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13 similar compounds to monomer 50090350

Compile data set for download or QSAR
Wt: 405.5
BDBM50074022
Wt: 405.5
BDBM50074024
Wt: 405.5
BDBM50074026
Wt: 391.4
BDBM50074027
Wt: 377.4
BDBM50074028
Wt: 341.4
BDBM50090347
Wt: 369.4
BDBM50090357
Wt: 413.4
BDBM50090364
Wt: 343.4
BDBM50090366
Wt: 345.4
BDBM50090375
Wt: 371.4
BDBM50090377
Wt: 299.3
BDBM50089210
Wt: 315.3
BDBM50089209

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50074022,50074024,50074026,50074027,50074028,50090347,50090357,50090364,50090366,50090375,50090377,50089210,50089209   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM50090364
PNG
(3-[2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl...)
Show SMILES CCOC(=O)C1CCCC(C1)C(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C19H27NO7S/c1-3-27-19(22)14-6-4-5-13(11-14)17(12-18(21)20-23)28(24,25)16-9-7-15(26-2)8-10-16/h7-10,13-14,17,23H,3-6,11-12H2,1-2H3,(H,20,21)
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0.800n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50090347
PNG
(3-Cyclohexyl-N-hydroxy-3-(4-methoxy-benzenesulfony...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(=O)NO)C1CCCCC1
Show InChI InChI=1S/C16H23NO5S/c1-22-13-7-9-14(10-8-13)23(20,21)15(11-16(18)17-19)12-5-3-2-4-6-12/h7-10,12,15,19H,2-6,11H2,1H3,(H,17,18)
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8n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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10n/an/an/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-2 (MMP-2).


J Med Chem 43: 305-41 (2000)

Checked by Author
Article DOI: 10.1021/jm990412m
BindingDB Entry DOI: 10.7270/Q2JD4XH4
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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10n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-A


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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20n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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20n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-A


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50090377
PNG
(3-(4-Methoxy-benzenesulfonyl)-5,7,7-trimethyl-octa...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(C)CC(C)(C)C)CC(=O)NO
Show InChI InChI=1S/C18H29NO5S/c1-13(12-18(2,3)4)10-16(11-17(20)19-21)25(22,23)15-8-6-14(24-5)7-9-15/h6-9,13,16,21H,10-12H2,1-5H3,(H,19,20)
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27n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50089209
PNG
(3-(4-Methoxy-benzenesulfonyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO5S/c1-3-4-5-13(10-14(16)15-17)21(18,19)12-8-6-11(20-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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30n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50090366
PNG
(3-(4-Methoxy-benzenesulfonyl)-nonanoic acid hydrox...)
Show SMILES CCCCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C16H25NO5S/c1-3-4-5-6-7-15(12-16(18)17-19)23(20,21)14-10-8-13(22-2)9-11-14/h8-11,15,19H,3-7,12H2,1-2H3,(H,17,18)
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31n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50090357
PNG
(5-Cyclohexyl-3-(4-methoxy-benzenesulfonyl)-pentano...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C18H27NO5S/c1-24-15-8-11-16(12-9-15)25(22,23)17(13-18(20)19-21)10-7-14-5-3-2-4-6-14/h8-9,11-12,14,17,21H,2-7,10,13H2,1H3,(H,19,20)
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36n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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44n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-2.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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50n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-A


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074022
PNG
(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(C)(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-21(16-20(23)22-24,15-7-6-10-17-8-4-3-5-9-17)28(25,26)19-13-11-18(27-2)12-14-19/h3-5,8-9,11-14,24H,6-7,10,15-16H2,1-2H3,(H,22,23)
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50n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-A


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50074026
PNG
(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)C(C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)
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60n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-A


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090364
PNG
(3-[2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl...)
Show SMILES CCOC(=O)C1CCCC(C1)C(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C19H27NO7S/c1-3-27-19(22)14-6-4-5-13(11-14)17(12-18(21)20-23)28(24,25)16-9-7-15(26-2)8-10-16/h7-10,13-14,17,23H,3-6,11-12H2,1-2H3,(H,20,21)
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60n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090347
PNG
(3-Cyclohexyl-N-hydroxy-3-(4-methoxy-benzenesulfony...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(=O)NO)C1CCCCC1
Show InChI InChI=1S/C16H23NO5S/c1-22-13-7-9-14(10-8-13)23(20,21)15(11-16(18)17-19)12-5-3-2-4-6-12/h7-10,12,15,19H,2-6,11H2,1H3,(H,17,18)
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86n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090357
PNG
(5-Cyclohexyl-3-(4-methoxy-benzenesulfonyl)-pentano...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C18H27NO5S/c1-24-15-8-11-16(12-9-15)25(22,23)17(13-18(20)19-21)10-7-14-5-3-2-4-6-14/h8-9,11-12,14,17,21H,2-7,10,13H2,1H3,(H,19,20)
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400n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50089209
PNG
(3-(4-Methoxy-benzenesulfonyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO5S/c1-3-4-5-13(10-14(16)15-17)21(18,19)12-8-6-11(20-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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404n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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500n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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500n/an/an/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-3 (MMP-3).


J Med Chem 43: 305-41 (2000)

Checked by Author
Article DOI: 10.1021/jm990412m
BindingDB Entry DOI: 10.7270/Q2JD4XH4
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090357
PNG
(5-Cyclohexyl-3-(4-methoxy-benzenesulfonyl)-pentano...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C18H27NO5S/c1-24-15-8-11-16(12-9-15)25(22,23)17(13-18(20)19-21)10-7-14-5-3-2-4-6-14/h8-9,11-12,14,17,21H,2-7,10,13H2,1H3,(H,19,20)
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590n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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600n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074026
PNG
(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)C(C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)
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600n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090377
PNG
(3-(4-Methoxy-benzenesulfonyl)-5,7,7-trimethyl-octa...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(C)CC(C)(C)C)CC(=O)NO
Show InChI InChI=1S/C18H29NO5S/c1-13(12-18(2,3)4)10-16(11-17(20)19-21)25(22,23)15-8-6-14(24-5)7-9-15/h6-9,13,16,21H,10-12H2,1-5H3,(H,19,20)
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676n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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700n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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700n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090366
PNG
(3-(4-Methoxy-benzenesulfonyl)-nonanoic acid hydrox...)
Show SMILES CCCCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C16H25NO5S/c1-3-4-5-6-7-15(12-16(18)17-19)23(20,21)14-10-8-13(22-2)9-11-14/h8-11,15,19H,3-7,12H2,1-2H3,(H,17,18)
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734n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074022
PNG
(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(C)(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-21(16-20(23)22-24,15-7-6-10-17-8-4-3-5-9-17)28(25,26)19-13-11-18(27-2)12-14-19/h3-5,8-9,11-14,24H,6-7,10,15-16H2,1-2H3,(H,22,23)
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1.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090364
PNG
(3-[2-Hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl...)
Show SMILES CCOC(=O)C1CCCC(C1)C(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C19H27NO7S/c1-3-27-19(22)14-6-4-5-13(11-14)17(12-18(21)20-23)28(24,25)16-9-7-15(26-2)8-10-16/h7-10,13-14,17,23H,3-6,11-12H2,1-2H3,(H,20,21)
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1.01E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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1.39E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-3.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090347
PNG
(3-Cyclohexyl-N-hydroxy-3-(4-methoxy-benzenesulfony...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(=O)NO)C1CCCCC1
Show InChI InChI=1S/C16H23NO5S/c1-22-13-7-9-14(10-8-13)23(20,21)15(11-16(18)17-19)12-5-3-2-4-6-12/h7-10,12,15,19H,2-6,11H2,1H3,(H,17,18)
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1.71E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090377
PNG
(3-(4-Methoxy-benzenesulfonyl)-5,7,7-trimethyl-octa...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CC(C)CC(C)(C)C)CC(=O)NO
Show InChI InChI=1S/C18H29NO5S/c1-13(12-18(2,3)4)10-16(11-17(20)19-21)25(22,23)15-8-6-14(24-5)7-9-15/h6-9,13,16,21H,10-12H2,1-5H3,(H,19,20)
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1.72E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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2.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074022
PNG
(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(C)(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-21(16-20(23)22-24,15-7-6-10-17-8-4-3-5-9-17)28(25,26)19-13-11-18(27-2)12-14-19/h3-5,8-9,11-14,24H,6-7,10,15-16H2,1-2H3,(H,22,23)
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2.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



University of Queensland

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloprotease-1 (MMP-1).


J Med Chem 43: 305-41 (2000)

Checked by Author
Article DOI: 10.1021/jm990412m
BindingDB Entry DOI: 10.7270/Q2JD4XH4
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074024
PNG
((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)
Show SMILES COc1ccc(cc1)S(=O)(=O)[C@H](CCCCc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)/t16-,20-/m1/s1
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2.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074026
PNG
(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)C(C)C(=O)NO
Show InChI InChI=1S/C21H27NO5S/c1-16(21(23)22-24)20(11-7-6-10-17-8-4-3-5-9-17)28(25,26)19-14-12-18(27-2)13-15-19/h3-5,8-9,12-16,20,24H,6-7,10-11H2,1-2H3,(H,22,23)
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2.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074028
PNG
(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H23NO5S/c1-25-16-10-12-17(13-11-16)26(23,24)18(14-19(21)20-22)9-5-8-15-6-3-2-4-7-15/h2-4,6-7,10-13,18,22H,5,8-9,14H2,1H3,(H,20,21)
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2.58E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50089209
PNG
(3-(4-Methoxy-benzenesulfonyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO5S/c1-3-4-5-13(10-14(16)15-17)21(18,19)12-8-6-11(20-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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4.17E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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5.00E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50074027
PNG
(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)
Show SMILES COc1ccc(cc1)S(=O)(=O)C(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C20H25NO5S/c1-26-17-11-13-18(14-12-17)27(24,25)19(15-20(22)21-23)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,11-14,19,23H,5-6,9-10,15H2,1H3,(H,21,22)
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5.00E+3n/an/an/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.


J Med Chem 42: 541-4 (1999)


Article DOI: 10.1021/jm980567e
BindingDB Entry DOI: 10.7270/Q2VQ31VC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090366
PNG
(3-(4-Methoxy-benzenesulfonyl)-nonanoic acid hydrox...)
Show SMILES CCCCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C16H25NO5S/c1-3-4-5-6-7-15(12-16(18)17-19)23(20,21)14-10-8-13(22-2)9-11-14/h8-11,15,19H,3-7,12H2,1-2H3,(H,17,18)
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9.59E+3n/an/an/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro inhibition of human recombinant Matrix metalloproteinase-1.


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50090375
PNG
(3-(3,4-Dimethoxy-benzenesulfonyl)-5-methyl-hexanoi...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)C(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C15H23NO6S/c1-10(2)7-12(9-15(17)16-18)23(19,20)11-5-6-13(21-3)14(8-11)22-4/h5-6,8,10,12,18H,7,9H2,1-4H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloproteinase-3


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50089209
PNG
(3-(4-Methoxy-benzenesulfonyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO5S/c1-3-4-5-13(10-14(16)15-17)21(18,19)12-8-6-11(20-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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n/an/a 31n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.


J Med Chem 43: 2324-31 (2000)


Article DOI: 10.1021/jm000018k
BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50090375
PNG
(3-(3,4-Dimethoxy-benzenesulfonyl)-5-methyl-hexanoi...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)C(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C15H23NO6S/c1-10(2)7-12(9-15(17)16-18)23(19,20)11-5-6-13(21-3)14(8-11)22-4/h5-6,8,10,12,18H,7,9H2,1-4H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
Phosphodiesterase 4 inhibitory activity measured against guinea pig macrophage homogenate


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM50090375
PNG
(3-(3,4-Dimethoxy-benzenesulfonyl)-5-methyl-hexanoi...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)C(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C15H23NO6S/c1-10(2)7-12(9-15(17)16-18)23(19,20)11-5-6-13(21-3)14(8-11)22-4/h5-6,8,10,12,18H,7,9H2,1-4H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloproteinase-1


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50090375
PNG
(3-(3,4-Dimethoxy-benzenesulfonyl)-5-methyl-hexanoi...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)C(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C15H23NO6S/c1-10(2)7-12(9-15(17)16-18)23(19,20)11-5-6-13(21-3)14(8-11)22-4/h5-6,8,10,12,18H,7,9H2,1-4H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Rhone Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloproteinase-2


Bioorg Med Chem Lett 10: 1637-40 (2000)


Article DOI: 10.1016/s0960-894x(00)00285-7
BindingDB Entry DOI: 10.7270/Q20G3JDK
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50089210
PNG
(3-(4-Methoxy-benzenesulfinyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO4S/c1-3-4-5-13(10-14(16)15-17)20(18)12-8-6-11(19-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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n/an/a 99n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.


J Med Chem 43: 2324-31 (2000)


Article DOI: 10.1021/jm000018k
BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair