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9 similar compounds to monomer 50065482

Compile data set for download or QSAR
Wt: 369.8
BDBM50065471
Wt: 383.9
BDBM50065472
Wt: 369.8
BDBM50065473
Wt: 383.9
BDBM50065478
Wt: 383.9
BDBM50065481
Wt: 397.9
BDBM50065483
Wt: 369.8
BDBM50065484
Wt: 398.9
BDBM50372621
Wt: 309.4
BDBM50372623

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50065471,50065472,50065473,50065478,50065481,50065483,50065484,50372621,50372623   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065481
PNG
(2-(4-Chloro-phenoxymethyl)-1-(3-piperidin-3-yl-pro...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCNC2)cc1
Show InChI InChI=1/C22H26ClN3O/c23-18-9-11-19(12-10-18)27-16-22-25-20-7-1-2-8-21(20)26(22)14-4-6-17-5-3-13-24-15-17/h1-2,7-12,17,24H,3-6,13-16H2
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700n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065471
PNG
(2-(4-Chloro-phenoxymethyl)-1-(2-piperidin-4-yl-eth...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCC2CCNCC2)cc1
Show InChI InChI=1S/C21H24ClN3O/c22-17-5-7-18(8-6-17)26-15-21-24-19-3-1-2-4-20(19)25(21)14-11-16-9-12-23-13-10-16/h1-8,16,23H,9-15H2
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940n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065472
PNG
(2-(4-Chloro-phenoxymethyl)-1-(3-piperidin-4-yl-pro...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCCC2CCNCC2)cc1
Show InChI InChI=1S/C22H26ClN3O/c23-18-7-9-19(10-8-18)27-16-22-25-20-5-1-2-6-21(20)26(22)15-3-4-17-11-13-24-14-12-17/h1-2,5-10,17,24H,3-4,11-16H2
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980n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065483
PNG
(2-(4-Chloro-phenoxymethyl)-1-(4-piperidin-3-yl-but...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCCCC2CCCNC2)cc1
Show InChI InChI=1/C23H28ClN3O/c24-19-10-12-20(13-11-19)28-17-23-26-21-8-1-2-9-22(21)27(23)15-4-3-6-18-7-5-14-25-16-18/h1-2,8-13,18,25H,3-7,14-17H2
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1.21E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065473
PNG
(2-(4-Chloro-phenoxymethyl)-1-(2-piperidin-3-yl-eth...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCC2CCCNC2)cc1
Show InChI InChI=1/C21H24ClN3O/c22-17-7-9-18(10-8-17)26-15-21-24-19-5-1-2-6-20(19)25(21)13-11-16-4-3-12-23-14-16/h1-2,5-10,16,23H,3-4,11-15H2
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1.28E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065478
PNG
(2-(4-Chloro-phenoxymethyl)-1-(3-piperidin-2-yl-pro...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCCN2)cc1
Show InChI InChI=1/C22H26ClN3O/c23-17-10-12-19(13-11-17)27-16-22-25-20-8-1-2-9-21(20)26(22)15-5-7-18-6-3-4-14-24-18/h1-2,8-13,18,24H,3-7,14-16H2
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3.23E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50065484
PNG
(2-(4-Chloro-phenoxymethyl)-1-(2-piperidin-2-yl-eth...)
Show SMILES Clc1ccc(OCc2nc3ccccc3n2CCC2CCCCN2)cc1
Show InChI InChI=1/C21H24ClN3O/c22-16-8-10-18(11-9-16)26-15-21-24-19-6-1-2-7-20(19)25(21)14-12-17-5-3-4-13-23-17/h1-2,6-11,17,23H,3-5,12-15H2
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7.86E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY


J Med Chem 41: 2709-19 (1998)


Article DOI: 10.1021/jm9706630
BindingDB Entry DOI: 10.7270/Q2TD9WGN
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50372623
PNG
(CHEMBL405860)
Show SMILES CN(C)CCCn1c(COc2ccccc2)nc2ccccc12
Show InChI InChI=1S/C19H23N3O/c1-21(2)13-8-14-22-18-12-7-6-11-17(18)20-19(22)15-23-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3
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n/an/an/an/a 2.60E+3n/an/an/an/a



Siena Biotech S.p.A.

Curated by ChEMBL


Assay Description
Agonist activity at rat alpha-7 nAChR expressed in GH4C1-F7 cells assessed as effect on calcium influx by FLIPR


Bioorg Med Chem 16: 2313-28 (2008)


Article DOI: 10.1016/j.bmc.2007.11.068
BindingDB Entry DOI: 10.7270/Q2SN09SB
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50372621
PNG
(CHEMBL403376)
Show SMILES CN1CCN(CCCn2c(COc3cccc(Cl)c3)nc3ccccc23)CC1
Show InChI InChI=1S/C22H27ClN4O/c1-25-12-14-26(15-13-25)10-5-11-27-21-9-3-2-8-20(21)24-22(27)17-28-19-7-4-6-18(23)16-19/h2-4,6-9,16H,5,10-15,17H2,1H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



Siena Biotech S.p.A.

Curated by ChEMBL


Assay Description
Agonist activity at rat alpha-7 nAChR expressed in GH4C1-F7 cells assessed as effect on calcium influx by FLIPR


Bioorg Med Chem 16: 2313-28 (2008)


Article DOI: 10.1016/j.bmc.2007.11.068
BindingDB Entry DOI: 10.7270/Q2SN09SB
More data for this
Ligand-Target Pair