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5 similar compounds to monomer 50106169

Compile data set for download or QSAR
Wt: 313.3
BDBM50106164
Wt: 353.4
BDBM50106167
Wt: 341.4
BDBM50106168
Wt: 329.4
BDBM50106178
Wt: 355.4
BDBM50106179

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50106164,50106167,50106168,50106178,50106179   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106164
PNG
(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C18H23N3O2/c1-12-20-17(23-21-12)14-8-6-13(7-9-14)16(22)19-11-15-5-4-10-18(15,2)3/h6-9,15H,4-5,10-11H2,1-3H3,(H,19,22)
UniProtKB/SwissProt

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n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106167
PNG
(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1nc(CC2CC2)no1
Show InChI InChI=1S/C21H27N3O2/c1-21(2)11-3-4-17(21)13-22-19(25)15-7-9-16(10-8-15)20-23-18(24-26-20)12-14-5-6-14/h7-10,14,17H,3-6,11-13H2,1-2H3,(H,22,25)
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106168
PNG
(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C20H27N3O2/c1-4-6-17-22-19(25-23-17)15-10-8-14(9-11-15)18(24)21-13-16-7-5-12-20(16,2)3/h8-11,16H,4-7,12-13H2,1-3H3,(H,21,24)
UniProtKB/SwissProt

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CHEMBL
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PC sid
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Article
PubMed
n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106168
PNG
(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C20H27N3O2/c1-4-6-17-22-19(25-23-17)15-10-8-14(9-11-15)18(24)21-13-16-7-5-12-20(16,2)3/h8-11,16H,4-7,12-13H2,1-3H3,(H,21,24)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
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Article
PubMed
n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106164
PNG
(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C18H23N3O2/c1-12-20-17(23-21-12)14-8-6-13(7-9-14)16(22)19-11-15-5-4-10-18(15,2)3/h6-9,15H,4-5,10-11H2,1-3H3,(H,19,22)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106178
PNG
(4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-...)
Show SMILES CCCCc1noc(n1)-c1ccc(cc1)C(=O)NCCC(C)(C)C
Show InChI InChI=1S/C19H27N3O2/c1-5-6-7-16-21-18(24-22-16)15-10-8-14(9-11-15)17(23)20-13-12-19(2,3)4/h8-11H,5-7,12-13H2,1-4H3,(H,20,23)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106179
PNG
(CHEMBL125327 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Show SMILES CCCCc1noc(n1)-c1ccc(cc1)C(=O)NC[C@H]1CCCC1(C)C
Show InChI InChI=1S/C21H29N3O2/c1-4-5-8-18-23-20(26-24-18)16-11-9-15(10-12-16)19(25)22-14-17-7-6-13-21(17,2)3/h9-12,17H,4-8,13-14H2,1-3H3,(H,22,25)/t17-/m1/s1
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106167
PNG
(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1nc(CC2CC2)no1
Show InChI InChI=1S/C21H27N3O2/c1-21(2)11-3-4-17(21)13-22-19(25)15-7-9-16(10-8-15)20-23-18(24-26-20)12-14-5-6-14/h7-10,14,17H,3-6,11-13H2,1-2H3,(H,22,25)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair