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3 similar compounds to monomer 50128264

Compile data set for download or QSAR
Wt: 172.1
BDBM50089901
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Wt: 172.1
BDBM50118481
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Wt: 311.3
BDBM50056268

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50089901,50118481,50056268   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50056268
PNG
(CHEMBL3322310)
Show SMILES OC[C@H]1O[C@@H](NC(=O)CCc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C15H21NO6/c17-8-10-12(19)13(20)14(21)15(22-10)16-11(18)7-6-9-4-2-1-3-5-9/h1-5,10,12-15,17,19-21H,6-8H2,(H,16,18)/t10-,12-,13+,14-,15-/s2
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8.50E+4n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release


Bioorg Med Chem 22: 4810-25 (2014)


Article DOI: 10.1016/j.bmc.2014.06.058
BindingDB Entry DOI: 10.7270/Q2KS6T58
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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2.50E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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2.50E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 1 using established second messenger assay systems.


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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4.90E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 5 using established second messenger assay systems.


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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4.90E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 4 using established second messenger assay systems.


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
The compound was tested for the receptor binding affinity at Metabotropic glutamate receptor 2 using established second messenger assay systems.


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Antagonist potency against cloned Metabotropic glutamate receptor 2


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50118481
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50118481
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Concentration of the compound which causes 50% reduction in receptor binding affinity against Ionotropic glutamate receptor ionotropic kainate using ...


J Med Chem 45: 988-91 (2002)


Article DOI: 10.1021/jm010443t
BindingDB Entry DOI: 10.7270/Q2M32V27
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50118481
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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n/an/an/an/a 2.50E+5n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50089901
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
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n/an/an/an/a 4.90E+5n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50118481
PNG
(2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid...)
Show SMILES N[C@H](Cc1cc(=O)[nH]o1)C(O)=O
Show InChI InChI=1S/C6H8N2O4/c7-4(6(10)11)1-3-2-5(9)8-12-3/h2,4H,1,7H2,(H,8,9)(H,10,11)/t4-/m1/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4


J Med Chem 45: 4240-5 (2002)


Article DOI: 10.1021/jm020122x
BindingDB Entry DOI: 10.7270/Q28G8K2W
More data for this
Ligand-Target Pair