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6 similar compounds to monomer 50048621

Wt: 462.5
BDBM50048625
Wt: 480.5
BDBM50048626
Wt: 467.5
BDBM50048629
Wt: 481.5
BDBM50048622
Wt: 495.5
BDBM50048630
Wt: 481.5
BDBM50048620
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50048625,50048626,50048629,50048622,50048630,50048620   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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700n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes assessed as reduction in hydrolysis of inhibition of [14C]-sn-1-oleoyl-2-arachidono...


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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800n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of ABHD6 (unknown origin)


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Monoacylglycerol lipase ABHD6


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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800n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human ABHD6 expressed in HEK293T cell membranes assessed as reduction in glycerol production using 2-arachidonoyl glycerol substrate


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048625
PNG
(CHEMBL3319636)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC#N)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C26H26N2O4S/c1-26(2)14-13-21-18-24(11-12-25(21)32-26)33(29,30)28(16-15-27)19-20-7-6-10-23(17-20)31-22-8-4-3-5-9-22/h3-12,17-18H,13-14,16,19H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of DAGLalpha (unknown origin)


Bioorg Med Chem 24: 1455-68 (2016)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048629
PNG
(CHEMBL3319632)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CCO)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C26H29NO5S/c1-26(2)14-13-21-18-24(11-12-25(21)32-26)33(29,30)27(15-16-28)19-20-7-6-10-23(17-20)31-22-8-4-3-5-9-22/h3-12,17-18,28H,13-16,19H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048630
PNG
(CHEMBL3319631)
Show SMILES COC(=O)CN(Cc1ccc(Oc2ccccc2)cc1)S(=O)(=O)c1ccc2OC(C)(C)CCc2c1
Show InChI InChI=1S/C27H29NO6S/c1-27(2)16-15-21-17-24(13-14-25(21)34-27)35(30,31)28(19-26(29)32-3)18-20-9-11-23(12-10-20)33-22-7-5-4-6-8-22/h4-14,17H,15-16,18-19H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Mus musculus)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 124n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of MB064 labeling of DAGLalpha in mouse brain homogenates by activity based protein profiling assay


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048622
PNG
(CHEMBL3319618)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-19-16-22(12-13-24(19)33-26)34(30,31)27(18-25(28)29)17-20-8-6-7-11-23(20)32-21-9-4-3-5-10-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 185n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048620
PNG
(CHEMBL3319620)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(O)=O)Cc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair
Sn1-specific diacylglycerol lipase alpha


(Homo sapiens)
BDBM50048626
PNG
(CHEMBL3319635)
Show SMILES CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(N)=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C26H28N2O5S/c1-26(2)14-13-20-16-23(11-12-24(20)33-26)34(30,31)28(18-25(27)29)17-19-7-6-10-22(15-19)32-21-8-4-3-5-9-21/h3-12,15-16H,13-14,17-18H2,1-2H3,(H2,27,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human DAGLalpha expressed in HEK293T cell membranes


J Med Chem 57: 6610-22 (2014)

More data for this
Ligand-Target Pair