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5 similar compounds to monomer 85330

Wt: 333.4
BDBM50042711
Wt: 319.4
BDBM50042712
Wt: 305.3
BDBM50042714
Wt: 347.4
BDBM50042717
Wt: 293.3
BDBM50241365
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50042711,50042712,50042714,50042717,50241365   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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0.190n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 3 receptor using [3H]- GR-65,630 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042714
PNG
(9-(2-Methyl-imidazol-1-ylmethyl)-4,5,8,9-tetrahydr...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCn2c13
Show InChI InChI=1S/C19H19N3O/c1-12-20-8-10-21(12)11-14-5-6-16-17(19(14)23)15-4-2-3-13-7-9-22(16)18(13)15/h2-4,8,10,14H,5-7,9,11H2,1H3
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0.230n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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0.25n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042711
PNG
(11-(2-Methyl-imidazol-1-ylmethyl)-4,5,6,7,10,11-he...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCCn2c13
Show InChI InChI=1S/C21H23N3O/c1-14-22-10-12-23(14)13-16-8-9-18-19(21(16)25)17-7-4-6-15-5-2-3-11-24(18)20(15)17/h4,6-7,10,12,16H,2-3,5,8-9,11,13H2,1H3
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0.75n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042711
PNG
(11-(2-Methyl-imidazol-1-ylmethyl)-4,5,6,7,10,11-he...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCCn2c13
Show InChI InChI=1S/C21H23N3O/c1-14-22-10-12-23(14)13-16-8-9-18-19(21(16)25)17-7-4-6-15-5-2-3-11-24(18)20(15)17/h4,6-7,10,12,16H,2-3,5,8-9,11,13H2,1H3
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0.75n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042717
PNG
(12-(2-methyl-1H-1-imidazolylmethyl)-5,6,7,8,10,11,...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCCCn2c13
Show InChI InChI=1S/C22H25N3O/c1-15-23-11-13-24(15)14-17-9-10-19-20(22(17)26)18-8-5-7-16-6-3-2-4-12-25(19)21(16)18/h5,7-8,11,13,17H,2-4,6,9-10,12,14H2,1H3
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1.10n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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340n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on sigma receptor using [3H]- (+)-3-PPP as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M1 and M2


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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910n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on muscarine M1 receptor using [3H]- pirenzepine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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960n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 4 receptor using [3H]- GR-113,808 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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4.90E+3n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 1C receptor using [3H]- serotonin as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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5.60E+3n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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6.50E+3n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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8.50E+3n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on mu-opiate receptor using [3H]- naloxone as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Leukotriene B4


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on leukotriene-D4 receptor using [3H]- LTD4 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
5-HT5B


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on tryptamine receptor using [3H]- tryptamine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on NMDA receptor using [3H]- CGS-19,755 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Interleukin-6 receptor alpha chain


(Rattus norvegicus)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on leukotriene-6 receptor using [3H]- IL-6 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Imidazoline receptor 1 (I1R)


(Homo sapiens (Human))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on imidazoline I2 receptor using [3H]- indazoxan as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity was measured on muscarine M2 receptor using [3H]- N-Me-SCOPOL as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on cholecystokinin type A receptor using [3H]- CCK-8 as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Opioid receptor


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on kappa-opiate receptor using [3H]- EKC as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
HTR1D


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 1A receptor using [3H]- 8-OH-DPAT as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on delta-opiate receptor using [3H]- dadle as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Dopamine receptor D1


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on dopamine receptor D1 using [3H]- dopamine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on TRH receptor using [3H]- MeTRH as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on 5-hydroxytryptamine 1B receptor using [3H]- serotonin as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Dopamine receptor D2 and D3


(Rattus norvegicus (Rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on dopamine receptor D3 using [3H]- dopamine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on histamine H3 receptor using [3H]- N-Me-histam as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on dopamine receptor D2 using [3H]- spiperone as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Glycine receptor alpha-4 chain


(Mus musculus)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
PDB
MMDB

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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on glycine receptor using [3H]- strychnine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Muscarinic receptor M2 and M3


(RAT)
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on muscarine M3 receptor using [3H]- N-Me-SCOPOL as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Adrenergic receptor alpha


(Rattus norvegicus (rat))
BDBM50042712
PNG
(10-(2-Methyl-imidazol-1-ylmethyl)-5,6,9,10-tetrahy...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1cccc3CCCn2c13
Show InChI InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Solvay Duphar B.V.

Curated by ChEMBL


Assay Description
The binding affinity of the compound was measured on alpha2-adrenergic receptor using [3H]- clonidine as radioligand.


J Med Chem 36: 3693-9 (1994)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50241365
PNG
((R)-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)...)
Show SMILES Cc1nccn1C[C@H]1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3/t13-/m1/s1
PDB
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Article
PubMed
n/an/a 810n/an/an/an/an/an/a



University of Vienna

Curated by ChEMBL


Assay Description
Inhibition of human ERG potassium channel


Citation and Details
More data for this
Ligand-Target Pair