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13 similar compounds to monomer 50230284

Compile data set for download or QSAR
Wt: 292.3
BDBM50138825
Wt: 350.3
BDBM50158577
Wt: 334.3
BDBM50158575
Wt: 262.2
BDBM50230286
Wt: 304.3
BDBM50230287
Wt: 294.3
BDBM50249848
Wt: 310.3
BDBM50249849
Wt: 354.4
BDBM50249851
Wt: 381.4
BDBM50249850
Wt: 368.8
BDBM50249903
Wt: 437.4
BDBM50249904
Wt: 413.4
BDBM50249905
Wt: 413.4
BDBM50249969

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50138825,50158577,50158575,50230286,50230287,50249848,50249849,50249851,50249850,50249903,50249904,50249905,50249969   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM50138825
PNG
(CHEMBL3754016)
Show SMILES O=C(Cn1c2ccccc2c2cccnc12)C1CCCCC1
Show InChI InChI=1S/C19H20N2O/c22-18(14-7-2-1-3-8-14)13-21-17-11-5-4-9-15(17)16-10-6-12-20-19(16)21/h4-6,9-12,14H,1-3,7-8,13H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of recombinant human IDO1 assessed as conversion of N-formylkynurenine to kynurenine incubated for 1 hr by fluorescence analysis


J Med Chem 59: 282-93 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01390
BindingDB Entry DOI: 10.7270/Q28917QW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50158577
PNG
(CHEMBL3781310)
Show SMILES COc1ccc(N2CC(=O)C(=C2N)c2nc3ccccc3[nH]2)c(OC)c1
Show InChI InChI=1S/C19H18N4O3/c1-25-11-7-8-14(16(9-11)26-2)23-10-15(24)17(18(23)20)19-21-12-5-3-4-6-13(12)22-19/h3-9H,10,20H2,1-2H3,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u...


Bioorg Med Chem 24: 2053-9 (2016)


Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50158575
PNG
(CHEMBL3781689)
Show SMILES CCOc1ccccc1N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C19H18N4O2/c1-2-25-16-10-6-5-9-14(16)23-11-15(24)17(18(23)20)19-21-12-7-3-4-8-13(12)22-19/h3-10H,2,11,20H2,1H3,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



NAS of Ukraine

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u...


Bioorg Med Chem 24: 2053-9 (2016)


Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50230286
PNG
(CHEMBL95509)
Show SMILES Oc1n(-c2ccccc2)c2ncccc2c2ncnc12
Show InChI InChI=1S/C15H10N4O/c20-15-13-12(17-9-18-13)11-7-4-8-16-14(11)19(15)10-5-2-1-3-6-10/h1-9,20H
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n/an/a 1.20E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Canine Tracheal Smooth Muscle PDE 4


J Med Chem 35: 4866-74 (1992)


Article DOI: 10.1021/jm00104a013
BindingDB Entry DOI: 10.7270/Q2C82CJ8
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens (Human))
BDBM50230287
PNG
(CHEMBL329961)
Show SMILES CC(C)n1cnc2c1c(=O)n(-c1ccccc1)c1ncccc21
Show InChI InChI=1S/C18H16N4O/c1-12(2)21-11-20-15-14-9-6-10-19-17(14)22(18(23)16(15)21)13-7-4-3-5-8-13/h3-12H,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Canine Tracheal Smooth Muscle PDE 4


J Med Chem 35: 4866-74 (1992)


Article DOI: 10.1021/jm00104a013
BindingDB Entry DOI: 10.7270/Q2C82CJ8
More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249848
PNG
(CHEMBL4094541)
Show SMILES Cc1cccc(\C=N\n2c(S)nnc2-c2ccccc2)c1
Show InChI InChI=1S/C16H14N4S/c1-12-6-5-7-13(10-12)11-17-20-15(18-19-16(20)21)14-8-3-2-4-9-14/h2-11H,1H3,(H,19,21)/b17-11+
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249969
PNG
(CHEMBL4062318)
Show SMILES CCN(CC)S(=O)(=O)c1cccc(NC(=O)c2c(C)onc2-c2ccccc2)c1
Show InChI InChI=1S/C21H23N3O4S/c1-4-24(5-2)29(26,27)18-13-9-12-17(14-18)22-21(25)19-15(3)28-23-20(19)16-10-7-6-8-11-16/h6-14H,4-5H2,1-3H3,(H,22,25)
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University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249850
PNG
(CHEMBL4065383)
Show SMILES CCN(CC)c1ccc(\C=N\n2c(S)nnc2-c2ccccc2)c(OC)c1
Show InChI InChI=1S/C20H23N5OS/c1-4-24(5-2)17-12-11-16(18(13-17)26-3)14-21-25-19(22-23-20(25)27)15-9-7-6-8-10-15/h6-14H,4-5H2,1-3H3,(H,23,27)/b21-14+
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249851
PNG
(CHEMBL3197779)
Show SMILES COc1cccc(\C=N\n2c(SC)nnc2-c2ccccc2)c1OC
Show InChI InChI=1S/C18H18N4O2S/c1-23-15-11-7-10-14(16(15)24-2)12-19-22-17(20-21-18(22)25-3)13-8-5-4-6-9-13/h4-12H,1-3H3/b19-12+
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249903
PNG
(CHEMBL4080486)
Show SMILES CCC(C)c1ccc(NC(=O)c2c(C)onc2-c2ccccc2Cl)cc1
Show InChI InChI=1/C21H21ClN2O2/c1-4-13(2)15-9-11-16(12-10-15)23-21(25)19-14(3)26-24-20(19)17-7-5-6-8-18(17)22/h5-13H,4H2,1-3H3,(H,23,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249904
PNG
(CHEMBL4098503)
Show SMILES Cc1onc(c1C(=O)Nc1cccc(c1)S(=O)(=O)NCc1ccco1)-c1ccccc1
Show InChI InChI=1S/C22H19N3O5S/c1-15-20(21(25-30-15)16-7-3-2-4-8-16)22(26)24-17-9-5-11-19(13-17)31(27,28)23-14-18-10-6-12-29-18/h2-13,23H,14H2,1H3,(H,24,26)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249905
PNG
(CHEMBL1571383)
Show SMILES Cc1onc(c1C(=O)Nc1ccc(cc1)-c1nnc2CCCCCn12)-c1ccccc1
Show InChI InChI=1S/C24H23N5O2/c1-16-21(22(28-31-16)17-8-4-2-5-9-17)24(30)25-19-13-11-18(12-14-19)23-27-26-20-10-6-3-7-15-29(20)23/h2,4-5,8-9,11-14H,3,6-7,10,15H2,1H3,(H,25,30)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair
Homeobox protein Nkx-2.5


(Mus musculus)
BDBM50249849
PNG
(CHEMBL4073991)
Show SMILES COc1cccc(\C=N\n2c(S)nnc2-c2ccccc2)c1
Show InChI InChI=1S/C16H14N4OS/c1-21-14-9-5-6-12(10-14)11-17-20-15(18-19-16(20)22)13-7-3-2-4-8-13/h2-11H,1H3,(H,19,22)/b17-11+
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Helsinki

Curated by ChEMBL


Assay Description
Inhibition of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase repor...


J Med Chem 60: 7781-7798 (2017)

More data for this
Ligand-Target Pair