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24 similar compounds to monomer 50189025

Compile data set for download or QSAR
Wt: 820.9
BDBM50037560
Wt: 820.9
BDBM50037565
Wt: 761.8
BDBM50054859
Wt: 932.0
BDBM50090728
Wt: 932.0
BDBM50090735
Wt: 890.0
BDBM50090753
Wt: 560.6
BDBM50189009
Wt: 617.7
BDBM50189014
Wt: 576.6
BDBM50189015
Wt: 562.6
BDBM50189016
Wt: 519.6
BDBM50189017
Wt: 575.6
BDBM50189019
Wt: 644.7
BDBM50189023
Wt: 547.6
BDBM50253658
Wt: 518.6
BDBM50253695
Displayed 1 to 15 (of 24 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 50037560,50037565,50054859,50090728,50090735,50090753,50189009,50189014,50189015,50189016,50189017,50189019,50189023,50253658,50253695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NPFF2


(RAT)
BDBM50037565
PNG
((S)-2-({(S)-1-[(S)-2-((S)-2-Amino-3-phenyl-propion...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H56N12O8/c40-25(21-23-9-3-1-4-10-23)34(55)49-28(16-18-32(42)53)38(59)51-20-8-14-30(51)37(58)48-27(15-17-31(41)52)36(57)47-26(13-7-19-46-39(44)45)35(56)50-29(33(43)54)22-24-11-5-2-6-12-24/h1-6,9-12,25-30H,7-8,13-22,40H2,(H2,41,52)(H2,42,53)(H2,43,54)(H,47,57)(H,48,58)(H,49,55)(H,50,56)(H4,44,45,46)/t25-,26-,27-,28-,29-,30-/m0/s1
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0.430n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)


Article DOI: 10.1021/jm00047a005
BindingDB Entry DOI: 10.7270/Q20R9NGR
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189014
PNG
((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O
Show InChI InChI=1S/C33H40FN7O4/c1-21(42)39-27(19-22-10-13-26(34)14-11-22)31(44)40-16-17-41(32(45)28(40)8-5-15-38-33(35)36)29(30(43)37-2)20-23-9-12-24-6-3-4-7-25(24)18-23/h3-4,6-7,9-14,18,27-29H,5,8,15-17,19-20H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t27-,28+,29+/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189023
PNG
((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C35H45FN8O3/c1-39-32(45)30(23-25-8-11-26-5-2-3-6-27(26)21-25)44-20-19-43(29(33(44)46)7-4-14-41-35(37)38)34(47)31(42-17-15-40-16-18-42)22-24-9-12-28(36)13-10-24/h2-3,5-6,8-13,21,29-31,40H,4,7,14-20,22-23H2,1H3,(H,39,45)(H4,37,38,41)/t29-,30-,31+/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189023
PNG
((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C35H45FN8O3/c1-39-32(45)30(23-25-8-11-26-5-2-3-6-27(26)21-25)44-20-19-43(29(33(44)46)7-4-14-41-35(37)38)34(47)31(42-17-15-40-16-18-42)22-24-9-12-28(36)13-10-24/h2-3,5-6,8-13,21,29-31,40H,4,7,14-20,22-23H2,1H3,(H,39,45)(H4,37,38,41)/t29-,30-,31+/m0/s1
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4.30n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189009
PNG
((S)-2-((S)-4-(3-(4-fluorophenyl)propanoyl)-3-(3-gu...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)CCc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O3/c1-35-29(40)27(20-22-8-12-23-5-2-3-6-24(23)19-22)38-18-17-37(26(30(38)41)7-4-16-36-31(33)34)28(39)15-11-21-9-13-25(32)14-10-21/h2-3,5-6,8-10,12-14,19,26-27H,4,7,11,15-18,20H2,1H3,(H,35,40)(H4,33,34,36)/t26-,27-/m0/s1
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5.30n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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7n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189014
PNG
((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O
Show InChI InChI=1S/C33H40FN7O4/c1-21(42)39-27(19-22-10-13-26(34)14-11-22)31(44)40-16-17-41(32(45)28(40)8-5-15-38-33(35)36)29(30(43)37-2)20-23-9-12-24-6-3-4-7-25(24)18-23/h3-4,6-7,9-14,18,27-29H,5,8,15-17,19-20H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t27-,28+,29+/m1/s1
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7n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189023
PNG
((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C35H45FN8O3/c1-39-32(45)30(23-25-8-11-26-5-2-3-6-27(26)21-25)44-20-19-43(29(33(44)46)7-4-14-41-35(37)38)34(47)31(42-17-15-40-16-18-42)22-24-9-12-28(36)13-10-24/h2-3,5-6,8-13,21,29-31,40H,4,7,14-20,22-23H2,1H3,(H,39,45)(H4,37,38,41)/t29-,30-,31+/m0/s1
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17n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189014
PNG
((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O
Show InChI InChI=1S/C33H40FN7O4/c1-21(42)39-27(19-22-10-13-26(34)14-11-22)31(44)40-16-17-41(32(45)28(40)8-5-15-38-33(35)36)29(30(43)37-2)20-23-9-12-24-6-3-4-7-25(24)18-23/h3-4,6-7,9-14,18,27-29H,5,8,15-17,19-20H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t27-,28+,29+/m1/s1
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18n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037560
PNG
((S)-2-({(R)-1-[(S)-2-((S)-2-Amino-3-phenyl-propion...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H56N12O8/c40-25(21-23-9-3-1-4-10-23)34(55)49-28(16-18-32(42)53)38(59)51-20-8-14-30(51)37(58)48-27(15-17-31(41)52)36(57)47-26(13-7-19-46-39(44)45)35(56)50-29(33(43)54)22-24-11-5-2-6-12-24/h1-6,9-12,25-30H,7-8,13-22,40H2,(H2,41,52)(H2,42,53)(H2,43,54)(H,47,57)(H,48,58)(H,49,55)(H,50,56)(H4,44,45,46)/t25-,26-,27-,28-,29-,30+/m0/s1
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45n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)


Article DOI: 10.1021/jm00047a005
BindingDB Entry DOI: 10.7270/Q20R9NGR
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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75n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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76n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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189n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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189n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189009
PNG
((S)-2-((S)-4-(3-(4-fluorophenyl)propanoyl)-3-(3-gu...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)CCc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O3/c1-35-29(40)27(20-22-8-12-23-5-2-3-6-24(23)19-22)38-18-17-37(26(30(38)41)7-4-16-36-31(33)34)28(39)15-11-21-9-13-25(32)14-10-21/h2-3,5-6,8-10,12-14,19,26-27H,4,7,11,15-18,20H2,1H3,(H,35,40)(H4,33,34,36)/t26-,27-/m0/s1
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206n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189015
PNG
(1-(3-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O4/c1-35-28(39)27(19-21-8-11-22-5-2-3-6-23(22)17-21)38-16-15-37(26(30(38)41)7-4-14-36-31(34)42)29(40)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,35,39)(H3,34,36,42)/t25-,26+,27+/m1/s1
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261n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189016
PNG
(1-(2-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN6O4/c1-34-27(38)26(18-20-6-9-21-4-2-3-5-22(21)16-20)37-15-14-36(25(29(37)40)12-13-35-30(33)41)28(39)24(32)17-19-7-10-23(31)11-8-19/h2-11,16,24-26H,12-15,17-18,32H2,1H3,(H,34,38)(H3,33,35,41)/t24-,25+,26+/m1/s1
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365n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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366n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189015
PNG
(1-(3-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O4/c1-35-28(39)27(19-21-8-11-22-5-2-3-6-23(22)17-21)38-16-15-37(26(30(38)41)7-4-14-36-31(34)42)29(40)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,35,39)(H3,34,36,42)/t25-,26+,27+/m1/s1
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461n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50253658
PNG
(2-[4-[2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-(2-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN(C)C)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN5O3/c1-34-29(38)28(20-22-8-11-23-6-4-5-7-24(23)18-22)37-17-16-36(27(31(37)40)14-15-35(2)3)30(39)26(33)19-21-9-12-25(32)13-10-21/h4-13,18,26-28H,14-17,19-20,33H2,1-3H3,(H,34,38)/t26-,27+,28+/m1/s1
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624n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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727n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189009
PNG
((S)-2-((S)-4-(3-(4-fluorophenyl)propanoyl)-3-(3-gu...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)CCc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O3/c1-35-29(40)27(20-22-8-12-23-5-2-3-6-24(23)19-22)38-18-17-37(26(30(38)41)7-4-16-36-31(33)34)28(39)15-11-21-9-13-25(32)14-10-21/h2-3,5-6,8-10,12-14,19,26-27H,4,7,11,15-18,20H2,1H3,(H,35,40)(H4,33,34,36)/t26-,27-/m0/s1
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958n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189015
PNG
(1-(3-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O4/c1-35-28(39)27(19-21-8-11-22-5-2-3-6-23(22)17-21)38-16-15-37(26(30(38)41)7-4-14-36-31(34)42)29(40)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,35,39)(H3,34,36,42)/t25-,26+,27+/m1/s1
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2.13E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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4.12E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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4.12E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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5.82E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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5.82E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189016
PNG
(1-(2-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN6O4/c1-34-27(38)26(18-20-6-9-21-4-2-3-5-22(21)16-20)37-15-14-36(25(29(37)40)12-13-35-30(33)41)28(39)24(32)17-19-7-10-23(31)11-8-19/h2-11,16,24-26H,12-15,17-18,32H2,1H3,(H,34,38)(H3,33,35,41)/t24-,25+,26+/m1/s1
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6.11E+3n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50253658
PNG
(2-[4-[2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-(2-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN(C)C)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN5O3/c1-34-29(38)28(20-22-8-11-23-6-4-5-7-24(23)18-22)37-17-16-36(27(31(37)40)14-15-35(2)3)30(39)26(33)19-21-9-12-25(32)13-10-21/h4-13,18,26-28H,14-17,19-20,33H2,1-3H3,(H,34,38)/t26-,27+,28+/m1/s1
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1.68E+4n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189016
PNG
(1-(2-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN6O4/c1-34-27(38)26(18-20-6-9-21-4-2-3-5-22(21)16-20)37-15-14-36(25(29(37)40)12-13-35-30(33)41)28(39)24(32)17-19-7-10-23(31)11-8-19/h2-11,16,24-26H,12-15,17-18,32H2,1H3,(H,34,38)(H3,33,35,41)/t24-,25+,26+/m1/s1
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2.17E+4n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50253658
PNG
(2-[4-[2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-(2-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN(C)C)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN5O3/c1-34-29(38)28(20-22-8-11-23-6-4-5-7-24(23)18-22)37-17-16-36(27(31(37)40)14-15-35(2)3)30(39)26(33)19-21-9-12-25(32)13-10-21/h4-13,18,26-28H,14-17,19-20,33H2,1-3H3,(H,34,38)/t26-,27+,28+/m1/s1
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2.63E+4n/an/an/an/an/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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n/an/an/an/a 1.60n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189017
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C29H34FN5O3/c1-33-27(36)26(18-20-6-9-21-4-2-3-5-22(21)16-20)35-15-14-34(25(12-13-31)29(35)38)28(37)24(32)17-19-7-10-23(30)11-8-19/h2-11,16,24-26H,12-15,17-18,31-32H2,1H3,(H,33,36)/t24-,25+,26+/m1/s1
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n/an/an/an/a 45n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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n/an/an/an/a 28n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189023
PNG
((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C35H45FN8O3/c1-39-32(45)30(23-25-8-11-26-5-2-3-6-27(26)21-25)44-20-19-43(29(33(44)46)7-4-14-41-35(37)38)34(47)31(42-17-15-40-16-18-42)22-24-9-12-28(36)13-10-24/h2-3,5-6,8-13,21,29-31,40H,4,7,14-20,22-23H2,1H3,(H,39,45)(H4,37,38,41)/t29-,30-,31+/m0/s1
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n/an/an/an/a 1.60n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189023
PNG
((S)-2-((S)-4-((R)-3-(4-fluorophenyl)-2-(piperazin-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)N1CCNCC1
Show InChI InChI=1S/C35H45FN8O3/c1-39-32(45)30(23-25-8-11-26-5-2-3-6-27(26)21-25)44-20-19-43(29(33(44)46)7-4-14-41-35(37)38)34(47)31(42-17-15-40-16-18-42)22-24-9-12-28(36)13-10-24/h2-3,5-6,8-13,21,29-31,40H,4,7,14-20,22-23H2,1H3,(H,39,45)(H4,37,38,41)/t29-,30-,31+/m0/s1
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n/an/an/an/a 5.60n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189009
PNG
((S)-2-((S)-4-(3-(4-fluorophenyl)propanoyl)-3-(3-gu...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)CCc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O3/c1-35-29(40)27(20-22-8-12-23-5-2-3-6-24(23)19-22)38-18-17-37(26(30(38)41)7-4-16-36-31(33)34)28(39)15-11-21-9-13-25(32)14-10-21/h2-3,5-6,8-10,12-14,19,26-27H,4,7,11,15-18,20H2,1H3,(H,35,40)(H4,33,34,36)/t26-,27-/m0/s1
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n/an/an/an/a 1.39E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189014
PNG
((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O
Show InChI InChI=1S/C33H40FN7O4/c1-21(42)39-27(19-22-10-13-26(34)14-11-22)31(44)40-16-17-41(32(45)28(40)8-5-15-38-33(35)36)29(30(43)37-2)20-23-9-12-24-6-3-4-7-25(24)18-23/h3-4,6-7,9-14,18,27-29H,5,8,15-17,19-20H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t27-,28+,29+/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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n/an/an/an/a 317n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189016
PNG
(1-(2-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN6O4/c1-34-27(38)26(18-20-6-9-21-4-2-3-5-22(21)16-20)37-15-14-36(25(29(37)40)12-13-35-30(33)41)28(39)24(32)17-19-7-10-23(31)11-8-19/h2-11,16,24-26H,12-15,17-18,32H2,1H3,(H,34,38)(H3,33,35,41)/t24-,25+,26+/m1/s1
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n/an/an/an/a 18n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50090753
PNG
(1-[2-(2-{2-[2-(2-Amino-3-naphthalen-2-yl-propionyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C47H59N11O7/c1-29(41(49)60)54-45(64)39-19-11-23-58(39)46(65)36(18-10-22-52-47(50)51)55-40(59)28-53-43(62)37(26-30-12-4-2-5-13-30)57-44(63)38(27-31-14-6-3-7-15-31)56-42(61)35(48)25-32-20-21-33-16-8-9-17-34(33)24-32/h2-9,12-17,20-21,24,29,35-39H,10-11,18-19,22-23,25-28,48H2,1H3,(H2,49,60)(H,53,62)(H,54,64)(H,55,59)(H,56,61)(H,57,63)(H4,50,51,52)/t29-,35-,36+,37+,38+,39+/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes


J Med Chem 43: 2831-6 (2000)


Article DOI: 10.1021/jm990433g
BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50189019
PNG
((S)-2-((S)-4-((R)-2-amino-3-(4-fluorophenyl)propan...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCN=C(N)N)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN7O3/c1-36-28(40)27(19-21-8-11-22-5-2-3-6-23(22)17-21)39-16-15-38(26(30(39)42)7-4-14-37-31(34)35)29(41)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,36,40)(H4,34,35,37)/t25-,26+,27+/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC3R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50090728
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61N11O8/c1-30(43(50)63)55-47(67)41-20-12-24-60(41)48(68)37(19-11-23-53-49(51)52)57-42(62)29-54-44(64)38(26-32-13-5-3-6-14-32)58-46(66)40(27-33-15-7-4-8-16-33)59-45(65)39(56-31(2)61)28-34-21-22-35-17-9-10-18-36(35)25-34/h3-10,13-18,21-22,25,30,37-41H,11-12,19-20,23-24,26-29H2,1-2H3,(H2,50,63)(H,54,64)(H,55,67)(H,56,61)(H,57,62)(H,58,66)(H,59,65)(H4,51,52,53)/t30-,37+,38+,39-,40+,41+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes


J Med Chem 43: 2831-6 (2000)


Article DOI: 10.1021/jm990433g
BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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n/an/an/an/a 1.51E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50253658
PNG
(2-[4-[2-Amino-3-(4-fluoro-phenyl)-propionyl]-3-(2-...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCN(C)C)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H38FN5O3/c1-34-29(38)28(20-22-8-11-23-6-4-5-7-24(23)18-22)37-17-16-36(27(31(37)40)14-15-35(2)3)30(39)26(33)19-21-9-12-25(32)13-10-21/h4-13,18,26-28H,14-17,19-20,33H2,1-3H3,(H,34,38)/t26-,27+,28+/m1/s1
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n/an/an/an/a 391n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054859
PNG
(2-{(R)-2-[2-(3-Acetylamino-propionylamino)-3-(4-fl...)
Show SMILES CC(C)CC(NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(F)cc1)NC(=O)CCNC(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H52FN9O6/c1-23(2)19-31(36(53)47-30(35(41)52)9-6-17-45-39(42)43)48-38(55)33(22-26-10-13-27-7-4-5-8-28(27)20-26)49-37(54)32(21-25-11-14-29(40)15-12-25)46-34(51)16-18-44-24(3)50/h4-5,7-8,10-15,20,23,30-33H,6,9,16-19,21-22H2,1-3H3,(H2,41,52)(H,44,50)(H,46,51)(H,47,53)(H,48,55)(H,49,54)(H4,42,43,45)/t30?,31?,32?,33-/m1/s1
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n/an/an/an/a 270n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50253695
PNG
((S)-2-((S)-4-((R)-2-Amino-3-(4-fluorophenyl)propan...)
Show SMILES CCC[C@@H]1N(CCN([C@@H](Cc2ccc3ccccc3c2)C(=O)NC)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C30H35FN4O3/c1-3-6-26-30(38)35(16-15-34(26)29(37)25(32)18-20-10-13-24(31)14-11-20)27(28(36)33-2)19-21-9-12-22-7-4-5-8-23(22)17-21/h4-5,7-14,17,25-27H,3,6,15-16,18-19,32H2,1-2H3,(H,33,36)/t25-,26+,27+/m1/s1
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n/an/an/an/a 149n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay


J Med Chem 51: 6055-66 (2008)


Article DOI: 10.1021/jm800525p
BindingDB Entry DOI: 10.7270/Q2DV1JQC
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50189014
PNG
((S)-2-((S)-4-((R)-2-acetamido-3-(4-fluorophenyl)pr...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(C)=O
Show InChI InChI=1S/C33H40FN7O4/c1-21(42)39-27(19-22-10-13-26(34)14-11-22)31(44)40-16-17-41(32(45)28(40)8-5-15-38-33(35)36)29(30(43)37-2)20-23-9-12-24-6-3-4-7-25(24)18-23/h3-4,6-7,9-14,18,27-29H,5,8,15-17,19-20H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t27-,28+,29+/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50189015
PNG
(1-(3-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propano...)
Show SMILES CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Show InChI InChI=1S/C31H37FN6O4/c1-35-28(39)27(19-21-8-11-22-5-2-3-6-23(22)17-21)38-16-15-37(26(30(38)41)7-4-14-36-31(34)42)29(40)25(33)18-20-9-12-24(32)13-10-20/h2-3,5-6,8-13,17,25-27H,4,7,14-16,18-19,33H2,1H3,(H,35,39)(H3,34,36,42)/t25-,26+,27+/m1/s1
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n/an/an/an/a 12n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human MC4R


Bioorg Med Chem Lett 16: 4668-73 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.087
BindingDB Entry DOI: 10.7270/Q2W66KDF
More data for this
Ligand-Target Pair
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