,2-4,6H2,1H3
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n/an/a<1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-glucosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Sucrase-isomaltase


(Homo sapiens (Human))
BDBM50024122
PNG
(6-(2-Hydroxy-1-hydroxymethyl-ethylamino)-4-hydroxy...)
Show SMILES OCC(CO)N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H19NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h1,6-17H,2-4H2/t7-,8+,9?,10+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Alpha-D-glucosidase inhibitory activity and enzyme inhibition in vitro against porcine sucrase


J Med Chem 29: 1038-46 (1986)


Article DOI: 10.1021/jm00156a023
BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166778
PNG
(CHEMBL3799140)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4c(Cl)cccc34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C14H27NO3/c1-2-3-4-5-6-7-10-15-11-8-9-12(16)14(18)13(11)17/h8-9,11-18H,2-7,10H2,1H3
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n/an/a 4.80n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166780
PNG
(CHEMBL3799024)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4cccc(Cl)c34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C9H17NO3/c1-2-5-10-6-3-4-7(11)9(13)8(6)12/h3-4,6-13H,2,5H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166781
PNG
(CHEMBL3797268)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4ccccc34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C12H23NO3/c1-2-3-4-5-8-13-9-6-7-10(14)12(16)11(9)15/h6-7,9-16H,2-5,8H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166781
PNG
(CHEMBL3797268)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4ccccc34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C12H23NO3/c1-2-3-4-5-8-13-9-6-7-10(14)12(16)11(9)15/h6-7,9-16H,2-5,8H2,1H3
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n/an/a>200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166780
PNG
(CHEMBL3799024)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4cccc(Cl)c34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C9H17NO3/c1-2-5-10-6-3-4-7(11)9(13)8(6)12/h3-4,6-13H,2,5H2,1H3
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n/an/a>200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50166778
PNG
(CHEMBL3799140)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4c(Cl)cccc34)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C14H27NO3/c1-2-3-4-5-6-7-10-15-11-8-9-12(16)14(18)13(11)17/h8-9,11-18H,2-7,10H2,1H3
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n/an/a>200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 in human SNU16 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
α-galactosidase


(Coffea arabica (Coffee beans))
BDBM50358322
PNG
(CHEMBL1922580)
Show SMILES CCCCCCCCN[C@@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13-,14+,15+/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Hokko Chemical Industry Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of green coffee beans alpha-galactosidase by spectrometry


Bioorg Med Chem Lett 21: 7189-92 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.067
BindingDB Entry DOI: 10.7270/Q2RF5VF0
More data for this
Ligand-Target Pair
β-galactosidase


(Bos taurus (Bovine))
BDBM50358322
PNG
(CHEMBL1922580)
Show SMILES CCCCCCCCN[C@@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13-,14+,15+/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Hokko Chemical Industry Co. Ltd

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-galactosidase by spectrometry


Bioorg Med Chem Lett 21: 7189-92 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.067
BindingDB Entry DOI: 10.7270/Q2RF5VF0
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289173
PNG
((1R,3S,6R)-6-Butylamino-4-hydroxymethyl-cyclohex-4...)
Show SMILES CCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H21NO4/c1-2-3-4-12-8-5-7(6-13)9(14)11(16)10(8)15/h5,8-16H,2-4,6H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289174
PNG
((1R,3S,6R)-4-Hydroxymethyl-6-octylamino-cyclohex-4...)
Show SMILES CCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289175
PNG
((1R,3S,6R)-6-Hexylamino-4-hydroxymethyl-cyclohex-4...)
Show SMILES CCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C13H25NO4/c1-2-3-4-5-6-14-10-7-9(8-15)11(16)13(18)12(10)17/h7,10-18H,2-6,8H2,1H3
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50289175
PNG
((1R,3S,6R)-6-Hexylamino-4-hydroxymethyl-cyclohex-4...)
Show SMILES CCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C13H25NO4/c1-2-3-4-5-6-14-10-7-9(8-15)11(16)13(18)12(10)17/h7,10-18H,2-6,8H2,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-glucosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289176
PNG
((1R,3S,6R)-6-Decylamino-4-hydroxymethyl-cyclohex-4...)
Show SMILES CCCCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C17H33NO4/c1-2-3-4-5-6-7-8-9-10-18-14-11-13(12-19)15(20)17(22)16(14)21/h11,14-22H,2-10,12H2,1H3
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n/an/a 70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289178
PNG
((1R,3S,6R)-4-Hydroxymethyl-6-tetradecylamino-cyclo...)
Show SMILES CCCCCCCCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C21H41NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-22-18-15-17(16-23)19(24)21(26)20(18)25/h15,18-26H,2-14,16H2,1H3
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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Beta-glucocerebrosidase


(Mus musculus (Mouse))
BDBM50289179
PNG
((1R,3S,6R)-4-Hydroxymethyl-6-octadecylamino-cycloh...)
Show SMILES CCCCCCCCCCCCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C25H49NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26-22-19-21(20-27)23(28)25(30)24(22)29/h19,22-30H,2-18,20H2,1H3
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against beta-glucocerebrosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50289174
PNG
((1R,3S,6R)-4-Hydroxymethyl-6-octylamino-cyclohex-4...)
Show SMILES CCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-glucosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50024122
PNG
(6-(2-Hydroxy-1-hydroxymethyl-ethylamino)-4-hydroxy...)
Show SMILES OCC(CO)N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C10H19NO6/c12-2-5-1-7(11-6(3-13)4-14)9(16)10(17)8(5)15/h1,6-17H,2-4H2/t7-,8+,9?,10+/m0/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine maltase


J Med Chem 29: 1038-46 (1986)


Article DOI: 10.1021/jm00156a023
BindingDB Entry DOI: 10.7270/Q27P8ZZV
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50289179
PNG
((1R,3S,6R)-4-Hydroxymethyl-6-octadecylamino-cycloh...)
Show SMILES CCCCCCCCCCCCCCCCCCNC1C=C(CO)C(O)C(O)C1O
Show InChI InChI=1S/C25H49NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26-22-19-21(20-27)23(28)25(30)24(22)29/h19,22-30H,2-18,20H2,1H3
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n/an/a<1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-glucosidase.


Bioorg Med Chem Lett 6: 929-932 (1996)


Article DOI: 10.1016/0960-894X(96)00146-1
BindingDB Entry DOI: 10.7270/Q2TX3FV3
More data for this
Ligand-Target Pair