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12 similar compounds to monomer 50091481

Compile data set for download or QSAR
Wt: 215.2
BDBM50091473
Wt: 201.2
BDBM50091474
Wt: 201.2
BDBM50091475
Wt: 213.2
BDBM50091477
Wt: 215.2
BDBM50091478
Wt: 215.2
BDBM50091479
Wt: 173.1
BDBM50091482
Wt: 187.1
BDBM50091483
Wt: 201.2
BDBM50091485
Wt: 199.2
BDBM50091486
Wt: 215.2
BDBM50091490
Wt: 227.2
BDBM50091493

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50091473,50091474,50091475,50091477,50091478,50091479,50091482,50091483,50091485,50091486,50091490,50091493   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic kainate


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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PubMed
33n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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54n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091485
PNG
((S)-2-Amino-4-butylidene-pentanedioic acid | CHEMB...)
Show SMILES CCC\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h4,7H,2-3,5,10H2,1H3,(H,11,12)(H,13,14)/b6-4-/t7-/m0/s1
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80n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091479
PNG
((S)-2-Amino-4-(2,2-dimethyl-propylidene)-pentanedi...)
Show SMILES CC(C)(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-10(2,3)5-6(8(12)13)4-7(11)9(14)15/h5,7H,4,11H2,1-3H3,(H,12,13)(H,14,15)/b6-5+/t7-/m0/s1
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86n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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94n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091478
PNG
((S)-2-Amino-4-pentylidene-pentanedioicacid | CHEMB...)
Show SMILES CCCC\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h5,8H,2-4,6,11H2,1H3,(H,12,13)(H,14,15)/b7-5-/t8-/m0/s1
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150n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091490
PNG
((S)-2-Amino-4-(3-methyl-butylidene)-pentanedioic a...)
Show SMILES CC(C)C\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h4,6,8H,3,5,11H2,1-2H3,(H,12,13)(H,14,15)/b7-4+/t8-/m0/s1
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224n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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241n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091486
PNG
((S)-2-Amino-4-cyclobutylidene-pentanedioic acid | ...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCC1)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-7(9(13)14)4-6(8(11)12)5-2-1-3-5/h7H,1-4,10H2,(H,11,12)(H,13,14)/t7-/m0/s1
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470n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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518n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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533n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 4 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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700n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091482
PNG
((S)-2-Amino-4-ethylidene-pentanedioic acid | CHEMB...)
Show SMILES C\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-4(6(9)10)3-5(8)7(11)12/h2,5H,3,8H2,1H3,(H,9,10)(H,11,12)/b4-2-/t5-/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091482
PNG
((S)-2-Amino-4-ethylidene-pentanedioic acid | CHEMB...)
Show SMILES C\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-4(6(9)10)3-5(8)7(11)12/h2,5H,3,8H2,1H3,(H,9,10)(H,11,12)/b4-2-/t5-/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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3.68E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 2 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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3.70E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 2 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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4.71E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 4 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091493
PNG
((S)-2-Amino-4-cyclohexylidene-pentanedioic acid | ...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCCC1)C(O)=O
Show InChI InChI=1S/C11H17NO4/c12-9(11(15)16)6-8(10(13)14)7-4-2-1-3-5-7/h9H,1-6,12H2,(H,13,14)(H,15,16)/t9-/m0/s1
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5.13E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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5.60E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 4 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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5.73E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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7.50E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Glutamate receptor (KA2) using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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1.03E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 4 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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1.05E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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1.24E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091483
PNG
((S)-2-Amino-4-isopropylidene-pentanedioic acid | C...)
Show SMILES CC(C)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-4(2)5(7(10)11)3-6(9)8(12)13/h6H,3,9H2,1-2H3,(H,10,11)(H,12,13)/t6-/m0/s1
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1.39E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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2.14E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Glutamate receptor (KA2) using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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4.49E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 2 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091485
PNG
((S)-2-Amino-4-butylidene-pentanedioic acid | CHEMB...)
Show SMILES CCC\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h4,7H,2-3,5,10H2,1H3,(H,11,12)(H,13,14)/b6-4-/t7-/m0/s1
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5.72E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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8.22E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Glutamate receptor (KA2) using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091474
PNG
((2S,4E)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3+/t7-/m0/s1
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8.25E+4n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091486
PNG
((S)-2-Amino-4-cyclobutylidene-pentanedioic acid | ...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCC1)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-7(9(13)14)4-6(8(11)12)5-2-1-3-5/h7H,1-4,10H2,(H,11,12)(H,13,14)/t7-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091479
PNG
((S)-2-Amino-4-(2,2-dimethyl-propylidene)-pentanedi...)
Show SMILES CC(C)(C)\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-10(2,3)5-6(8(12)13)4-7(11)9(14)15/h5,7H,4,11H2,1-3H3,(H,12,13)(H,14,15)/b6-5+/t7-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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1.13E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091478
PNG
((S)-2-Amino-4-pentylidene-pentanedioicacid | CHEMB...)
Show SMILES CCCC\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h5,8H,2-4,6,11H2,1H3,(H,12,13)(H,14,15)/b7-5-/t8-/m0/s1
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1.25E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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2.07E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091493
PNG
((S)-2-Amino-4-cyclohexylidene-pentanedioic acid | ...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCCC1)C(O)=O
Show InChI InChI=1S/C11H17NO4/c12-9(11(15)16)6-8(10(13)14)7-4-2-1-3-5-7/h9H,1-6,12H2,(H,13,14)(H,15,16)/t9-/m0/s1
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2.55E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50091473
PNG
((S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic a...)
Show SMILES CCC(CC)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-3-6(4-2)7(9(12)13)5-8(11)10(14)15/h8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t8-/m0/s1
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2.81E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 2 using cell membranes prepared from HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091483
PNG
((S)-2-Amino-4-isopropylidene-pentanedioic acid | C...)
Show SMILES CC(C)=C(C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-4(2)5(7(10)11)3-6(9)8(12)13/h6H,3,9H2,1-2H3,(H,10,11)(H,12,13)/t6-/m0/s1
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>4.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091475
PNG
((2S,4Z)-2-amino-4-(2-methylpropylidene)pentanedioi...)
Show SMILES CC(C)\C=C(\C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h3,5,7H,4,10H2,1-2H3,(H,11,12)(H,13,14)/b6-3-/t7-/m0/s1
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>5.00E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091490
PNG
((S)-2-Amino-4-(3-methyl-butylidene)-pentanedioic a...)
Show SMILES CC(C)C\C=C(/C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h4,6,8H,3,5,11H2,1-2H3,(H,12,13)(H,14,15)/b7-4+/t8-/m0/s1
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6.34E+5n/an/an/an/an/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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n/an/an/an/a 6.20E+3n/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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n/an/an/an/a 1.05E+3n/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Compound was tested for agonistic activity on rat dorsal root ganglion neurons (thought to express GluR5 receptors)


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50091477
PNG
((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O
Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Eli Lilly and Company Ltd

Curated by ChEMBL


Assay Description
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...


Bioorg Med Chem Lett 10: 1807-10 (2000)


Article DOI: 10.1016/s0960-894x(00)00346-2
BindingDB Entry DOI: 10.7270/Q2765FVB
More data for this
Ligand-Target Pair