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1 similar compounds to monomer 50272598

Compile data set for download or QSAR
Wt: 365.7
BDBM50128099

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50128099   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128099
PNG
(CHEMBL3628083)
Show SMILES Clc1cc(NC(=O)c2ccc[nH]2)ccc1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H12ClN3O3/c20-14-10-11(22-17(24)15-6-3-9-21-15)7-8-16(14)23-18(25)12-4-1-2-5-13(12)19(23)26/h1-10,21H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128099
PNG
(CHEMBL3628083)
Show SMILES Clc1cc(NC(=O)c2ccc[nH]2)ccc1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H12ClN3O3/c20-14-10-11(22-17(24)15-6-3-9-21-15)7-8-16(14)23-18(25)12-4-1-2-5-13(12)19(23)26/h1-10,21H,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair