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4 similar compounds to monomer 50043280

Compile data set for download or QSAR
Wt: 500.5
BDBM50043244
Wt: 398.4
BDBM50043261
Wt: 398.4
BDBM50043278
Wt: 536.6
BDBM50292632

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50043244,50043261,50043278,50292632   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50043244
PNG
(4'-(1-Methyl-2'-propyl-1H-[2,5']bibenzoimidazolyl-...)
Show SMILES CCCc1nc2ccc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Show InChI InChI=1S/C32H28N4O2/c1-3-8-30-33-27-18-17-23(31-34-26-11-6-7-12-28(26)35(31)2)19-29(27)36(30)20-21-13-15-22(16-14-21)24-9-4-5-10-25(24)32(37)38/h4-7,9-19H,3,8,20H2,1-2H3,(H,37,38)
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Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


J Med Chem 36: 4040-51 (1994)


Article DOI: 10.1021/jm00077a007
BindingDB Entry DOI: 10.7270/Q2V98746
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(Bos taurus)
BDBM50292632
PNG
(4'-{[2-n-propyl-4-methyl-6-(1-methylbenzoimidazol-...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1ncc[nH]1)-c1nc2ccccc2n1C
Show InChI InChI=1S/C35H32N6/c1-4-9-32-39-33-23(2)20-26(35-38-29-12-7-8-13-30(29)40(35)3)21-31(33)41(32)22-24-14-16-25(17-15-24)27-10-5-6-11-28(27)34-36-18-19-37-34/h5-8,10-21H,4,9,22H2,1-3H3,(H,36,37)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortex


Bioorg Med Chem 16: 10301-10 (2008)


Article DOI: 10.1016/j.bmc.2008.10.040
BindingDB Entry DOI: 10.7270/Q2HT2P5T
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043278
PNG
(4'-(2-Butyl-4-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2c(C)cccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-12-24-27-25-18(2)8-7-11-23(25)28(24)17-19-13-15-20(16-14-19)21-9-5-6-10-22(21)26(29)30/h5-11,13-16H,3-4,12,17H2,1-2H3,(H,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


J Med Chem 36: 4040-51 (1994)


Article DOI: 10.1021/jm00077a007
BindingDB Entry DOI: 10.7270/Q2V98746
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50043261
PNG
(4'-(2-Butyl-6-methyl-benzoimidazol-1-ylmethyl)-bip...)
Show SMILES CCCCc1nc2ccc(C)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H26N2O2/c1-3-4-9-25-27-23-15-10-18(2)16-24(23)28(25)17-19-11-13-20(14-12-19)21-7-5-6-8-22(21)26(29)30/h5-8,10-16H,3-4,9,17H2,1-2H3,(H,29,30)
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Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Dr. Karl Thomae GmbH

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparation


J Med Chem 36: 4040-51 (1994)


Article DOI: 10.1021/jm00077a007
BindingDB Entry DOI: 10.7270/Q2V98746
More data for this
Ligand-Target Pair