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10 similar compounds to monomer 50280292

Wt: 476.5
BDBM50148089
Wt: 490.5
BDBM50148093
Wt: 490.5
BDBM50148094
Wt: 476.5
BDBM50148099
Wt: 462.5
BDBM50148103
Wt: 520.6
BDBM50148105
Wt: 462.5
BDBM50148108
Wt: 504.6
BDBM50148109
Wt: 458.5
BDBM50280291
Wt: 484.5
BDBM50281874

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50148089,50148093,50148094,50148099,50148103,50148105,50148108,50148109,50280291,50281874   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(HUMAN)
BDBM50280291
PNG
(7-[3-(4-Ethoxy-2-ethyl-5-hydroxy-phenoxy)-propoxy]...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2CCC(Oc12)C(O)=O
Show InChI InChI=1S/C26H34O7/c1-4-8-19-21(11-9-18-10-12-22(26(28)29)33-25(18)19)31-13-7-14-32-23-16-20(27)24(30-6-3)15-17(23)5-2/h9,11,15-16,22,27H,4-8,10,12-14H2,1-3H3,(H,28,29)
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3.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity using [3H]-LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay


Bioorg Med Chem Lett 2: 1675-1680 (1992)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50281874
PNG
(6-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2CCC(Oc12)C(O)=O
Show InChI InChI=1S/C28H36O7/c1-5-8-19-16-21(17-20-10-12-25(28(30)31)35-26(19)20)33-14-7-15-34-24-13-11-22(18(3)29)27(32-4)23(24)9-6-2/h11,13,16-17,25H,5-10,12,14-15H2,1-4H3,(H,30,31)
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15n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against LTB4 receptor in guinea pig membrane


Bioorg Med Chem Lett 3: 1147-1152 (1993)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148109
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-2-propy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CCC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O6/c1-3-9-24-21-27(36-25-10-6-5-7-11-25)14-15-28(24)35-20-8-19-34-26-13-12-23-16-18-31(17-4-2,30(32)33)37-29(23)22-26/h5-7,10-15,21-22H,3-4,8-9,16-20H2,1-2H3,(H,32,33)
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n/an/an/an/a 120n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148108
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-21-18-24(33-22-8-4-3-5-9-22)13-15-25(21)32-17-6-16-31-23-12-10-20-11-14-26(28(29)30)34-27(20)19-23/h3-5,8-10,12-13,15,18-19,26H,2,6-7,11,14,16-17H2,1H3,(H,29,30)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148094
PNG
(2-Ethyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-6-5-7-11-24)14-15-27(23)34-19-8-18-33-25-13-12-22-16-17-30(4-2,29(31)32)36-28(22)21-25/h5-7,10-15,20-21H,3-4,8-9,16-19H2,1-2H3,(H,31,32)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148099
PNG
(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-2-8-22-19-25(34-23-9-4-3-5-10-23)14-16-26(22)33-18-7-6-17-32-24-13-11-21-12-15-27(29(30)31)35-28(21)20-24/h3-5,9-11,13-14,16,19-20,27H,2,6-8,12,15,17-18H2,1H3,(H,30,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148099
PNG
(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-2-8-22-19-25(34-23-9-4-3-5-10-23)14-16-26(22)33-18-7-6-17-32-24-13-11-21-12-15-27(29(30)31)35-28(21)20-24/h3-5,9-11,13-14,16,19-20,27H,2,6-8,12,15,17-18H2,1H3,(H,30,31)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148099
PNG
(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-2-8-22-19-25(34-23-9-4-3-5-10-23)14-16-26(22)33-18-7-6-17-32-24-13-11-21-12-15-27(29(30)31)35-28(21)20-24/h3-5,9-11,13-14,16,19-20,27H,2,6-8,12,15,17-18H2,1H3,(H,30,31)
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n/an/an/an/a 1.60E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148093
PNG
(2-Methyl-7-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-5-4-6-11-24)14-15-27(23)34-19-8-7-18-33-25-13-12-22-16-17-30(2,29(31)32)36-28(22)21-25/h4-6,10-15,20-21H,3,7-9,16-19H2,1-2H3,(H,31,32)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148089
PNG
(2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-3-8-22-19-25(34-23-9-5-4-6-10-23)13-14-26(22)33-18-7-17-32-24-12-11-21-15-16-29(2,28(30)31)35-27(21)20-24/h4-6,9-14,19-20H,3,7-8,15-18H2,1-2H3,(H,30,31)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148093
PNG
(2-Methyl-7-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-5-4-6-11-24)14-15-27(23)34-19-8-7-18-33-25-13-12-22-16-17-30(2,29(31)32)36-28(22)21-25/h4-6,10-15,20-21H,3,7-9,16-19H2,1-2H3,(H,31,32)
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PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148093
PNG
(2-Methyl-7-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-5-4-6-11-24)14-15-27(23)34-19-8-7-18-33-25-13-12-22-16-17-30(2,29(31)32)36-28(22)21-25/h4-6,10-15,20-21H,3,7-9,16-19H2,1-2H3,(H,31,32)
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n/an/an/an/a 3.60E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148094
PNG
(2-Ethyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-6-5-7-11-24)14-15-27(23)34-19-8-18-33-25-13-12-22-16-17-30(4-2,29(31)32)36-28(22)21-25/h5-7,10-15,20-21H,3-4,8-9,16-19H2,1-2H3,(H,31,32)
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n/an/a 440n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148108
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-21-18-24(33-22-8-4-3-5-9-22)13-15-25(21)32-17-6-16-31-23-12-10-20-11-14-26(28(29)30)34-27(20)19-23/h3-5,8-10,12-13,15,18-19,26H,2,6-7,11,14,16-17H2,1H3,(H,29,30)
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n/an/an/an/a 3.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148105
PNG
(2-Ethyl-7-{3-[4-(4-methoxy-phenoxy)-2-propyl-pheno...)
Show SMILES CCCc1cc(Oc2ccc(OC)cc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O7/c1-4-7-23-20-27(37-25-12-10-24(34-3)11-13-25)14-15-28(23)36-19-6-18-35-26-9-8-22-16-17-31(5-2,30(32)33)38-29(22)21-26/h8-15,20-21H,4-7,16-19H2,1-3H3,(H,32,33)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148109
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-2-propy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CCC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O6/c1-3-9-24-21-27(36-25-10-6-5-7-11-25)14-15-28(24)35-20-8-19-34-26-13-12-23-16-18-31(17-4-2,30(32)33)37-29(23)22-26/h5-7,10-15,21-22H,3-4,8-9,16-20H2,1-2H3,(H,32,33)
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n/an/a 370n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148105
PNG
(2-Ethyl-7-{3-[4-(4-methoxy-phenoxy)-2-propyl-pheno...)
Show SMILES CCCc1cc(Oc2ccc(OC)cc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O7/c1-4-7-23-20-27(37-25-12-10-24(34-3)11-13-25)14-15-28(23)36-19-6-18-35-26-9-8-22-16-17-31(5-2,30(32)33)38-29(22)21-26/h8-15,20-21H,4-7,16-19H2,1-3H3,(H,32,33)
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n/an/an/an/a 890n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148094
PNG
(2-Ethyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-6-5-7-11-24)14-15-27(23)34-19-8-18-33-25-13-12-22-16-17-30(4-2,29(31)32)36-28(22)21-25/h5-7,10-15,20-21H,3-4,8-9,16-19H2,1-2H3,(H,31,32)
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n/an/an/an/a 30n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148089
PNG
(2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-3-8-22-19-25(34-23-9-5-4-6-10-23)13-14-26(22)33-18-7-17-32-24-12-11-21-15-16-29(2,28(30)31)35-27(21)20-24/h4-6,9-14,19-20H,3,7-8,15-18H2,1-2H3,(H,30,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148108
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-21-18-24(33-22-8-4-3-5-9-22)13-15-25(21)32-17-6-16-31-23-12-10-20-11-14-26(28(29)30)34-27(20)19-23/h3-5,8-10,12-13,15,18-19,26H,2,6-7,11,14,16-17H2,1H3,(H,29,30)
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n/an/an/an/a 7.30E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148109
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-2-propy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CCC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O6/c1-3-9-24-21-27(36-25-10-6-5-7-11-25)14-15-28(24)35-20-8-19-34-26-13-12-23-16-18-31(17-4-2,30(32)33)37-29(23)22-26/h5-7,10-15,21-22H,3-4,8-9,16-20H2,1-2H3,(H,32,33)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148105
PNG
(2-Ethyl-7-{3-[4-(4-methoxy-phenoxy)-2-propyl-pheno...)
Show SMILES CCCc1cc(Oc2ccc(OC)cc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O7/c1-4-7-23-20-27(37-25-12-10-24(34-3)11-13-25)14-15-28(23)36-19-6-18-35-26-9-8-22-16-17-31(5-2,30(32)33)38-29(22)21-26/h8-15,20-21H,4-7,16-19H2,1-3H3,(H,32,33)
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n/an/a 630n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148103
PNG
(6-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2OC(CCc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-20-19-24(33-22-8-4-3-5-9-22)12-14-25(20)32-17-6-16-31-23-11-15-26-21(18-23)10-13-27(34-26)28(29)30/h3-5,8-9,11-12,14-15,18-19,27H,2,6-7,10,13,16-17H2,1H3,(H,29,30)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148089
PNG
(2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-3-8-22-19-25(34-23-9-5-4-6-10-23)13-14-26(22)33-18-7-17-32-24-12-11-21-15-16-29(2,28(30)31)35-27(21)20-24/h4-6,9-14,19-20H,3,7-8,15-18H2,1-2H3,(H,30,31)
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n/an/an/an/a 100n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148089
PNG
(2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-3-8-22-19-25(34-23-9-5-4-6-10-23)13-14-26(22)33-18-7-17-32-24-12-11-21-15-16-29(2,28(30)31)35-27(21)20-24/h4-6,9-14,19-20H,3,7-8,15-18H2,1-2H3,(H,30,31)
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n/an/a 750n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148099
PNG
(7-[4-(4-Phenoxy-2-propyl-phenoxy)-butoxy]-chroman-...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C29H32O6/c1-2-8-22-19-25(34-23-9-4-3-5-10-23)14-16-26(22)33-18-7-6-17-32-24-13-11-21-12-15-27(29(30)31)35-28(21)20-24/h3-5,9-11,13-14,16,19-20,27H,2,6-8,12,15,17-18H2,1H3,(H,30,31)
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n/an/an/an/a 6.30E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148109
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-2-propy...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CCC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O6/c1-3-9-24-21-27(36-25-10-6-5-7-11-25)14-15-28(24)35-20-8-19-34-26-13-12-23-16-18-31(17-4-2,30(32)33)37-29(23)22-26/h5-7,10-15,21-22H,3-4,8-9,16-20H2,1-2H3,(H,32,33)
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n/an/an/an/a 830n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148108
PNG
(7-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(Oc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-21-18-24(33-22-8-4-3-5-9-22)13-15-25(21)32-17-6-16-31-23-12-10-20-11-14-26(28(29)30)34-27(20)19-23/h3-5,8-10,12-13,15,18-19,26H,2,6-7,11,14,16-17H2,1H3,(H,29,30)
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n/an/a 980n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor gamma using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148105
PNG
(2-Ethyl-7-{3-[4-(4-methoxy-phenoxy)-2-propyl-pheno...)
Show SMILES CCCc1cc(Oc2ccc(OC)cc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C31H36O7/c1-4-7-23-20-27(37-25-12-10-24(34-3)11-13-25)14-15-28(23)36-19-6-18-35-26-9-8-22-16-17-31(5-2,30(32)33)38-29(22)21-26/h8-15,20-21H,4-7,16-19H2,1-3H3,(H,32,33)
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n/an/an/an/a 4.60E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human Peroxisome proliferator activated receptor alpha using chimeric Gal4-hPPAR transactivation ass...


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (human))
BDBM50148103
PNG
(6-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2OC(CCc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-20-19-24(33-22-8-4-3-5-9-22)12-14-25(20)32-17-6-16-31-23-11-15-26-21(18-23)10-13-27(34-26)28(29)30/h3-5,8-9,11-12,14-15,18-19,27H,2,6-7,10,13,16-17H2,1H3,(H,29,30)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro potency of PPAR gene activation against human PPAR gamma receptor using chimeric Gal4-hPPAR transactivation assay (TA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50280291
PNG
(7-[3-(4-Ethoxy-2-ethyl-5-hydroxy-phenoxy)-propoxy]...)
Show SMILES CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2CCC(Oc12)C(O)=O
Show InChI InChI=1S/C26H34O7/c1-4-8-19-21(11-9-18-10-12-22(26(28)29)33-25(18)19)31-13-7-14-32-23-16-20(27)24(30-6-3)15-17(23)5-2/h9,11,15-16,22,27H,4-8,10,12-14H2,1-3H3,(H,28,29)
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n/an/a 4.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity using [3H]-LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay


Bioorg Med Chem Lett 2: 1675-1680 (1992)

More data for this
Ligand-Target Pair
LTB4R


(HUMAN)
BDBM50281874
PNG
(6-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Show SMILES CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2CCC(Oc12)C(O)=O
Show InChI InChI=1S/C28H36O7/c1-5-8-19-16-21(17-20-10-12-25(28(30)31)35-26(19)20)33-14-7-15-34-24-13-11-22(18(3)29)27(32-4)23(24)9-6-2/h11,13,16-17,25H,5-10,12,14-15H2,1-4H3,(H,30,31)
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n/an/a 41.3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against LTB4 receptor in human neutrophil


Bioorg Med Chem Lett 3: 1147-1152 (1993)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148103
PNG
(6-[3-(4-Phenoxy-2-propyl-phenoxy)-propoxy]-chroman...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2OC(CCc2c1)C(O)=O
Show InChI InChI=1S/C28H30O6/c1-2-7-20-19-24(33-22-8-4-3-5-9-22)12-14-25(20)32-17-6-16-31-23-11-15-26-21(18-23)10-13-27(34-26)28(29)30/h3-5,8-9,11-12,14-15,18-19,27H,2,6-7,10,13,16-17H2,1H3,(H,29,30)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148093
PNG
(2-Methyl-7-[4-(4-phenoxy-2-propyl-phenoxy)-butoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-5-4-6-11-24)14-15-27(23)34-19-8-7-18-33-25-13-12-22-16-17-30(2,29(31)32)36-28(22)21-25/h4-6,10-15,20-21H,3,7-9,16-19H2,1-2H3,(H,31,32)
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n/an/a>1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50148094
PNG
(2-Ethyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]...)
Show SMILES CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(CC)(Oc2c1)C(O)=O
Show InChI InChI=1S/C30H34O6/c1-3-9-23-20-26(35-24-10-6-5-7-11-24)14-15-27(23)34-19-8-18-33-25-13-12-22-16-17-30(4-2,29(31)32)36-28(22)21-25/h5-7,10-15,20-21H,3-4,8-9,16-19H2,1-2H3,(H,31,32)
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n/an/a 360n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro binding affinity for human peroxisome proliferator activated receptor alpha using scintillation proximity assay (SPA)


J Med Chem 47: 3255-63 (2004)

More data for this
Ligand-Target Pair