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22 similar compounds to monomer 50069762

Compile data set for download or QSAR
Wt: 380.4
BDBM50180618
Wt: 653.1
BDBM50069749
Wt: 412.5
BDBM50069760
Wt: 435.9
BDBM50069766
Wt: 266.6
BDBM50069768
Wt: 312.4
BDBM50069752
Purchase
Wt: 298.4
BDBM50069753
Wt: 312.4
BDBM50069755
Wt: 569.6
BDBM50069756
Purchase
Wt: 468.5
BDBM50069751
Wt: 312.4
BDBM50069754
Wt: 360.4
BDBM50069757
Purchase
Wt: 271.2
BDBM50069761
Purchase
Wt: 320.3
BDBM50180613
Wt: 296.3
BDBM50180616
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50180618,50069749,50069760,50069766,50069768,50069752,50069753,50069755,50069756,50069751,50069754,50069757,50069761,50180613,50180616   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Scavenger receptor class B member 1


(Mus musculus)
BDBM50069749
PNG
(CHEMBL3400858)
Show SMILES C[C@H](CO)N1C[C@@H](C)[C@@H](CN(C)S(=O)(=O)c2ccc(Cl)cc2)Oc2ccc(NC(=O)Cc3cn(C)c4ccccc34)cc2C1=O
Show InChI InChI=1/C33H37ClN4O6S/c1-21-17-38(22(2)20-39)33(41)28-16-25(35-32(40)15-23-18-36(3)29-8-6-5-7-27(23)29)11-14-30(28)44-31(21)19-37(4)45(42,43)26-12-9-24(34)10-13-26/h5-14,16,18,21-22,31,39H,15,17,19-20H2,1-4H3,(H,35,40)/t21-,22-,31-/s2
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n/an/a 8.90E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells afte...


Bioorg Med Chem Lett 25: 2100-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.073
BindingDB Entry DOI: 10.7270/Q2P84DKP
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50180618
PNG
(CHEMBL3814765)
Show SMILES OC1=C(CCC\C1=C/c1cccc(Cc2ccccc2)c1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H24O2/c28-26(23-13-5-2-6-14-23)25-16-8-15-24(27(25)29)19-22-12-7-11-21(18-22)17-20-9-3-1-4-10-20/h1-7,9-14,18-19,29H,8,15-17H2/b24-19+
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n/an/a 7.80E+3n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellm...


Bioorg Med Chem 24: 3742-51 (2016)


Article DOI: 10.1016/j.bmc.2016.06.016
BindingDB Entry DOI: 10.7270/Q208677P
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069752
PNG
(CHEMBL3407539)
Show SMILES C[C@]12CC[C@H]3[C@@H](C=C(CO)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-19-7-5-13(22)10-17(19)12(11-21)9-14-15-3-4-18(23)20(15,2)8-6-16(14)19/h5,7,9-10,14-16,21H,3-4,6,8,11H2,1-2H3/t14-,15-,16-,19+,20-/s2
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n/an/a 980n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069753
PNG
(CHEMBL3407538)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16,18,22H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,18-,19+,20-/s2
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n/an/a 250n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069754
PNG
(CHEMBL3407537)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)[C@@H]5O[C@@H]5[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-10-8-11-12-4-5-16(22)19(12,2)7-6-13(11)20(3)14(10)9-15(21)17-18(20)23-17/h9,11-13,17-18H,1,4-8H2,2-3H3/t11-,12-,13-,17-,18-,19-,20+/s2
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n/an/a 1.18E+3n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069755
PNG
(CHEMBL3407536)
Show SMILES C[C@]12CC[C@H]3[C@@H](C[C@]4(CO4)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-18-7-5-12(21)9-16(18)20(11-23-20)10-13-14-3-4-17(22)19(14,2)8-6-15(13)18/h5,7,9,13-15H,3-4,6,8,10-11H2,1-2H3/t13-,14-,15-,18+,19-,20-/s2
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n/an/a 730n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069752
PNG
(CHEMBL3407539)
Show SMILES C[C@]12CC[C@H]3[C@@H](C=C(CO)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-19-7-5-13(22)10-17(19)12(11-21)9-14-15-3-4-18(23)20(15,2)8-6-16(14)19/h5,7,9-10,14-16,21H,3-4,6,8,11H2,1-2H3/t14-,15-,16-,19+,20-/s2
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n/an/a 670n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069753
PNG
(CHEMBL3407538)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@@H]2O
Show InChI InChI=1/C20H26O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16,18,22H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,18-,19+,20-/s2
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n/an/a 100n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069754
PNG
(CHEMBL3407537)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)[C@@H]5O[C@@H]5[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-10-8-11-12-4-5-16(22)19(12,2)7-6-13(11)20(3)14(10)9-15(21)17-18(20)23-17/h9,11-13,17-18H,1,4-8H2,2-3H3/t11-,12-,13-,17-,18-,19-,20+/s2
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n/an/a 810n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Homo sapiens (Human))
BDBM50069755
PNG
(CHEMBL3407536)
Show SMILES C[C@]12CC[C@H]3[C@@H](C[C@]4(CO4)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O
Show InChI InChI=1/C20H24O3/c1-18-7-5-12(21)9-16(18)20(11-23-20)10-13-14-3-4-17(22)19(14,2)8-6-15(13)18/h5,7,9,13-15H,3-4,6,8,10-11H2,1-2H3/t13-,14-,15-,18+,19-,20-/s2
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n/an/a 620n/an/an/an/an/an/a



University of Coimbra

Curated by ChEMBL


Assay Description
Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting


Eur J Med Chem 87: 336-45 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.074
BindingDB Entry DOI: 10.7270/Q2JH3NWD
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50069756
PNG
(CHEMBL3407547)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/s2
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n/an/a 1.70n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant His-tagged ACC2 assessed as malonyl-CoA level


J Med Chem 58: 525-36 (2015)


Article DOI: 10.1021/jm500695e
BindingDB Entry DOI: 10.7270/Q2DR2X6J
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM50069756
PNG
(CHEMBL3407547)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/s2
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n/an/a 2.60n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant His-tagged ACC1 assessed as malonyl-CoA level


J Med Chem 58: 525-36 (2015)


Article DOI: 10.1021/jm500695e
BindingDB Entry DOI: 10.7270/Q2DR2X6J
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM50069757
PNG
(CHEMBL3407545)
Show SMILES CCOC(=O)N1CCN(CC1)c1nc(C)nc2sc3CCCCc3c12
Show InChI InChI=1S/C18H24N4O2S/c1-3-24-18(23)22-10-8-21(9-11-22)16-15-13-6-4-5-7-14(13)25-17(15)20-12(2)19-16/h3-11H2,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant His-tagged ACC1 assessed as malonyl-CoA level


J Med Chem 58: 525-36 (2015)


Article DOI: 10.1021/jm500695e
BindingDB Entry DOI: 10.7270/Q2DR2X6J
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 2 (ACC2)


(Homo sapiens (Human))
BDBM50069760
PNG
(CHEMBL3407541)
Show SMILES CCCOc1ccc(C2CCN(CC2)c2ccc(cc2F)C(C)NC(C)=O)c(C)c1
Show InChI InChI=1/C25H33FN2O2/c1-5-14-30-22-7-8-23(17(2)15-22)20-10-12-28(13-11-20)25-9-6-21(16-24(25)26)18(3)27-19(4)29/h6-9,15-16,18,20H,5,10-14H2,1-4H3,(H,27,29)
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n/an/a 60n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ACC2 assessed as malonyl CoA formation by NADH-linked kinetic method


J Med Chem 58: 525-36 (2015)


Article DOI: 10.1021/jm500695e
BindingDB Entry DOI: 10.7270/Q2DR2X6J
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 13


(Homo sapiens (Human))
BDBM50069761
PNG
(CHEMBL2391504)
Show SMILES Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1
Show InChI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
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n/an/a 600n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of USP13 (unknown origin) by Ub-AMC assay


J Med Chem 58: 1581-95 (2015)


Article DOI: 10.1021/jm501061a
BindingDB Entry DOI: 10.7270/Q29025GH
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 10


(Homo sapiens (Human))
BDBM50069761
PNG
(CHEMBL2391504)
Show SMILES Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1
Show InChI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
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n/an/a 600n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of USP10 (unknown origin) by Ub-AMC assay


J Med Chem 58: 1581-95 (2015)


Article DOI: 10.1021/jm501061a
BindingDB Entry DOI: 10.7270/Q29025GH
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM50069766
PNG
(CHEMBL3407550)
Show SMILES CCN(CCCNC(=O)c1ccc2c(Cl)c3CCCCc3nc2c1)Cc1ccccc1
Show InChI InChI=1S/C26H30ClN3O/c1-2-30(18-19-9-4-3-5-10-19)16-8-15-28-26(31)20-13-14-22-24(17-20)29-23-12-7-6-11-21(23)25(22)27/h3-5,9-10,13-14,17H,2,6-8,11-12,15-16,18H2,1H3,(H,28,31)
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n/an/a 2.26E+4n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of human USP7 by Ub-AMC assay


J Med Chem 58: 1581-95 (2015)


Article DOI: 10.1021/jm501061a
BindingDB Entry DOI: 10.7270/Q29025GH
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM50069768
PNG
(CHEMBL3407548)
Show SMILES Clc1ccc2C(=O)c3nc(C#N)c(nc3-c2c1)C#N
Show InChI InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)11-12(13(7)19)18-10(5-16)9(4-15)17-11/h1-3H
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n/an/a 420n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of USP7 (unknown origin) by Ub-AMC assay


J Med Chem 58: 1581-95 (2015)


Article DOI: 10.1021/jm501061a
BindingDB Entry DOI: 10.7270/Q29025GH
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)
BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...


Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)
BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...


Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)
BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/an/an/a 270n/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as increase in binding of Alexa-488-labeled HDL particles to cells


Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50180613
PNG
(CHEMBL3601632)
Show SMILES COc1cccc(\C=C2/CCCC(C(=O)c3ccccc3)=C2O)c1
Show InChI InChI=1S/C21H20O3/c1-24-18-11-5-7-15(14-18)13-17-10-6-12-19(21(17)23)20(22)16-8-3-2-4-9-16/h2-5,7-9,11,13-14,23H,6,10,12H2,1H3/b17-13+
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n/an/a 7.40E+3n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellm...


Bioorg Med Chem 24: 3742-51 (2016)


Article DOI: 10.1016/j.bmc.2016.06.016
BindingDB Entry DOI: 10.7270/Q208677P
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50180616
PNG
(CHEMBL3601747)
Show SMILES OC1=C(CCC\C1=C/c1cccs1)C(=O)c1ccccc1
Show InChI InChI=1S/C18H16O2S/c19-17(13-6-2-1-3-7-13)16-10-4-8-14(18(16)20)12-15-9-5-11-21-15/h1-3,5-7,9,11-12,20H,4,8,10H2/b14-12+
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n/an/a 5.10E+3n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellm...


Bioorg Med Chem 24: 3742-51 (2016)


Article DOI: 10.1016/j.bmc.2016.06.016
BindingDB Entry DOI: 10.7270/Q208677P
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)
BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid sci...


Bioorg Med Chem Lett 25: 2100-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.073
BindingDB Entry DOI: 10.7270/Q2P84DKP
More data for this
Ligand-Target Pair