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25 similar compounds to monomer 50123636

Compile data set for download or QSAR
Wt: 424.3
BDBM50070319
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Wt: 440.3
BDBM50123635
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Wt: 440.3
BDBM50123641
Purchase
Wt: 434.4
BDBM50208059
Wt: 454.4
BDBM50208060
Wt: 396.3
BDBM50208062
Wt: 452.4
BDBM50208063
Wt: 368.3
BDBM50208066
Wt: 468.4
BDBM50208067
Wt: 482.4
BDBM50208069
Wt: 440.3
BDBM50208070
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Wt: 440.3
BDBM50208073
Wt: 424.3
BDBM50208074
Wt: 380.4
BDBM50208075
Wt: 424.3
BDBM50208078
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50070319,50123635,50123641,50208059,50208060,50208062,50208063,50208066,50208067,50208069,50208070,50208073,50208074,50208075,50208078   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50070319
PNG
(8-(tert-butyl)-6,12,17-trihydroxy-16-methyl-2,4,14...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)C34[C@H]5C[C@@H](C(C)(C)C)C33C(O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10?,11+,15+,17?,18?,19-,20-/m1/s1
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643n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50070319
PNG
(8-(tert-butyl)-6,12,17-trihydroxy-16-methyl-2,4,14...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)C34[C@H]5C[C@@H](C(C)(C)C)C33C(O)C(=O)O[C@H]3O[C@@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10?,11+,15+,17?,18?,19-,20-/m1/s1
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964n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)


BindingDB Entry DOI: 10.7270/Q2JW8CC2
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50123635
PNG
(8-(tert-butyl)-6,9,12,17-tetrahydroxy-16-methyl-(6...)
Show SMILES C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C43C([C@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7?,8+,9+,10?,11?,15?,17?,18?,19-,20?/m1/s1
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4.26E+3n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane


J Med Chem 46: 601-8 (2003)


Article DOI: 10.1021/jm0203985
BindingDB Entry DOI: 10.7270/Q2CC1023
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50123641
PNG
(8-(tert-butyl)-6,9,12,17-tetrahydroxy-16-methyl-(6...)
Show SMILES C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C43C([C@@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6+,7?,8+,9+,10?,11?,15?,17?,18?,19-,20?/m1/s1
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1.26E+4n/an/an/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane


J Med Chem 46: 601-8 (2003)


Article DOI: 10.1021/jm0203985
BindingDB Entry DOI: 10.7270/Q2CC1023
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208059
PNG
(CHEMBL412384)
Show SMILES C[C@@H]1[C@H]2[C@H](C[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OC(C)=O)O[C@]24C(=O)O5)OC1=O
Show InChI InChI=1S/C22H26O9/c1-8-13-10(28-15(8)24)7-20-12-6-11(19(3,4)5)21(20)14(27-9(2)23)16(25)30-18(21)31-22(13,20)17(26)29-12/h8,10-14,18H,6-7H2,1-5H3/t8-,10+,11+,12?,13+,14+,18?,20-,21?,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208063
PNG
(10-methoxymethyloxy-ginkgolide A | CHEMBL225470)
Show SMILES COCO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5C[C@@H](C(C)(C)C)[C@]12[C@@]35C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C22H28O10/c1-9-14(23)29-12-7-19-10-6-11(18(2,3)4)20(19)13(28-8-27-5)16(25)30-17(20)32-22(19,21(9,12)26)31-15(10)24/h9-13,17,26H,6-8H2,1-5H3/t9-,10+,11+,12+,13+,17+,19+,20+,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208062
PNG
((1R,6R,8S,11S)-8-tert-butyl-6,13-dimethoxy-2,4,14,...)
Show SMILES CO[C@H]1C(=O)OC2O[C@@]34C(=O)OC5C[C@@H](C(C)(C)C)C12[C@]35CC(OC)OC4=O
Show InChI InChI=1S/C19H24O9/c1-16(2,3)8-6-9-17-7-10(23-4)26-14(22)19(17,13(21)25-9)28-15-18(8,17)11(24-5)12(20)27-15/h8-11,15H,6-7H2,1-5H3/t8-,9?,10?,11-,15?,17+,18?,19+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208066
PNG
((1R,2R,3S,6S,8S,10R,11R)-10-tert-butyl-2,11,16-tri...)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@]34C5OC(=O)[C@]3(OC(O)C4[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C18H24O8/c1-6-12(20)24-7-5-16-9-8(15(2,3)4)10(19)11(16)25-14(22)18(16,17(6,7)23)26-13(9)21/h6-11,13,19,21,23H,5H2,1-4H3/t6-,7+,8+,9?,10-,11?,13?,16+,17-,18-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208067
PNG
(CHEMBL223081 | methyl (2R)-2-[(1S,2R,3S,6S,8S,10S)...)
Show SMILES CO[C@@H](C(=O)OC)C12C(OC)O[C@@]34C(=O)OC(C[C@H]1C(C)(C)C)[C@]23C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C23H32O10/c1-10-15(24)31-13-9-20-12-8-11(19(2,3)4)21(20,14(28-5)16(25)29-6)18(30-7)33-23(20,17(26)32-12)22(10,13)27/h10-14,18,27H,8-9H2,1-7H3/t10-,11+,12?,13+,14+,18?,20-,21?,22-,23+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208066
PNG
((1R,2R,3S,6S,8S,10R,11R)-10-tert-butyl-2,11,16-tri...)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@]34C5OC(=O)[C@]3(OC(O)C4[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C18H24O8/c1-6-12(20)24-7-5-16-9-8(15(2,3)4)10(19)11(16)25-14(22)18(16,17(6,7)23)26-13(9)21/h6-11,13,19,21,23H,5H2,1-4H3/t6-,7+,8+,9?,10-,11?,13?,16+,17-,18-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208066
PNG
((1R,2R,3S,6S,8S,10R,11R)-10-tert-butyl-2,11,16-tri...)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@]34C5OC(=O)[C@]3(OC(O)C4[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C18H24O8/c1-6-12(20)24-7-5-16-9-8(15(2,3)4)10(19)11(16)25-14(22)18(16,17(6,7)23)26-13(9)21/h6-11,13,19,21,23H,5H2,1-4H3/t6-,7+,8+,9?,10-,11?,13?,16+,17-,18-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208069
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,1...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5OC(C)=O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C22H26O12/c1-6-14(26)31-13-10(24)20-12-8(30-7(2)23)9(18(3,4)5)19(20)11(25)15(27)33-17(19)34-22(20,16(28)32-12)21(6,13)29/h6,8-13,17,24-25,29H,1-5H3/t6-,8+,9+,10+,11+,12?,13+,17?,19?,20-,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208070
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,9...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15?,17?,18-,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208070
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,9...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15?,17?,18-,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208067
PNG
(CHEMBL223081 | methyl (2R)-2-[(1S,2R,3S,6S,8S,10S)...)
Show SMILES CO[C@@H](C(=O)OC)C12C(OC)O[C@@]34C(=O)OC(C[C@H]1C(C)(C)C)[C@]23C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C23H32O10/c1-10-15(24)31-13-9-20-12-8-11(19(2,3)4)21(20,14(28-5)16(25)29-6)18(30-7)33-23(20,17(26)32-12)22(10,13)27/h10-14,18,27H,8-9H2,1-7H3/t10-,11+,12?,13+,14+,18?,20-,21?,22-,23+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208069
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,1...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5OC(C)=O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C22H26O12/c1-6-14(26)31-13-10(24)20-12-8(30-7(2)23)9(18(3,4)5)19(20)11(25)15(27)33-17(19)34-22(20,16(28)32-12)21(6,13)29/h6,8-13,17,24-25,29H,1-5H3/t6-,8+,9+,10+,11+,12?,13+,17?,19?,20-,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208075
PNG
((1S,6R,8S,11S,13S,16R,17R)-8-tert-butyl-6,17-dihyd...)
Show SMILES C[C@@H]1CO[C@H]2C[C@@]34C5C[C@@H](C(C)(C)C)C33[C@@H](O)COC3O[C@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H28O7/c1-9-7-24-13-6-17-12-5-10(16(2,3)4)18(17)11(21)8-25-15(18)27-20(17,14(22)26-12)19(9,13)23/h9-13,15,21,23H,5-8H2,1-4H3/t9-,10+,11+,12?,13+,15?,17-,18?,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208078
PNG
((6R,8S,11S,16R,17S)-8-tert-butyl-6,16,17-trihydrox...)
Show SMILES CC(C)(C)[C@@H]1CC2OC(=O)C34OC5OC(=O)[C@H](O)C15[C@@]23CC1OC(=O)[C@](C)(O)[C@]41O
Show InChI InChI=1S/C20H24O10/c1-15(2,3)7-5-8-17-6-9-19(26,16(4,25)12(23)28-9)20(17,13(24)27-8)30-14-18(7,17)10(21)11(22)29-14/h7-10,14,21,25-26H,5-6H2,1-4H3/t7-,8?,9?,10-,14?,16-,17+,18?,19-,20?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208078
PNG
((6R,8S,11S,16R,17S)-8-tert-butyl-6,16,17-trihydrox...)
Show SMILES CC(C)(C)[C@@H]1CC2OC(=O)C34OC5OC(=O)[C@H](O)C15[C@@]23CC1OC(=O)[C@](C)(O)[C@]41O
Show InChI InChI=1S/C20H24O10/c1-15(2,3)7-5-8-17-6-9-19(26,16(4,25)12(23)28-9)20(17,13(24)27-8)30-14-18(7,17)10(21)11(22)29-14/h7-10,14,21,25-26H,5-6H2,1-4H3/t7-,8?,9?,10-,14?,16-,17+,18?,19-,20?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208075
PNG
((1S,6R,8S,11S,13S,16R,17R)-8-tert-butyl-6,17-dihyd...)
Show SMILES C[C@@H]1CO[C@H]2C[C@@]34C5C[C@@H](C(C)(C)C)C33[C@@H](O)COC3O[C@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H28O7/c1-9-7-24-13-6-17-12-5-10(16(2,3)4)18(17)11(21)8-25-15(18)27-20(17,14(22)26-12)19(9,13)23/h9-13,15,21,23H,5-8H2,1-4H3/t9-,10+,11+,12?,13+,15?,17-,18?,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208062
PNG
((1R,6R,8S,11S)-8-tert-butyl-6,13-dimethoxy-2,4,14,...)
Show SMILES CO[C@H]1C(=O)OC2O[C@@]34C(=O)OC5C[C@@H](C(C)(C)C)C12[C@]35CC(OC)OC4=O
Show InChI InChI=1S/C19H24O9/c1-16(2,3)8-6-9-17-7-10(23-4)26-14(22)19(17,13(21)25-9)28-15-18(8,17)11(24-5)12(20)27-15/h8-11,15H,6-7H2,1-5H3/t8-,9?,10?,11-,15?,17+,18?,19+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208059
PNG
(CHEMBL412384)
Show SMILES C[C@@H]1[C@H]2[C@H](C[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OC(C)=O)O[C@]24C(=O)O5)OC1=O
Show InChI InChI=1S/C22H26O9/c1-8-13-10(28-15(8)24)7-20-12-6-11(19(3,4)5)21(20)14(27-9(2)23)16(25)30-18(21)31-22(13,20)17(26)29-12/h8,10-14,18H,6-7H2,1-5H3/t8-,10+,11+,12?,13+,14+,18?,20-,21?,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208060
PNG
(10-methoxy-ginkgolide C | CHEMBL221823)
Show SMILES CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C21H26O11/c1-6-13(24)29-11-10(23)19-7-8(22)9(17(2,3)4)18(19)12(28-5)15(26)30-16(18)32-21(19,20(6,11)27)31-14(7)25/h6-12,16,22-23,27H,1-5H3/t6-,7+,8+,9+,10+,11+,12+,16+,18+,19+,20-,21+/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208063
PNG
(10-methoxymethyloxy-ginkgolide A | CHEMBL225470)
Show SMILES COCO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5C[C@@H](C(C)(C)C)[C@]12[C@@]35C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C22H28O10/c1-9-14(23)29-12-7-19-10-6-11(18(2,3)4)20(19)13(28-8-27-5)16(25)30-17(20)32-22(19,21(9,12)26)31-15(10)24/h9-13,17,26H,6-8H2,1-5H3/t9-,10+,11+,12+,13+,17+,19+,20+,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208063
PNG
(10-methoxymethyloxy-ginkgolide A | CHEMBL225470)
Show SMILES COCO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5C[C@@H](C(C)(C)C)[C@]12[C@@]35C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C22H28O10/c1-9-14(23)29-12-7-19-10-6-11(18(2,3)4)20(19)13(28-8-27-5)16(25)30-17(20)32-22(19,21(9,12)26)31-15(10)24/h9-13,17,26H,6-8H2,1-5H3/t9-,10+,11+,12+,13+,17+,19+,20+,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208069
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,1...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5OC(C)=O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C22H26O12/c1-6-14(26)31-13-10(24)20-12-8(30-7(2)23)9(18(3,4)5)19(20)11(25)15(27)33-17(19)34-22(20,16(28)32-12)21(6,13)29/h6,8-13,17,24-25,29H,1-5H3/t6-,8+,9+,10+,11+,12?,13+,17?,19?,20-,21-,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208070
PNG
((1S,6R,8S,9S,11R,12R,13S,16S,17R)-8-tert-butyl-6,9...)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)[C@@]3(OC3OC(=O)[C@H](O)C43[C@@H]([C@@H]5O)C(C)(C)C)[C@@]12O
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15?,17?,18-,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208067
PNG
(CHEMBL223081 | methyl (2R)-2-[(1S,2R,3S,6S,8S,10S)...)
Show SMILES CO[C@@H](C(=O)OC)C12C(OC)O[C@@]34C(=O)OC(C[C@H]1C(C)(C)C)[C@]23C[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C23H32O10/c1-10-15(24)31-13-9-20-12-8-11(19(2,3)4)21(20,14(28-5)16(25)29-6)18(30-7)33-23(20,17(26)32-12)22(10,13)27/h10-14,18,27H,8-9H2,1-7H3/t10-,11+,12?,13+,14+,18?,20-,21?,22-,23+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 30 uM glycine-induced current by whole-cell patch clamp experiment


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 300 uM glycine-induced current by whole-cell patch clamp experiment


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208078
PNG
((6R,8S,11S,16R,17S)-8-tert-butyl-6,16,17-trihydrox...)
Show SMILES CC(C)(C)[C@@H]1CC2OC(=O)C34OC5OC(=O)[C@H](O)C15[C@@]23CC1OC(=O)[C@](C)(O)[C@]41O
Show InChI InChI=1S/C20H24O10/c1-15(2,3)7-5-8-17-6-9-19(26,16(4,25)12(23)28-9)20(17,13(24)27-8)30-14-18(7,17)10(21)11(22)29-14/h7-10,14,21,25-26H,5-6H2,1-4H3/t7-,8?,9?,10-,14?,16-,17+,18?,19-,20?/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208073
PNG
(CHEMBL221821 | ginkgolide C)
Show SMILES C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)19-14(26)29-10-6(21)7(16(2,3)4)17(20(10,19)18(5,11)27)9(23)13(25)30-15(17)31-19/h5-11,15,21-23,27H,1-4H3/t5-,6+,7+,8+,9+,10?,11+,15+,17+,18-,19-,20-/m1/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells assessed as inhibition of 3000 uM glycine-induced current by whole-cell patch clamp experiment


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208075
PNG
((1S,6R,8S,11S,13S,16R,17R)-8-tert-butyl-6,17-dihyd...)
Show SMILES C[C@@H]1CO[C@H]2C[C@@]34C5C[C@@H](C(C)(C)C)C33[C@@H](O)COC3O[C@]4(C(=O)O5)[C@@]12O
Show InChI InChI=1S/C20H28O7/c1-9-7-24-13-6-17-12-5-10(16(2,3)4)18(17)11(21)8-25-15(18)27-20(17,14(22)26-12)19(9,13)23/h9-13,15,21,23H,5-8H2,1-4H3/t9-,10+,11+,12?,13+,15?,17-,18?,19-,20+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208062
PNG
((1R,6R,8S,11S)-8-tert-butyl-6,13-dimethoxy-2,4,14,...)
Show SMILES CO[C@H]1C(=O)OC2O[C@@]34C(=O)OC5C[C@@H](C(C)(C)C)C12[C@]35CC(OC)OC4=O
Show InChI InChI=1S/C19H24O9/c1-16(2,3)8-6-9-17-7-10(23-4)26-14(22)19(17,13(21)25-9)28-15-18(8,17)11(24-5)12(20)27-15/h8-11,15H,6-7H2,1-5H3/t8-,9?,10?,11-,15?,17+,18?,19+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208060
PNG
(10-methoxy-ginkgolide C | CHEMBL221823)
Show SMILES CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C21H26O11/c1-6-13(24)29-11-10(23)19-7-8(22)9(17(2,3)4)18(19)12(28-5)15(26)30-16(18)32-21(19,20(6,11)27)31-14(7)25/h6-12,16,22-23,27H,1-5H3/t6-,7+,8+,9+,10+,11+,12+,16+,18+,19+,20-,21+/m1/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-2


(Homo sapiens (Human))
BDBM50208060
PNG
(10-methoxy-ginkgolide C | CHEMBL221823)
Show SMILES CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Show InChI InChI=1S/C21H26O11/c1-6-13(24)29-11-10(23)19-7-8(22)9(17(2,3)4)18(19)12(28-5)15(26)30-16(18)32-21(19,20(6,11)27)31-14(7)25/h6-12,16,22-23,27H,1-5H3/t6-,7+,8+,9+,10+,11+,12+,16+,18+,19+,20-,21+/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha2GlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208059
PNG
(CHEMBL412384)
Show SMILES C[C@@H]1[C@H]2[C@H](C[C@@]34C5C[C@@H](C(C)(C)C)C33C(OC(=O)[C@@H]3OC(C)=O)O[C@]24C(=O)O5)OC1=O
Show InChI InChI=1S/C22H26O9/c1-8-13-10(28-15(8)24)7-20-12-6-11(19(3,4)5)21(20)14(27-9(2)23)16(25)30-18(21)31-22(13,20)17(26)29-12/h8,10-14,18H,6-7H2,1-5H3/t8-,10+,11+,12?,13+,14+,18?,20-,21?,22+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-1


(Homo sapiens (Human))
BDBM50208074
PNG
(CHEMBL374004 | ginkgolide J)
Show SMILES C[C@@H]1C(=O)O[C@H]2C[C@@]34O[C@@H]5OC(=O)[C@H](O)[C@@]55[C@@H]([C@H](O)C(OC3=O)[C@@]45[C@@]12O)C(C)(C)C
Show InChI InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-14(25)28-11-8(21)9(16(2,3)4)18(20(11,17)19(6,7)26)10(22)13(24)29-15(18)30-17/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8+,9+,10+,11?,15+,17-,18+,19-,20-/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human alpha1betaGlyR expressed in HEK293 cells by FMP assay


J Med Chem 50: 1610-7 (2007)


Article DOI: 10.1021/jm070003n
BindingDB Entry DOI: 10.7270/Q2GB23QT
More data for this
Ligand-Target Pair