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8 similar compounds to monomer 50105456

Compile data set for download or QSAR
Wt: 440.5
BDBM50105425
Wt: 490.5
BDBM50105451
Wt: 484.5
BDBM50105453
Wt: 378.4
BDBM50105455
Wt: 454.5
BDBM50105458
Wt: 388.4
BDBM50105459
Wt: 392.4
BDBM50105460
Wt: 378.4
BDBM50105461

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50105425,50105451,50105453,50105455,50105458,50105459,50105460,50105461   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105425
PNG
((S)-2-(Benzyl-methyl-amino)-N-hydroxy-3-(4-phenoxy...)
Show SMILES CN(Cc1ccccc1)[C@H](CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-25(16-18-8-4-2-5-9-18)22(23(26)24-27)17-31(28,29)21-14-12-20(13-15-21)30-19-10-6-3-7-11-19/h2-15,22,27H,16-17H2,1H3,(H,24,26)/t22-/m1/s1
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PubMed
n/an/a 4.75E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-1


Bioorg Med Chem Lett 11: 2719-22 (2001)


Article DOI: 10.1016/s0960-894x(01)00556-x
BindingDB Entry DOI: 10.7270/Q2TD9WNW
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105460
PNG
(2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(=O)NC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O6S/c1-13(21)19-18(2,17(22)20-23)12-27(24,25)16-10-8-15(9-11-16)26-14-6-4-3-5-7-14/h3-11,23H,12H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 40n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105460
PNG
(2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(=O)NC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O6S/c1-13(21)19-18(2,17(22)20-23)12-27(24,25)16-10-8-15(9-11-16)26-14-6-4-3-5-7-14/h3-11,23H,12H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 40n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 0.500n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 1.40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 1.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 2.35E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105460
PNG
(2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(=O)NC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O6S/c1-13(21)19-18(2,17(22)20-23)12-27(24,25)16-10-8-15(9-11-16)26-14-6-4-3-5-7-14/h3-11,23H,12H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105460
PNG
(2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(=O)NC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O6S/c1-13(21)19-18(2,17(22)20-23)12-27(24,25)16-10-8-15(9-11-16)26-14-6-4-3-5-7-14/h3-11,23H,12H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-1


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105460
PNG
(2-Acetylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(=O)NC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H20N2O6S/c1-13(21)19-18(2,17(22)20-23)12-27(24,25)16-10-8-15(9-11-16)26-14-6-4-3-5-7-14/h3-11,23H,12H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 42n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-13


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Matrix metalloprotease-2


Bioorg Med Chem Lett 11: 2723-5 (2001)


Article DOI: 10.1016/s0960-894x(01)00557-1
BindingDB Entry DOI: 10.7270/Q29G5NCX
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50105425
PNG
((S)-2-(Benzyl-methyl-amino)-N-hydroxy-3-(4-phenoxy...)
Show SMILES CN(Cc1ccccc1)[C@H](CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-25(16-18-8-4-2-5-9-18)22(23(26)24-27)17-31(28,29)21-14-12-20(13-15-21)30-19-10-6-3-7-11-19/h2-15,22,27H,16-17H2,1H3,(H,24,26)/t22-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloproteinase-13


Bioorg Med Chem Lett 11: 2719-22 (2001)


Article DOI: 10.1016/s0960-894x(01)00556-x
BindingDB Entry DOI: 10.7270/Q2TD9WNW
More data for this
Ligand-Target Pair