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5 similar compounds to monomer 50076390

Compile data set for download or QSAR
Wt: 161.1
BDBM50031702
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Wt: 161.1
BDBM50031703
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Wt: 161.1
BDBM50031704
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Wt: 161.1
BDBM50031705
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Wt: 177.1
BDBM50251951

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50031702,50031703,50031704,50031705,50251951   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, kainate 1


(RAT)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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0.663n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR5


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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5.69n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR7


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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10n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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15n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR6


J Med Chem 51: 4093-103 (2008)


Article DOI: 10.1021/jm800092x
BindingDB Entry DOI: 10.7270/Q20V8DP6
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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2.00E+3n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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6.60E+3n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)


Article DOI: 10.1021/jm050597z
BindingDB Entry DOI: 10.7270/Q2MP52V1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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1.30E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT2 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)


Article DOI: 10.1021/jm050597z
BindingDB Entry DOI: 10.7270/Q2MP52V1
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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1.40E+5n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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4.70E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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3.00E+6n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50031702
PNG
((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Show SMILES C[C@@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)


Article DOI: 10.1021/jm049092j
BindingDB Entry DOI: 10.7270/Q23X87FM
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031705
PNG
((2R,4R)-2-Amino-4-methyl-pentanedioic acid | CHEMB...)
Show SMILES C[C@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031705
PNG
((2R,4R)-2-Amino-4-methyl-pentanedioic acid | CHEMB...)
Show SMILES C[C@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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n/an/a 3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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n/an/a 3.00E+5n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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n/an/a 3.00E+6n/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assay


J Med Chem 51: 4085-92 (2008)

Checked by Author
Article DOI: 10.1021/jm800091e
BindingDB Entry DOI: 10.7270/Q24M95FC
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031702
PNG
((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Show SMILES C[C@@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031702
PNG
((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Show SMILES C[C@@H](C[C@@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m0/s1
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n/an/a>7.00E+3n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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n/an/a>7.00E+3n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-CGS-19,755 binding to AMPA receptors.


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031703
PNG
((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Show SMILES C[C@@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4-/m0/s1
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Symphony Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPA


J Med Chem 38: 2518-20 (1995)


Article DOI: 10.1021/jm00014a002
BindingDB Entry DOI: 10.7270/Q2R210DW
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ...


Eur J Med Chem 45: 69-77 (2010)


Article DOI: 10.1016/j.ejmech.2009.09.025
BindingDB Entry DOI: 10.7270/Q28S4QVF
More data for this
Ligand-Target Pair