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55 similar compounds to monomer 50148603

Compile data set for download or QSAR
Wt: 256.2
BDBM50226339
Wt: 256.2
BDBM50226347
Wt: 415.4
BDBM50148604
Wt: 310.3
BDBM50148609
Wt: 254.2
BDBM50148620
Wt: 284.2
BDBM50148621
Wt: 205.1
BDBM50148624
Wt: 221.2
BDBM50148627
Wt: 531.6
BDBM50148630
Wt: 417.4
BDBM50148600
Wt: 280.2
BDBM50148613
Wt: 294.3
BDBM50148614
Wt: 299.1
BDBM50148607
Wt: 234.2
BDBM50148608
Wt: 234.2
BDBM50148619
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50226339,50226347,50148604,50148609,50148620,50148621,50148624,50148627,50148630,50148600,50148613,50148614,50148607,50148608,50148619   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transmembrane domain-containing protein TMIGD3


(Homo sapiens (Human))
BDBM50148600
PNG
(CHEMBL3770003)
Show SMILES CCOC(=O)C1=C(C)NC(=C(C1\C=C\c1ccccc1)C(=O)OCC)c1ccccc1
Show InChI InChI=1/C26H27NO4/c1-4-30-25(28)22-18(3)27-24(20-14-10-7-11-15-20)23(26(29)31-5-2)21(22)17-16-19-12-8-6-9-13-19/h6-17,21,27H,4-5H2,1-3H3/b17-16+
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108n/an/an/an/an/an/an/an/a



Georgia Institute of Technology

Curated by ChEMBL


Assay Description
Displacement of [125I]AB-MECA from human brain adenosine A3 receptor expressed in HEK293 cells


J Med Chem 59: 788-809 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00828
BindingDB Entry DOI: 10.7270/Q25M67MM
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50148604
PNG
(CHEMBL3770576)
Show SMILES COC(=O)CC1N=C(c2cc(OC)ccc2-n2c(C)nnc12)c1cccc2[nH]ccc12
Show InChI InChI=1/C23H21N5O3/c1-13-26-27-23-19(12-21(29)31-3)25-22(16-5-4-6-18-15(16)9-10-24-18)17-11-14(30-2)7-8-20(17)28(13)23/h4-11,19,24H,12H2,1-3H3
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n/an/an/a 520n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged BRD4 bromodomain 1 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...


J Med Chem 59: 1492-500 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01135
BindingDB Entry DOI: 10.7270/Q21V5GVF
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50148604
PNG
(CHEMBL3770576)
Show SMILES COC(=O)CC1N=C(c2cc(OC)ccc2-n2c(C)nnc12)c1cccc2[nH]ccc12
Show InChI InChI=1/C23H21N5O3/c1-13-26-27-23-19(12-21(29)31-3)25-22(16-5-4-6-18-15(16)9-10-24-18)17-11-14(30-2)7-8-20(17)28(13)23/h4-11,19,24H,12H2,1-3H3
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n/an/an/a 45n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged BRD2 bromodomain 2 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...


J Med Chem 59: 1492-500 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01135
BindingDB Entry DOI: 10.7270/Q21V5GVF
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50148604
PNG
(CHEMBL3770576)
Show SMILES COC(=O)CC1N=C(c2cc(OC)ccc2-n2c(C)nnc12)c1cccc2[nH]ccc12
Show InChI InChI=1/C23H21N5O3/c1-13-26-27-23-19(12-21(29)31-3)25-22(16-5-4-6-18-15(16)9-10-24-18)17-11-14(30-2)7-8-20(17)28(13)23/h4-11,19,24H,12H2,1-3H3
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n/an/an/a 780n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged BRD2 bromodomain 1 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...


J Med Chem 59: 1492-500 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01135
BindingDB Entry DOI: 10.7270/Q21V5GVF
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148607
PNG
(CHEMBL3769683)
Show SMILES ONC(=O)c1csc(n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-7-3-1-6(2-4-7)10-12-8(5-16-10)9(14)13-15/h1-5,15H,(H,13,14)
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n/an/a 1.75E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148608
PNG
(CHEMBL3770119)
Show SMILES ONC(=O)c1csc(Cc2ccccc2)n1
Show InChI InChI=1S/C11H10N2O2S/c14-11(13-15)9-7-16-10(12-9)6-8-4-2-1-3-5-8/h1-5,7,15H,6H2,(H,13,14)
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n/an/a 8.36E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148609
PNG
(CHEMBL3770484)
Show SMILES ONC(=O)c1csc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2S/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 4.77E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148613
PNG
(CHEMBL3771326)
Show SMILES ONC(=O)c1coc(n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-15(18-20)14-10-21-16(17-14)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,20H,(H,18,19)
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n/an/a 2.95E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148614
PNG
(CHEMBL3770136)
Show SMILES ONC(=O)c1coc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 9.39E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148619
PNG
(CHEMBL3769415)
Show SMILES COc1ccc(cc1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C11H10N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-6,15H,1H3,(H,13,14)
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n/an/a 3.29E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148620
PNG
(CHEMBL3769820)
Show SMILES ONC(=O)c1coc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C14H10N2O3/c17-13(16-18)12-8-19-14(15-12)11-6-5-9-3-1-2-4-10(9)7-11/h1-8,18H,(H,16,17)
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n/an/a 1.22E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148621
PNG
(CHEMBL3770029)
Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)
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n/an/a 2.25E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148624
PNG
(CHEMBL3770180)
Show SMILES ONC(=O)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C9H7N3O3/c13-8(11-14)7-10-9(15-12-7)6-4-2-1-3-5-6/h1-5,14H,(H,11,13)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148627
PNG
(CHEMBL3771312)
Show SMILES ONC(=O)c1csc(n1)-c1cccnc1
Show InChI InChI=1S/C9H7N3O2S/c13-8(12-14)7-5-15-9(11-7)6-2-1-3-10-4-6/h1-5,14H,(H,12,13)
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n/an/a 300n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148607
PNG
(CHEMBL3769683)
Show SMILES ONC(=O)c1csc(n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-7-3-1-6(2-4-7)10-12-8(5-16-10)9(14)13-15/h1-5,15H,(H,13,14)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148608
PNG
(CHEMBL3770119)
Show SMILES ONC(=O)c1csc(Cc2ccccc2)n1
Show InChI InChI=1S/C11H10N2O2S/c14-11(13-15)9-7-16-10(12-9)6-8-4-2-1-3-5-8/h1-5,7,15H,6H2,(H,13,14)
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n/an/a 2.54E+3n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148609
PNG
(CHEMBL3770484)
Show SMILES ONC(=O)c1csc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2S/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 3.69E+3n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148613
PNG
(CHEMBL3771326)
Show SMILES ONC(=O)c1coc(n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-15(18-20)14-10-21-16(17-14)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,20H,(H,18,19)
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n/an/a 89n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148614
PNG
(CHEMBL3770136)
Show SMILES ONC(=O)c1coc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 9.37E+3n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148619
PNG
(CHEMBL3769415)
Show SMILES COc1ccc(cc1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C11H10N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-6,15H,1H3,(H,13,14)
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n/an/a 195n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148620
PNG
(CHEMBL3769820)
Show SMILES ONC(=O)c1coc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C14H10N2O3/c17-13(16-18)12-8-19-14(15-12)11-6-5-9-3-1-2-4-10(9)7-11/h1-8,18H,(H,16,17)
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n/an/a 89n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148621
PNG
(CHEMBL3770029)
Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)
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n/an/a 182n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148624
PNG
(CHEMBL3770180)
Show SMILES ONC(=O)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C9H7N3O3/c13-8(11-14)7-10-9(15-12-7)6-4-2-1-3-5-6/h1-5,14H,(H,11,13)
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n/an/a 112n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148607
PNG
(CHEMBL3769683)
Show SMILES ONC(=O)c1csc(n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-7-3-1-6(2-4-7)10-12-8(5-16-10)9(14)13-15/h1-5,15H,(H,13,14)
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n/an/a 3.64E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148608
PNG
(CHEMBL3770119)
Show SMILES ONC(=O)c1csc(Cc2ccccc2)n1
Show InChI InChI=1S/C11H10N2O2S/c14-11(13-15)9-7-16-10(12-9)6-8-4-2-1-3-5-8/h1-5,7,15H,6H2,(H,13,14)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148609
PNG
(CHEMBL3770484)
Show SMILES ONC(=O)c1csc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O2S/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 1.29E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148613
PNG
(CHEMBL3771326)
Show SMILES ONC(=O)c1coc(n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C16H12N2O3/c19-15(18-20)14-10-21-16(17-14)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-10,20H,(H,18,19)
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n/an/a 2.73E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148614
PNG
(CHEMBL3770136)
Show SMILES ONC(=O)c1coc(n1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O3/c20-16(19-21)14-11-22-17(18-14)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,15,21H,(H,19,20)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148619
PNG
(CHEMBL3769415)
Show SMILES COc1ccc(cc1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C11H10N2O4/c1-16-8-4-2-7(3-5-8)11-12-9(6-17-11)10(14)13-15/h2-6,15H,1H3,(H,13,14)
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n/an/a 5.09E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148620
PNG
(CHEMBL3769820)
Show SMILES ONC(=O)c1coc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C14H10N2O3/c17-13(16-18)12-8-19-14(15-12)11-6-5-9-3-1-2-4-10(9)7-11/h1-8,18H,(H,16,17)
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n/an/a 2.62E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148621
PNG
(CHEMBL3770029)
Show SMILES COc1ccc2cc(ccc2c1)-c1nc(co1)C(=O)NO
Show InChI InChI=1S/C15H12N2O4/c1-20-12-5-4-9-6-11(3-2-10(9)7-12)15-16-13(8-21-15)14(18)17-19/h2-8,19H,1H3,(H,17,18)
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n/an/a 2.91E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148624
PNG
(CHEMBL3770180)
Show SMILES ONC(=O)c1noc(n1)-c1ccccc1
Show InChI InChI=1S/C9H7N3O3/c13-8(11-14)7-10-9(15-12-7)6-4-2-1-3-5-6/h1-5,14H,(H,11,13)
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n/an/a 3.85E+4n/an/an/an/an/an/a



Albert-Ludwigs-University Freiburg

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 using Z-L-Lys(eta-trifluoroacetyl)-AMC as substrate after 90 mins by fluorescence analysis


J Med Chem 59: 1545-55 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01493
BindingDB Entry DOI: 10.7270/Q2X350BD
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50148630
PNG
(CHEMBL3771206)
Show SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccc(CNC(=O)C[C@H](OC1=O)\C=C\CCSC(C)=O)cc2
Show InChI InChI=1/C26H33N3O5S2/c1-16(2)22-24(32)34-20(7-5-6-12-35-17(3)30)13-21(31)27-14-18-8-10-19(11-9-18)23-29-26(4,15-36-23)25(33)28-22/h5,7-11,16,20,22H,6,12-15H2,1-4H3,(H,27,31)(H,28,33)/b7-5+/t20-,22+,26+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human KDAC8


J Med Chem 59: 1613-33 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01632
BindingDB Entry DOI: 10.7270/Q2SB47MP
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50148630
PNG
(CHEMBL3771206)
Show SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccc(CNC(=O)C[C@H](OC1=O)\C=C\CCSC(C)=O)cc2
Show InChI InChI=1/C26H33N3O5S2/c1-16(2)22-24(32)34-20(7-5-6-12-35-17(3)30)13-21(31)27-14-18-8-10-19(11-9-18)23-29-26(4,15-36-23)25(33)28-22/h5,7-11,16,20,22H,6,12-15H2,1-4H3,(H,27,31)(H,28,33)/b7-5+/t20-,22+,26+/s2
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n/an/a 1.61E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human KDAC6


J Med Chem 59: 1613-33 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01632
BindingDB Entry DOI: 10.7270/Q2SB47MP
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50148630
PNG
(CHEMBL3771206)
Show SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccc(CNC(=O)C[C@H](OC1=O)\C=C\CCSC(C)=O)cc2
Show InChI InChI=1/C26H33N3O5S2/c1-16(2)22-24(32)34-20(7-5-6-12-35-17(3)30)13-21(31)27-14-18-8-10-19(11-9-18)23-29-26(4,15-36-23)25(33)28-22/h5,7-11,16,20,22H,6,12-15H2,1-4H3,(H,27,31)(H,28,33)/b7-5+/t20-,22+,26+/s2
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n/an/a 470n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human KDAC3


J Med Chem 59: 1613-33 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01632
BindingDB Entry DOI: 10.7270/Q2SB47MP
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50148630
PNG
(CHEMBL3771206)
Show SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccc(CNC(=O)C[C@H](OC1=O)\C=C\CCSC(C)=O)cc2
Show InChI InChI=1/C26H33N3O5S2/c1-16(2)22-24(32)34-20(7-5-6-12-35-17(3)30)13-21(31)27-14-18-8-10-19(11-9-18)23-29-26(4,15-36-23)25(33)28-22/h5,7-11,16,20,22H,6,12-15H2,1-4H3,(H,27,31)(H,28,33)/b7-5+/t20-,22+,26+/s2
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n/an/a 3.48E+3n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human KDAC1


J Med Chem 59: 1613-33 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01632
BindingDB Entry DOI: 10.7270/Q2SB47MP
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50226339
PNG
(CHEMBL33378)
Show SMILES OC(=O)Cc1ccc2Oc3ccccc3OCc2c1
Show InChI InChI=1S/C15H12O4/c16-15(17)8-10-5-6-12-11(7-10)9-18-13-3-1-2-4-14(13)19-12/h1-7H,8-9H2,(H,16,17)
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase of ram seminal vesicle microsomes


J Med Chem 29: 1436-41 (1986)


Article DOI: 10.1021/jm00158a020
BindingDB Entry DOI: 10.7270/Q2X06974
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50226347
PNG
(CHEMBL33527)
Show SMILES OC(=O)Cc1ccc2COc3ccccc3Oc2c1
Show InChI InChI=1S/C15H12O4/c16-15(17)8-10-5-6-11-9-18-12-3-1-2-4-13(12)19-14(11)7-10/h1-7H,8-9H2,(H,16,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase of ram seminal vesicle microsomes


J Med Chem 29: 1436-41 (1986)


Article DOI: 10.1021/jm00158a020
BindingDB Entry DOI: 10.7270/Q2X06974
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Schistosoma mansoni)
BDBM50148630
PNG
(CHEMBL3771206)
Show SMILES CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2ccc(CNC(=O)C[C@H](OC1=O)\C=C\CCSC(C)=O)cc2
Show InChI InChI=1/C26H33N3O5S2/c1-16(2)22-24(32)34-20(7-5-6-12-35-17(3)30)13-21(31)27-14-18-8-10-19(11-9-18)23-29-26(4,15-36-23)25(33)28-22/h5,7-11,16,20,22H,6,12-15H2,1-4H3,(H,27,31)(H,28,33)/b7-5+/t20-,22+,26+/s2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assay


Bioorg Med Chem 25: 2105-2132 (2017)


Article DOI: 10.1016/j.bmc.2017.02.020
BindingDB Entry DOI: 10.7270/Q2PG1V0C
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50148604
PNG
(CHEMBL3770576)
Show SMILES COC(=O)CC1N=C(c2cc(OC)ccc2-n2c(C)nnc12)c1cccc2[nH]ccc12
Show InChI InChI=1/C23H21N5O3/c1-13-26-27-23-19(12-21(29)31-3)25-22(16-5-4-6-18-15(16)9-10-24-18)17-11-14(30-2)7-8-20(17)28(13)23/h4-11,19,24H,12H2,1-3H3
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n/an/an/a 50n/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged BRD4 bromodomain 2 (unknown origin) expressed in competent Escherichia coli BL21(DE3) cells by isothermal ...


J Med Chem 59: 1492-500 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01135
BindingDB Entry DOI: 10.7270/Q21V5GVF
More data for this
Ligand-Target Pair