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18 similar compounds to monomer 50144092

Compile data set for download or QSAR
Wt: 543.0
BDBM50144083
Wt: 485.9
BDBM50144093
Wt: 514.0
BDBM50144094
Wt: 595.1
BDBM50144097
Wt: 485.9
BDBM50144103
Wt: 473.9
BDBM50144104
Wt: 558.0
BDBM50144106
Wt: 557.0
BDBM50144111
Wt: 597.1
BDBM50144112
Wt: 544.0
BDBM50144116
Wt: 529.9
BDBM50144118
Wt: 611.1
BDBM50144128
Wt: 488.0
BDBM50144131
Wt: 571.0
BDBM50144132
Wt: 500.0
BDBM50144133
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50144083,50144093,50144094,50144097,50144103,50144104,50144106,50144111,50144112,50144116,50144118,50144128,50144131,50144132,50144133   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM50144083
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(N)=O)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C25H27ClN6O4S/c1-30-9-8-28-24(30)16-2-4-17(5-3-16)25(34)32-11-10-31(15-20(32)14-22(27)33)37(35,36)23-13-18-12-19(26)6-7-21(18)29-23/h2-7,12-13,20,29H,8-11,14-15H2,1H3,(H2,27,33)
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n/an/a 18n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144133
PNG
(CHEMBL65816 | [4-(5-Chloro-1H-indole-2-sulfonyl)-p...)
Show SMILES CCN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H26ClN5O3S/c1-2-28-10-9-26-23(28)17-3-5-18(6-4-17)24(31)29-11-13-30(14-12-29)34(32,33)22-16-19-15-20(25)7-8-21(19)27-22/h3-8,15-16,27H,2,9-14H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144094
PNG
(CHEMBL65613 | [4-(5-Chloro-1H-indole-2-sulfonyl)-p...)
Show SMILES Clc1ccc2[nH]c(cc2c1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C(=N)N1CCCCC1
Show InChI InChI=1S/C25H28ClN5O3S/c26-21-8-9-22-20(16-21)17-23(28-22)35(33,34)31-14-12-30(13-15-31)25(32)19-6-4-18(5-7-19)24(27)29-10-2-1-3-11-29/h4-9,16-17,27-28H,1-3,10-15H2
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n/an/a 120n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144097
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN(CC#C)C(=O)CC1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C29H31ClN6O4S/c1-4-12-33(2)27(37)18-24-19-35(41(39,40)26-17-22-16-23(30)9-10-25(22)32-26)14-15-36(24)29(38)21-7-5-20(6-8-21)28-31-11-13-34(28)3/h1,5-10,16-17,24,32H,11-15,18-19H2,2-3H3
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n/an/a 14n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144103
PNG
(CHEMBL417738 | [4-(Azetidin-1-yl-imino-methyl)-phe...)
Show SMILES Clc1ccc2[nH]c(cc2c1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(cc1)C(=N)N1CCC1
Show InChI InChI=1S/C23H24ClN5O3S/c24-19-6-7-20-18(14-19)15-21(26-20)33(31,32)29-12-10-28(11-13-29)23(30)17-4-2-16(3-5-17)22(25)27-8-1-9-27/h2-7,14-15,25-26H,1,8-13H2
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n/an/a 24n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144104
PNG
(4-[4-(5-Chloro-1H-indole-2-sulfonyl)-piperazine-1-...)
Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C22H24ClN5O3S/c1-26(2)21(24)15-3-5-16(6-4-15)22(29)27-9-11-28(12-10-27)32(30,31)20-14-17-13-18(23)7-8-19(17)25-20/h3-8,13-14,24-25H,9-12H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144111
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CNC(=O)CC1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C26H29ClN6O4S/c1-28-23(34)15-21-16-32(38(36,37)24-14-19-13-20(27)7-8-22(19)30-24)11-12-33(21)26(35)18-5-3-17(4-6-18)25-29-9-10-31(25)2/h3-8,13-14,21,30H,9-12,15-16H2,1-2H3,(H,28,34)
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n/an/a 11n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144106
PNG
(CHEMBL65146 | {4-(5-Chloro-1H-indole-2-sulfonyl)-1...)
Show SMILES COC(=O)CC1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C26H28ClN5O5S/c1-30-10-9-28-25(30)17-3-5-18(6-4-17)26(34)32-12-11-31(16-21(32)15-24(33)37-2)38(35,36)23-14-19-13-20(27)7-8-22(19)29-23/h3-8,13-14,21,29H,9-12,15-16H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144116
PNG
(CHEMBL292941 | {4-(5-Chloro-1H-indole-2-sulfonyl)-...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(O)=O)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C25H26ClN5O5S/c1-29-9-8-27-24(29)16-2-4-17(5-3-16)25(34)31-11-10-30(15-20(31)14-23(32)33)37(35,36)22-13-18-12-19(26)6-7-21(18)28-22/h2-7,12-13,20,28H,8-11,14-15H2,1H3,(H,32,33)
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n/an/a 41n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144112
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCCC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C29H33ClN6O4S/c1-33-13-10-31-28(33)20-4-6-21(7-5-20)29(38)36-15-14-35(19-24(36)18-27(37)34-11-2-3-12-34)41(39,40)26-17-22-16-23(30)8-9-25(22)32-26/h4-9,16-17,24,32H,2-3,10-15,18-19H2,1H3
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n/an/a 7n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144118
PNG
(4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methyl-4...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1C(O)=O)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C24H24ClN5O5S/c1-28-9-8-26-22(28)15-2-4-16(5-3-15)23(31)30-11-10-29(14-20(30)24(32)33)36(34,35)21-13-17-12-18(25)6-7-19(17)27-21/h2-7,12-13,20,27H,8-11,14H2,1H3,(H,32,33)
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n/an/a 12n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144128
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1CC(=O)N1CCCCC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C30H35ClN6O4S/c1-34-14-11-32-29(34)21-5-7-22(8-6-21)30(39)37-16-15-36(20-25(37)19-28(38)35-12-3-2-4-13-35)42(40,41)27-18-23-17-24(31)9-10-26(23)33-27/h5-10,17-18,25,33H,2-4,11-16,19-20H2,1H3
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n/an/a 7n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144132
PNG
(2-{4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methy...)
Show SMILES CN(C)C(=O)CC1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C27H31ClN6O4S/c1-31(2)25(35)16-22-17-33(39(37,38)24-15-20-14-21(28)8-9-23(20)30-24)12-13-34(22)27(36)19-6-4-18(5-7-19)26-29-10-11-32(26)3/h4-9,14-15,22,30H,10-13,16-17H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144131
PNG
(4-[4-(5-Chloro-1H-indole-2-sulfonyl)-piperazine-1-...)
Show SMILES CCN(C)C(=N)c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C23H26ClN5O3S/c1-3-27(2)22(25)16-4-6-17(7-5-16)23(30)28-10-12-29(13-11-28)33(31,32)21-15-18-14-19(24)8-9-20(18)26-21/h4-9,14-15,25-26H,3,10-13H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144093
PNG
(CHEMBL293425 | [4-(6-Chloro-1H-indole-2-sulfonyl)-...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C23H24ClN5O3S/c1-27-9-8-25-22(27)16-2-4-17(5-3-16)23(30)28-10-12-29(13-11-28)33(31,32)21-14-18-6-7-19(24)15-20(18)26-21/h2-7,14-15,26H,8-13H2,1H3
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n/an/a 590n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair