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4 similar compounds to monomer 50006968

Compile data set for download or QSAR
Wt: 305.4
BDBM50037703
Wt: 319.4
BDBM50037705
Wt: 319.4
BDBM50037706
Wt: 293.4
BDBM50037702

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50037703,50037705,50037706,50037702   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50037706
PNG
(CHEMBL3357791)
Show SMILES C1C[C@H](CC[C@H]1NC1CCc2ccccc2CC1)c1ccccc1
Show InChI InChI=1/C23H29N/c1-2-6-18(7-3-1)21-12-16-23(17-13-21)24-22-14-10-19-8-4-5-9-20(19)11-15-22/h1-9,21-24H,10-17H2/t21-,23+
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PubMed
2.30n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50037705
PNG
(CHEMBL3357790)
Show SMILES C(C1CCN(CC1)C1CCc2ccccc2CC1)c1ccccc1
Show InChI InChI=1S/C23H29N/c1-2-6-19(7-3-1)18-20-14-16-24(17-15-20)23-12-10-21-8-4-5-9-22(21)11-13-23/h1-9,20,23H,10-18H2
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2.90n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50037705
PNG
(CHEMBL3357790)
Show SMILES C(C1CCN(CC1)C1CCc2ccccc2CC1)c1ccccc1
Show InChI InChI=1S/C23H29N/c1-2-6-19(7-3-1)18-20-14-16-24(17-15-20)23-12-10-21-8-4-5-9-22(21)11-13-23/h1-9,20,23H,10-18H2
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PubMed
5.70n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50037703
PNG
(CHEMBL3357788)
Show SMILES C1CN(CCC1c1ccccc1)C1CCc2ccccc2CC1
Show InChI InChI=1S/C22H27N/c1-2-6-18(7-3-1)21-14-16-23(17-15-21)22-12-10-19-8-4-5-9-20(19)11-13-22/h1-9,21-22H,10-17H2
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6.90n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50037706
PNG
(CHEMBL3357791)
Show SMILES C1C[C@H](CC[C@H]1NC1CCc2ccccc2CC1)c1ccccc1
Show InChI InChI=1/C23H29N/c1-2-6-18(7-3-1)21-12-16-23(17-13-21)24-22-14-10-19-8-4-5-9-20(19)11-15-22/h1-9,21-24H,10-17H2/t21-,23+
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GoogleScholar
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PubMed
14n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B


(Homo sapiens (Human))
BDBM50037702
PNG
(CHEMBL3357787)
Show SMILES C(CCc1ccccc1)CNC1CCc2ccccc2CC1
Show InChI InChI=1S/C21H27N/c1-2-8-18(9-3-1)10-6-7-17-22-21-15-13-19-11-4-5-12-20(19)14-16-21/h1-5,8-9,11-12,21-22H,6-7,10,13-17H2
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17n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50037703
PNG
(CHEMBL3357788)
Show SMILES C1CN(CCC1c1ccccc1)C1CCc2ccccc2CC1
Show InChI InChI=1S/C22H27N/c1-2-6-18(7-3-1)21-14-16-23(17-15-21)22-12-10-19-8-4-5-9-20(19)11-13-22/h1-9,21-22H,10-17H2
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PC sid
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PubMed
22n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50037702
PNG
(CHEMBL3357787)
Show SMILES C(CCc1ccccc1)CNC1CCc2ccccc2CC1
Show InChI InChI=1S/C21H27N/c1-2-8-18(9-3-1)10-6-7-17-22-21-15-13-19-11-4-5-12-20(19)14-16-21/h1-5,8-9,11-12,21-22H,6-7,10,13-17H2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
216n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranes after 180 mins by scintillation counting method


Bioorg Med Chem 22: 6638-46 (2015)


Article DOI: 10.1016/j.bmc.2014.10.004
BindingDB Entry DOI: 10.7270/Q2ZW1NH7
More data for this
Ligand-Target Pair