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12 similar compounds to monomer 50154937

Compile data set for download or QSAR
Wt: 300.3
BDBM50097460
Wt: 399.4
BDBM50154940
Wt: 431.5
BDBM50154931
Wt: 403.4
BDBM50154933
Wt: 375.4
BDBM50154941
Wt: 368.4
BDBM50154947
Wt: 371.4
BDBM50154951
Wt: 373.4
BDBM50154953
Wt: 401.4
BDBM50154956
Wt: 368.4
BDBM50154946
Wt: 331.3
BDBM50154962
Wt: 361.3
BDBM50154960

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50097460,50154940,50154931,50154933,50154941,50154947,50154951,50154953,50154956,50154946,50154962,50154960   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine oxidase B


(Bos taurus)
BDBM50097460
PNG
(CHEMBL3585818)
Show SMILES COC(=O)C(C)N1C(Nc2ccccc2C1=O)c1ccco1
Show InChI InChI=1S/C16H16N2O4/c1-10(16(20)21-2)18-14(13-8-5-9-22-13)17-12-7-4-3-6-11(12)15(18)19/h3-10,14,17H,1-2H3
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n/an/a 6.10n/an/an/an/an/an/a



Alexandria University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain mitochondria MAO-B using benzylamine substrate after 60 mins by fluorimetric method


Bioorg Med Chem 23: 3574-85 (2015)


Article DOI: 10.1016/j.bmc.2015.04.021
BindingDB Entry DOI: 10.7270/Q28K7BVZ
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154962
PNG
(CHEMBL3775614)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(N)=O)cc1
Show InChI InChI=1S/C19H17N5O/c1-24-11-15(10-21-24)13-4-2-12(3-5-13)8-18-16-9-14(19(20)25)6-7-17(16)22-23-18/h2-7,9-11H,8H2,1H3,(H2,20,25)(H,22,23)
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n/an/a 270n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (Human))
BDBM50154931
PNG
(CHEMBL3775792)
Show SMILES CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(NCC(C)(C)O)nc12
Show InChI InChI=1S/C24H29N7O/c1-15(2)19-20-21(31-30-19)22(29-23(28-20)27-14-24(3,4)32)26-13-16-8-10-17(11-9-16)18-7-5-6-12-25-18/h5-12,15,32H,13-14H2,1-4H3,(H,30,31)(H2,26,27,28,29)
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n/an/a 1n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany AS CR

Curated by ChEMBL


Assay Description
Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATP


Eur J Med Chem 110: 291-301 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.011
BindingDB Entry DOI: 10.7270/Q2SQ927C
More data for this
Ligand-Target Pair
Cyclin-dependent kinase


(Homo sapiens (Human))
BDBM50154933
PNG
(CHEMBL3775502)
Show SMILES CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(NCCO)nc12
Show InChI InChI=1S/C22H25N7O/c1-14(2)18-19-20(29-28-18)21(27-22(26-19)24-11-12-30)25-13-15-6-8-16(9-7-15)17-5-3-4-10-23-17/h3-10,14,30H,11-13H2,1-2H3,(H,28,29)(H2,24,25,26,27)
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n/an/a 49n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany AS CR

Curated by ChEMBL


Assay Description
Inhibition of CDK5 (unknown origin) using histone H1 as substrate in presence of [gamma33P]-ATP


Eur J Med Chem 110: 291-301 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.011
BindingDB Entry DOI: 10.7270/Q2SQ927C
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50154931
PNG
(CHEMBL3775792)
Show SMILES CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(NCC(C)(C)O)nc12
Show InChI InChI=1S/C24H29N7O/c1-15(2)19-20-21(31-30-19)22(29-23(28-20)27-14-24(3,4)32)26-13-16-8-10-17(11-9-16)18-7-5-6-12-25-18/h5-12,15,32H,13-14H2,1-4H3,(H,30,31)(H2,26,27,28,29)
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n/an/a 9n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany AS CR

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP


Eur J Med Chem 110: 291-301 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.011
BindingDB Entry DOI: 10.7270/Q2SQ927C
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM50154933
PNG
(CHEMBL3775502)
Show SMILES CC(C)c1n[nH]c2c(NCc3ccc(cc3)-c3ccccn3)nc(NCCO)nc12
Show InChI InChI=1S/C22H25N7O/c1-14(2)18-19-20(29-28-18)21(27-22(26-19)24-11-12-30)25-13-15-6-8-16(9-7-15)17-5-3-4-10-23-17/h3-10,14,30H,11-13H2,1-2H3,(H,28,29)(H2,24,25,26,27)
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n/an/a 31n/an/an/an/an/an/a



Palack£ University and Institute of Experimental Botany AS CR

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATP


Eur J Med Chem 110: 291-301 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.011
BindingDB Entry DOI: 10.7270/Q2SQ927C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154940
PNG
(CHEMBL3775384)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C24H25N5O/c1-28-16-20(15-25-28)18-7-5-17(6-8-18)13-23-21-14-19(9-10-22(21)26-27-23)24(30)29-11-3-2-4-12-29/h5-10,14-16H,2-4,11-13H2,1H3,(H,26,27)
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n/an/a 6n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154940
PNG
(CHEMBL3775384)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C24H25N5O/c1-28-16-20(15-25-28)18-7-5-17(6-8-18)13-23-21-14-19(9-10-22(21)26-27-23)24(30)29-11-3-2-4-12-29/h5-10,14-16H,2-4,11-13H2,1H3,(H,26,27)
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n/an/a 13n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154941
PNG
(CHEMBL3775024)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC[C@H](O)C3)ccc12
Show InChI InChI=1S/C21H21N5O2/c1-25-20-5-2-13(8-15(20)11-22-25)9-19-17-10-14(3-4-18(17)23-24-19)21(28)26-7-6-16(27)12-26/h2-5,8,10-11,16,27H,6-7,9,12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154941
PNG
(CHEMBL3775024)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC[C@H](O)C3)ccc12
Show InChI InChI=1S/C21H21N5O2/c1-25-20-5-2-13(8-15(20)11-22-25)9-19-17-10-14(3-4-18(17)23-24-19)21(28)26-7-6-16(27)12-26/h2-5,8,10-11,16,27H,6-7,9,12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154946
PNG
(CHEMBL3775519)
Show SMILES Cn1cnc(c1)-c1ccc2[nH]nc(Cc3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C22H20N6/c1-27-13-22(23-14-27)17-7-8-20-19(10-17)21(26-25-20)9-15-3-5-16(6-4-15)18-11-24-28(2)12-18/h3-8,10-14H,9H2,1-2H3,(H,25,26)
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n/an/a 78n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154946
PNG
(CHEMBL3775519)
Show SMILES Cn1cnc(c1)-c1ccc2[nH]nc(Cc3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C22H20N6/c1-27-13-22(23-14-27)17-7-8-20-19(10-17)21(26-25-20)9-15-3-5-16(6-4-15)18-11-24-28(2)12-18/h3-8,10-14H,9H2,1-2H3,(H,25,26)
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n/an/a 200n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154947
PNG
(CHEMBL3774757)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)-c2nccn2C)cc1
Show InChI InChI=1S/C22H20N6/c1-27-10-9-23-22(27)17-7-8-20-19(12-17)21(26-25-20)11-15-3-5-16(6-4-15)18-13-24-28(2)14-18/h3-10,12-14H,11H2,1-2H3,(H,25,26)
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n/an/a 32n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154947
PNG
(CHEMBL3774757)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)-c2nccn2C)cc1
Show InChI InChI=1S/C22H20N6/c1-27-10-9-23-22(27)17-7-8-20-19(12-17)21(26-25-20)11-15-3-5-16(6-4-15)18-13-24-28(2)14-18/h3-10,12-14H,11H2,1-2H3,(H,25,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154951
PNG
(CHEMBL3775547)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)N2CCCC2=O)cc1
Show InChI InChI=1S/C22H21N5O/c1-26-14-17(13-23-26)16-6-4-15(5-7-16)11-21-19-12-18(8-9-20(19)24-25-21)27-10-2-3-22(27)28/h4-9,12-14H,2-3,10-11H2,1H3,(H,24,25)
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n/an/a 36n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154951
PNG
(CHEMBL3775547)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)N2CCCC2=O)cc1
Show InChI InChI=1S/C22H21N5O/c1-26-14-17(13-23-26)16-6-4-15(5-7-16)11-21-19-12-18(8-9-20(19)24-25-21)27-10-2-3-22(27)28/h4-9,12-14H,2-3,10-11H2,1H3,(H,24,25)
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n/an/a 82n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154953
PNG
(CHEMBL3774744)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)N2CCOCC2)cc1
Show InChI InChI=1S/C22H23N5O/c1-26-15-18(14-23-26)17-4-2-16(3-5-17)12-22-20-13-19(6-7-21(20)24-25-22)27-8-10-28-11-9-27/h2-7,13-15H,8-12H2,1H3,(H,24,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154953
PNG
(CHEMBL3774744)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)N2CCOCC2)cc1
Show InChI InChI=1S/C22H23N5O/c1-26-15-18(14-23-26)17-4-2-16(3-5-17)12-22-20-13-19(6-7-21(20)24-25-22)27-8-10-28-11-9-27/h2-7,13-15H,8-12H2,1H3,(H,24,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154956
PNG
(CHEMBL3775317)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154956
PNG
(CHEMBL3775317)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154956
PNG
(CHEMBL3775317)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Binding affinity to CDK8/Cyclin C (unknown origin) by reporter displacement assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154960
PNG
(CHEMBL3775123)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC(O)C3)ccc12
Show InChI InChI=1S/C20H19N5O2/c1-24-19-5-2-12(6-14(19)9-21-24)7-18-16-8-13(3-4-17(16)22-23-18)20(27)25-10-15(26)11-25/h2-6,8-9,15,26H,7,10-11H2,1H3,(H,22,23)
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50154960
PNG
(CHEMBL3775123)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC(O)C3)ccc12
Show InChI InChI=1S/C20H19N5O2/c1-24-19-5-2-12(6-14(19)9-21-24)7-18-16-8-13(3-4-17(16)22-23-18)20(27)25-10-15(26)11-25/h2-6,8-9,15,26H,7,10-11H2,1H3,(H,22,23)
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n/an/a 160n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50154962
PNG
(CHEMBL3775614)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(N)=O)cc1
Show InChI InChI=1S/C19H17N5O/c1-24-11-15(10-21-24)13-4-2-12(3-5-13)8-18-16-9-14(19(20)25)6-7-17(16)22-23-18/h2-7,9-11H,8H2,1H3,(H2,20,25)(H,22,23)
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n/an/a 110n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Monoamine oxidase A


(Bos taurus)
BDBM50097460
PNG
(CHEMBL3585818)
Show SMILES COC(=O)C(C)N1C(Nc2ccccc2C1=O)c1ccco1
Show InChI InChI=1S/C16H16N2O4/c1-10(16(20)21-2)18-14(13-8-5-9-22-13)17-12-7-4-3-6-11(12)15(18)19/h3-10,14,17H,1-2H3
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n/an/a 8.20n/an/an/an/an/an/a



Alexandria University

Curated by ChEMBL


Assay Description
Inhibition of bovine brain mitochondria MAO-A using serotonin substrate after 60 mins by fluorimetric method


Bioorg Med Chem 23: 3574-85 (2015)


Article DOI: 10.1016/j.bmc.2015.04.021
BindingDB Entry DOI: 10.7270/Q28K7BVZ
More data for this
Ligand-Target Pair