BindingDB logo
myBDB logout

4 similar compounds to monomer 50193853

Compile data set for download or QSAR
Wt: 473.9
BDBM50144087
Wt: 544.0
BDBM50144088
Wt: 529.9
BDBM50144118
Wt: 546.0
BDBM50193837

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50144087,50144088,50144118,50193837   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50193837
PNG
((R)-4-(5-chloro-1H-indole-2-sulfonyl)-1-[4-(N,N-di...)
Show SMILES CCOC(=O)[C@H]1CN(CC(=O)N1Cc1ccc(cc1)C(=N)N(C)C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C25H28ClN5O5S/c1-4-36-25(33)21-14-30(37(34,35)22-12-18-11-19(26)9-10-20(18)28-22)15-23(32)31(21)13-16-5-7-17(8-6-16)24(27)29(2)3/h5-12,21,27-28H,4,13-15H2,1-3H3/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
71n/an/an/an/an/an/an/an/a



Portola Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cells


Bioorg Med Chem Lett 16: 5507-12 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.039
BindingDB Entry DOI: 10.7270/Q2SF2X05
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144118
PNG
(4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methyl-4...)
Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)N1CCN(CC1C(O)=O)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C24H24ClN5O5S/c1-28-9-8-26-22(28)15-2-4-16(5-3-15)23(31)30-11-10-29(14-20(30)24(32)33)36(34,35)21-13-17-12-18(25)6-7-19(17)27-21/h2-7,12-13,20,27H,8-11,14H2,1H3,(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144087
PNG
(4-[4-(5-Chloro-1H-indole-2-sulfonyl)-2-oxo-piperaz...)
Show SMILES CN(C)C(=N)c1ccc(CN2CCN(CC2=O)S(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C22H24ClN5O3S/c1-26(2)22(24)16-5-3-15(4-6-16)13-27-9-10-28(14-21(27)29)32(30,31)20-12-17-11-18(23)7-8-19(17)25-20/h3-8,11-12,24-25H,9-10,13-14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM50144088
PNG
(4-(5-Chloro-1H-indole-2-sulfonyl)-1-[4-(1-methyl-4...)
Show SMILES COC(=O)C1CN(CCN1C(=O)c1ccc(cc1)C1=NCCN1C)S(=O)(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1/C25H26ClN5O5S/c1-29-10-9-27-23(29)16-3-5-17(6-4-16)24(32)31-12-11-30(15-21(31)25(33)36-2)37(34,35)22-14-18-13-19(26)7-8-20(18)28-22/h3-8,13-14,21,28H,9-12,15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Coagulation factor X was determined


Bioorg Med Chem Lett 14: 2073-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.049
BindingDB Entry DOI: 10.7270/Q2P84B98
More data for this
Ligand-Target Pair