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4 similar compounds to monomer 50098412

Wt: 256.3
BDBM50098432
Wt: 270.3
BDBM50098436
Wt: 270.3
BDBM50098438

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50098432,50098436,50098438   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50098432
PNG
(CHEMBL3593428)
Show SMILES O=c1[nH]c2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C14H16N4O/c19-14-17-11-8-16-13-10(6-7-15-13)12(11)18(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,15,16)(H,17,19)
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Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM50098432
PNG
(CHEMBL3593428)
Show SMILES O=c1[nH]c2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C14H16N4O/c19-14-17-11-8-16-13-10(6-7-15-13)12(11)18(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,15,16)(H,17,19)
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Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50098432
PNG
(CHEMBL3593428)
Show SMILES O=c1[nH]c2cnc3[nH]ccc3c2n1C1CCCCC1
Show InChI InChI=1S/C14H16N4O/c19-14-17-11-8-16-13-10(6-7-15-13)12(11)18(14)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,15,16)(H,17,19)
PDB

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PubMed
n/an/a 79n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50098436
PNG
(CHEMBL3593579)
Show SMILES C[C@@H]1CCCC[C@@H]1n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-4-2-3-5-12(9)19-13-10-6-7-16-14(10)17-8-11(13)18-15(19)20/h6-9,12H,2-5H2,1H3,(H,16,17)(H,18,20)/t9-,12+/s2
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n/an/a 3n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50098438
PNG
(CHEMBL3593581)
Show SMILES CC1CCCC(C1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-3-2-4-10(7-9)19-13-11-5-6-16-14(11)17-8-12(13)18-15(19)20/h5-6,8-10H,2-4,7H2,1H3,(H,16,17)(H,18,20)
PDB

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Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50098436
PNG
(CHEMBL3593579)
Show SMILES C[C@@H]1CCCC[C@@H]1n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-4-2-3-5-12(9)19-13-10-6-7-16-14(10)17-8-11(13)18-15(19)20/h6-9,12H,2-5H2,1H3,(H,16,17)(H,18,20)/t9-,12+/s2
PDB

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Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50098438
PNG
(CHEMBL3593581)
Show SMILES CC1CCCC(C1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-3-2-4-10(7-9)19-13-11-5-6-16-14(11)17-8-12(13)18-15(19)20/h5-6,8-10H,2-4,7H2,1H3,(H,16,17)(H,18,20)
PDB

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Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM50098438
PNG
(CHEMBL3593581)
Show SMILES CC1CCCC(C1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-3-2-4-10(7-9)19-13-11-5-6-16-14(11)17-8-12(13)18-15(19)20/h5-6,8-10H,2-4,7H2,1H3,(H,16,17)(H,18,20)
PDB

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Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM50098436
PNG
(CHEMBL3593579)
Show SMILES C[C@@H]1CCCC[C@@H]1n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1/C15H18N4O/c1-9-4-2-3-5-12(9)19-13-10-6-7-16-14(10)17-8-11(13)18-15(19)20/h6-9,12H,2-5H2,1H3,(H,16,17)(H,18,20)/t9-,12+/s2
PDB

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PubMed
n/an/a 4.40n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair