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4 similar compounds to monomer 50053577

Compile data set for download or QSAR
Wt: 249.2
BDBM50053576
Wt: 303.3
BDBM50053583
Wt: 261.2
BDBM50053640
Wt: 289.2
BDBM50053584
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50053576,50053583,50053640,50053584   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053583
PNG
(CHEMBL3327225)
Show SMILES CCCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C14H17N5O3/c1-2-5-18-13(21)9-6-8(11(16)20)10(15)17-12(9)19(14(18)22)7-3-4-7/h6-7H,2-5H2,1H3,(H2,15,17)(H2,16,20)
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Article
PubMed
n/an/a 930n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053576
PNG
(CHEMBL3326371)
Show SMILES Cn1c2nc(N)c(cc2c(=O)n(C)c1=O)C(N)=O
Show InChI InChI=1S/C10H11N5O3/c1-14-8-5(9(17)15(2)10(14)18)3-4(7(12)16)6(11)13-8/h3H,1-2H3,(H2,11,13)(H2,12,16)
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n/an/a>2.50E+4n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053640
PNG
(CHEMBL3327223)
Show SMILES NC(=O)c1cc2c(nc1N)n(C1CC1)c(=O)[nH]c2=O
Show InChI InChI=1S/C11H11N5O3/c12-7-5(8(13)17)3-6-9(14-7)16(4-1-2-4)11(19)15-10(6)18/h3-4H,1-2H2,(H2,12,14)(H2,13,17)(H,15,18,19)
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n/an/a 6.60E+3n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053584
PNG
(CHEMBL1977874)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)
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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/a 420n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053584
PNG
(CHEMBL1977874)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)
PDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
ATP competitive inhibition of human eEF-2K using 5 uM ATP


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair