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14 similar compounds to monomer 50066490

Compile data set for download or QSAR
Wt: 359.8
BDBM50035483
Wt: 325.3
BDBM50066493
Wt: 325.3
BDBM50066494
Wt: 339.3
BDBM50066495
Wt: 339.3
BDBM50066496
Wt: 355.3
BDBM50066484
Wt: 369.4
BDBM50066485
Wt: 355.3
BDBM50066487
Wt: 355.3
BDBM50066488
Wt: 325.3
BDBM50066491
Wt: 369.4
BDBM50162310
Wt: 353.4
BDBM50253581
Wt: 367.4
BDBM50253612
Wt: 381.4
BDBM50253614

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 109 hits for monomerid = 50035483,50066493,50066494,50066495,50066496,50066484,50066485,50066487,50066488,50066491,50162310,50253581,50253612,50253614   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50035483
PNG
(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)
Show SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2Cl)c1
Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-3-6-13(25-2)9(7-10)8-21-12-5-4-11-14(15(12)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23)
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10.2n/an/an/an/an/an/an/an/a



Kenya Medical Research Institute/Wellcome Trust Collaborative Research Program

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assay


Antimicrob Agents Chemother 54: 2603-10 (2010)


Article DOI: 10.1128/AAC.01526-09
BindingDB Entry DOI: 10.7270/Q2VX0GQW
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066495
PNG
(CHEMBL113816 | N*6*-(3,5-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-6-13(24-2)9-14(7-11)25-3)12-4-5-16-15(8-12)17(19)22-18(20)21-16/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 37n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei ( lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 100n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 3.70E+4n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 410n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066494
PNG
(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-4-6-15(24-2)10(7-12)9-20-11-3-5-14-13(8-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 390n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066485
PNG
(CHEMBL117750 | N*6*-Methyl-N*6*-(2,3,4-trimethoxy-...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C19H23N5O3/c1-24(10-11-5-8-15(25-2)17(27-4)16(11)26-3)12-6-7-14-13(9-12)18(20)23-19(21)22-14/h5-9H,10H2,1-4H3,(H4,20,21,22,23)
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n/an/a 52n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066488
PNG
(CHEMBL114833 | N*6*-(2,4,5-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1
Show InChI InChI=1S/C18H21N5O3/c1-24-14-8-16(26-3)15(25-2)6-10(14)9-21-11-4-5-13-12(7-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 540n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066485
PNG
(CHEMBL117750 | N*6*-Methyl-N*6*-(2,3,4-trimethoxy-...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C19H23N5O3/c1-24(10-11-5-8-15(25-2)17(27-4)16(11)26-3)12-6-7-14-13(9-12)18(20)23-19(21)22-14/h5-9H,10H2,1-4H3,(H4,20,21,22,23)
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n/an/a 5.40n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066494
PNG
(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-4-6-15(24-2)10(7-12)9-20-11-3-5-14-13(8-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 420n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 420n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066485
PNG
(CHEMBL117750 | N*6*-Methyl-N*6*-(2,3,4-trimethoxy-...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C19H23N5O3/c1-24(10-11-5-8-15(25-2)17(27-4)16(11)26-3)12-6-7-14-13(9-12)18(20)23-19(21)22-14/h5-9H,10H2,1-4H3,(H4,20,21,22,23)
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n/an/a 8.10n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066488
PNG
(CHEMBL114833 | N*6*-(2,4,5-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1
Show InChI InChI=1S/C18H21N5O3/c1-24-14-8-16(26-3)15(25-2)6-10(14)9-21-11-4-5-13-12(7-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 39n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066495
PNG
(CHEMBL113816 | N*6*-(3,5-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-6-13(24-2)9-14(7-11)25-3)12-4-5-16-15(8-12)17(19)22-18(20)21-16/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 24n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066488
PNG
(CHEMBL114833 | N*6*-(2,4,5-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1
Show InChI InChI=1S/C18H21N5O3/c1-24-14-8-16(26-3)15(25-2)6-10(14)9-21-11-4-5-13-12(7-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 140n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066485
PNG
(CHEMBL117750 | N*6*-Methyl-N*6*-(2,3,4-trimethoxy-...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C19H23N5O3/c1-24(10-11-5-8-15(25-2)17(27-4)16(11)26-3)12-6-7-14-13(9-12)18(20)23-19(21)22-14/h5-9H,10H2,1-4H3,(H4,20,21,22,23)
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n/an/a 59n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066494
PNG
(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-4-6-15(24-2)10(7-12)9-20-11-3-5-14-13(8-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 840n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066494
PNG
(CHEMBL116816 | N*6*-(2,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-4-6-15(24-2)10(7-12)9-20-11-3-5-14-13(8-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066495
PNG
(CHEMBL113816 | N*6*-(3,5-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-6-13(24-2)9-14(7-11)25-3)12-4-5-16-15(8-12)17(19)22-18(20)21-16/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 4.70n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 810n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 120n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Pneumocystis carinii)
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 1.16E+5n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50066488
PNG
(CHEMBL114833 | N*6*-(2,4,5-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1
Show InChI InChI=1S/C18H21N5O3/c1-24-14-8-16(26-3)15(25-2)6-10(14)9-21-11-4-5-13-12(7-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066495
PNG
(CHEMBL113816 | N*6*-(3,5-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-6-13(24-2)9-14(7-11)25-3)12-4-5-16-15(8-12)17(19)22-18(20)21-16/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 2.80n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 950n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 780n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 840n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 3.90n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50066496
PNG
(CHEMBL115804 | N*6*-(2,4-Dimethoxy-benzyl)-N*6*-me...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O2/c1-23(10-11-4-6-13(24-2)9-16(11)25-3)12-5-7-15-14(8-12)17(19)22-18(20)21-15/h4-9H,10H2,1-3H3,(H4,19,20,21,22)
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n/an/a 43n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066488
PNG
(CHEMBL114833 | N*6*-(2,4,5-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(OC)cc1CNc1ccc2nc(N)nc(N)c2c1
Show InChI InChI=1S/C18H21N5O3/c1-24-14-8-16(26-3)15(25-2)6-10(14)9-21-11-4-5-13-12(7-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 540n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50066484
PNG
(CHEMBL114058 | N*6*-(2,4,6-Trimethoxy-benzyl)-quin...)
Show SMILES COc1cc(OC)c(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C18H21N5O3/c1-24-11-7-15(25-2)13(16(8-11)26-3)9-21-10-4-5-14-12(6-10)17(19)23-18(20)22-14/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 2.27E+4n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50066487
PNG
(CHEMBL116637 | N*6*-(2,3,4-Trimethoxy-benzyl)-quin...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C18H21N5O3/c1-24-14-7-4-10(15(25-2)16(14)26-3)9-21-11-5-6-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50066485
PNG
(CHEMBL117750 | N*6*-Methyl-N*6*-(2,3,4-trimethoxy-...)
Show SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1OC
Show InChI InChI=1S/C19H23N5O3/c1-24(10-11-5-8-15(25-2)17(27-4)16(11)26-3)12-6-7-14-13(9-12)18(20)23-19(21)22-14/h5-9H,10H2,1-4H3,(H4,20,21,22,23)
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n/an/a 52n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 390n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Homo sapiens (human))
BDBM50066491
PNG
(CHEMBL116815 | N*6*-(3,5-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1cc(CNc2ccc3nc(N)nc(N)c3c2)cc(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-10(6-13(8-12)24-2)9-20-11-3-4-15-14(7-11)16(18)22-17(19)21-15/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM50066493
PNG
(CHEMBL116200 | N*6*-(2,4-Dimethoxy-benzyl)-quinazo...)
Show SMILES COc1ccc(CNc2ccc3nc(N)nc(N)c3c2)c(OC)c1
Show InChI InChI=1S/C17H19N5O2/c1-23-12-5-3-10(15(8-12)24-2)9-20-11-4-6-14-13(7-11)16(18)22-17(19)21-14/h3-8,20H,9H2,1-2H3,(H4,18,19,21,22)
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n/an/a 780n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)


J Med Chem 41: 3426-34 (1998)


Article DOI: 10.1021/jm980081y
BindingDB Entry DOI: 10.7270/Q27H1HQZ
More data for this
Ligand-Target Pair
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