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13 similar compounds to monomer 50105329

Compile data set for download or QSAR
Wt: 492.4
BDBM50105336
Wt: 478.4
BDBM50105338
Wt: 482.1
BDBM50105324
Wt: 358.4
BDBM50105330
Purchase
Wt: 450.5
BDBM50105337
Wt: 469.5
BDBM50105326
Wt: 374.2
BDBM50105309
Wt: 496.6
BDBM50105341
Wt: 496.6
BDBM50105344
Wt: 528.8
BDBM50105355
Wt: 556.0
BDBM50105358
Wt: 482.1
BDBM50105316
Wt: 437.6
BDBM50105320

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50105336,50105338,50105324,50105330,50105337,50105326,50105309,50105341,50105344,50105355,50105358,50105316,50105320   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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16n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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19n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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21n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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23n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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24n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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27n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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28n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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43n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC11


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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48n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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107n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC7


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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247n/an/an/an/an/an/an/an/a



St Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Nitric Oxide Synthase, inducible


(Mus musculus (mouse))
BDBM50105344
PNG
(CHEMBL3597258)
Show SMILES O=c1sc2ccccc2n1CCCCCN1CCN(CCCn2c3ccccc3sc2=O)CC1
Show InChI InChI=1S/C26H32N4O2S2/c31-25-29(21-9-2-4-11-23(21)33-25)15-7-1-6-13-27-17-19-28(20-18-27)14-8-16-30-22-10-3-5-12-24(22)34-26(30)32/h2-5,9-12H,1,6-8,13-20H2
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n/an/a 2.55E+3n/an/an/an/an/an/a



Beni-Suef University

Curated by ChEMBL


Assay Description
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...


Bioorg Med Chem 23: 3248-59 (2015)


Article DOI: 10.1016/j.bmc.2015.04.057
BindingDB Entry DOI: 10.7270/Q26H4K5F
More data for this
Ligand-Target Pair
Nitric Oxide Synthase, inducible


(Mus musculus (mouse))
BDBM50105355
PNG
(CHEMBL3597268)
Show SMILES C(CCN1CCN(CCCCSc2nc3ccccc3s2)CC1)CSc1nc2ccccc2s1
Show InChI InChI=1S/C26H32N4S4/c1-3-11-23-21(9-1)27-25(33-23)31-19-7-5-13-29-15-17-30(18-16-29)14-6-8-20-32-26-28-22-10-2-4-12-24(22)34-26/h1-4,9-12H,5-8,13-20H2
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n/an/a 410n/an/an/an/an/an/a



Beni-Suef University

Curated by ChEMBL


Assay Description
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...


Bioorg Med Chem 23: 3248-59 (2015)


Article DOI: 10.1016/j.bmc.2015.04.057
BindingDB Entry DOI: 10.7270/Q26H4K5F
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50105358
PNG
(CHEMBL3597403)
Show SMILES OC(=O)Cc1cn(Cc2ccccc2)c2ccc(OCCCOc3cccc(OCc4ccc(Cl)cc4)c3)cc12
Show InChI InChI=1S/C33H30ClNO5/c34-27-12-10-25(11-13-27)23-40-29-9-4-8-28(19-29)38-16-5-17-39-30-14-15-32-31(20-30)26(18-33(36)37)22-35(32)21-24-6-2-1-3-7-24/h1-4,6-15,19-20,22H,5,16-18,21,23H2,(H,36,37)
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n/an/an/an/a 8.60E+3n/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Agonist activity at PPAR-alpha (unknown origin) expressed in CV-1 cells co-transfected with tk-PPRE-luciferase vector after 24 hrs by by transactivat...


Bioorg Med Chem 23: 3322-36 (2015)


Article DOI: 10.1016/j.bmc.2015.04.046
BindingDB Entry DOI: 10.7270/Q22R3TFQ
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50105358
PNG
(CHEMBL3597403)
Show SMILES OC(=O)Cc1cn(Cc2ccccc2)c2ccc(OCCCOc3cccc(OCc4ccc(Cl)cc4)c3)cc12
Show InChI InChI=1S/C33H30ClNO5/c34-27-12-10-25(11-13-27)23-40-29-9-4-8-28(19-29)38-16-5-17-39-30-14-15-32-31(20-30)26(18-33(36)37)22-35(32)21-24-6-2-1-3-7-24/h1-4,6-15,19-20,22H,5,16-18,21,23H2,(H,36,37)
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n/an/an/an/a 500n/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Agonist activity at PPAR-gamma (unknown origin) expressed in CV-1 cells co-transfected with tk-PPRE-luciferase vector after 24 hrs by by transactivat...


Bioorg Med Chem 23: 3322-36 (2015)


Article DOI: 10.1016/j.bmc.2015.04.046
BindingDB Entry DOI: 10.7270/Q22R3TFQ
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50105358
PNG
(CHEMBL3597403)
Show SMILES OC(=O)Cc1cn(Cc2ccccc2)c2ccc(OCCCOc3cccc(OCc4ccc(Cl)cc4)c3)cc12
Show InChI InChI=1S/C33H30ClNO5/c34-27-12-10-25(11-13-27)23-40-29-9-4-8-28(19-29)38-16-5-17-39-30-14-15-32-31(20-30)26(18-33(36)37)22-35(32)21-24-6-2-1-3-7-24/h1-4,6-15,19-20,22H,5,16-18,21,23H2,(H,36,37)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Agonist activity at PPAR-delta (unknown origin) expressed in HEK293t cells co-transfected with tk-PPRE-luciferase vector after 24 hrs by by transacti...


Bioorg Med Chem 23: 3322-36 (2015)


Article DOI: 10.1016/j.bmc.2015.04.046
BindingDB Entry DOI: 10.7270/Q22R3TFQ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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n/an/a>1.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition ...


J Med Chem 60: 1817-1828 (2017)

More data for this
Ligand-Target Pair
Nitric Oxide Synthase, inducible


(Mus musculus (mouse))
BDBM50105341
PNG
(CHEMBL3597254)
Show SMILES O=c1sc2ccccc2n1CCCCCCN1CCN(CCn2c3ccccc3sc2=O)CC1
Show InChI InChI=1S/C26H32N4O2S2/c31-25-29(21-9-3-5-11-23(21)33-25)14-8-2-1-7-13-27-15-17-28(18-16-27)19-20-30-22-10-4-6-12-24(22)34-26(30)32/h3-6,9-12H,1-2,7-8,13-20H2
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n/an/a 3.43E+3n/an/an/an/an/an/a



Beni-Suef University

Curated by ChEMBL


Assay Description
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...


Bioorg Med Chem 23: 3248-59 (2015)


Article DOI: 10.1016/j.bmc.2015.04.057
BindingDB Entry DOI: 10.7270/Q26H4K5F
More data for this
Ligand-Target Pair
Nitric Oxide Synthase, inducible


(Mus musculus (mouse))
BDBM50105337
PNG
(CHEMBL3597251)
Show SMILES O=c1oc2ccccc2n1CCCCCN1CCN(CCn2c3ccccc3oc2=O)CC1
Show InChI InChI=1S/C25H30N4O4/c30-24-28(20-8-2-4-10-22(20)32-24)13-7-1-6-12-26-14-16-27(17-15-26)18-19-29-21-9-3-5-11-23(21)33-25(29)31/h2-5,8-11H,1,6-7,12-19H2
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n/an/a 4.98E+3n/an/an/an/an/an/a



Beni-Suef University

Curated by ChEMBL


Assay Description
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...


Bioorg Med Chem 23: 3248-59 (2015)


Article DOI: 10.1016/j.bmc.2015.04.057
BindingDB Entry DOI: 10.7270/Q26H4K5F
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105326
PNG
(CHEMBL3597679)
Show SMILES Clc1ccc(Br)cc1C1CC(Nc2nnnn12)c1cccc(Br)c1
Show InChI InChI=1S/C16H12Br2ClN5/c17-10-3-1-2-9(6-10)14-8-15(24-16(20-14)21-22-23-24)12-7-11(18)4-5-13(12)19/h1-7,14-15H,8H2,(H,20,21,23)
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n/an/an/a 126n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105324
PNG
(CHEMBL3597677)
Show SMILES Brc1cccc(c1)C1CC(c2cccc(I)c2)n2nnnc2N1
Show InChI InChI=1S/C16H13BrIN5/c17-12-5-1-3-10(7-12)14-9-15(11-4-2-6-13(18)8-11)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)
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n/an/an/a 103n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50105309
PNG
(CHEMBL3597785)
Show SMILES Fc1cc(Br)cc(c1)[C@H]1C[C@@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B S304M mutant (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibi...


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105309
PNG
(CHEMBL3597785)
Show SMILES Fc1cc(Br)cc(c1)[C@H]1C[C@@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type GST-tagged HIF-2alpha PAS-B (240 to 350) (unknown origin) expressed in Escherichia coli assessed as inhibition of inter...


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105316
PNG
(CHEMBL3597670)
Show SMILES Brc1cccc(c1)C1CC(c2ccccc2I)n2nnnc2N1
Show InChI InChI=1S/C16H13BrIN5/c17-11-5-3-4-10(8-11)14-9-15(12-6-1-2-7-13(12)18)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)
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n/an/an/a 766n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105309
PNG
(CHEMBL3597785)
Show SMILES Fc1cc(Br)cc(c1)[C@H]1C[C@@H](c2ccccc2)n2nnnc2N1
Show InChI InChI=1S/C16H13BrFN5/c17-12-6-11(7-13(18)8-12)14-9-15(10-4-2-1-3-5-10)23-16(19-14)20-21-22-23/h1-8,14-15H,9H2,(H,19,20,22)/t14-,15+/m1/s1
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n/an/an/a>2.00E+3n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Endothelial PAS domain-containing protein 1


(Homo sapiens (Human))
BDBM50105320
PNG
(CHEMBL3597674)
Show SMILES Clc1ccccc1C1CC(Nc2nnnn12)c1cccc(I)c1
Show InChI InChI=1S/C16H13ClIN5/c17-13-7-2-1-6-12(13)15-9-14(10-4-3-5-11(18)8-10)19-16-20-21-22-23(15)16/h1-8,14-15H,9H2,(H,19,20,22)
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n/an/an/a 837n/an/an/an/an/a



University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Binding affinity to wild type His6-Gbeta1-fused HIF-2alpha PAS-B domain (240 to 350) (unknown origin) expressed in Escherichia coli by ITC analysis


J Med Chem 58: 5930-41 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00529
BindingDB Entry DOI: 10.7270/Q2G162K1
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50105330
PNG
(CHEMBL1851943)
Show SMILES CCCCc1nc2cc(\C=C\C(=O)NO)ccc2n1CCN(CC)CC
Show InChI InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
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n/an/a>1.00E+4n/an/an/an/an/an/a



East China University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibitory activity towards Alpha-mannosidase from Jack bean


J Med Chem 60: 1817-1828 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50105338
PNG
((S)-2-[(S)-(3,4-Dichloro-phenyl)-hydroxy-methyl]-p...)
Show SMILES CC(C)(C)C(=O)NCc1ccc(NC(=O)N2CCC[C@H]2[C@@H](O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C24H29Cl2N3O3/c1-24(2,3)22(31)27-14-15-6-9-17(10-7-15)28-23(32)29-12-4-5-20(29)21(30)16-8-11-18(25)19(26)13-16/h6-11,13,20-21,30H,4-5,12,14H2,1-3H3,(H,27,31)(H,28,32)/t20-,21-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of the compound against platelet thrombin receptor


Bioorg Med Chem Lett 11: 2691-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00538-8
BindingDB Entry DOI: 10.7270/Q26Q1WJ1
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50105336
PNG
((2S,5S)-2-[(S)-(3,4-Dichloro-phenyl)-hydroxy-methy...)
Show SMILES C[C@H]1CC[C@@H]([C@@H](O)c2ccc(Cl)c(Cl)c2)N1C(=O)Nc1ccc(CNC(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C25H31Cl2N3O3/c1-15-5-12-21(22(31)17-8-11-19(26)20(27)13-17)30(15)24(33)29-18-9-6-16(7-10-18)14-28-23(32)25(2,3)4/h6-11,13,15,21-22,31H,5,12,14H2,1-4H3,(H,28,32)(H,29,33)/t15-,21-,22-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of the compound against platelet thrombin receptor


Bioorg Med Chem Lett 11: 2691-6 (2001)


Article DOI: 10.1016/s0960-894x(01)00538-8
BindingDB Entry DOI: 10.7270/Q26Q1WJ1
More data for this
Ligand-Target Pair