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3 similar compounds to monomer 50148914

Compile data set for download or QSAR
Wt: 429.5
BDBM50148909
Wt: 451.5
BDBM50148912
Wt: 306.3
BDBM50148915

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50148909,50148912,50148915   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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6.5n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat MOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (Human))
BDBM50148915
PNG
(CHEMBL3770514)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C15H18N2O5/c18-7-10-11(19)12(20)13(21)14(22-10)15-16-6-9(17-15)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2,(H,16,17)/t10-,11-,12+,13-,14-/m1/s1
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156n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorg...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50148915
PNG
(CHEMBL3770514)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C15H18N2O5/c18-7-10-11(19)12(20)13(21)14(22-10)15-16-6-9(17-15)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2,(H,16,17)/t10-,11-,12+,13-,14-/m1/s1
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226n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phospha...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50148915
PNG
(CHEMBL3770514)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C15H18N2O5/c18-7-10-11(19)12(20)13(21)14(22-10)15-16-6-9(17-15)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2,(H,16,17)/t10-,11-,12+,13-,14-/m1/s1
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280n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b using alpha-D-glucose-1-phosphate as substrate by Dixon plot analysis


ACS Med Chem Lett 6: 1215-9 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00361
BindingDB Entry DOI: 10.7270/Q2W37Z56
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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390n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat DOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50148912
PNG
(CHEMBL3770284)
Show SMILES N[C@@H](Cc1ccc2cccc(O)c2c1)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C29H29N3O2/c30-25(18-21-9-11-22-7-4-8-28(33)23(22)16-21)29(34)32-27-13-14-31-26-12-10-20(17-24(26)27)15-19-5-2-1-3-6-19/h1-12,16-17,25,27,31,33H,13-15,18,30H2,(H,32,34)/t25-,27+/m0/s1
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440n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat MOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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730n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50148912
PNG
(CHEMBL3770284)
Show SMILES N[C@@H](Cc1ccc2cccc(O)c2c1)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C29H29N3O2/c30-25(18-21-9-11-22-7-4-8-28(33)23(22)16-21)29(34)32-27-13-14-31-26-12-10-20(17-24(26)27)15-19-5-2-1-3-6-19/h1-12,16-17,25,27,31,33H,13-15,18,30H2,(H,32,34)/t25-,27+/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from rat DOR expressed in rat C6 cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50148912
PNG
(CHEMBL3770284)
Show SMILES N[C@@H](Cc1ccc2cccc(O)c2c1)C(=O)N[C@@H]1CCNc2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C29H29N3O2/c30-25(18-21-9-11-22-7-4-8-28(33)23(22)16-21)29(34)32-27-13-14-31-26-12-10-20(17-24(26)27)15-19-5-2-1-3-6-19/h1-12,16-17,25,27,31,33H,13-15,18,30H2,(H,32,34)/t25-,27+/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting method


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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n/an/an/an/a 39n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat MOR expressed in rat C6 cells after 1 hr by [35S]GTPgammaS binding assay


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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n/an/an/an/a 5.90E+3n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at rat DOR expressed in rat C6 cells after 1 hr by [35S]GTPgammaS binding assay


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50148909
PNG
(CHEMBL3770677)
Show SMILES Cc1cc(C[C@H](N)C(=O)N[C@@H]2CCNc3ccc(Cc4ccccc4)cc23)c(C)cc1O
Show InChI InChI=1S/C27H31N3O2/c1-17-13-26(31)18(2)12-21(17)16-23(28)27(32)30-25-10-11-29-24-9-8-20(15-22(24)25)14-19-6-4-3-5-7-19/h3-9,12-13,15,23,25,29,31H,10-11,14,16,28H2,1-2H3,(H,30,32)/t23-,25+/m0/s1
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n/an/an/an/a 370n/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Agonist activity at human KOR expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay


ACS Med Chem Lett 6: 1199-203 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00344
BindingDB Entry DOI: 10.7270/Q20V8FN5
More data for this
Ligand-Target Pair