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6 similar compounds to monomer 50408171

Compile data set for download or QSAR
Wt: 343.4
BDBM50058283
Wt: 253.3
BDBM50082004
Wt: 267.3
BDBM50081970
Wt: 267.3
BDBM50081975
Wt: 293.3
BDBM50408165
Wt: 329.3
BDBM50408172

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50058283,50082004,50081970,50081975,50408165,50408172   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(RAT)
BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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2.40n/an/an/an/an/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate


J Med Chem 52: 6946-50 (2009)


Article DOI: 10.1021/jm901126m
BindingDB Entry DOI: 10.7270/Q2H9963M
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 0.977n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 0.000813n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Homo sapiens (Human))
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/an/an/a 32n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/a 9.30n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells (using [3H]-zacopride as radioligand)


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 2.30n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 5.40n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells using [3H]-zacopride as radioligand


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Homo sapiens (Human))
BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/an/an/a 1.70n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50082004
PNG
(6-Piperazin-1-yl-pyrido[2,3-e]pyrrolo[1,2-a]pyrazi...)
Show SMILES C1CN(CCN1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C14H15N5/c1-3-11-13(16-5-1)17-14(12-4-2-8-19(11)12)18-9-6-15-7-10-18/h1-5,8,15H,6-7,9-10H2
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n/an/a 3.10n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand


J Med Chem 42: 4362-79 (1999)


Article DOI: 10.1021/jm990151g
BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
HTR3A


(GUINEA PIG)
BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/an/an/a 340n/an/an/an/a



European Research Centre for Drug Discovery and Development

Curated by ChEMBL


Assay Description
Intrinsic activity at 5HT3 receptor in voltage-stimulated guinea pig left atrium assessed as positive inotropic potency relative to serotonin


J Med Chem 52: 6946-50 (2009)


Article DOI: 10.1021/jm901126m
BindingDB Entry DOI: 10.7270/Q2H9963M
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 245n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 2.95E+3n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 1.32E+4n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 1.51E+4n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(Sus scrofa)
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 955n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 117n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 204n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 1.74E+3n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(Sus scrofa)
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 372n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 97.7n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(Sus scrofa)
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 955n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor


(Sus scrofa)
BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 2.95E+4n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 2.51E+4n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 7.94E+3n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 275n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50408172
PNG
(CHEMBL51225)
Show SMILES C1CN(CCN1c1ccccc1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C20H19N5/c1-2-6-16(7-3-1)23-12-14-24(15-13-23)20-18-9-5-11-25(18)19-17(22-20)8-4-10-21-19/h1-11H,12-15H2
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n/an/a 2.75E+4n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50408165
PNG
(CHEMBL299231)
Show SMILES C=CCN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C17H19N5/c1-2-8-20-10-12-21(13-11-20)17-15-6-4-9-22(15)16-14(19-17)5-3-7-18-16/h2-7,9H,1,8,10-13H2
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n/an/a 0.00398n/an/an/an/an/an/a



Universit£ de Caen

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand


J Med Chem 40: 1808-19 (1997)


Article DOI: 10.1021/jm960501o
BindingDB Entry DOI: 10.7270/Q20R9QMC
More data for this
Ligand-Target Pair