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7 similar compounds to monomer 50061098

Compile data set for download or QSAR
Wt: 275.3
BDBM50343023
Wt: 286.4
BDBM50061071
Wt: 260.3
BDBM50061126
Wt: 248.3
BDBM50061142
Wt: 260.3
BDBM50061138
Wt: 248.3
BDBM50061143
Wt: 234.3
BDBM50036705

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50343023,50061071,50061126,50061142,50061138,50061143,50036705   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343023
PNG
((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-17-12-6-7-20(10-12)13-8-14(16)19-15(9-13)18-11-4-2-3-5-11/h8-9,11-12,17H,2-7,10H2,1H3,(H3,16,18,19)/t12-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061143
PNG
(CHEMBL3393526 | US9732087, 22)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NCC(C)C)c1
Show InChI InChI=1S/C14H24N4/c1-11(2)9-17-14-8-13(4-6-16-14)18-7-5-12(10-18)15-3/h4,6,8,11-12,15H,5,7,9-10H2,1-3H3,(H,16,17)/t12-/m1/s1
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US Patent
1.70n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA N.V.

US Patent


Assay Description
Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...


US Patent US9732087 (2017)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061143
PNG
(CHEMBL3393526 | US9732087, 22)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NCC(C)C)c1
Show InChI InChI=1S/C14H24N4/c1-11(2)9-17-14-8-13(4-6-16-14)18-7-5-12(10-18)15-3/h4,6,8,11-12,15H,5,7,9-10H2,1-3H3,(H,16,17)/t12-/m1/s1
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2n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061138
PNG
(CHEMBL3393532)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC2CCCC2)c1
Show InChI InChI=1S/C15H24N4/c1-16-13-7-9-19(11-13)14-6-8-17-15(10-14)18-12-4-2-3-5-12/h6,8,10,12-13,16H,2-5,7,9,11H2,1H3,(H,17,18)/t13-/m1/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061071
PNG
(CHEMBL3393535)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NC2CC3CCC2C3)c1
Show InChI InChI=1S/C17H26N4/c1-18-14-5-7-21(11-14)15-4-6-19-17(10-15)20-16-9-12-2-3-13(16)8-12/h4,6,10,12-14,16,18H,2-3,5,7-9,11H2,1H3,(H,19,20)/t12?,13?,14-,16?/m0/s1
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6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 24: 5489-92 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.013
BindingDB Entry DOI: 10.7270/Q25M67B1
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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19n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061126
PNG
(CHEMBL3393533)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NC2CCCC2)c1
Show InChI InChI=1S/C15H24N4/c1-16-13-7-9-19(11-13)14-6-8-17-15(10-14)18-12-4-2-3-5-12/h6,8,10,12-13,16H,2-5,7,9,11H2,1H3,(H,17,18)/t13-/m0/s1
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33n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061142
PNG
(CHEMBL3393527 | US9732087, 15)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NCC(C)C)c1
Show InChI InChI=1S/C14H24N4/c1-11(2)9-17-14-8-13(4-6-16-14)18-7-5-12(10-18)15-3/h4,6,8,11-12,15H,5,7,9-10H2,1-3H3,(H,16,17)/t12-/m0/s1
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US Patent
54.3n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA N.V.

US Patent


Assay Description
Cell pellets from SK-N-MC cells stably or transiently transfected with human H4 receptor (NCBI accession No. AF312230) were used for the binding assa...


US Patent US9732087 (2017)

More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061142
PNG
(CHEMBL3393527 | US9732087, 15)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NCC(C)C)c1
Show InChI InChI=1S/C14H24N4/c1-11(2)9-17-14-8-13(4-6-16-14)18-7-5-12(10-18)15-3/h4,6,8,11-12,15H,5,7,9-10H2,1-3H3,(H,16,17)/t12-/m0/s1
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96n/an/an/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061126
PNG
(CHEMBL3393533)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NC2CCCC2)c1
Show InChI InChI=1S/C15H24N4/c1-16-13-7-9-19(11-13)14-6-8-17-15(10-14)18-12-4-2-3-5-12/h6,8,10,12-13,16H,2-5,7,9,11H2,1H3,(H,17,18)/t13-/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061071
PNG
(CHEMBL3393535)
Show SMILES CN[C@H]1CCN(C1)c1ccnc(NC2CC3CCC2C3)c1
Show InChI InChI=1S/C17H26N4/c1-18-14-5-7-21(11-14)15-4-6-19-17(10-15)20-16-9-12-2-3-13(16)8-12/h4,6,10,12-14,16,18H,2-3,5,7-9,11H2,1H3,(H,19,20)/t12?,13?,14-,16?/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343023
PNG
((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-17-12-6-7-20(10-12)13-8-14(16)19-15(9-13)18-11-4-2-3-5-11/h8-9,11-12,17H,2-7,10H2,1H3,(H3,16,18,19)/t12-/m1/s1
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50036705
PNG
(CHEMBL3354816)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC(C)C)c1
Show InChI InChI=1S/C13H22N4/c1-10(2)16-13-8-12(4-6-15-13)17-7-5-11(9-17)14-3/h4,6,8,10-11,14H,5,7,9H2,1-3H3,(H,15,16)/t11-/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50061138
PNG
(CHEMBL3393532)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NC2CCCC2)c1
Show InChI InChI=1S/C15H24N4/c1-16-13-7-9-19(11-13)14-6-8-17-15(10-14)18-12-4-2-3-5-12/h6,8,10,12-13,16H,2-5,7,9,11H2,1H3,(H,17,18)/t13-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.027
BindingDB Entry DOI: 10.7270/Q2639RDD
More data for this
Ligand-Target Pair