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8 similar compounds to monomer 50153073

Wt: 469.5
BDBM50153067
Wt: 485.6
BDBM50153048
Wt: 480.6
BDBM50153062
Wt: 453.5
BDBM50153059
Wt: 486.6
BDBM50153050
Wt: 428.5
BDBM50153052
Wt: 457.5
BDBM50153053
Wt: 446.5
BDBM50153071

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50153067,50153048,50153062,50153059,50153050,50153052,50153053,50153071   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor XI


(Homo sapiens (human))
BDBM50153067
PNG
(CHEMBL3781202)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N[C@H](Cc1ccccc1)c1cc(ccn1)-c1ccc2c(N)noc2c1
Show InChI InChI=1/C28H31N5O2/c29-17-19-6-8-20(9-7-19)28(34)32-25(14-18-4-2-1-3-5-18)24-15-22(12-13-31-24)21-10-11-23-26(16-21)35-33-27(23)30/h1-5,10-13,15-16,19-20,25H,6-9,14,17,29H2,(H2,30,33)(H,32,34)/t19-,20-,25-/s2
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PubMed
3.20n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153062
PNG
(CHEMBL3781505)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)NC(Cc1ccccc1)c1cc(ccn1)-c1ccc2c(N)ncnc2c1
Show InChI InChI=1/C29H32N6O/c30-17-20-6-8-21(9-7-20)29(36)35-27(14-19-4-2-1-3-5-19)26-16-23(12-13-32-26)22-10-11-24-25(15-22)33-18-34-28(24)31/h1-5,10-13,15-16,18,20-21,27H,6-9,14,17,30H2,(H,35,36)(H2,31,33,34)/t20-,21-,27?
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10n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153050
PNG
(CHEMBL3781580)
Show SMILES COC(=O)Nc1ccc(cc1)-c1ccnc(c1)C(Cc1ccccc1)NC(=O)[C@H]1CC[C@H](CN)CC1
Show InChI InChI=1/C29H34N4O3/c1-36-29(35)32-25-13-11-22(12-14-25)24-15-16-31-26(18-24)27(17-20-5-3-2-4-6-20)33-28(34)23-9-7-21(19-30)8-10-23/h2-6,11-16,18,21,23,27H,7-10,17,19,30H2,1H3,(H,32,35)(H,33,34)/t21-,23-,27?
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12n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153048
PNG
(CHEMBL3780127)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cccc(c1)[C@H](Cc1ccccc1)NC(=O)[C@H]1CC[C@H](CN)CC1
Show InChI InChI=1/C30H35N3O3/c1-36-30(35)32-27-16-14-23(15-17-27)25-8-5-9-26(19-25)28(18-21-6-3-2-4-7-21)33-29(34)24-12-10-22(20-31)11-13-24/h2-9,14-17,19,22,24,28H,10-13,18,20,31H2,1H3,(H,32,35)(H,33,34)/t22-,24-,28-/s2
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17n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153052
PNG
(CHEMBL3781981)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)NC(Cc1ccccc1)c1cc(ccn1)-c1ccc(N)cc1
Show InChI InChI=1/C27H32N4O/c28-18-20-6-8-22(9-7-20)27(32)31-26(16-19-4-2-1-3-5-19)25-17-23(14-15-30-25)21-10-12-24(29)13-11-21/h1-5,10-15,17,20,22,26H,6-9,16,18,28-29H2,(H,31,32)/t20-,22-,26?
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56n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153059
PNG
(CHEMBL3780930)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)NC(Cc1ccccc1)c1cc(ccn1)-c1ccc2[nH]ncc2c1
Show InChI InChI=1/C28H31N5O/c29-17-20-6-8-21(9-7-20)28(34)32-27(14-19-4-2-1-3-5-19)26-16-23(12-13-30-26)22-10-11-25-24(15-22)18-31-33-25/h1-5,10-13,15-16,18,20-21,27H,6-9,14,17,29H2,(H,31,33)(H,32,34)/t20-,21-,27?
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61n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (human))
BDBM50153053
PNG
(CHEMBL3780389)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)NC(Cc1ccccc1)c1cc(ccn1)-c1cccc(c1)C(O)=O
Show InChI InChI=1/C28H31N3O3/c29-18-20-9-11-21(12-10-20)27(32)31-26(15-19-5-2-1-3-6-19)25-17-23(13-14-30-25)22-7-4-8-24(16-22)28(33)34/h1-8,13-14,16-17,20-21,26H,9-12,15,18,29H2,(H,31,32)(H,33,34)/t20-,21-,26?
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205n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Competitive inhibition of human coagulation factor 11a assessed as reduction in release of p-nitroaniline after 10 to 120 mins by Michaelis-Menten eq...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5C


(Homo sapiens)
BDBM50153071
PNG
(CHEMBL3775130)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(Cc3noc(n3)C3CC3)CC2)cn1
Show InChI InChI=1S/C23H26N8O2/c32-22-18-3-7-24-21(20(18)25-14-26-22)31-13-16(12-27-31)6-10-30-8-4-15(5-9-30)11-19-28-23(33-29-19)17-1-2-17/h3,7,12-15,17H,1-2,4-6,8-11H2,(H,25,26,32)
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n/an/a 57n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4B


(Homo sapiens)
BDBM50153071
PNG
(CHEMBL3775130)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(Cc3noc(n3)C3CC3)CC2)cn1
Show InChI InChI=1S/C23H26N8O2/c32-22-18-3-7-24-21(20(18)25-14-26-22)31-13-16(12-27-31)6-10-30-8-4-15(5-9-30)11-19-28-23(33-29-19)17-1-2-17/h3,7,12-15,17H,1-2,4-6,8-11H2,(H,25,26,32)
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n/an/a 247n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotin-H3K9me3 as s...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B (KDM5Flag-5B-FL)


(Homo sapiens (Human))
BDBM50153071
PNG
(CHEMBL3775130)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(Cc3noc(n3)C3CC3)CC2)cn1
Show InChI InChI=1S/C23H26N8O2/c32-22-18-3-7-24-21(20(18)25-14-26-22)31-13-16(12-27-31)6-10-30-8-4-15(5-9-30)11-19-28-23(33-29-19)17-1-2-17/h3,7,12-15,17H,1-2,4-6,8-11H2,(H,25,26,32)
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n/an/a 43n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4A


(Homo sapiens (Human))
BDBM50153071
PNG
(CHEMBL3775130)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(Cc3noc(n3)C3CC3)CC2)cn1
Show InChI InChI=1S/C23H26N8O2/c32-22-18-3-7-24-21(20(18)25-14-26-22)31-13-16(12-27-31)6-10-30-8-4-15(5-9-30)11-19-28-23(33-29-19)17-1-2-17/h3,7,12-15,17H,1-2,4-6,8-11H2,(H,25,26,32)
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n/an/a 770n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


Citation and Details
More data for this
Ligand-Target Pair