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6 similar compounds to monomer 50033851

Compile data set for download or QSAR
Wt: 408.5
BDBM50033835
Wt: 394.5
BDBM50033839
Wt: 408.5
BDBM50033842
Wt: 394.5
BDBM50033858
Wt: 394.5
BDBM50073614
Wt: 394.5
BDBM50073621

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50033835,50033839,50033842,50033858,50073614,50073621   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cerebral cortex


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 of rat corpora striata synaptic membranes


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from Dopamine receptor D2 of rat corpora striata synaptic membranes


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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37n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-YM-09151-2 from human Dopamine receptor D4.2 expressed in baculovirus Sf9 cells


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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43n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-YM-09151-2 from human Dopamine receptor D4.2 expressed in baculovirus Sf9 cells


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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65n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cerebral cortex


Bioorg Med Chem Lett 7: 1327-1330 (1997)


Article DOI: 10.1016/S0960-894X(97)00218-7
BindingDB Entry DOI: 10.7270/Q2P55NJG
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 92.8n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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n/an/a 1.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 1.73n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 60n/an/an/an/an/an/a



Universitá di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity at human cloned Dopamine receptor D4.2 by [3H]-YM-09151-2 displacement.


J Med Chem 41: 4903-9 (1998)


Article DOI: 10.1021/jm981041x
BindingDB Entry DOI: 10.7270/Q2S46R3V
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Universitá di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity at human cloned Dopamine receptor D2 by [3H]-spiroperidol displacement.


J Med Chem 41: 4903-9 (1998)


Article DOI: 10.1021/jm981041x
BindingDB Entry DOI: 10.7270/Q2S46R3V
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Universitá di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity at human cloned Dopamine receptor D2 by [3H]-spiroperidol displacement.


J Med Chem 41: 4903-9 (1998)


Article DOI: 10.1021/jm981041x
BindingDB Entry DOI: 10.7270/Q2S46R3V
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



Universitá di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity at human cloned Dopamine receptor D4.2 by [3H]-YM-09151-2 displacement.


J Med Chem 41: 4903-9 (1998)


Article DOI: 10.1021/jm981041x
BindingDB Entry DOI: 10.7270/Q2S46R3V
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-spiroperidol binding to rat Dopamine D2 receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50073614
PNG
(1-(2-Methoxy-phenyl)-4-[3-((R)-5-methoxy-1,2,3,4-t...)
Show SMILES COc1cccc2[C@@H](CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3/t20-/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-spiroperidol binding to rat Dopamine D2 receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50073614
PNG
(1-(2-Methoxy-phenyl)-4-[3-((R)-5-methoxy-1,2,3,4-t...)
Show SMILES COc1cccc2[C@@H](CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3/t20-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-8-OH-DPAT binding to rat 5-HT 1a receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50073621
PNG
(1-(2-Methoxy-phenyl)-4-[3-((S)-5-methoxy-1,2,3,4-t...)
Show SMILES COc1cccc2[C@H](CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3/t20-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-8-OH-DPAT binding to rat 5-HT 1a receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-8-OH-DPAT binding to rat 5-HT 1a receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50073621
PNG
(1-(2-Methoxy-phenyl)-4-[3-((S)-5-methoxy-1,2,3,4-t...)
Show SMILES COc1cccc2[C@H](CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3/t20-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-spiroperidol binding to rat Dopamine D2 receptors.


J Med Chem 42: 490-6 (1999)


Article DOI: 10.1021/jm980420n
BindingDB Entry DOI: 10.7270/Q29W0DP9
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 330n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was evaluated using [3H]- ketanserin as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 0.770n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 was evaluated using [3H]- spiroperidol as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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PubMed
n/an/a 51.5n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033858
PNG
(1-(2-Methoxy-phenyl)-4-[3-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C25H34N2O2/c1-28-22-13-12-21-8-5-7-20(23(21)19-22)9-6-14-26-15-17-27(18-16-26)24-10-3-4-11-25(24)29-2/h3-4,10-13,19-20H,5-9,14-18H2,1-2H3
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PubMed
n/an/a 64.1n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 15.4n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 50.9n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on dopamine receptor D2 using [3H]-spiroperidol as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 59.9n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligand


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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PubMed
n/an/a 0.320n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033842
PNG
(1-(2-Methoxy-phenyl)-4-[4-(7-methoxy-1,2,3,4-tetra...)
Show SMILES COc1ccc2CCCC(CCCCN3CCN(CC3)c3ccccc3OC)c2c1
Show InChI InChI=1S/C26H36N2O2/c1-29-23-14-13-22-10-7-9-21(24(22)20-23)8-5-6-15-27-16-18-28(19-17-27)25-11-3-4-12-26(25)30-2/h3-4,11-14,20-21H,5-10,15-19H2,1-2H3
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n/an/a 8.83n/an/an/an/an/an/a



Università di Bari

Curated by ChEMBL


Assay Description
In vitro binding affinity measured on serotonin 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 38: 942-9 (1995)


Article DOI: 10.1021/jm00006a013
BindingDB Entry DOI: 10.7270/Q2SQ8ZD0
More data for this
Ligand-Target Pair