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2 similar compounds to monomer 50098410

Wt: 270.3
BDBM50098439

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50098439   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50098439
PNG
(CHEMBL3593582)
Show SMILES CC1CCC(CC1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1S/C15H18N4O/c1-9-2-4-10(5-3-9)19-13-11-6-7-16-14(11)17-8-12(13)18-15(19)20/h6-10H,2-5H2,1H3,(H,16,17)(H,18,20)
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PC cid
PC sid
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AffyNet 
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50098439
PNG
(CHEMBL3593582)
Show SMILES CC1CCC(CC1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1S/C15H18N4O/c1-9-2-4-10(5-3-9)19-13-11-6-7-16-14(11)17-8-12(13)18-15(19)20/h6-10H,2-5H2,1H3,(H,16,17)(H,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair
JAK2/TYK2


(Homo sapiens (Human))
BDBM50098439
PNG
(CHEMBL3593582)
Show SMILES CC1CCC(CC1)n1c2c(cnc3[nH]ccc23)[nH]c1=O
Show InChI InChI=1S/C15H18N4O/c1-9-2-4-10(5-3-9)19-13-11-6-7-16-14(11)17-8-12(13)18-15(19)20/h6-10H,2-5H2,1H3,(H,16,17)(H,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroaki.yamagishi@astellas.com.

Curated by ChEMBL


Assay Description
Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method


Citation and Details
More data for this
Ligand-Target Pair