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4 similar compounds to monomer 50052551

Wt: 228.2
BDBM50052554
Wt: 214.2
BDBM50052555
Wt: 200.1
BDBM50060718
Wt: 200.1
BDBM50060719

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50052554,50052555,50060718,50060719   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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5.80E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
metabotropic glutamate 1c


(HUMAN)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
GRM7


(HUMAN)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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>5.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).


J Med Chem 43: 2609-45 (2000)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 1


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 4


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 2


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 4


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a 5.80E+4n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 6


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>5.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 7


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 3


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052554
PNG
(2-Amino-6-(3-hydroxy-5-methyl-isoxazol-4-yl)-hexan...)
Show SMILES Cc1o[nH]c(=O)c1CCCCC(N)C(O)=O
Show InChI InChI=1S/C10H16N2O4/c1-6-7(9(13)12-16-6)4-2-3-5-8(11)10(14)15/h8H,2-5,11H2,1H3,(H,12,13)(H,14,15)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu1-alpha receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052555
PNG
(2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-penta...)
Show SMILES Cc1o[nH]c(=O)c1CCCC(N)C(O)=O
Show InChI InChI=1S/C9H14N2O4/c1-5-6(8(12)11-15-5)3-2-4-7(10)9(13)14/h7H,2-4,10H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu1-alpha receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052555
PNG
(2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-penta...)
Show SMILES Cc1o[nH]c(=O)c1CCCC(N)C(O)=O
Show InChI InChI=1S/C9H14N2O4/c1-5-6(8(12)11-15-5)3-2-4-7(10)9(13)14/h7H,2-4,10H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a>3.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu4a receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50052555
PNG
(2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-penta...)
Show SMILES Cc1o[nH]c(=O)c1CCCC(N)C(O)=O
Show InChI InChI=1S/C9H14N2O4/c1-5-6(8(12)11-15-5)3-2-4-7(10)9(13)14/h7H,2-4,10H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a 4.10E+5n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu6 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052555
PNG
(2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-penta...)
Show SMILES Cc1o[nH]c(=O)c1CCCC(N)C(O)=O
Show InChI InChI=1S/C9H14N2O4/c1-5-6(8(12)11-15-5)3-2-4-7(10)9(13)14/h7H,2-4,10H2,1H3,(H,11,12)(H,13,14)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu2 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052554
PNG
(2-Amino-6-(3-hydroxy-5-methyl-isoxazol-4-yl)-hexan...)
Show SMILES Cc1o[nH]c(=O)c1CCCCC(N)C(O)=O
Show InChI InChI=1S/C10H16N2O4/c1-6-7(9(13)12-16-6)4-2-3-5-8(11)10(14)15/h8H,2-5,11H2,1H3,(H,12,13)(H,14,15)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu2 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 5


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 6


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 5


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7)


(Rattus norvegicus (Rat))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>5.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 7


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
metabotropic glutamate 1/2


(RAT)
BDBM50060719
PNG
((S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 1


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50052554
PNG
(2-Amino-6-(3-hydroxy-5-methyl-isoxazol-4-yl)-hexan...)
Show SMILES Cc1o[nH]c(=O)c1CCCCC(N)C(O)=O
Show InChI InChI=1S/C10H16N2O4/c1-6-7(9(13)12-16-6)4-2-3-5-8(11)10(14)15/h8H,2-5,11H2,1H3,(H,12,13)(H,14,15)
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonistic activity at mGlu6 receptor expressed in CHO cells


J Med Chem 39: 3188-94 (1996)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 2


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50060718
PNG
((R)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-b...)
Show SMILES Cc1o[nH]c(=O)c1CC[C@@H](N)C(O)=O
Show InChI InChI=1S/C8H12N2O4/c1-4-5(7(11)10-14-4)2-3-6(9)8(12)13/h6H,2-3,9H2,1H3,(H,10,11)(H,12,13)/t6-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 3


J Med Chem 40: 3700-5 (1997)

More data for this
Ligand-Target Pair