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14 similar compounds to monomer 13531

Wt: 349.7
BDBM50071885
Wt: 313.3
BDBM50077976
Wt: 391.4
BDBM50104348
Wt: 345.3
BDBM50104351
Wt: 315.3
BDBM50104356
Wt: 329.3
BDBM50104357
Wt: 333.3
BDBM50104360
Wt: 357.4
BDBM50104365
Wt: 340.3
BDBM50104373
Wt: 327.3
BDBM50237721
Wt: 331.3
BDBM50284482
Wt: 359.3
BDBM50284489
Wt: 344.3
BDBM50403384
Wt: 443.5
BDBM50403405

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50071885,50077976,50104348,50104351,50104356,50104357,50104360,50104365,50104373,50237721,50284482,50284489,50403384,50403405   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))
BDBM50071885
PNG
(4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imid...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClFN3/c21-16-5-1-15(2-6-16)20-24-18(13-3-7-17(22)8-4-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Affinity for human glucagon receptor in presence of Mg2+


Citation and Details
More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50104373
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H13FN4/c22-18-7-5-15(6-8-18)19-20(16-9-11-24-12-10-16)26-21(25-19)17-3-1-14(13-23)2-4-17/h1-12H,(H,25,26)
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50077976
PNG
(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Show SMILES Oc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H15N3O/c24-17-8-6-14(7-9-17)18-19(15-10-12-21-13-11-15)23-20(22-18)16-4-2-1-3-5-16/h1-13,24H,(H,22,23)
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n/an/a 390n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase


J Med Chem 42: 2180-90 (1999)

More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50237721
PNG
(4-(4-(4-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...)
Show SMILES COc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C21H17N3O/c1-25-18-9-7-15(8-10-18)19-20(16-11-13-22-14-12-16)24-21(23-19)17-5-3-2-4-6-17/h2-14H,1H3,(H,23,24)
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n/an/a 950n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase


J Med Chem 42: 2180-90 (1999)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104348
PNG
(4-[2-Biphenyl-4-yl-5-(4-fluoro-phenyl)-3H-imidazol...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-12-10-20(11-13-23)24-25(21-14-16-28-17-15-21)30-26(29-24)22-8-6-19(7-9-22)18-4-2-1-3-5-18/h1-17H,(H,29,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50071885
PNG
(4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imid...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClFN3/c21-16-5-1-15(2-6-16)20-24-18(13-3-7-17(22)8-4-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25)
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n/an/a 400n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104365
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-isopropyl-phenyl)-3H-i...)
Show SMILES CC(C)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H20FN3/c1-15(2)16-3-5-19(6-4-16)23-26-21(17-7-9-20(24)10-8-17)22(27-23)18-11-13-25-14-12-18/h3-15H,1-2H3,(H,26,27)
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n/an/a 700n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104373
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H13FN4/c22-18-7-5-15(6-8-18)19-20(16-9-11-24-12-10-16)26-21(25-19)17-3-1-14(13-23)2-4-17/h1-12H,(H,25,26)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104357
PNG
(4-[5-(4-Fluoro-phenyl)-2-p-tolyl-3H-imidazol-4-yl]...)
Show SMILES Cc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3/c1-14-2-4-17(5-3-14)21-24-19(15-6-8-18(22)9-7-15)20(25-21)16-10-12-23-13-11-16/h2-13H,1H3,(H,24,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104351
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imi...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3O/c1-26-18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104360
PNG
(4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Fc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13F2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50104351
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imi...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3O/c1-26-18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 7.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50284482
PNG
(2-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Oc1ccccc1-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H14FN3O/c21-15-7-5-13(6-8-15)18-19(14-9-11-22-12-10-14)24-20(23-18)16-3-1-2-4-17(16)25/h1-12,25H,(H,23,24)
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n/an/a 4.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50284489
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Cc1cc(cc(C)c1O)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H18FN3O/c1-13-11-17(12-14(2)21(13)27)22-25-19(15-3-5-18(23)6-4-15)20(26-22)16-7-9-24-10-8-16/h3-12,27H,1-2H3,(H,25,26)
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n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50077976
PNG
(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Show SMILES Oc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H15N3O/c24-17-8-6-14(7-9-17)18-19(15-10-12-21-13-11-15)23-20(22-18)16-4-2-1-3-5-16/h1-13,24H,(H,22,23)
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n/an/an/a 316n/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity at bRaf kinase in fluorescent ligand displacement assay


Bioorg Med Chem Lett 16: 378-81 (2005)

More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (human))
BDBM50077976
PNG
(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Show SMILES Oc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H15N3O/c24-17-8-6-14(7-9-17)18-19(15-10-12-21-13-11-15)23-20(22-18)16-4-2-1-3-5-16/h1-13,24H,(H,22,23)
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n/an/a 339n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition bRaf kinase activity


Bioorg Med Chem Lett 16: 378-81 (2005)

More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104373
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H13FN4/c22-18-7-5-15(6-8-18)19-20(16-9-11-24-12-10-16)26-21(25-19)17-3-1-14(13-23)2-4-17/h1-12H,(H,25,26)
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n/an/a 210n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104351
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imi...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3O/c1-26-18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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n/an/a 100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104348
PNG
(4-[2-Biphenyl-4-yl-5-(4-fluoro-phenyl)-3H-imidazol...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-12-10-20(11-13-23)24-25(21-14-16-28-17-15-21)30-26(29-24)22-8-6-19(7-9-22)18-4-2-1-3-5-18/h1-17H,(H,29,30)
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n/an/a 301n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104365
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-isopropyl-phenyl)-3H-i...)
Show SMILES CC(C)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H20FN3/c1-15(2)16-3-5-19(6-4-16)23-26-21(17-7-9-20(24)10-8-17)22(27-23)18-11-13-25-14-12-18/h3-15H,1-2H3,(H,26,27)
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n/an/a 281n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104357
PNG
(4-[5-(4-Fluoro-phenyl)-2-p-tolyl-3H-imidazol-4-yl]...)
Show SMILES Cc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3/c1-14-2-4-17(5-3-14)21-24-19(15-6-8-18(22)9-7-15)20(25-21)16-10-12-23-13-11-16/h2-13H,1H3,(H,24,25)
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n/an/a 90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104360
PNG
(4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Fc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13F2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
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n/an/a 100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50071885
PNG
(4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imid...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClFN3/c21-16-5-1-15(2-6-16)20-24-18(13-3-7-17(22)8-4-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25)
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n/an/a 80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50237721
PNG
(4-(4-(4-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...)
Show SMILES COc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C21H17N3O/c1-25-18-9-7-15(8-10-18)19-20(16-11-13-22-14-12-16)24-21(23-19)17-5-3-2-4-6-17/h2-14H,1H3,(H,23,24)
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n/an/a 950n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Raf1 kinase


Bioorg Med Chem Lett 18: 2346-50 (2008)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 154n/an/an/an/an/an/a



University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK


J Med Chem 55: 8429-39 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50284489
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Cc1cc(cc(C)c1O)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C22H18FN3O/c1-13-11-17(12-14(2)21(13)27)22-25-19(15-3-5-18(23)6-4-15)20(26-22)16-7-9-24-10-8-16/h3-12,27H,1-2H3,(H,25,26)
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50403384
PNG
(CHEMBL17445)
Show SMILES NCc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H17FN4/c22-18-7-5-15(6-8-18)19-20(16-9-11-24-12-10-16)26-21(25-19)17-3-1-14(13-23)2-4-17/h1-12H,13,23H2,(H,25,26)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50284482
PNG
(2-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES Oc1ccccc1-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H14FN3O/c21-15-7-5-13(6-8-15)18-19(14-9-11-22-12-10-14)24-20(23-18)16-3-1-2-4-17(16)25/h1-12,25H,(H,23,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50104351
PNG
(4-[5-(4-Fluoro-phenyl)-2-(4-methoxy-phenyl)-3H-imi...)
Show SMILES COc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H16FN3O/c1-26-18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
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TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (human))
BDBM50403405
PNG
(CHEMBL274279)
Show SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C28H30FN3O/c1-27(2,3)21-15-19(16-22(25(21)33)28(4,5)6)26-31-23(17-7-9-20(29)10-8-17)24(32-26)18-11-13-30-14-12-18/h7-16,33H,1-6H3,(H,31,32)
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n/an/a>5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)

More data for this
Ligand-Target Pair
MAP kinase p38 alpha


(Rattus norvegicus)
BDBM50071885
PNG
(4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imid...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H13ClFN3/c21-16-5-1-15(2-6-16)20-24-18(13-3-7-17(22)8-4-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25)
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Merck Research Laboratory

Curated by ChEMBL


Assay Description
Inhibitory potency evaluated against rat p38 kinase


Citation and Details
More data for this
Ligand-Target Pair