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35 similar compounds to monomer 50150070

Compile data set for download or QSAR
Wt: 424.9
BDBM50150057
Wt: 458.4
BDBM50150063
Wt: 459.3
BDBM50150072
Wt: 474.4
BDBM50150073
Wt: 487.4
BDBM50150706
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Wt: 459.3
BDBM50150709
Purchase
Wt: 438.9
BDBM50150710
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Wt: 473.3
BDBM50150712
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Wt: 418.5
BDBM50150717
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Wt: 447.3
BDBM50172413
Wt: 461.3
BDBM50172432
Wt: 502.5
BDBM50172438
Wt: 445.3
BDBM50172440
Wt: 474.4
BDBM50177273
Wt: 426.9
BDBM50177278
Displayed 1 to 15 (of 35 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50150057,50150063,50150072,50150073,50150706,50150709,50150710,50150712,50150717,50172413,50172432,50172438,50172440,50177273,50177278   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150706
PNG
(2-(2,4-Dichloro-phenoxy)-N-[2-(4-ethyl-piperazin-1...)
Show SMILES CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)C(C)Oc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C25H28Cl2N4O2/c1-4-30-9-11-31(12-10-30)24-13-16(2)20-15-19(6-7-22(20)29-24)28-25(32)17(3)33-23-8-5-18(26)14-21(23)27/h5-8,13-15,17H,4,9-12H2,1-3H3,(H,28,32)
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n/an/a 230n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells


J Med Chem 47: 3962-71 (2004)


Article DOI: 10.1021/jm040762v
BindingDB Entry DOI: 10.7270/Q2668CP3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 50n/an/an/an/an/an/a



Dr. Reddy's Laboratories Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by SPA binding assay


Bioorg Med Chem Lett 22: 3157-62 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.050
BindingDB Entry DOI: 10.7270/Q2D79CFJ
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a 10n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells


J Med Chem 47: 3962-71 (2004)


Article DOI: 10.1021/jm040762v
BindingDB Entry DOI: 10.7270/Q2668CP3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150710
PNG
(2-(4-Chloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)...)
Show SMILES CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-28-10-12-29(13-11-28)23-14-17(2)21-15-19(6-9-22(21)27-23)26-24(30)16-31-20-7-4-18(25)5-8-20/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,26,30)
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n/an/a 30n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells


J Med Chem 47: 3962-71 (2004)


Article DOI: 10.1021/jm040762v
BindingDB Entry DOI: 10.7270/Q2668CP3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150712
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C24H26Cl2N4O2/c1-15-12-23(30-10-8-29(3)9-11-30)28-21-6-5-18(14-19(15)21)27-24(31)16(2)32-22-7-4-17(25)13-20(22)26/h4-7,12-14,16H,8-11H2,1-3H3,(H,27,31)
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n/an/a 790n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells


J Med Chem 47: 3962-71 (2004)


Article DOI: 10.1021/jm040762v
BindingDB Entry DOI: 10.7270/Q2668CP3
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150717
PNG
(CHEMBL187430 | N-[2-(4-Ethyl-piperazin-1-yl)-4-met...)
Show SMILES CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3cccc(C)c3)ccc2n1
Show InChI InChI=1S/C25H30N4O2/c1-4-28-10-12-29(13-11-28)24-15-19(3)22-16-20(8-9-23(22)27-24)26-25(30)17-31-21-7-5-6-18(2)14-21/h5-9,14-16H,4,10-13,17H2,1-3H3,(H,26,30)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Argenta Discovery Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells


J Med Chem 47: 3962-71 (2004)


Article DOI: 10.1021/jm040762v
BindingDB Entry DOI: 10.7270/Q2668CP3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50150057
PNG
(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
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n/an/a 2.18E+3n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human 5-HT2A receptor


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150057
PNG
(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
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n/an/a 71n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1R


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50150063
PNG
(CHEMBL364863 | N-[4-Methyl-2-(4-methyl-piperazin-1...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H25F3N4O2/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-5-18(14-20(16)21)28-23(32)15-33-19-6-3-17(4-7-19)24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 442n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human 5-HT2B receptor


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50150057
PNG
(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
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n/an/a 349n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human 5-HT2B receptor


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150063
PNG
(CHEMBL364863 | N-[4-Methyl-2-(4-methyl-piperazin-1...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H25F3N4O2/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-5-18(14-20(16)21)28-23(32)15-33-19-6-3-17(4-7-19)24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 63n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1R


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50150057
PNG
(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
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n/an/a 970n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human 5-HT2C receptor


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50150072
PNG
(2-(2,3-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3cccc(Cl)c3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-12-21(29-10-8-28(2)9-11-29)27-19-7-6-16(13-17(15)19)26-22(30)14-31-20-5-3-4-18(24)23(20)25/h3-7,12-13H,8-11,14H2,1-2H3,(H,26,30)
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n/an/a 201n/an/an/an/an/an/a



Argenta Discovery Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against human 5-HT2B receptor


Bioorg Med Chem Lett 14: 4099-102 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.051
BindingDB Entry DOI: 10.7270/Q2WW7H49
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 6.80n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150057
PNG
(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-13-22(28-11-9-27(2)10-12-28)26-21-8-5-18(14-20(16)21)25-23(29)15-30-19-6-3-17(24)4-7-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
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n/an/a 58n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 2.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 29n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172432
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
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n/an/a 5.90n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a 21n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 770n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 25n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 16n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 28n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 74n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150710
PNG
(2-(4-Chloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)...)
Show SMILES CCN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C24H27ClN4O2/c1-3-28-10-12-29(13-11-28)23-14-17(2)21-15-19(6-9-22(21)27-23)26-24(30)16-31-20-7-4-18(25)5-8-20/h4-9,14-15H,3,10-13,16H2,1-2H3,(H,26,30)
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n/an/a 22n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 6.10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172413
PNG
(2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-...)
Show SMILES CNCCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14-10-21(28(3)9-8-25-2)27-19-6-5-16(12-17(14)19)26-22(29)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12,25H,8-9,13H2,1-3H3,(H,26,29)
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n/an/a 6.90n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172432
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
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n/an/a 4.5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172432
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
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n/an/a 66n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a 109n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a>10n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a 8.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 5n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a 6.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50172440
PNG
(2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1...)
Show SMILES Cc1cc(nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12)N1CCNCC1
Show InChI InChI=1S/C22H22Cl2N4O2/c1-14-10-21(28-8-6-25-7-9-28)27-19-4-3-16(12-17(14)19)26-22(29)13-30-20-5-2-15(23)11-18(20)24/h2-5,10-12,25H,6-9,13H2,1H3,(H,26,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50172432
PNG
(2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-et...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30)
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n/an/a 9.40n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a 24n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cells


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a 89n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositol


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50150709
PNG
(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C23H24Cl2N4O2/c1-15-11-22(29-9-7-28(2)8-10-29)27-20-5-4-17(13-18(15)20)26-23(30)14-31-21-6-3-16(24)12-19(21)25/h3-6,11-13H,7-10,14H2,1-2H3,(H,26,30)
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n/an/a 610n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50172438
PNG
(CHEMBL194691 | N-{2-[(1-Ethyl-pyrrolidin-2-ylmethy...)
Show SMILES CCN1CCCC1CNc1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C26H29F3N4O3/c1-3-33-12-4-5-19(33)15-30-24-13-17(2)22-14-18(6-11-23(22)32-24)31-25(34)16-35-20-7-9-21(10-8-20)36-26(27,28)29/h6-11,13-14,19H,3-5,12,15-16H2,1-2H3,(H,30,32)(H,31,34)
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n/an/a 4.70E+3n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergine


J Med Chem 48: 5684-97 (2005)


Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177273
PNG
((S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 33n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 83n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 2.30n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from human MCH1 receptor expressed in CHO cell by WC assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177273
PNG
((S)-N-(4-methyl-2-(3-methylpiperazin-1-yl)quinolin...)
Show SMILES C[C@H]1CN(CCN1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-15-11-22(31-10-9-28-16(2)13-31)30-21-8-3-17(12-20(15)21)29-23(32)14-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,11-12,16,28H,9-10,13-14H2,1-2H3,(H,29,32)/t16-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50177278
PNG
(2-(4-chlorophenoxy)-N-(2-((2-(dimethylamino)ethyl)...)
Show SMILES CN(C)CCN(C)c1cc(C)c2cc(NC(=O)COc3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C23H27ClN4O2/c1-16-13-22(28(4)12-11-27(2)3)26-21-10-7-18(14-20(16)21)25-23(29)15-30-19-8-5-17(24)6-9-19/h5-10,13-14H,11-12,15H2,1-4H3,(H,25,29)
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n/an/a 807n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 29n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Inhibition of human MCH1 receptor by SPA assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50150073
PNG
(CHEMBL184084 | N-(4-methyl-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1cc(C)c2cc(NC(=O)COc3ccc(OC(F)(F)F)cc3)ccc2n1
Show InChI InChI=1S/C24H25F3N4O3/c1-16-13-22(31-11-9-30(2)10-12-31)29-21-8-3-17(14-20(16)21)28-23(32)15-33-18-4-6-19(7-5-18)34-24(25,26)27/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,32)
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n/an/a 25n/an/an/an/an/an/a



7TM Pharma A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]myo-inositol from human MCH1 receptor expressed in CHO cell by IP3 assay


Bioorg Med Chem Lett 16: 1070-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.066
BindingDB Entry DOI: 10.7270/Q2G73D82
More data for this
Ligand-Target Pair
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