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21 similar compounds to monomer 50406244

Compile data set for download or QSAR
Wt: 218.2
BDBM50063719
Wt: 204.2
BDBM50291753
Wt: 204.2
BDBM50291756
Wt: 190.1
BDBM50291757
Purchase
Wt: 218.2
BDBM50291758
Wt: 232.2
BDBM50291760
Wt: 232.2
BDBM50291761
Wt: 246.3
BDBM50291763
Wt: 218.2
BDBM50288101
Wt: 232.2
BDBM50406208
Wt: 246.3
BDBM50406210
Wt: 246.3
BDBM50406211
Wt: 266.2
BDBM50406259
Wt: 244.2
BDBM50406228
Wt: 246.3
BDBM50406276
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50063719,50291753,50291756,50291757,50291758,50291760,50291761,50291763,50288101,50406208,50406210,50406211,50406259,50406228,50406276   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291760
PNG
(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Show SMILES CCc1cccc2nc(NC(C)C)oc(=O)c12
Show InChI InChI=1S/C13H16N2O2/c1-4-9-6-5-7-10-11(9)12(16)17-13(15-10)14-8(2)3/h5-8H,4H2,1-3H3,(H,14,15)
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0.940n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291760
PNG
(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Show SMILES CCc1cccc2nc(NC(C)C)oc(=O)c12
Show InChI InChI=1S/C13H16N2O2/c1-4-9-6-5-7-10-11(9)12(16)17-13(15-10)14-8(2)3/h5-8H,4H2,1-3H3,(H,14,15)
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1n/an/an/an/a 0.0000661 7.08E+4n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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1.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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1.58n/an/an/an/a 0.0000178 1.18E+4n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291763
PNG
(2-Butylamino-5-ethyl-benzo[d][1,3]oxazin-4-one | C...)
Show SMILES CCCCNc1nc2cccc(CC)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-3-5-9-15-14-16-11-8-6-7-10(4-2)12(11)13(17)18-14/h6-8H,3-5,9H2,1-2H3,(H,15,16)
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3.98n/an/an/an/a 0.000537 1.29E+5n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291763
PNG
(2-Butylamino-5-ethyl-benzo[d][1,3]oxazin-4-one | C...)
Show SMILES CCCCNc1nc2cccc(CC)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-3-5-9-15-14-16-11-8-6-7-10(4-2)12(11)13(17)18-14/h6-8H,3-5,9H2,1-2H3,(H,15,16)
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4.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291758
PNG
(5-Methyl-2-propylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-3-7-13-12-14-9-6-4-5-8(2)10(9)11(15)16-12/h4-6H,3,7H2,1-2H3,(H,13,14)
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291758
PNG
(5-Methyl-2-propylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-3-7-13-12-14-9-6-4-5-8(2)10(9)11(15)16-12/h4-6H,3,7H2,1-2H3,(H,13,14)
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6.31n/an/an/an/a 0.000339 5.62E+4n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406208
PNG
(CHEMBL146004)
Show SMILES CC(C)Nc1nc2cc(C)cc(C)c2c(=O)o1
Show InChI InChI=1S/C13H16N2O2/c1-7(2)14-13-15-10-6-8(3)5-9(4)11(10)12(16)17-13/h5-7H,1-4H3,(H,14,15)
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6.31n/an/an/an/a 0.0000151 2.57E+3n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291761
PNG
(2-Butylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C13H16N2O2/c1-3-4-8-14-13-15-10-7-5-6-9(2)11(10)12(16)17-13/h5-7H,3-4,8H2,1-2H3,(H,14,15)
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23n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291761
PNG
(2-Butylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C13H16N2O2/c1-3-4-8-14-13-15-10-7-5-6-9(2)11(10)12(16)17-13/h5-7H,3-4,8H2,1-2H3,(H,14,15)
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25.1n/an/an/an/a 0.000174 7.59E+3n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291753
PNG
(2-Ethylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-3-12-11-13-8-6-4-5-7(2)9(8)10(14)15-11/h4-6H,3H2,1-2H3,(H,12,13)
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31.6n/an/an/an/a 0.00178 5.25E+4n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291753
PNG
(2-Ethylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-3-12-11-13-8-6-4-5-7(2)9(8)10(14)15-11/h4-6H,3H2,1-2H3,(H,12,13)
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34n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50288101
PNG
(2-Butylamino-benzo[d][1,3]oxazin-4-one | CHEMBL799...)
Show SMILES CCCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-2-3-8-13-12-14-10-7-5-4-6-9(10)11(15)16-12/h4-7H,2-3,8H2,1H3,(H,13,14)
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PubMed
79.4n/an/an/an/a 0.00549 6.61E+4n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50288101
PNG
(2-Butylamino-benzo[d][1,3]oxazin-4-one | CHEMBL799...)
Show SMILES CCCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-2-3-8-13-12-14-10-7-5-4-6-9(10)11(15)16-12/h4-7H,2-3,8H2,1H3,(H,13,14)
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84n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291756
PNG
(2-Propylamino-benzo[d][1,3]oxazin-4-one | CHEMBL34...)
Show SMILES CCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-2-7-12-11-13-9-6-4-3-5-8(9)10(14)15-11/h3-6H,2,7H2,1H3,(H,12,13)
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91n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291756
PNG
(2-Propylamino-benzo[d][1,3]oxazin-4-one | CHEMBL34...)
Show SMILES CCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-2-7-12-11-13-9-6-4-3-5-8(9)10(14)15-11/h3-6H,2,7H2,1H3,(H,12,13)
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100n/an/an/an/a 0.0407 4.47E+5n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406228
PNG
(CHEMBL145185)
Show SMILES Cc1cccc2nc(NC3CCCC3)oc(=O)c12
Show InChI InChI=1S/C14H16N2O2/c1-9-5-4-8-11-12(9)13(17)18-14(16-11)15-10-6-2-3-7-10/h4-5,8,10H,2-3,6-7H2,1H3,(H,15,16)
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200n/an/an/an/a 0.0000813 407n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406210
PNG
(CHEMBL443745)
Show SMILES CCC(C)CNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-4-9(2)8-15-14-16-11-7-5-6-10(3)12(11)13(17)18-14/h5-7,9H,4,8H2,1-3H3,(H,15,16)
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631n/an/an/an/a 0.0000741 112n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406259
PNG
(CHEMBL142779)
Show SMILES O=c1oc(NCCc2ccccc2)nc2ccccc12
Show InChI InChI=1S/C16H14N2O2/c19-15-13-8-4-5-9-14(13)18-16(20-15)17-11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,17,18)
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1.59E+3n/an/an/an/a 0.00191 1.12E+3n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406276
PNG
(CHEMBL357379)
Show SMILES CC(C)CCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-9(2)7-8-15-14-16-11-6-4-5-10(3)12(11)13(17)18-14/h4-6,9H,7-8H2,1-3H3,(H,15,16)
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1.59E+3n/an/an/an/a 0.000513 331n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50406211
PNG
(CHEMBL145724)
Show SMILES CCCCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-3-4-5-9-15-14-16-11-8-6-7-10(2)12(11)13(17)18-14/h6-8H,3-5,9H2,1-2H3,(H,15,16)
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3.16E+3n/an/an/an/a 0.00141 417n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291757
PNG
(5-Methyl-2-methylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C10H10N2O2/c1-6-4-3-5-7-8(6)9(13)14-10(11-2)12-7/h3-5H,1-2H3,(H,11,12)
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3.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291757
PNG
(5-Methyl-2-methylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C10H10N2O2/c1-6-4-3-5-7-8(6)9(13)14-10(11-2)12-7/h3-5H,1-2H3,(H,11,12)
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3.16E+4n/an/an/an/a 0.151 4.90E+3n/an/a



Syntex Research

Curated by ChEMBL


Assay Description
Component deacylation rate constant for interaction with human leukocyte elastase


J Med Chem 33: 464-79 (1990)

Checked by Author
Article DOI: 10.1021/jm00164a002
BindingDB Entry DOI: 10.7270/Q2PR7X6X
More data for this
Ligand-Target Pair
Human herpesvirus 1 protease


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50288101
PNG
(2-Butylamino-benzo[d][1,3]oxazin-4-one | CHEMBL799...)
Show SMILES CCCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-2-3-8-13-12-14-10-7-5-4-6-9(10)11(15)16-12/h4-7H,2-3,8H2,1H3,(H,13,14)
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n/an/a 3.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against herpes simplex type 1 protease (HSV-1 pr).


Bioorg Med Chem Lett 6: 2463-2466 (1996)


Article DOI: 10.1016/0960-894X(96)00455-6
BindingDB Entry DOI: 10.7270/Q2F47P4R
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291760
PNG
(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Show SMILES CCc1cccc2nc(NC(C)C)oc(=O)c12
Show InChI InChI=1S/C13H16N2O2/c1-4-9-6-5-7-10-11(9)12(16)17-13(15-10)14-8(2)3/h5-8H,4H2,1-3H3,(H,14,15)
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n/an/an/an/an/a 0.0000660n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291757
PNG
(5-Methyl-2-methylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C10H10N2O2/c1-6-4-3-5-7-8(6)9(13)14-10(11-2)12-7/h3-5H,1-2H3,(H,11,12)
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n/an/an/an/an/a 0.150n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291763
PNG
(2-Butylamino-5-ethyl-benzo[d][1,3]oxazin-4-one | C...)
Show SMILES CCCCNc1nc2cccc(CC)c2c(=O)o1
Show InChI InChI=1S/C14H18N2O2/c1-3-5-9-15-14-16-11-8-6-7-10(4-2)12(11)13(17)18-14/h6-8H,3-5,9H2,1-2H3,(H,15,16)
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n/an/an/an/an/a 0.000530n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291756
PNG
(2-Propylamino-benzo[d][1,3]oxazin-4-one | CHEMBL34...)
Show SMILES CCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-2-7-12-11-13-9-6-4-3-5-8(9)10(14)15-11/h3-6H,2,7H2,1H3,(H,12,13)
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n/an/an/an/an/a 0.0410n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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n/an/an/an/an/a 0.0000180n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291758
PNG
(5-Methyl-2-propylamino-benzo[d][1,3]oxazin-4-one |...)
Show SMILES CCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-3-7-13-12-14-9-6-4-5-8(2)10(9)11(15)16-12/h4-6H,3,7H2,1-2H3,(H,13,14)
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n/an/an/an/an/a 0.000340n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50288101
PNG
(2-Butylamino-benzo[d][1,3]oxazin-4-one | CHEMBL799...)
Show SMILES CCCCNc1nc2ccccc2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-2-3-8-13-12-14-10-7-5-4-6-9(10)11(15)16-12/h4-7H,2-3,8H2,1H3,(H,13,14)
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n/an/an/an/an/a 0.00550n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291753
PNG
(2-Ethylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C11H12N2O2/c1-3-12-11-13-8-6-4-5-7(2)9(8)10(14)15-11/h4-6H,3H2,1-2H3,(H,12,13)
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n/an/an/an/an/a 0.00180n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50291761
PNG
(2-Butylamino-5-methyl-benzo[d][1,3]oxazin-4-one | ...)
Show SMILES CCCCNc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C13H16N2O2/c1-3-4-8-14-13-15-10-7-5-6-9(2)11(10)12(16)17-13/h5-7H,3-4,8H2,1-2H3,(H,14,15)
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n/an/an/an/an/a 0.000170n/an/an/a



TBA

Curated by ChEMBL


Assay Description
Rate of deacylation by human leukocyte elastase


J Med Chem 30: 589-591 (1987)


Article DOI: 10.1021/jm00387a001
BindingDB Entry DOI: 10.7270/Q2GQ6XRH
More data for this
Ligand-Target Pair
Human rhinovirus A protease


(Human rhinovirus B)
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against human cytomegalovirus protease variant expressing a beta galactosidase reporter gene


Bioorg Med Chem Lett 7: 2105-2108 (1997)


Article DOI: 10.1016/S0960-894X(97)00368-5
BindingDB Entry DOI: 10.7270/Q2RR1Z6P
More data for this
Ligand-Target Pair
Chymotrypsinogen B


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against human chymotrypsin


Bioorg Med Chem Lett 7: 2105-2108 (1997)


Article DOI: 10.1016/S0960-894X(97)00368-5
BindingDB Entry DOI: 10.7270/Q2RR1Z6P
More data for this
Ligand-Target Pair
Leukocyte elastase


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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n/an/a 33n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration against human leukocyte elastase (HLE)


Bioorg Med Chem Lett 7: 2105-2108 (1997)


Article DOI: 10.1016/S0960-894X(97)00368-5
BindingDB Entry DOI: 10.7270/Q2RR1Z6P
More data for this
Ligand-Target Pair
Complement C1r subcomponent


(Homo sapiens (Human))
BDBM50063719
PNG
(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Show SMILES CC(C)Nc1nc2cccc(C)c2c(=O)o1
Show InChI InChI=1S/C12H14N2O2/c1-7(2)13-12-14-9-6-4-5-8(3)10(9)11(15)16-12/h4-7H,1-3H3,(H,13,14)
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n/an/a>6.25E+4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrate


J Med Chem 41: 1060-7 (1998)


Article DOI: 10.1021/jm970394d
BindingDB Entry DOI: 10.7270/Q2PZ57ZT
More data for this
Ligand-Target Pair