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13 similar compounds to monomer 50074694

Wt: 550.5
BDBM50074693
Wt: 488.5
BDBM50074702
Wt: 530.5
BDBM50074771
Wt: 504.6
BDBM50074777
Wt: 572.5
BDBM50074795
Wt: 572.5
BDBM50074796
Wt: 554.5
BDBM50074799
Wt: 566.5
BDBM50074804
Wt: 620.5
BDBM50074813
Wt: 604.5
BDBM50074818
Wt: 490.6
BDBM50074784
Wt: 614.6
BDBM50074812
Wt: 572.5
BDBM50074798

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50074693,50074702,50074771,50074777,50074795,50074796,50074799,50074804,50074813,50074818,50074784,50074812,50074798   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074693
PNG
(CHEMBL3410162)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H29F3N4O3/c1-18-9-8-12-20(17-18)24(26(34)38)22(15-16-30(31,32)33)28(39)36-27-29(40)37(2)23-14-7-6-13-21(23)25(35-27)19-10-4-3-5-11-19/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074795
PNG
(CHEMBL3410170)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-20(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)21(11-12-29(32,33)34)23(25(35)39)17-13-18(30)15-19(31)14-17/h2-10,13-15,21,23,26H,11-12H2,1H3,(H2,35,39)(H,37,40)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074771
PNG
(CHEMBL3410153)
Show SMILES CCC(CC)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C28H33F3N4O3/c1-4-17(5-2)22(24(32)36)20(15-16-28(29,30)31)26(37)34-25-27(38)35(3)21-14-10-9-13-19(21)23(33-25)18-11-7-6-8-12-18/h6-14,17,20,22,25H,4-5,15-16H2,1-3H3,(H2,32,36)(H,34,37)/t20-,22+,25-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074777
PNG
(CHEMBL3410152)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H40N4O3/c1-7-19(8-2)24(26(31)35)22(18-30(3,4)5)28(36)33-27-29(37)34(6)23-17-13-12-16-21(23)25(32-27)20-14-10-9-11-15-20/h9-17,19,22,24,27H,7-8,18H2,1-6H3,(H2,31,35)(H,33,36)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074784
PNG
(CHEMBL3410151)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C29H38N4O3/c1-6-19(7-2)24(26(30)34)22(17-18(3)4)28(35)32-27-29(36)33(5)23-16-12-11-15-21(23)25(31-27)20-13-9-8-10-14-20/h8-16,18-19,22,24,27H,6-7,17H2,1-5H3,(H2,30,34)(H,32,35)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074795
PNG
(CHEMBL3410170)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-20(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)21(11-12-29(32,33)34)23(25(35)39)17-13-18(30)15-19(31)14-17/h2-10,13-15,21,23,26H,11-12H2,1H3,(H2,35,39)(H,37,40)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074796
PNG
(CHEMBL3410169)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-19(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)20(13-14-29(32,33)34)23(25(35)39)18-12-11-17(30)15-21(18)31/h2-12,15,20,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t20-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074798
PNG
(CHEMBL3410168)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-18(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)19(13-14-29(32,33)34)23(25(35)39)17-11-12-20(30)21(31)15-17/h2-12,15,19,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t19-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074799
PNG
(CHEMBL3410167)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)C1=O)c1ccccc1
Show InChI InChI=1/C29H26F4N4O3/c1-37-22-10-6-5-9-20(22)24(18-7-3-2-4-8-18)35-26(28(37)40)36-27(39)21(15-16-29(31,32)33)23(25(34)38)17-11-13-19(30)14-12-17/h2-14,21,23,26H,15-16H2,1H3,(H2,34,38)(H,36,39)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074804
PNG
(CHEMBL3410166)
Show SMILES COc1ccc(cc1)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H29F3N4O4/c1-37-23-11-7-6-10-21(23)25(19-8-4-3-5-9-19)35-27(29(37)40)36-28(39)22(16-17-30(31,32)33)24(26(34)38)18-12-14-20(41-2)15-13-18/h3-15,22,24,27H,16-17H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074812
PNG
(CHEMBL3410165)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)S(C)(=O)=O)C1=O)c1ccccc1
Show InChI InChI=1/C30H29F3N4O5S/c1-37-23-14-7-6-13-21(23)25(18-9-4-3-5-10-18)35-27(29(37)40)36-28(39)22(15-16-30(31,32)33)24(26(34)38)19-11-8-12-20(17-19)43(2,41)42/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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n/an/a 2.06E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074813
PNG
(CHEMBL3410164)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(OC(F)(F)F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O4/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)44-30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074818
PNG
(CHEMBL3410163)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)C(F)(F)F)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O3/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074693
PNG
(CHEMBL3410162)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H29F3N4O3/c1-18-9-8-12-20(17-18)24(26(34)38)22(15-16-30(31,32)33)28(39)36-27-29(40)37(2)23-14-7-6-13-21(23)25(35-27)19-10-4-3-5-11-19/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074702
PNG
(CHEMBL3410154)
Show SMILES CCC[C@@H]([C@@H](CC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C25H27F3N4O3/c1-3-9-16(21(29)33)18(14-25(26,27)28)23(34)31-22-24(35)32(2)19-13-8-7-12-17(19)20(30-22)15-10-5-4-6-11-15/h4-8,10-13,16,18,22H,3,9,14H2,1-2H3,(H2,29,33)(H,31,34)/t16-,18+,22+/s2
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074771
PNG
(CHEMBL3410153)
Show SMILES CCC(CC)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C28H33F3N4O3/c1-4-17(5-2)22(24(32)36)20(15-16-28(29,30)31)26(37)34-25-27(38)35(3)21-14-10-9-13-19(21)23(33-25)18-11-7-6-8-12-18/h6-14,17,20,22,25H,4-5,15-16H2,1-3H3,(H2,32,36)(H,34,37)/t20-,22+,25-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074777
PNG
(CHEMBL3410152)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H40N4O3/c1-7-19(8-2)24(26(31)35)22(18-30(3,4)5)28(36)33-27-29(37)34(6)23-17-13-12-16-21(23)25(32-27)20-14-10-9-11-15-20/h9-17,19,22,24,27H,7-8,18H2,1-6H3,(H2,31,35)(H,33,36)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074784
PNG
(CHEMBL3410151)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C29H38N4O3/c1-6-19(7-2)24(26(30)34)22(17-18(3)4)28(35)32-27-29(36)33(5)23-16-12-11-15-21(23)25(31-27)20-13-9-8-10-14-20/h8-16,18-19,22,24,27H,6-7,17H2,1-5H3,(H2,30,34)(H,32,35)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


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More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074818
PNG
(CHEMBL3410163)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)C(F)(F)F)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O3/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074813
PNG
(CHEMBL3410164)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(OC(F)(F)F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O4/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)44-30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074812
PNG
(CHEMBL3410165)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)S(C)(=O)=O)C1=O)c1ccccc1
Show InChI InChI=1/C30H29F3N4O5S/c1-37-23-14-7-6-13-21(23)25(18-9-4-3-5-10-18)35-27(29(37)40)36-28(39)22(15-16-30(31,32)33)24(26(34)38)19-11-8-12-20(17-19)43(2,41)42/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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n/an/a 2.24E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074804
PNG
(CHEMBL3410166)
Show SMILES COc1ccc(cc1)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H29F3N4O4/c1-37-23-11-7-6-10-21(23)25(19-8-4-3-5-9-19)35-27(29(37)40)36-28(39)22(16-17-30(31,32)33)24(26(34)38)18-12-14-20(41-2)15-13-18/h3-15,22,24,27H,16-17H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074799
PNG
(CHEMBL3410167)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)C1=O)c1ccccc1
Show InChI InChI=1/C29H26F4N4O3/c1-37-22-10-6-5-9-20(22)24(18-7-3-2-4-8-18)35-26(28(37)40)36-27(39)21(15-16-29(31,32)33)23(25(34)38)17-11-13-19(30)14-12-17/h2-14,21,23,26H,15-16H2,1H3,(H2,34,38)(H,36,39)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074798
PNG
(CHEMBL3410168)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-18(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)19(13-14-29(32,33)34)23(25(35)39)17-11-12-20(30)21(31)15-17/h2-12,15,19,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t19-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074796
PNG
(CHEMBL3410169)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-19(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)20(13-14-29(32,33)34)23(25(35)39)18-12-11-17(30)15-21(18)31/h2-12,15,20,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t20-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 3 intracellular domain (Notch 3)


(Homo sapiens (Human))
BDBM50074702
PNG
(CHEMBL3410154)
Show SMILES CCC[C@@H]([C@@H](CC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C25H27F3N4O3/c1-3-9-16(21(29)33)18(14-25(26,27)28)23(34)31-22-24(35)32(2)19-13-8-7-12-17(19)20(30-22)15-10-5-4-6-11-15/h4-8,10-13,16,18,22H,3,9,14H2,1-2H3,(H2,29,33)(H,31,34)/t16-,18+,22+/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair