BindingDB logo
myBDB logout

3 similar compounds to monomer 50019959

Compile data set for download or QSAR
Wt: 342.4
BDBM50056026
Wt: 352.4
BDBM50123704
Wt: 366.4
BDBM50123705

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056026,50123704,50123705   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50056026
PNG
(1-[4-(4-Fluoro-phenyl)-butyl]-4-(2-methoxy-phenyl)...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H27FN2O/c1-25-21-8-3-2-7-20(21)24-16-14-23(15-17-24)13-5-4-6-18-9-11-19(22)12-10-18/h2-3,7-12H,4-6,13-17H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...


J Med Chem 40: 300-12 (1997)


Article DOI: 10.1021/jm960496o
BindingDB Entry DOI: 10.7270/Q27W6B96
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50056026
PNG
(1-[4-(4-Fluoro-phenyl)-butyl]-4-(2-methoxy-phenyl)...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc(F)cc2)CC1
Show InChI InChI=1S/C21H27FN2O/c1-25-21-8-3-2-7-20(21)24-16-14-23(15-17-24)13-5-4-6-18-9-11-19(22)12-10-18/h2-3,7-12H,4-6,13-17H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.30n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.


J Med Chem 40: 300-12 (1997)


Article DOI: 10.1021/jm960496o
BindingDB Entry DOI: 10.7270/Q27W6B96
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50123705
PNG
(6-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-h...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C23H30N2O2/c1-27-23-14-8-7-12-21(23)25-18-16-24(17-19-25)15-9-3-6-13-22(26)20-10-4-2-5-11-20/h2,4-5,7-8,10-12,14H,3,6,9,13,15-19H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.40n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor


J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50123704
PNG
(5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-p...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O2/c1-26-22-13-6-5-11-20(22)24-17-15-23(16-18-24)14-8-7-12-21(25)19-9-3-2-4-10-19/h2-6,9-11,13H,7-8,12,14-18H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor


J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50123705
PNG
(6-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-h...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C23H30N2O2/c1-27-23-14-8-7-12-21(23)25-18-16-24(17-19-25)15-9-3-6-13-22(26)20-10-4-2-5-11-20/h2,4-5,7-8,10-12,14H,3,6,9,13,15-19H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
28.4n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor


J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50123704
PNG
(5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-p...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O2/c1-26-22-13-6-5-11-20(22)24-17-15-23(16-18-24)14-8-7-12-21(25)19-9-3-2-4-10-19/h2-6,9-11,13H,7-8,12,14-18H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
43.5n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor


J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair