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7 similar compounds to monomer 50064582

Compile data set for download or QSAR
Wt: 353.4
BDBM50064572
Wt: 371.4
BDBM50064579
Wt: 397.5
BDBM50064583
Wt: 355.4
BDBM50064585
Wt: 369.4
BDBM50064587
Wt: 383.5
BDBM50064588
Wt: 411.5
BDBM50064589

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50064572,50064579,50064583,50064585,50064587,50064588,50064589   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 520n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064579
PNG
(6-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-3...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccc(F)cc3)cc2sc1=O
Show InChI InChI=1S/C20H22FN3OS/c1-22-18-7-2-15(14-19(18)26-20(22)25)8-9-23-10-12-24(13-11-23)17-5-3-16(21)4-6-17/h2-7,14H,8-13H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064579
PNG
(6-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-3...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccc(F)cc3)cc2sc1=O
Show InChI InChI=1S/C20H22FN3OS/c1-22-18-7-2-15(14-19(18)26-20(22)25)8-9-23-10-12-24(13-11-23)17-5-3-16(21)4-6-17/h2-7,14H,8-13H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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n/an/a>100n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 360n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 0.700n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 10n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 530n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 27n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 0.600n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064579
PNG
(6-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-3...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccc(F)cc3)cc2sc1=O
Show InChI InChI=1S/C20H22FN3OS/c1-22-18-7-2-15(14-19(18)26-20(22)25)8-9-23-10-12-24(13-11-23)17-5-3-16(21)4-6-17/h2-7,14H,8-13H2,1H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064585
PNG
(6-{2-[4-(2-Hydroxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES Oc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C19H21N3O2S/c23-17-4-2-1-3-16(17)22-11-9-21(10-12-22)8-7-14-5-6-15-18(13-14)25-19(24)20-15/h1-6,13,23H,7-12H2,(H,20,24)
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n/an/a 260n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 20n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 0.800n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 240n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 300n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064579
PNG
(6-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-3...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccc(F)cc3)cc2sc1=O
Show InChI InChI=1S/C20H22FN3OS/c1-22-18-7-2-15(14-19(18)26-20(22)25)8-9-23-10-12-24(13-11-23)17-5-3-16(21)4-6-17/h2-7,14H,8-13H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064572
PNG
(3-Methyl-6-[2-(4-phenyl-piperazin-1-yl)-ethyl]-3H-...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccccc3)cc2sc1=O
Show InChI InChI=1S/C20H23N3OS/c1-21-18-8-7-16(15-19(18)25-20(21)24)9-10-22-11-13-23(14-12-22)17-5-3-2-4-6-17/h2-8,15H,9-14H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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n/an/a 0.300n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1A receptor in membranes from bovine hippocampus using [3H]-OH-DPAT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064583
PNG
(6-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-23-19-10-9-17(16-21(19)28-22(23)26)6-5-11-24-12-14-25(15-13-24)18-7-3-4-8-20(18)27-2/h3-4,7-10,16H,5-6,11-15H2,1-2H3
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n/an/a 560n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
DRD2


(BOVINE)
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-raclopride


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50064589
PNG
(6-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C23H29N3O2S/c1-24-20-11-10-18(17-22(20)29-23(24)27)7-5-6-12-25-13-15-26(16-14-25)19-8-3-4-9-21(19)28-2/h3-4,8-11,17H,5-7,12-16H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]-prazosin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50064588
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3n(C)c(=O)sc3c2)CC1
Show InChI InChI=1S/C21H25N3O2S/c1-22-18-8-7-16(15-20(18)27-21(22)25)9-10-23-11-13-24(14-12-23)17-5-3-4-6-19(17)26-2/h3-8,15H,9-14H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 1B receptor in membranes from rat frontal cortex using [3H]-5-HT


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50064587
PNG
(6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3[nH]c(=O)sc3c2)CC1
Show InChI InChI=1S/C20H23N3O2S/c1-25-18-5-3-2-4-17(18)23-12-10-22(11-13-23)9-8-15-6-7-16-19(14-15)26-20(24)21-16/h2-7,14H,8-13H2,1H3,(H,21,24)
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Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2C receptor in membranes from pig choroid plexus using [3H]-N-methyl-mesulergine


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair
Serotonin 2a (5-HT2a) receptor


(BOVINE)
BDBM50064579
PNG
(6-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethyl}-3...)
Show SMILES Cn1c2ccc(CCN3CCN(CC3)c3ccc(F)cc3)cc2sc1=O
Show InChI InChI=1S/C20H22FN3OS/c1-22-18-7-2-15(14-19(18)26-20(22)25)8-9-23-10-12-24(13-11-23)17-5-3-16(21)4-6-17/h2-7,14H,8-13H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Institut de Chimie Pharmaceutique

Curated by ChEMBL


Assay Description
Affinity towards 5-hydroxytryptamine 2A receptor in membranes from bovine frontal cortex using [3H]-Ketanserin


J Med Chem 41: 2010-8 (1998)


Article DOI: 10.1021/jm970298c
BindingDB Entry DOI: 10.7270/Q2FB522Q
More data for this
Ligand-Target Pair