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33 similar compounds to monomer 50074195

Compile data set for download or QSAR
Wt: 309.4
BDBM50060431
Wt: 324.4
BDBM50060435
Wt: 414.5
BDBM50060421
Wt: 442.5
BDBM50060422
Wt: 428.5
BDBM50060423
Wt: 399.5
BDBM50065419
Wt: 428.5
BDBM50074150
Wt: 310.3
BDBM50074191
Wt: 428.5
BDBM50074208
Wt: 422.5
BDBM50083653
Wt: 424.5
BDBM50083654
Wt: 464.6
BDBM50083655
Wt: 438.6
BDBM50083657
Wt: 415.5
BDBM50083658
Wt: 424.5
BDBM50083659
Displayed 1 to 15 (of 33 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50060431,50060435,50060421,50060422,50060423,50065419,50074150,50074191,50074208,50083653,50083654,50083655,50083657,50083658,50083659   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/an/an/a 1.60n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Measurement of agonist induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT from human 5HT-1B receptor expressed in CHO cells


J Med Chem 58: 8315-59 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00258
BindingDB Entry DOI: 10.7270/Q22J6DPZ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/a 0.950n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/an/an/a 53n/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing 5-hydroxytryptamine 1D receptor


J Med Chem 40: 3501-3 (1997)


Article DOI: 10.1021/jm9704560
BindingDB Entry DOI: 10.7270/Q2DZ07D8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/an/an/a 0.600n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist induced [35S]-GTP-gammaS, binding in CHO cells expressing 5-HT 1d receptor


J Med Chem 41: 2667-70 (1998)


Article DOI: 10.1021/jm980204e
BindingDB Entry DOI: 10.7270/Q22Z14PW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/an/an/a 1.60n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist induced [35S]-GTP-gammaS, binding in CHO cells expressing 5-HT 1d receptor


J Med Chem 41: 2667-70 (1998)


Article DOI: 10.1021/jm980204e
BindingDB Entry DOI: 10.7270/Q22Z14PW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/an/an/a 0.600n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 2.10n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1B receptor expressed in CHO cells


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060421
PNG
(Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)...)
Show SMILES C(CN1CCC(CC1)NCc1ccccc1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H30N6/c1-2-5-20(6-3-1)16-26-22-10-13-30(14-11-22)12-4-7-21-17-27-25-9-8-23(15-24(21)25)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,22,26-27H,4,7,10-14,16H2
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n/an/a 125n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060421
PNG
(Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)...)
Show SMILES C(CN1CCC(CC1)NCc1ccccc1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H30N6/c1-2-5-20(6-3-1)16-26-22-10-13-30(14-11-22)12-4-7-21-17-27-25-9-8-23(15-24(21)25)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,22,26-27H,4,7,10-14,16H2
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n/an/a 4.80n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060431
PNG
(3-(3-Piperidin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCCCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C18H23N5/c1-2-8-22(9-3-1)10-4-5-15-12-19-18-7-6-16(11-17(15)18)23-13-20-21-14-23/h6-7,11-14,19H,1-5,8-10H2
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n/an/a 24n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]-5-HT displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 145n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060431
PNG
(3-(3-Piperidin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCCCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C18H23N5/c1-2-8-22(9-3-1)10-4-5-15-12-19-18-7-6-16(11-17(15)18)23-13-20-21-14-23/h6-7,11-14,19H,1-5,8-10H2
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n/an/a 15n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/an/an/a 0.900n/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Measurement of agonist induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.


J Med Chem 40: 3497-500 (1997)


Article DOI: 10.1021/jm9704558
BindingDB Entry DOI: 10.7270/Q2JQ103J
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells


J Med Chem 40: 3501-3 (1997)


Article DOI: 10.1021/jm9704560
BindingDB Entry DOI: 10.7270/Q2DZ07D8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/a 430n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells


J Med Chem 40: 3501-3 (1997)


Article DOI: 10.1021/jm9704560
BindingDB Entry DOI: 10.7270/Q2DZ07D8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/a 0.350n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells


J Med Chem 41: 2667-70 (1998)


Article DOI: 10.1021/jm980204e
BindingDB Entry DOI: 10.7270/Q22Z14PW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells


J Med Chem 41: 2667-70 (1998)


Article DOI: 10.1021/jm980204e
BindingDB Entry DOI: 10.7270/Q22Z14PW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50074191
PNG
(3-(3-Piperazin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCNCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C17H22N6/c1(7-22-8-5-18-6-9-22)2-14-11-19-17-4-3-15(10-16(14)17)23-12-20-21-13-23/h3-4,10-13,18-19H,1-2,5-9H2
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n/an/a 31n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/a 309n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50074191
PNG
(3-(3-Piperazin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCNCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C17H22N6/c1(7-22-8-5-18-6-9-22)2-14-11-19-17-4-3-15(10-16(14)17)23-12-20-21-13-23/h3-4,10-13,18-19H,1-2,5-9H2
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n/an/a 145n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50074208
PNG
(3-{3-[4-(3-Phenyl-propyl)-piperazin-1-yl]-propyl}-...)
Show SMILES C(CN1CCN(CCCc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C26H32N6/c1-2-6-22(7-3-1)8-4-12-30-14-16-31(17-15-30)13-5-9-23-19-27-26-11-10-24(18-25(23)26)32-20-28-29-21-32/h1-3,6-7,10-11,18-21,27H,4-5,8-9,12-17H2
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n/an/a 85n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060431
PNG
(3-(3-Piperidin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCCCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C18H23N5/c1-2-8-22(9-3-1)10-4-5-15-12-19-18-7-6-16(11-17(15)18)23-13-20-21-14-23/h6-7,11-14,19H,1-5,8-10H2
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n/an/a 24n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50074208
PNG
(3-{3-[4-(3-Phenyl-propyl)-piperazin-1-yl]-propyl}-...)
Show SMILES C(CN1CCN(CCCc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C26H32N6/c1-2-6-22(7-3-1)8-4-12-30-14-16-31(17-15-30)13-5-9-23-19-27-26-11-10-24(18-25(23)26)32-20-28-29-21-32/h1-3,6-7,10-11,18-21,27H,4-5,8-9,12-17H2
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n/an/a 4.90n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060431
PNG
(3-(3-Piperidin-1-yl-propyl)-5-[1,2,4]triazol-4-yl-...)
Show SMILES C(CN1CCCCC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C18H23N5/c1-2-8-22(9-3-1)10-4-5-15-12-19-18-7-6-16(11-17(15)18)23-13-20-21-14-23/h6-7,11-14,19H,1-5,8-10H2
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n/an/a 15n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50074208
PNG
(3-{3-[4-(3-Phenyl-propyl)-piperazin-1-yl]-propyl}-...)
Show SMILES C(CN1CCN(CCCc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C26H32N6/c1-2-6-22(7-3-1)8-4-12-30-14-16-31(17-15-30)13-5-9-23-19-27-26-11-10-24(18-25(23)26)32-20-28-29-21-32/h1-3,6-7,10-11,18-21,27H,4-5,8-9,12-17H2
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n/an/an/an/a 4n/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060435
PNG
(3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C18H24N6/c1-22-7-9-23(10-8-22)6-2-3-15-12-19-18-5-4-16(11-17(15)18)24-13-20-21-14-24/h4-5,11-14,19H,2-3,6-10H2,1H3
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n/an/an/an/a 54n/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor


J Med Chem 42: 691-705 (1999)


Article DOI: 10.1021/jm980569z
BindingDB Entry DOI: 10.7270/Q2ZG6RDW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50074150
PNG
(Benzyl-methyl-{(S)-1-[3-(5-[1,2,4]triazol-4-yl-1H-...)
Show SMILES CN(C[C@@H]1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)C1)Cc1ccccc1
Show InChI InChI=1S/C26H32N6/c1-30(16-21-6-3-2-4-7-21)17-22-11-13-31(18-22)12-5-8-23-15-27-26-10-9-24(14-25(23)26)32-19-28-29-20-32/h2-4,6-7,9-10,14-15,19-20,22,27H,5,8,11-13,16-18H2,1H3/t22-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 677-90 (1999)


Article DOI: 10.1021/jm9805687
BindingDB Entry DOI: 10.7270/Q23777W5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50074150
PNG
(Benzyl-methyl-{(S)-1-[3-(5-[1,2,4]triazol-4-yl-1H-...)
Show SMILES CN(C[C@@H]1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)C1)Cc1ccccc1
Show InChI InChI=1S/C26H32N6/c1-30(16-21-6-3-2-4-7-21)17-22-11-13-31(18-22)12-5-8-23-15-27-26-10-9-24(14-25(23)26)32-19-28-29-20-32/h2-4,6-7,9-10,14-15,19-20,22,27H,5,8,11-13,16-18H2,1H3/t22-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



Merck, Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells


J Med Chem 42: 677-90 (1999)


Article DOI: 10.1021/jm9805687
BindingDB Entry DOI: 10.7270/Q23777W5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/a 0.300n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cells


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/an/an/a 1.5n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptor


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/an/an/a 120n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


J Med Chem 42: 2087-104 (1999)


Article DOI: 10.1021/jm981133m
BindingDB Entry DOI: 10.7270/Q2765DHF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060421
PNG
(Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)...)
Show SMILES C(CN1CCC(CC1)NCc1ccccc1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H30N6/c1-2-5-20(6-3-1)16-26-22-10-13-30(14-11-22)12-4-7-21-17-27-25-9-8-23(15-24(21)25)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,22,26-27H,4,7,10-14,16H2
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n/an/a 4.60n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060421
PNG
(Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)...)
Show SMILES C(CN1CCC(CC1)NCc1ccccc1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H30N6/c1-2-5-20(6-3-1)16-26-22-10-13-30(14-11-22)12-4-7-21-17-27-25-9-8-23(15-24(21)25)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,22,26-27H,4,7,10-14,16H2
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n/an/a 120n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060421
PNG
(Benzyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)...)
Show SMILES C(CN1CCC(CC1)NCc1ccccc1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H30N6/c1-2-5-20(6-3-1)16-26-22-10-13-30(14-11-22)12-4-7-21-17-27-25-9-8-23(15-24(21)25)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,22,26-27H,4,7,10-14,16H2
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n/an/an/an/a 7.60n/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060423
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(Cc1ccccc1)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H32N6/c1-30(18-21-6-3-2-4-7-21)23-11-14-31(15-12-23)13-5-8-22-17-27-26-10-9-24(16-25(22)26)32-19-28-29-20-32/h2-4,6-7,9-10,16-17,19-20,23,27H,5,8,11-15,18H2,1H3
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n/an/an/an/a 1.5n/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/an/an/a 0.900n/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/a 0.900n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50060422
PNG
(Benzyl-methyl-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indo...)
Show SMILES CN(CC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C27H34N6/c1-31(18-22-6-3-2-4-7-22)19-23-11-14-32(15-12-23)13-5-8-24-17-28-27-10-9-25(16-26(24)27)33-20-29-30-21-33/h2-4,6-7,9-10,16-17,20-21,23,28H,5,8,11-15,18-19H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50083653
PNG
(4-[(Cyclopropylmethyl-methyl-amino)-methyl]-1-[3-(...)
Show SMILES CN(CC1CC1)CC1(O)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C24H34N6O/c1-28(15-19-4-5-19)16-24(31)8-11-29(12-9-24)10-2-3-20-14-25-23-7-6-21(13-22(20)23)30-17-26-27-18-30/h6-7,13-14,17-19,25,31H,2-5,8-12,15-16H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro


Bioorg Med Chem Lett 9: 3369-74 (2000)


Article DOI: 10.1016/s0960-894x(99)00614-9
BindingDB Entry DOI: 10.7270/Q22F7MNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM50083654
PNG
(4-[(2,2-Dimethyl-propylamino)-methyl]-1-[3-(5-[1,2...)
Show SMILES CC(C)(C)CNCC1(O)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C24H36N6O/c1-23(2,3)15-25-16-24(31)8-11-29(12-9-24)10-4-5-19-14-26-22-7-6-20(13-21(19)22)30-17-27-28-18-30/h6-7,13-14,17-18,25-26,31H,4-5,8-12,15-16H2,1-3H3
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n/an/a 7.30n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitro


Bioorg Med Chem Lett 9: 3369-74 (2000)


Article DOI: 10.1016/s0960-894x(99)00614-9
BindingDB Entry DOI: 10.7270/Q22F7MNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50083655
PNG
(4-[(Cyclohexylmethyl-methyl-amino)-methyl]-1-[3-(5...)
Show SMILES CN(CC1CCCCC1)CC1(O)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C27H40N6O/c1-31(18-22-6-3-2-4-7-22)19-27(34)11-14-32(15-12-27)13-5-8-23-17-28-26-10-9-24(16-25(23)26)33-20-29-30-21-33/h9-10,16-17,20-22,28,34H,2-8,11-15,18-19H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro


Bioorg Med Chem Lett 9: 3369-74 (2000)


Article DOI: 10.1016/s0960-894x(99)00614-9
BindingDB Entry DOI: 10.7270/Q22F7MNB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))
BDBM50083657
PNG
(4-{[(2,2-Dimethyl-propyl)-methyl-amino]-methyl}-1-...)
Show SMILES CN(CC(C)(C)C)CC1(O)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C25H38N6O/c1-24(2,3)16-29(4)17-25(32)9-12-30(13-10-25)11-5-6-20-15-26-23-8-7-21(14-22(20)23)31-18-27-28-19-31/h7-8,14-15,18-19,26,32H,5-6,9-13,16-17H2,1-4H3
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n/an/a 61n/an/an/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells determined in vitro


Bioorg Med Chem Lett 9: 3369-74 (2000)


Article DOI: 10.1016/s0960-894x(99)00614-9
BindingDB Entry DOI: 10.7270/Q22F7MNB
More data for this
Ligand-Target Pair
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