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4 similar compounds to monomer 50143019

Wt: 426.4
BDBM50143025
Wt: 2183.7
BDBM50307398
Wt: 1784.4
BDBM50307399
Wt: 1840.5
BDBM50307402

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50143025,50307398,50307399,50307402   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heparanase


(Homo sapiens)
BDBM50307398
PNG
(CHEMBL603122 | Hexadecasodium [2-(benzyloxy)-3-({4...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C37H58O74S16/c38-112(39,40)87-7-13-18(101-117(53,54)55)23(97-35-30(109-125(77,78)79)24(19(102-118(56,57)58)14(94-35)8-88-113(41,42)43)99-37-32(111-127(83,84)85)27(107-123(71,72)73)22(105-121(65,66)67)17(96-37)11-91-116(50,51)52)29(108-124(74,75)76)34(93-13)98-25-20(103-119(59,60)61)15(9-89-114(44,45)46)95-36(31(25)110-126(80,81)82)100-28-26(106-122(68,69)70)21(104-120(62,63)64)16(10-90-115(47,48)49)92-33(28)86-6-12-4-2-1-3-5-12/h1-5,13-37H,6-11H2,(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82)(H,83,84,85)/p-16/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-/m1/s1
PDB

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n/an/an/a 370n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant heparanase


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens)
BDBM50307399
PNG
(Benzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosy...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H48O60S13/c32-92(33,34)72-7-12-16(83-96(44,45)46)20(81-31-27(91-104(68,69)70)23(88-101(59,60)61)19(86-99(53,54)55)15(79-31)10-75-95(41,42)43)25(89-102(62,63)64)29(77-12)80-21-17(84-97(47,48)49)13(8-73-93(35,36)37)78-30(26(21)90-103(65,66)67)82-24-22(87-100(56,57)58)18(85-98(50,51)52)14(9-74-94(38,39)40)76-28(24)71-6-11-4-2-1-3-5-11/h1-5,12-31H,6-10H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-13/t12-,13-,14-,15-,16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29-,30-,31-/m1/s1
PDB

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n/an/an/a 280n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant heparanase


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Heparanase


(Homo sapiens)
BDBM50307402
PNG
(4-Butylbenzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannop...)
Show SMILES CCCCc1ccc(CO[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]2O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)cc1
Show InChI InChI=1S/C35H56O60S13/c1-2-3-4-14-5-7-15(8-6-14)9-75-32-28(26(91-104(60,61)62)22(89-102(54,55)56)18(80-32)12-78-98(42,43)44)86-34-30(94-107(69,70)71)25(21(88-101(51,52)53)17(82-34)11-77-97(39,40)41)84-33-29(93-106(66,67)68)24(20(87-100(48,49)50)16(81-33)10-76-96(36,37)38)85-35-31(95-108(72,73)74)27(92-105(63,64)65)23(90-103(57,58)59)19(83-35)13-79-99(45,46)47/h5-8,16-35H,2-4,9-13H2,1H3,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)/p-13/t16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-/m1/s1
PDB

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n/an/an/a 310n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of human recombinant heparanase


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307398
PNG
(CHEMBL603122 | Hexadecasodium [2-(benzyloxy)-3-({4...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C37H58O74S16/c38-112(39,40)87-7-13-18(101-117(53,54)55)23(97-35-30(109-125(77,78)79)24(19(102-118(56,57)58)14(94-35)8-88-113(41,42)43)99-37-32(111-127(83,84)85)27(107-123(71,72)73)22(105-121(65,66)67)17(96-37)11-91-116(50,51)52)29(108-124(74,75)76)34(93-13)98-25-20(103-119(59,60)61)15(9-89-114(44,45)46)95-36(31(25)110-126(80,81)82)100-28-26(106-122(68,69)70)21(104-120(62,63)64)16(10-90-115(47,48)49)92-33(28)86-6-12-4-2-1-3-5-12/h1-5,13-37H,6-11H2,(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82)(H,83,84,85)/p-16/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-/m1/s1
PDB
MMDB

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n/an/an/a 160n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF1 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307399
PNG
(Benzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosy...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H48O60S13/c32-92(33,34)72-7-12-16(83-96(44,45)46)20(81-31-27(91-104(68,69)70)23(88-101(59,60)61)19(86-99(53,54)55)15(79-31)10-75-95(41,42)43)25(89-102(62,63)64)29(77-12)80-21-17(84-97(47,48)49)13(8-73-93(35,36)37)78-30(26(21)90-103(65,66)67)82-24-22(87-100(56,57)58)18(85-98(50,51)52)14(9-74-94(38,39)40)76-28(24)71-6-11-4-2-1-3-5-11/h1-5,12-31H,6-10H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-13/t12-,13-,14-,15-,16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29-,30-,31-/m1/s1
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n/an/an/a 240n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF1 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307402
PNG
(4-Butylbenzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannop...)
Show SMILES CCCCc1ccc(CO[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]2O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)cc1
Show InChI InChI=1S/C35H56O60S13/c1-2-3-4-14-5-7-15(8-6-14)9-75-32-28(26(91-104(60,61)62)22(89-102(54,55)56)18(80-32)12-78-98(42,43)44)86-34-30(94-107(69,70)71)25(21(88-101(51,52)53)17(82-34)11-77-97(39,40)41)84-33-29(93-106(66,67)68)24(20(87-100(48,49)50)16(81-33)10-76-96(36,37)38)85-35-31(95-108(72,73)74)27(92-105(63,64)65)23(90-103(57,58)59)19(83-35)13-79-99(45,46)47/h5-8,16-35H,2-4,9-13H2,1H3,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)/p-13/t16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-/m1/s1
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n/an/an/a 210n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF1 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143025
PNG
(3-(benzyloxy)-6-methoxy-2-methyl-5-(sulfonatooxy)t...)
Show SMILES COC1OC(C)C(OCc2ccccc2)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C14H20O11S2/c1-9-11(22-8-10-6-4-3-5-7-10)12(24-26(15,16)17)13(14(21-2)23-9)25-27(18,19)20/h3-7,9,11-14H,8H2,1-2H3,(H,15,16,17)(H,18,19,20)/p-2
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n/an/an/a 2.49E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 2


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307399
PNG
(Benzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosy...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H48O60S13/c32-92(33,34)72-7-12-16(83-96(44,45)46)20(81-31-27(91-104(68,69)70)23(88-101(59,60)61)19(86-99(53,54)55)15(79-31)10-75-95(41,42)43)25(89-102(62,63)64)29(77-12)80-21-17(84-97(47,48)49)13(8-73-93(35,36)37)78-30(26(21)90-103(65,66)67)82-24-22(87-100(56,57)58)18(85-98(50,51)52)14(9-74-94(38,39)40)76-28(24)71-6-11-4-2-1-3-5-11/h1-5,12-31H,6-10H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-13/t12-,13-,14-,15-,16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29-,30-,31-/m1/s1
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n/an/an/a 129n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF2 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307402
PNG
(4-Butylbenzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannop...)
Show SMILES CCCCc1ccc(CO[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]2O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)cc1
Show InChI InChI=1S/C35H56O60S13/c1-2-3-4-14-5-7-15(8-6-14)9-75-32-28(26(91-104(60,61)62)22(89-102(54,55)56)18(80-32)12-78-98(42,43)44)86-34-30(94-107(69,70)71)25(21(88-101(51,52)53)17(82-34)11-77-97(39,40)41)84-33-29(93-106(66,67)68)24(20(87-100(48,49)50)16(81-33)10-76-96(36,37)38)85-35-31(95-108(72,73)74)27(92-105(63,64)65)23(90-103(57,58)59)19(83-35)13-79-99(45,46)47/h5-8,16-35H,2-4,9-13H2,1H3,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)/p-13/t16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-/m1/s1
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n/an/an/a 160n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF2 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM50307398
PNG
(CHEMBL603122 | Hexadecasodium [2-(benzyloxy)-3-({4...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C37H58O74S16/c38-112(39,40)87-7-13-18(101-117(53,54)55)23(97-35-30(109-125(77,78)79)24(19(102-118(56,57)58)14(94-35)8-88-113(41,42)43)99-37-32(111-127(83,84)85)27(107-123(71,72)73)22(105-121(65,66)67)17(96-37)11-91-116(50,51)52)29(108-124(74,75)76)34(93-13)98-25-20(103-119(59,60)61)15(9-89-114(44,45)46)95-36(31(25)110-126(80,81)82)100-28-26(106-122(68,69)70)21(104-120(62,63)64)16(10-90-115(47,48)49)92-33(28)86-6-12-4-2-1-3-5-12/h1-5,13-37H,6-11H2,(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82)(H,83,84,85)/p-16/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-/m1/s1
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n/an/an/a 1.80n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to VEGF by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM50307399
PNG
(Benzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosy...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H48O60S13/c32-92(33,34)72-7-12-16(83-96(44,45)46)20(81-31-27(91-104(68,69)70)23(88-101(59,60)61)19(86-99(53,54)55)15(79-31)10-75-95(41,42)43)25(89-102(62,63)64)29(77-12)80-21-17(84-97(47,48)49)13(8-73-93(35,36)37)78-30(26(21)90-103(65,66)67)82-24-22(87-100(56,57)58)18(85-98(50,51)52)14(9-74-94(38,39)40)76-28(24)71-6-11-4-2-1-3-5-11/h1-5,12-31H,6-10H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-13/t12-,13-,14-,15-,16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29-,30-,31-/m1/s1
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n/an/an/a 21n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to VEGF by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM50307402
PNG
(4-Butylbenzyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannop...)
Show SMILES CCCCc1ccc(CO[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]2O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)cc1
Show InChI InChI=1S/C35H56O60S13/c1-2-3-4-14-5-7-15(8-6-14)9-75-32-28(26(91-104(60,61)62)22(89-102(54,55)56)18(80-32)12-78-98(42,43)44)86-34-30(94-107(69,70)71)25(21(88-101(51,52)53)17(82-34)11-77-97(39,40)41)84-33-29(93-106(66,67)68)24(20(87-100(48,49)50)16(81-33)10-76-96(36,37)38)85-35-31(95-108(72,73)74)27(92-105(63,64)65)23(90-103(57,58)59)19(83-35)13-79-99(45,46)47/h5-8,16-35H,2-4,9-13H2,1H3,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)/p-13/t16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-/m1/s1
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n/an/an/a 12n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to VEGF by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair
Acidic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143025
PNG
(3-(benzyloxy)-6-methoxy-2-methyl-5-(sulfonatooxy)t...)
Show SMILES COC1OC(C)C(OCc2ccccc2)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C14H20O11S2/c1-9-11(22-8-10-6-4-3-5-7-10)12(24-26(15,16)17)13(14(21-2)23-9)25-27(18,19)20/h3-7,9,11-14H,8H2,1-2H3,(H,15,16,17)(H,18,19,20)/p-2
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n/an/an/a 3.38E+5n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Dissociation constant for Fibroblast growth factor 1


J Med Chem 47: 1683-93 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50307398
PNG
(CHEMBL603122 | Hexadecasodium [2-(benzyloxy)-3-({4...)
Show SMILES [O-]S(=O)(=O)OC[C@H]1O[C@H](OCc2ccccc2)[C@@H](O[C@H]2O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]4O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H]5OS([O-])(=O)=O)[C@@H]4OS([O-])(=O)=O)[C@@H]3OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C37H58O74S16/c38-112(39,40)87-7-13-18(101-117(53,54)55)23(97-35-30(109-125(77,78)79)24(19(102-118(56,57)58)14(94-35)8-88-113(41,42)43)99-37-32(111-127(83,84)85)27(107-123(71,72)73)22(105-121(65,66)67)17(96-37)11-91-116(50,51)52)29(108-124(74,75)76)34(93-13)98-25-20(103-119(59,60)61)15(9-89-114(44,45)46)95-36(31(25)110-126(80,81)82)100-28-26(106-122(68,69)70)21(104-120(62,63)64)16(10-90-115(47,48)49)92-33(28)86-6-12-4-2-1-3-5-12/h1-5,13-37H,6-11H2,(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82)(H,83,84,85)/p-16/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-/m1/s1
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n/an/an/a 95n/an/an/an/an/a



Progen Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Binding affinity to FGF2 by surface plasmon-based solution affinity assay


J Med Chem 53: 1686-99 (2010)

More data for this
Ligand-Target Pair