BindingDB logo
myBDB logout

5 similar compounds to monomer 50125831

Wt: 348.4
BDBM50125804
Purchase
Wt: 356.4
BDBM50125810
Purchase
Wt: 346.3
BDBM50125813
Purchase
Wt: 413.4
BDBM50125824
Wt: 323.2
BDBM50125792

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50125804,50125810,50125813,50125824,50125792   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50125792
PNG
(CHEMBL3623853)
Show SMILES C[C@H](CN[C@H](c1ccc(F)cc1)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C16H19FNO3P/c1-12(13-5-3-2-4-6-13)11-18-16(22(19,20)21)14-7-9-15(17)10-8-14/h2-10,12,16,18H,11H2,1H3,(H2,19,20,21)/t12-,16+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a>2.00E+5n/an/an/an/an/a



Bioinformatics Institute (BII)

Curated by ChEMBL


Assay Description
Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assay


J Med Chem 58: 8285-91 (2015)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50125804
PNG
(CHEMBL1568528)
Show SMILES OC(=O)Cn1c(SCc2cccc3ccccc23)nc2ccccc12
Show InChI InChI=1S/C20H16N2O2S/c23-19(24)12-22-18-11-4-3-10-17(18)21-20(22)25-13-15-8-5-7-14-6-1-2-9-16(14)15/h1-11H,12-13H2,(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.20E+5n/an/an/an/an/a



Bioinformatics Institute (BII)

Curated by ChEMBL


Assay Description
Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assay


J Med Chem 58: 8285-91 (2015)

More data for this
Ligand-Target Pair
Protein-serine O-palmitoleoyltransferase porcupine


(Homo sapiens)
BDBM50125824
PNG
(CHEMBL3623893)
Show SMILES Cc1cc(ccn1)-c1ccc(SCC(=O)Nc2ccc(cn2)-c2cnccn2)cc1
Show InChI InChI=1S/C23H19N5OS/c1-16-12-18(8-9-25-16)17-2-5-20(6-3-17)30-15-23(29)28-22-7-4-19(13-27-22)21-14-24-10-11-26-21/h2-14H,15H2,1H3,(H,27,28,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 0.530n/an/an/an/an/an/a



Soochow University

Curated by ChEMBL


Assay Description
Inhibition of porcupine (unknown origin) expressed in mouse L Wnt3A cells co-cultured with TM3 cells harboring luciferase reporter gene assessed as r...


Bioorg Med Chem 23: 6855-68 (2015)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50125813
PNG
(CHEMBL1310463)
Show SMILES OC(=O)Cn1c(SCCOc2ccccc2F)nc2ccccc12
Show InChI InChI=1S/C17H15FN2O3S/c18-12-5-1-4-8-15(12)23-9-10-24-17-19-13-6-2-3-7-14(13)20(17)11-16(21)22/h1-8H,9-11H2,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a>2.00E+5n/an/an/an/an/a



Bioinformatics Institute (BII)

Curated by ChEMBL


Assay Description
Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assay


J Med Chem 58: 8285-91 (2015)

More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50125810
PNG
(CHEMBL3623848)
Show SMILES Cc1cccc(OCCSc2nc3ccccc3n2CC(O)=O)c1C
Show InChI InChI=1S/C19H20N2O3S/c1-13-6-5-9-17(14(13)2)24-10-11-25-19-20-15-7-3-4-8-16(15)21(19)12-18(22)23/h3-9H,10-12H2,1-2H3,(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.10E+5n/an/an/an/an/a



Bioinformatics Institute (BII)

Curated by ChEMBL


Assay Description
Displacement of PIFtide from human PDK1 PIF pocket after 1 hr by fluorescence polarization assay


J Med Chem 58: 8285-91 (2015)

More data for this
Ligand-Target Pair