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8 similar compounds to monomer 50111391

Compile data set for download or QSAR
Wt: 236.2
BDBM50111370
Wt: 236.2
BDBM50111371
Wt: 439.5
BDBM50111374
Wt: 486.5
BDBM50111378
Wt: 334.1
BDBM50111382
Wt: 340.3
BDBM50111387
Wt: 301.2
BDBM50111390
Wt: 368.3
BDBM50111392

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50111370,50111371,50111374,50111378,50111382,50111387,50111390,50111392   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111370
PNG
(CHEMBL3604773)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-11(7-9-13)14-10-16-17-15(14)12-4-2-1-3-5-12/h1-10,18H,(H,16,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111374
PNG
(CHEMBL3604888)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H27F2N5O/c1-15(2)28-24-27-14-19(17-12-20(25)23(32)21(26)13-17)22(29-24)16-4-6-18(7-5-16)31-10-8-30(3)9-11-31/h4-7,12-15,32H,8-11H2,1-3H3,(H,27,28,29)
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n/an/an/an/a 610n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111374
PNG
(CHEMBL3604888)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H27F2N5O/c1-15(2)28-24-27-14-19(17-12-20(25)23(32)21(26)13-17)22(29-24)16-4-6-18(7-5-16)31-10-8-30(3)9-11-31/h4-7,12-15,32H,8-11H2,1-3H3,(H,27,28,29)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111378
PNG
(CHEMBL3604884)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(Nc2ccc(C)cc2)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C29H28F2N4O/c1-19-3-7-22(8-4-19)33-28-17-24(25(18-32-28)21-15-26(30)29(36)27(31)16-21)20-5-9-23(10-6-20)35-13-11-34(2)12-14-35/h3-10,15-18,36H,11-14H2,1-2H3,(H,32,33)
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111382
PNG
(CHEMBL3604796)
Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10Cl2FNO/c18-15-7-11(8-16(19)17(15)22)14-9-21-6-5-13(14)10-1-3-12(20)4-2-10/h1-9,22H
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n/an/a 4.80E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111387
PNG
(CHEMBL3604791)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H14F2N2O2/c1-22-19(25)12-4-2-11(3-5-12)14-6-7-23-10-15(14)13-8-16(20)18(24)17(21)9-13/h2-10,24H,1H3,(H,22,25)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111390
PNG
(CHEMBL3604788)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10F3NO/c18-12-3-1-10(2-4-12)13-5-6-21-9-14(13)11-7-15(19)17(22)16(20)8-11/h1-9,22H
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n/an/a 94n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111392
PNG
(CHEMBL3604786)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-5-4-17(18)14-2-1-3-16(10-14)25-6-8-27-9-7-25/h1-5,10-13,26H,6-9H2
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n/an/a 18n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111370
PNG
(CHEMBL3604773)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-11(7-9-13)14-10-16-17-15(14)12-4-2-1-3-5-12/h1-10,18H,(H,16,17)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50111371
PNG
(CHEMBL3604772)
Show SMILES Oc1ccc(cc1)-c1[nH]ncc1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-12(7-9-13)15-14(10-16-17-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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n/an/a 150n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111392
PNG
(CHEMBL3604786)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-5-4-17(18)14-2-1-3-16(10-14)25-6-8-27-9-7-25/h1-5,10-13,26H,6-9H2
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n/an/an/an/a 2.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111390
PNG
(CHEMBL3604788)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10F3NO/c18-12-3-1-10(2-4-12)13-5-6-21-9-14(13)11-7-15(19)17(22)16(20)8-11/h1-9,22H
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n/an/an/an/a 1.04E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111387
PNG
(CHEMBL3604791)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H14F2N2O2/c1-22-19(25)12-4-2-11(3-5-12)14-6-7-23-10-15(14)13-8-16(20)18(24)17(21)9-13/h2-10,24H,1H3,(H,22,25)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111382
PNG
(CHEMBL3604796)
Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10Cl2FNO/c18-15-7-11(8-16(19)17(15)22)14-9-21-6-5-13(14)10-1-3-12(20)4-2-10/h1-9,22H
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111378
PNG
(CHEMBL3604884)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(Nc2ccc(C)cc2)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C29H28F2N4O/c1-19-3-7-22(8-4-19)33-28-17-24(25(18-32-28)21-15-26(30)29(36)27(31)16-21)20-5-9-23(10-6-20)35-13-11-34(2)12-14-35/h3-10,15-18,36H,11-14H2,1-2H3,(H,32,33)
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n/an/an/an/a 690n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111371
PNG
(CHEMBL3604772)
Show SMILES Oc1ccc(cc1)-c1[nH]ncc1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-12(7-9-13)15-14(10-16-17-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair