Compounds in cluster

39 similar compounds to monomer 50165133

Wt: 486.2 BDBM50101906	Wt: 453.6 BDBM50027053	Wt: 458.5 BDBM50165118	Wt: 799.4 BDBM50294220	Wt: 533.1 BDBM50294222
Wt: 549.2 BDBM50294223	Wt: 453.3 BDBM50316305	Wt: 471.3 BDBM50316306	Wt: 487.7 BDBM50316307	Wt: 487.7 BDBM50316308
Wt: 487.7 BDBM50316309	Wt: 505.7 BDBM50316310	Wt: 471.3 BDBM50316311	Wt: 497.3 BDBM50316312	Wt: 483.3 BDBM50316313

Displayed 1 to 15 (of 38 total ) | Next | Last >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50101906,50027053,50165118,50294220,50294222,50294223,50316305,50316306,50316307,50316308,50316309,50316310,50316311,50316312,50316313
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50027053 (CHEMBL2111681) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig brain				J Med Chem 46: 3127-37 (2003) Article DOI: 10.1021/jm030094y BindingDB Entry DOI: 10.7270/Q2319WM4
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Nociceptin/mu opioid receptor (Rattus norvegicus (rat))	BDBM50027053 (CHEMBL2111681) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	208	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain tissue				J Med Chem 46: 3127-37 (2003) Article DOI: 10.1021/jm030094y BindingDB Entry DOI: 10.7270/Q2319WM4
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Opioid receptors; mu & delta (Rattus norvegicus (rat))	BDBM50027053 (CHEMBL2111681) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>5.05E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain tissue				J Med Chem 46: 3127-37 (2003) Article DOI: 10.1021/jm030094y BindingDB Entry DOI: 10.7270/Q2319WM4
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294220 (2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.71E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294222 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294223 (2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294223 (2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294222 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316305 (((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316306 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-fluorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316307 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.99E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316308 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50316307 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316310 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-chloro-5-fluorobenz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316311 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-fluorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316312 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-carboxybenzyl)-6-ox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.59E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316313 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-methoxybenzyl)-6-ox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316305 (((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in absence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316306 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-fluorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.23E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in absence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316311 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-fluorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.36E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in absence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294220 (2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...				Bioorg Med Chem 20: 1699-710 (2012) Article DOI: 10.1016/j.bmc.2012.01.013 BindingDB Entry DOI: 10.7270/Q2ZW1MC1
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294220 (2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay				Bioorg Med Chem 20: 1699-710 (2012) Article DOI: 10.1016/j.bmc.2012.01.013 BindingDB Entry DOI: 10.7270/Q2ZW1MC1
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Fucosyltransferase 5 (Homo sapiens (Human))	BDBM50101906 (CHEMBL53188 \| GDP-Azasugar analogue) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEBI CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universit£t Berlin Curated by ChEMBL					Assay Description Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine				Bioorg Med Chem Lett 11: 1809-11 (2001) Article DOI: 10.1016/s0960-894x(01)00282-7 BindingDB Entry DOI: 10.7270/Q2FF3SWF
Technische Universit£t Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E) (Homo sapiens (Human))	BDBM50165118 (2-Amino-7-benzyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E				Bioorg Med Chem Lett 15: 2177-80 (2005) Article DOI: 10.1016/j.bmcl.2005.01.080 BindingDB Entry DOI: 10.7270/Q27D2VWP
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E) (Homo sapiens (Human))	BDBM50316305 (((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (eIF4E) (Homo sapiens (Human))	BDBM50316308 (((2R,3S,4R,5R)-5-(2-Amino-7-(3-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E) (Homo sapiens (Human))	BDBM50316309 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.45E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E) (Homo sapiens (Human))	BDBM50316307 (((2R,3S,4R,5R)-5-(2-Amino-7-(4-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50316305 (((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294223 (2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294223 (2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294222 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Oryctolagus cuniculus)	BDBM50294220 (2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...				Bioorg Med Chem Lett 19: 1921-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.053 BindingDB Entry DOI: 10.7270/Q2NP24FN
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Eukaryotic translation initiation factor 4E (Mus musculus)	BDBM50316309 (((2R,3S,4R,5R)-5-(2-Amino-7-(2-chlorobenzyl)-6-oxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.24E+3	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair