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9 similar compounds to monomer 50053584

Compile data set for download or QSAR
Wt: 249.2
BDBM50053576
Wt: 277.2
BDBM50053577
Wt: 271.2
BDBM50053578
Wt: 318.3
BDBM50053579
Wt: 305.3
BDBM50053580
Wt: 396.3
BDBM50053582
Wt: 303.3
BDBM50053583
Wt: 261.2
BDBM50053640
Wt: 366.3
BDBM50053581

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50053576,50053577,50053578,50053579,50053580,50053582,50053583,50053640,50053581   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053583
PNG
(CHEMBL3327225)
Show SMILES CCCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C14H17N5O3/c1-2-5-18-13(21)9-6-8(11(16)20)10(15)17-12(9)19(14(18)22)7-3-4-7/h6-7H,2-5H2,1H3,(H2,15,17)(H2,16,20)
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PubMed
n/an/a 930n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053576
PNG
(CHEMBL3326371)
Show SMILES Cn1c2nc(N)c(cc2c(=O)n(C)c1=O)C(N)=O
Show InChI InChI=1S/C10H11N5O3/c1-14-8-5(9(17)15(2)10(14)18)3-4(7(12)16)6(11)13-8/h3H,1-2H3,(H2,11,13)(H2,12,16)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053577
PNG
(CHEMBL3326370)
Show SMILES CCn1c2nc(N)c(cc2c(=O)n(CC)c1=O)C(N)=O
Show InChI InChI=1S/C12H15N5O3/c1-3-16-10-7(11(19)17(4-2)12(16)20)5-6(9(14)18)8(13)15-10/h5H,3-4H2,1-2H3,(H2,13,15)(H2,14,18)
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053580
PNG
(CHEMBL3327228)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=S
Show InChI InChI=1S/C13H15N5O2S/c1-2-17-12(19)8-5-7(10(15)21)9(14)16-11(8)18(13(17)20)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,21)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053640
PNG
(CHEMBL3327223)
Show SMILES NC(=O)c1cc2c(nc1N)n(C1CC1)c(=O)[nH]c2=O
Show InChI InChI=1S/C11H11N5O3/c12-7-5(8(13)17)3-6-9(14-7)16(4-1-2-4)11(19)15-10(6)18/h3-4H,1-2H2,(H2,12,14)(H2,13,17)(H,15,18,19)
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n/an/a 6.60E+3n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053582
PNG
(CHEMBL3327226)
Show SMILES NC(=O)c1cc2c(nc1N)n(C1CC1)c(=O)n(Cc1ccc(cc1)[N+]([O-])=O)c2=O
Show InChI InChI=1S/C18H16N6O5/c19-14-12(15(20)25)7-13-16(21-14)23(10-5-6-10)18(27)22(17(13)26)8-9-1-3-11(4-2-9)24(28)29/h1-4,7,10H,5-6,8H2,(H2,19,21)(H2,20,25)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053579
PNG
(CHEMBL3326368)
Show SMILES CCOC(=O)c1cc2c(nc1N)n(C1CC1)c(=O)n(CC)c2=O
Show InChI InChI=1S/C15H18N4O4/c1-3-18-13(20)10-7-9(14(21)23-4-2)11(16)17-12(10)19(15(18)22)8-5-6-8/h7-8H,3-6H2,1-2H3,(H2,16,17)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053581
PNG
(CHEMBL3327227)
Show SMILES NC(=O)c1cc2c(nc1N)n(C1CC1)c(=O)n(Cc1ccc(N)cc1)c2=O
Show InChI InChI=1S/C18H18N6O3/c19-10-3-1-9(2-4-10)8-23-17(26)13-7-12(15(21)25)14(20)22-16(13)24(18(23)27)11-5-6-11/h1-4,7,11H,5-6,8,19H2,(H2,20,22)(H2,21,25)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053578
PNG
(CHEMBL3326369)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C#N
Show InChI InChI=1S/C13H13N5O2/c1-2-17-12(19)9-5-7(6-14)10(15)16-11(9)18(13(17)20)8-3-4-8/h5,8H,2-4H2,1H3,(H2,15,16)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair