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11 similar compounds to monomer 50260229

Compile data set for download or QSAR
Wt: 321.3
BDBM50077957
Wt: 322.3
BDBM50077958
Wt: 351.4
BDBM50089122
Wt: 323.3
BDBM50089123
Wt: 295.3
BDBM50089127
Wt: 337.3
BDBM50089130
Wt: 309.3
BDBM50089132
Wt: 315.3
BDBM50104356
Wt: 333.3
BDBM50104360
Wt: 343.3
BDBM50104376
Wt: 295.3
BDBM50176322

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50077957,50077958,50089122,50089123,50089127,50089130,50089132,50104356,50104360,50104376,50176322   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089132
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50104360
PNG
(4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Fc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13F2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089123
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089122
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25)
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n/an/a 200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089130
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50077957
PNG
(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)C1CCCCC1
Show InChI InChI=1S/C20H20FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h6-13,16H,1-5H2,(H,23,24)
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n/an/a 29n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-terminal kinase 2-alpha 1


J Med Chem 42: 2180-90 (1999)


Article DOI: 10.1021/jm9805236
BindingDB Entry DOI: 10.7270/Q2Q81C8D
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50077958
PNG
(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)C1CCNCC1
Show InChI InChI=1S/C19H19FN4/c20-16-3-1-13(2-4-16)17-18(14-5-9-21-10-6-14)24-19(23-17)15-7-11-22-12-8-15/h1-6,9-10,15,22H,7-8,11-12H2,(H,23,24)
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n/an/a 80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase


J Med Chem 42: 2180-90 (1999)


Article DOI: 10.1021/jm9805236
BindingDB Entry DOI: 10.7270/Q2Q81C8D
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50077957
PNG
(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)C1CCCCC1
Show InChI InChI=1S/C20H20FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h6-13,16H,1-5H2,(H,23,24)
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n/an/a 135n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase


J Med Chem 42: 2180-90 (1999)


Article DOI: 10.1021/jm9805236
BindingDB Entry DOI: 10.7270/Q2Q81C8D
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50077958
PNG
(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)C1CCNCC1
Show InChI InChI=1S/C19H19FN4/c20-16-3-1-13(2-4-16)17-18(14-5-9-21-10-6-14)24-19(23-17)15-7-11-22-12-8-15/h1-6,9-10,15,22H,7-8,11-12H2,(H,23,24)
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n/an/a 210n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-terminal kinase 2-alpha 1


J Med Chem 42: 2180-90 (1999)


Article DOI: 10.1021/jm9805236
BindingDB Entry DOI: 10.7270/Q2Q81C8D
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089122
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25)
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n/an/a 76n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089123
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23)
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n/an/a 80n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089127
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21)
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n/an/a 20n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089130
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24)
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n/an/a 120n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089132
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104360
PNG
(4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Fc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13F2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50104376
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenethyl-3H-imidazol-4-y...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(CCc2ccccc2)nc1-c1ccncc1
Show InChI InChI=1S/C22H18FN3/c23-19-9-7-17(8-10-19)21-22(18-12-14-24-15-13-18)26-20(25-21)11-6-16-4-2-1-3-5-16/h1-5,7-10,12-15H,6,11H2,(H,25,26)
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n/an/a 690n/an/an/an/an/an/a



Eberhard-Karls-University Tübingen

Curated by ChEMBL


Assay Description
Inhibition of Mitogen-activated protein kinase p38 (P38 MAPK)


J Med Chem 45: 4695-705 (2002)


Article DOI: 10.1021/jm020873z
BindingDB Entry DOI: 10.7270/Q27D2TGW
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50176322
PNG
(4-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-y...)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C18H18FN3/c1-18(2,3)17-21-15(12-4-6-14(19)7-5-12)16(22-17)13-8-10-20-11-9-13/h4-11H,1-3H3,(H,21,22)
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n/an/a 900n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition bRaf kinase activity


Bioorg Med Chem Lett 16: 378-81 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.072
BindingDB Entry DOI: 10.7270/Q2Z038Z9
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104376
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenethyl-3H-imidazol-4-y...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(CCc2ccccc2)nc1-c1ccncc1
Show InChI InChI=1S/C22H18FN3/c23-19-9-7-17(8-10-19)21-22(18-12-14-24-15-13-18)26-20(25-21)11-6-16-4-2-1-3-5-16/h1-5,7-10,12-15H,6,11H2,(H,25,26)
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TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details

Article DOI: 10.1007/s00044-013-0869-9
BindingDB Entry DOI: 10.7270/Q23R0V9H
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104360
PNG
(4-[2,5-Bis-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyr...)
Show SMILES Fc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H13F2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
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n/an/a 100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details

Article DOI: 10.1007/s00044-013-0869-9
BindingDB Entry DOI: 10.7270/Q23R0V9H
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 130n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human glucagon receptor expressed in CHO cell membranes by radioligand displacement assay


Citation and Details

Article DOI: 10.1007/s00044-013-0869-9
BindingDB Entry DOI: 10.7270/Q23R0V9H
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 154n/an/an/an/an/an/a



University of Tuebingen

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAPK


J Med Chem 55: 8429-39 (2012)


Article DOI: 10.1021/jm300852w
BindingDB Entry DOI: 10.7270/Q2765GGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytes


Bioorg Med Chem Lett 5: 1171-1176 (1995)


Article DOI: 10.1016/0960-894X(95)00189-Z
BindingDB Entry DOI: 10.7270/Q28S4PV1
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50104376
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenethyl-3H-imidazol-4-y...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(CCc2ccccc2)nc1-c1ccncc1
Show InChI InChI=1S/C22H18FN3/c23-19-9-7-17(8-10-19)21-22(18-12-14-24-15-13-18)26-20(25-21)11-6-16-4-2-1-3-5-16/h1-5,7-10,12-15H,6,11H2,(H,25,26)
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50104356
PNG
(4-[5-(4-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
Show InChI InChI=1S/C20H14FN3/c21-17-8-6-14(7-9-17)18-19(15-10-12-22-13-11-15)24-20(23-18)16-4-2-1-3-5-16/h1-13H,(H,23,24)
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50


Bioorg Med Chem Lett 11: 2549-53 (2001)


Article DOI: 10.1016/s0960-894x(01)00498-x
BindingDB Entry DOI: 10.7270/Q2FB527Z
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089127
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00200-6
BindingDB Entry DOI: 10.7270/Q2XS5TMT
More data for this
Ligand-Target Pair