BindingDB logo
myBDB logout

38 similar compounds to monomer 50165129

Compile data set for download or QSAR
Wt: 572.3
BDBM50101904
Wt: 486.2
BDBM50101906
Wt: 440.2
BDBM50101907
Wt: 453.6
BDBM50027053
Wt: 431.3
BDBM50165117
Wt: 458.5
BDBM50165118
Wt: 382.4
BDBM50165119
Wt: 517.4
BDBM50165122
Wt: 367.4
BDBM50165127
Wt: 396.4
BDBM50165134
Wt: 503.4
BDBM50165142
Wt: 799.4
BDBM50294220
Wt: 533.1
BDBM50294222
Wt: 549.2
BDBM50294223
Wt: 680.6
BDBM50035396
Displayed 1 to 15 (of 37 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50101904,50101906,50101907,50027053,50165117,50165118,50165119,50165122,50165127,50165134,50165142,50294220,50294222,50294223,50035396   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50027053
PNG
(CHEMBL2111681)
Show SMILES CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H39N3O3/c1-18(2)25(29-26(33)24(28)14-20-8-10-22(31)11-9-20)17-30-13-12-27(4,19(3)16-30)21-6-5-7-23(32)15-21/h5-11,15,18-19,24-25,31-32H,12-14,16-17,28H2,1-4H3,(H,29,33)/t19-,24-,25+,27+/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brain


J Med Chem 46: 3127-37 (2003)


Article DOI: 10.1021/jm030094y
BindingDB Entry DOI: 10.7270/Q2319WM4
More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50027053
PNG
(CHEMBL2111681)
Show SMILES CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H39N3O3/c1-18(2)25(29-26(33)24(28)14-20-8-10-22(31)11-9-20)17-30-13-12-27(4,19(3)16-30)21-6-5-7-23(32)15-21/h5-11,15,18-19,24-25,31-32H,12-14,16-17,28H2,1-4H3,(H,29,33)/t19-,24-,25+,27+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
208n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain tissue


J Med Chem 46: 3127-37 (2003)


Article DOI: 10.1021/jm030094y
BindingDB Entry DOI: 10.7270/Q2319WM4
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50027053
PNG
(CHEMBL2111681)
Show SMILES CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C27H39N3O3/c1-18(2)25(29-26(33)24(28)14-20-8-10-22(31)11-9-20)17-30-13-12-27(4,19(3)16-30)21-6-5-7-23(32)15-21/h5-11,15,18-19,24-25,31-32H,12-14,16-17,28H2,1-4H3,(H,29,33)/t19-,24-,25+,27+/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.05E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain tissue


J Med Chem 46: 3127-37 (2003)


Article DOI: 10.1021/jm030094y
BindingDB Entry DOI: 10.7270/Q2319WM4
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.71E+4n/an/an/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50035396
PNG
(CHEMBL3343375)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccc(C)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H32F4N6O5/c1-21-4-7-23(8-5-21)44-32(34(36,37)38)31(41-42-44)33(45)40-22-6-9-28(25(35)18-22)49-27-10-11-39-26-20-30(29(46-2)19-24(26)27)48-15-3-12-43-13-16-47-17-14-43/h4-11,18-20H,3,12-17H2,1-2H3,(H,40,45)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay


Bioorg Med Chem 22: 6438-52 (2014)


Article DOI: 10.1016/j.bmc.2014.09.037
BindingDB Entry DOI: 10.7270/Q2BG2QM2
More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens (Human))
BDBM50101904
PNG
(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20E+4n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of 10 mM fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)


Article DOI: 10.1016/s0960-894x(01)00282-7
BindingDB Entry DOI: 10.7270/Q2FF3SWF
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.44E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens (Human))
BDBM50101904
PNG
(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibition of GnRH-stimulated luteinizing hormone (LH) release in rat pituitary cells


Bioorg Med Chem Lett 11: 1809-11 (2001)


Article DOI: 10.1016/s0960-894x(01)00282-7
BindingDB Entry DOI: 10.7270/Q2FF3SWF
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.39E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)


Article DOI: 10.1016/j.bmc.2012.01.013
BindingDB Entry DOI: 10.7270/Q2ZW1MC1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)


Article DOI: 10.1016/j.bmc.2012.01.013
BindingDB Entry DOI: 10.7270/Q2ZW1MC1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Fucosyltransferase 5


(Homo sapiens (Human))
BDBM50101906
PNG
(CHEMBL53188 | GDP-Azasugar analogue)
Show SMILES [NH3+]CCOP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C12H20N6O11P2/c13-1-2-26-30(22,23)29-31(24,25)27-3-5-7(19)8(20)11(28-5)18-4-15-6-9(18)16-12(14)17-10(6)21/h4-5,7-8,11,19-20H,1-3,13H2,(H,22,23)(H,24,25)(H3,14,16,17,21)/t5-,7-,8-,11-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEBI
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)


Article DOI: 10.1016/s0960-894x(01)00282-7
BindingDB Entry DOI: 10.7270/Q2FF3SWF
More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens (Human))
BDBM50101907
PNG
(({[(2R,3S,4R,5R)-5-(2-azaniumyl-6-hydroxy-9H-purin...)
Show SMILES CP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C11H17N5O10P2/c1-27(20,21)26-28(22,23)24-2-4-6(17)7(18)10(25-4)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H,20,21)(H,22,23)(H3,12,14,15,19)/p-1/t4-,6-,7-,10-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)


Article DOI: 10.1016/s0960-894x(01)00282-7
BindingDB Entry DOI: 10.7270/Q2FF3SWF
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165117
PNG
(2-amino-6-hydroxy-9-[(2R,4S,5R)-5-[(phosphinatooxy...)
Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C16H26N5O7P/c1-7(2)26-11-9(5-25-29(23)24)28-15(12(11)27-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)22/h6-9,11-12,15,29H,5H2,1-4H3,(H,23,24)(H3,17,19,20,22)/t9-,11+,12?,15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165118
PNG
(2-Amino-7-benzyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4...)
Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C23H31N5O5/c1-13(2)31-18-16(11-29)33-22(19(18)32-14(3)4)28-12-27(10-15-8-6-5-7-9-15)17-20(28)25-23(24)26-21(17)30/h5-9,12-14,16,18-19,22,29H,10-11H2,1-4H3,(H2-,24,25,26,30)/p+1/t16-,18+,19?,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165119
PNG
(2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopro...)
Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](C)c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C17H27N5O5/c1-8(2)25-12-10(6-23)27-16(13(12)26-9(3)4)22-7-21(5)11-14(22)19-17(18)20-15(11)24/h7-10,12-13,16,23H,6H2,1-5H3,(H2-,18,19,20,24)/p+1/t10-,12+,13?,16-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165122
PNG
(CHEMBL195283 | disodium 2-amino-9-[(2R,4S,5R)-5-[(...)
Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C19H31N6O9P/c1-9(2)32-14-11(7-31-35(29,30)22-6-5-12(26)27)34-18(15(14)33-10(3)4)25-8-21-13-16(25)23-19(20)24-17(13)28/h8-11,14-15,18H,5-7H2,1-4H3,(H,26,27)(H2,22,29,30)(H3,20,23,24,28)/p-1/t11-,14+,15?,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165127
PNG
(2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopro...)
Show SMILES CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1cnc2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C16H25N5O5/c1-7(2)24-11-9(5-22)26-15(12(11)25-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)23/h6-9,11-12,15,22H,5H2,1-4H3,(H3,17,19,20,23)/t9-,11+,12?,15-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165134
PNG
(2-Amino-7-ethyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-...)
Show SMILES CC[n+]1cn([C@@H]2O[C@H](CO)[C@H](OC(C)C)C2OC(C)C)c2nc(N)[nH]c(=O)c12
Show InChI InChI=1S/C18H29N5O5/c1-6-22-8-23(15-12(22)16(25)21-18(19)20-15)17-14(27-10(4)5)13(26-9(2)3)11(7-24)28-17/h8-11,13-14,17,24H,6-7H2,1-5H3,(H2-,19,20,21,25)/p+1/t11-,13+,14?,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50165142
PNG
(CHEMBL194978 | disodium 2-amino-9-[(2R,4S,5R)-5-[(...)
Show SMILES CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C18H29N6O9P/c1-8(2)31-13-10(6-30-34(28,29)21-5-11(25)26)33-17(14(13)32-9(3)4)24-7-20-12-15(24)22-18(19)23-16(12)27/h7-10,13-14,17H,5-6H2,1-4H3,(H,25,26)(H2,21,28,29)(H3,19,22,23,27)/p-1/t10-,13+,14?,17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E


Bioorg Med Chem Lett 15: 2177-80 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.080
BindingDB Entry DOI: 10.7270/Q27D2VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.053
BindingDB Entry DOI: 10.7270/Q2NP24FN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)